Dacomitinib (PF299804, PF299) - ≥99%, high purity , Receptor protein-tyrosine kinase erbB-4 inhibitor, CAS No.1110813-31-4, Receptor protein-tyrosine kinase erbB-4 inhibitor

Item Number

D129347

• Synonyms: Dacomitinib | 1110813-31-4 | PF-00299804 | PF299804 | Dacomitinib (PF299804, PF299) | (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide | Dacomitinib anhydrous | (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-qu
• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: Potent irreversible pan ErbB inhibitor (IC50values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively). Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant toIres
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Receptor protein-tyrosine kinase erbB-4 inhibitor
• Note: 5mg、50mg、10mg卖完停产，不再备货

Product Description

PF-299804 is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM, effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation.
A potent and selective inhibitor of EGFR and ERBB phosphorylation.