Daminozide - 99%, high purity , CAS No.1596-84-5, Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8
Daminozide - 99%, high purity , CAS No.1596-84-5, Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8
Description: IC50 Value: N/A Inhibition of shoot elongation in dwarf and tall peas by the 1,1-dimethylhydrazide of succinic acid (B-995) was correlated with the inhibition of the oxidation of tryptamine-2-C(14) to indoleacetaldehyde-2-C(14) in homogenates
Storage Temp
Argon charged
Shipped In
Normal
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Introduction
Daminozide is a commonly used plant growth regulator, which acts by inhibiting 2-oxoglutarate-dependent dioxygenase activity in the gibberellin biosynthesis pathway.
Application
Daminozide may be used as a reference standard for the determination of daminozide in fruits and vegetables by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). It may also be used as a reference standard for the determination of daminozide in Ophiopogon japonicus plants and soil by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS). Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
1.Pengshuai Zhang, Jixiu Deng, Xiaoyu Jiang, Liang Xu, Yu Huang, Han Sun, Mi Gao, Xianghan Wang, Yulong Gao, Kangning Fan, Lu Zhang, Shuoye Yang. (2024) Equilibrium solubility and thermodynamic study of daminozide in twelve neat solvents from (283.15 to 323.15) K. JOURNAL OF CHEMICAL THERMODYNAMICS, 189 (30):(107202). [PMID:19762596][10.1016/j.jct.2023.107202]
2.Linlu Shen, Hongyi Wang, Jing Kang, Jimin Shen, Pengwei Yan, Yingxu Gong, Jiaxu Zhang, Gang Fu, Shuyu Wang, Yizhen Cheng, Shengxin Zhao, Zhonglin Chen. (2023) Simultaneous elimination of N,N-dimethylhydrazine compounds and its oxidation by-product N-nitrosodimethylamine by UV-activated peroxymonosulfate process: Multiple-path mechanism validation and toxicity alteration. CHEMICAL ENGINEERING JOURNAL, 474 (15):(145837). [PMID:19010891][10.1016/j.cej.2023.145837]
References
1.Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.. J Med Chem, 55 (14):(6639-43). [PMID:22724510][10.1021/op500134e]
2.Pengshuai Zhang, Jixiu Deng, Xiaoyu Jiang, Liang Xu, Yu Huang, Han Sun, Mi Gao, Xianghan Wang, Yulong Gao, Kangning Fan, Lu Zhang, Shuoye Yang. (2024) Equilibrium solubility and thermodynamic study of daminozide in twelve neat solvents from (283.15 to 323.15) K. JOURNAL OF CHEMICAL THERMODYNAMICS, 189 (30):(107202). [PMID:19762596][10.1016/j.jct.2023.107202]
3.Linlu Shen, Hongyi Wang, Jing Kang, Jimin Shen, Pengwei Yan, Yingxu Gong, Jiaxu Zhang, Gang Fu, Shuyu Wang, Yizhen Cheng, Shengxin Zhao, Zhonglin Chen. (2023) Simultaneous elimination of N,N-dimethylhydrazine compounds and its oxidation by-product N-nitrosodimethylamine by UV-activated peroxymonosulfate process: Multiple-path mechanism validation and toxicity alteration. CHEMICAL ENGINEERING JOURNAL, 474 (15):(145837). [PMID:19010891][10.1016/j.cej.2023.145837]
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