Potent and selective μ opioid receptor agonist (K i values are 2.0, >1000 and >1000 nM for opioid receptor subtypes μ, κ and δ, respectively). Partial central activity following systemic administration. Antinociceptive.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of κ receptor;Agonist of μ receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4):(644-657.e6). [PMID:34998469]
2.Copits BA et al.. (2021) A photoswitchable GPCR-based opsin for presynaptic inhibition.. Neuron, 109 (11):(1791-1809.e11). [PMID:33979635]
3.Bull FA et al.. (2017) Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by ß-arrestin2 and c-Src.. Sci Rep, 7 (9969). [PMID:28855588]
4.Bachmutsky I et al.. (2020) Opioids depress breathing through two small brainstem sites.. Elife, 9 [PMID:32073401]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
K2110375