Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129847-250mg | 250mg | In stock | $39.90 | |
D129847-1g | 1g | In stock | $129.90 | |
D129847-5g | 5g | In stock | $585.90 | |
D129847-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,632.90 |
DNA alkylating agent. Chemotherapeutic.
Synonyms | DTIC | 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)- | Dicarbazine | Tox21_201010 | (E)-Dacarbazine | 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | Carboxamide, Dimethyl Imidazole | Dacarbazine (DTIC-Dome) | Dakarbazin | Dimethyltria |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | DNA alkylating agent. Chemotherapeutic. Induces cell cycle arrest and cell death in vitro and in vivo . Crosses the blood-brain barrier. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | -0.6 |
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IUPAC Name | 4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide |
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INCHI | InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+ |
InChi Key | FDKXTQMXEQVLRF-ZHACJKMWSA-N |
Canonical SMILES | CN(C)N=NC1=C(NC=N1)C(=O)N |
Isomeric SMILES | CN(C)/N=N/C1=C(NC=N1)C(=O)N |
RTECS | NI3950000 |
PubChem CID | 135398738 |
Molecular Weight | 182.18 |
Reaxy-Rn | 521487 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Chart | Certificate Type | Date | Item |
---|---|---|---|---|
F1510006 | Certificate of Analysis | Jan 16, 2023 | D129847 | |
D2411083 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
H2402040 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
I2215189 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
I2215190 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
I2215191 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
I2215192 | Certificate of Analysis | Jul 08, 2022 | D129847 | |
J2430120 | Certificate of Analysis | Jul 08, 2022 | D129847 |
Solubility | Slightly soluble in water or ethanol |
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Sensitivity | Light & Heat sensitive |
Melt Point(°C) | 255°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H340:May cause genetic defects H350:May cause cancer H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
RTECS | NI3950000 |
Reaxy-Rn | 521487 |
Merck Index | 2798 |
1. Pan Li, Chun Hui Liu, Yan Yan Zhao, Da Dong Cao, Bo Zhi Chen, Xin Dong Guo, Weifen Zhang. (2023) Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment. BIOMACROMOLECULES, [PMID:37475132] [10.1021/acs.biomac.3c00488] |
2. Jingyi Zhu, Xiangning Li, Wenling Gao, Jian Jing. (2023) Integrin Targeting Enhances the Antimelanoma Effect of Annexin V in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (4): (3859). [PMID:36835282] [10.3390/ijms24043859] |
3. Jia Li, Bo-Xiang Wang, De-Hong Cheng, Yue Zhang, Qiang Yao, Xin-bin Ji, Jing Guo, Yan-Hua Lu. (2023) An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems. Gels, 9 (1): (4). [PMID:36661772] [10.3390/gels9010004] |
4. Bei Bei Zhou, Dan Liu, Jia Cheng Qian, Ren Xiang Tan. (2022) Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics. PHYTOTHERAPY RESEARCH, 36 (11): (4278-4292). [PMID:35883268] [10.1002/ptr.7565] |
5. Dong Zhang, Weifen Zhang, Xinghan Wu, Qian Li, Zhiyi Mu, Fengshuo Sun, Mogen Zhang, Guoyan Liu, Linlin Hu. (2021) Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy. International Journal of Nanomedicine, 16 ( 3457–3472). [PMID:34045853] [10.2147/IJN.S306269] |
1. Pan Li, Chun Hui Liu, Yan Yan Zhao, Da Dong Cao, Bo Zhi Chen, Xin Dong Guo, Weifen Zhang. (2023) Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment. BIOMACROMOLECULES, [PMID:37475132] [10.1021/acs.biomac.3c00488] |
2. Jingyi Zhu, Xiangning Li, Wenling Gao, Jian Jing. (2023) Integrin Targeting Enhances the Antimelanoma Effect of Annexin V in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (4): (3859). [PMID:36835282] [10.3390/ijms24043859] |
3. Jia Li, Bo-Xiang Wang, De-Hong Cheng, Yue Zhang, Qiang Yao, Xin-bin Ji, Jing Guo, Yan-Hua Lu. (2023) An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems. Gels, 9 (1): (4). [PMID:36661772] [10.3390/gels9010004] |
4. Bei Bei Zhou, Dan Liu, Jia Cheng Qian, Ren Xiang Tan. (2022) Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics. PHYTOTHERAPY RESEARCH, 36 (11): (4278-4292). [PMID:35883268] [10.1002/ptr.7565] |
5. Dong Zhang, Weifen Zhang, Xinghan Wu, Qian Li, Zhiyi Mu, Fengshuo Sun, Mogen Zhang, Guoyan Liu, Linlin Hu. (2021) Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy. International Journal of Nanomedicine, 16 ( 3457–3472). [PMID:34045853] [10.2147/IJN.S306269] |