Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Daidzein Daidzein is a natural isoflavone phytoestrogen found in Leguminosae, used as a component of foods and dietary supplements. Daidzein is a soy isoflavone, which acts as a PPAR activator. In vitro Daidzein inhibits iNOS protein and mRNA expression and also NO production in a dose-dependent manner. Daidzein also inhibits the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. Daidzein (1 μM and 10 μM) causes a significant elevation of protein content, alkaline phosphatase activity, and DNA content in cells; those increases are about 1.4-, 1.5-, and 2.0-fold, respectively. Daidzein (2-50 mM) increases the viability of osteoblasts by about 1.4-fold. Daidzein (2-100 mM) increases the alkaline phosphatase activity and osteocalcin synthesis of osteoblasts by about 1.4- and 2.0-fold, respectively. Daidzein stimulates osteoblast differentiation at various stages (from osteoprogenitors to terminally differentiated osteoblasts). Daidzein (1 μM and 10 μM) causes a significant increase of alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in bone tissues. Daidzein-induced increase of calcium content and alkaline phosphatase activity in bone tissues is completely prevented by cycloheximide (1 μM). In vivo Daidzein results in reduced body weight, a fact that may be explained by reduced feed consumption in female rats. Daidzein results in slight, but not significant, decreases in ovarian and uterine weights, and mammary gland size in female rats. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

Associated Targets(Human)

CA4 Tclin Carbonic anhydrase 4 (1 Activities)

Discover Target: CA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 (1 Activities)

Discover Target: CA12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA7 Tclin Carbonic anhydrase 7 (1 Activities)

Discover Target: CA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Canonical SMILES	OC1=CC=C(C=C1)C2=COC3=CC(=CC=C3C2=O)O
Molecular Weight	254.24

Certificates

Certificate of Analysis(COA)

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Citations of This Product

1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010]
2. Wei Zhang, Hui Li, Weihong Cao, Zhenghong Guo, Zhengping Fang, Juan Li, Peng Chen. (2023) A key role of a bio-based charring-coupling agent in flame retardant and anti-dripping performance of polyamide 6/aluminum diethylphosphinate. JOURNAL OF APPLIED POLYMER SCIENCE, 140 (34): (e54327). [PMID:]
3. Qin Yuan, Meng Fuliang, Xu Chunyu, Hu Zhenguo, Zhang Yimiao, Jia Yufei, Li Songjun, Yuan Xinhua. (2023) Preparation and Performance of Novel Flavonoid Phenols-Based Biomass-Modified Phenol Formaldehyde Resins. Journal of Inorganic and Organometallic Polymers and Materials, 33 (7): (1817-1829). [PMID:]
4. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705]
5. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100]
6. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340]
7. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558]
8. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046]
9. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372]
10. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei. (2022) Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. PROCESS BIOCHEMISTRY, 113 (150). [PMID:]
11. Yonggang Du, Ge Zhao, Gonghui Shi, Yiming Wang, Wei Li, Shitong Ren. (2022) Effect of crosslink structure on mechanical properties, thermal stability and flame retardancy of natural flavonoid based epoxy resins. EUROPEAN POLYMER JOURNAL, 162 (110898). [PMID:]
12. Zhou Lu, Yat-Tin Chan, Kenneth Ka-Hei Lo, Vincy Wing-Si Wong, Yuk-Fan Ng, Shi-Ying Li, Wing-Wa Ho, Man-Sau Wong, Danyue Zhao. (2021) Levels of polyphenols and phenolic metabolites in breast milk and their association with plant-based food intake in Hong Kong lactating women. Food & Function, 12 (24): (12683-12695). [PMID:34825914]

References

1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010]
2. Wei Zhang, Hui Li, Weihong Cao, Zhenghong Guo, Zhengping Fang, Juan Li, Peng Chen. (2023) A key role of a bio-based charring-coupling agent in flame retardant and anti-dripping performance of polyamide 6/aluminum diethylphosphinate. JOURNAL OF APPLIED POLYMER SCIENCE, 140 (34): (e54327). [PMID:]
3. Qin Yuan, Meng Fuliang, Xu Chunyu, Hu Zhenguo, Zhang Yimiao, Jia Yufei, Li Songjun, Yuan Xinhua. (2023) Preparation and Performance of Novel Flavonoid Phenols-Based Biomass-Modified Phenol Formaldehyde Resins. Journal of Inorganic and Organometallic Polymers and Materials, 33 (7): (1817-1829). [PMID:]
4. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705]
5. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100]
6. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340]
7. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558]
8. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046]
9. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372]
10. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei. (2022) Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk. PROCESS BIOCHEMISTRY, 113 (150). [PMID:]
11. Yonggang Du, Ge Zhao, Gonghui Shi, Yiming Wang, Wei Li, Shitong Ren. (2022) Effect of crosslink structure on mechanical properties, thermal stability and flame retardancy of natural flavonoid based epoxy resins. EUROPEAN POLYMER JOURNAL, 162 (110898). [PMID:]
12. Zhou Lu, Yat-Tin Chan, Kenneth Ka-Hei Lo, Vincy Wing-Si Wong, Yuk-Fan Ng, Shi-Ying Li, Wing-Wa Ho, Man-Sau Wong, Danyue Zhao. (2021) Levels of polyphenols and phenolic metabolites in breast milk and their association with plant-based food intake in Hong Kong lactating women. Food & Function, 12 (24): (12683-12695). [PMID:34825914]

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Daidzein - 10mM in DMSO, high purity , CAS No.486-66-8(DMSO)