Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D106438-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
D106438-5g | 5g | In stock | $227.90 | |
D106438-25g | 25g | In stock | $830.90 |
Phytoestrogen
Synonyms | Diadzein | KBioSS_000735 | 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | NPI 031E | Spectrum5_000857 | d-(+)-alpha-methylbenzyl amine | Spectrum2_000053 | HMS3261C06 | BSPBio_001741 | Daidzein (Standard) | GTPL2828 | LMPK12050038 | DAIDZEIN [MART. |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Daidzein is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. Arrests cell cycle at G1 in Swiss 3T3 cells.Phytoestrogen, and soy isoflavone. Analog of genistein . Various biological actions, including a weak estrogeni |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR, AGONIST |
Mechanism of action | Agonist of Estrogen-related receptor-α;Agonist of Estrogen-related receptor-β;Agonist of Estrogen-related receptor-γ;Activator of TRPC5 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one |
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INCHI | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H |
InChi Key | ZQSIJRDFPHDXIC-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O |
Isomeric SMILES | C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O |
WGK Germany | 3 |
RTECS | DJ3100040 |
PubChem CID | 5281708 |
Molecular Weight | 254.24 |
Beilstein | 231523 |
PubChem CID | 5281708 |
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BindingDB Ligand | 23420 |
Wikipedia | Daidzein |
ChEBI | CHEBI:28197 |
CAS Registry No. | 486-66-8 |
ChEMBL Ligand | CHEMBL8145 |
NURSA Ligand | 10.1621/IPLF9AY27L |
RCSB PDB Ligand | ZF1 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L1616007 | Certificate of Analysis | Jul 03, 2024 | D106438 |
A2403216 | Certificate of Analysis | Dec 18, 2023 | D106438 |
A2403217 | Certificate of Analysis | Dec 18, 2023 | D106438 |
C1907028 | Certificate of Analysis | Dec 14, 2022 | D106438 |
J1429032 | Certificate of Analysis | Jun 28, 2022 | D106438 |
C2219318 | Certificate of Analysis | Feb 23, 2022 | D106438 |
C2219320 | Certificate of Analysis | Feb 23, 2022 | D106438 |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DJ3100040 |
Merck Index | 2801 |
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1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010] |
2. Wei Zhang, Hui Li, Weihong Cao, Zhenghong Guo, Zhengping Fang, Juan Li, Peng Chen. (2023) A key role of a bio-based charring-coupling agent in flame retardant and anti-dripping performance of polyamide 6/aluminum diethylphosphinate. JOURNAL OF APPLIED POLYMER SCIENCE, 140 (34): (e54327). [PMID:] |
3. Qin Yuan, Meng Fuliang, Xu Chunyu, Hu Zhenguo, Zhang Yimiao, Jia Yufei, Li Songjun, Yuan Xinhua. (2023) Preparation and Performance of Novel Flavonoid Phenols-Based Biomass-Modified Phenol Formaldehyde Resins. Journal of Inorganic and Organometallic Polymers and Materials, 33 (7): (1817-1829). [PMID:] |
4. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] |
5. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] |
6. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] |
7. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558] |
8. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046] |
9. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] |
10. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei. (2022) Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. PROCESS BIOCHEMISTRY, 113 (150). [PMID:] |
11. Yonggang Du, Ge Zhao, Gonghui Shi, Yiming Wang, Wei Li, Shitong Ren. (2022) Effect of crosslink structure on mechanical properties, thermal stability and flame retardancy of natural flavonoid based epoxy resins. EUROPEAN POLYMER JOURNAL, 162 (110898). [PMID:] |
12. Zhou Lu, Yat-Tin Chan, Kenneth Ka-Hei Lo, Vincy Wing-Si Wong, Yuk-Fan Ng, Shi-Ying Li, Wing-Wa Ho, Man-Sau Wong, Danyue Zhao. (2021) Levels of polyphenols and phenolic metabolites in breast milk and their association with plant-based food intake in Hong Kong lactating women. Food & Function, 12 (24): (12683-12695). [PMID:34825914] |
13. Yufan Zhu, Zhiqiang Yang, Yuanlong Xie, Min Yang, Yufeng Zhang, Zhouming Deng, Lin Cai. (2021) Investigation of inhibition effect of daidzein on osteosarcoma cells based on experimental validation and systematic pharmacology analysis. PeerJ, 9 (e12072). [PMID:34540371] |
14. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang. (2020) The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract. Foods, 9 (12): (1816). [PMID:33297502] |
15. Yu-ting Li, Ming-shun Chen, Li-zhen Deng, Ya-zhen Liang, Yi-kun Liu, Wei Liu, Jun Chen, Cheng-mei Liu. (2021) Whole soybean milk produced by a novel industry-scale micofluidizer system without soaking and filtering. JOURNAL OF FOOD ENGINEERING, 291 (110228). [PMID:] |
16. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] |
17. Lizhen Liu, Zhi Mi, Ziying Guo, Junling Wang, Feng Feng. (2020) A label-free fluorescent sensor based on carbon quantum dots with enhanced sensitive for the determination of myricetin in real samples. MICROCHEMICAL JOURNAL, 157 (104956). [PMID:] |
18. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] |
19. Yujuan Zhang, Jinhu Huang, Xiangxiu Li, Ci Fang, Liping Wang. (2020) Identification of Functional Transcriptional Binding Sites within Chicken Abcg2 Gene Promoter and Screening Its Regulators. Genes, 11 (2): (186). [PMID:32050731] |
20. Xianli Gao, Ermeng Liu, Junke Zhang, Mingquan Yang, Sui Chen, Zhan Liu, Haile Ma, Feng Hu. (2019) Effects of sonication during moromi fermentation on antioxidant activities of compounds in raw soy sauce. LWT-FOOD SCIENCE AND TECHNOLOGY, 116 (108605). [PMID:] |
21. Xiaonan Zhang, Hongwei Zhang, Xinghao Xia, Nan Pu, Zhuping Yu, Mourtada Nabih, Ying Zhu, Shuang Zhang, Lianzhou Jiang. (2019) Preparation and physicochemical characterization of soy isoflavone (SIF) nanoparticles by a liquid antisolvent precipitation method. ADVANCED POWDER TECHNOLOGY, 30 (1522). [PMID:] |
22. Xingyu Hou, Wei Huang, Fugui Zhu, Fang Geng, Miaomiao Tian. (2019) A new boronate-affinity hollow solid phase extraction adsorbent for the enrichment of cis-diol-containing isoflavones in soybean milk samples. Analytical Methods, 11 (3): (317-326). [PMID:] |
23. Binle Zhang, Zixuan Yang, Weining Huang, Jacob Ojobi Omedi, Feng Wang, Qibo Zou, Jianxin Zheng. (2018) Isoflavone aglycones enrichment in soybean sourdough bread fermented by lactic acid bacteria strains isolated from traditional Qu starters: Effects on in vitro gastrointestinal digestion, nutritional, and baking properties. CEREAL CHEMISTRY, 96 (1): (129-141). [PMID:] |
24. Hui Wang, Wenxi Zhang, Yatao Cheng, Xinyu Zhang, Nannan Xue, Gaorong Wu, Meng Chen, Kang Fang, Wenbo Guo, Fei Zhou, Herong Cui, Tao Ma, Penglong Wang, Haimin Lei. (2018) Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents. MOLECULES, 23 (9): (2187). [PMID:30200208] |
25. Jinyue Dai, Yunyan Peng, Na Teng, Yuan Liu, Chuanchuan Liu, Xiaobin Shen, Sakil Mahmud, Jin Zhu, Xiaoqing Liu. (2018) High-Performing and Fire-Resistant Biobased Epoxy Resin from Renewable Sources. ACS Sustainable Chemistry & Engineering, 6 (6): (7589–7599). [PMID:] |
26. Hu Yue, Xia Qinfei, Huang Wei, Hou Xingyu, Tian Miaomiao. (2018) Boronate-modified hollow molecularly imprinted polymers for selective enrichment of glycosides. MICROCHIMICA ACTA, 185 (1): (1-9). [PMID:29594569] |
27. Shujing Li, Li Yuan, Yong Chen, Wei Zhou, Xinrui Wang. (2017) Studies on the Inclusion Complexes of Daidzein with β-Cyclodextrin and Derivatives. MOLECULES, 22 (12): (2183). [PMID:29292784] |
28. Zhongxiang Xiao, Chang Le, Zhenghao Xu, Zhefeng Gu, Junfei Lv, Imran Haider Shamsi. (2017) Vertical Leaching of Allelochemicals Affecting Their Bioactivity and the Microbial Community of Soil. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65 (36): (7847–7853). [PMID:28800227] |
29. Ying-Hui DENG, Li-Na SU, Yan-Hua PANG, Ya-Fei GUO, Fen WANG, Xia-Li LIAO, Bo YANG. (2017) Preparation, Characterization and Water Solubility of Inclusion Complexes of Daidzein with Amino-Modified β-Cyclodextrins. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 45 (648). [PMID:] |
30. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, 32 (296). [PMID:] |
31. Yamin Fu, Lu Wang, Yinghao Duan, Lina Zou, Baoxian Ye. (2017) Facile synthesized SnO2 decorated functionalized graphene modified electrode for sensitive determination of daidzein. TALANTA, 168 (1). [PMID:28391825] |
32. Yinghui Deng, Yanhua Pang, Yafei Guo, Yufeng Ren, Fen Wang, Xiali Liao, Bo Yang. (2016) Host-guest inclusion systems of daidzein with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD): Preparation, binding behaviors and water solubility. JOURNAL OF MOLECULAR STRUCTURE, 1118 (307). [PMID:] |
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