Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D275414-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $53.90 | |
D275414-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $97.90 | |
D275414-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $369.90 | |
D275414-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $666.90 |
Potent and selective μ opioid receptor agonist
Synonyms | HB2409 | H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol | Tyr-D-Ala-Gly-N(CH3)Phe-Gly-ol | (2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide | 158: PN: US20030176421 PAGE: 54 |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Potent and selective μ opioid receptor agonist (K i values are 2.0, >1000 and >1000 nM for opioid receptor subtypes μ, κ and δ, respectively). Partial central activity following systemic administration. Antinociceptive. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of κ receptor;Agonist of μ receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | (2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide |
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INCHI | InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1 |
InChi Key | HPZJMUBDEAMBFI-WTNAPCKOSA-N |
Canonical SMILES | CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N |
Isomeric SMILES | C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N |
PubChem CID | 5462471 |
Molecular Weight | 513.59 |
PubChem CID | 5462471 |
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Wikipedia | DAMGO |
ChEMBL Ligand | CHEMBL38874 |
BindingDB Ligand | 21015 |
CAS Registry No. | 78123-71-4 |
GPCRdb Ligand | DAMGO |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2110375 | Certificate of Analysis | Jun 14, 2023 | D275414 |
K2110376 | Certificate of Analysis | Sep 09, 2022 | D275414 |
K2111140 | Certificate of Analysis | Sep 09, 2022 | D275414 |
K2111141 | Certificate of Analysis | Sep 09, 2022 | D275414 |
Solubility | Soluble in water to 1 mg/ml |
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1. Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4): (644-657.e6). [PMID:34998469] |
2. Copits BA et al.. (2021) A photoswitchable GPCR-based opsin for presynaptic inhibition.. Neuron, 109 (11): (1791-1809.e11). [PMID:33979635] |
3. Bull FA et al.. (2017) Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src.. Sci Rep, 7 (9969). [PMID:28855588] |
4. Bachmutsky I et al.. (2020) Opioids depress breathing through two small brainstem sites.. Elife, 9 [PMID:32073401] |