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D105966-250mg

250mg

Available within 4-8 weeks(?)

$55.90

Basic Description

Synonyms	Daminozide \| 1596-84-5 \| Aminozide \| Succinic acid 2,2-dimethylhydrazide \| ALAR \| DMASA \| Kylar \| N-(Dimethylamino)succinamic acid \| Dimas \| SADH \| B-Nine \| DYaK \| Butanedioic acid, mono(2,2-dimethylhydrazide) \| Alar 85 \| Dimethylaminosuccinamic acid \| 4-(2,2-dimethylhydrazinyl)-4-oxo
Specifications & Purity	Moligand™, analytical standard
Biochemical and Physiological Mechanisms	Description: IC50 Value: N/A Inhibition of shoot elongation in dwarf and tall peas by the 1,1-dimethylhydrazide of succinic acid (B-995) was correlated with the inhibition of the oxidation of tryptamine-2-C(14) to indoleacetaldehyde-2-C(1
Shipped In	Normal
Grade	analytical standard, Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8

Associated Targets(Human)

PHF8 Tchem Histone lysine demethylase PHF8 (3 Activities)

Discover Target: PHF8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM7A Tchem Lysine-specific demethylase 7A (1 Activities)

Discover Target: KDM7A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM2A Tchem Lysine-specific demethylase 2A (1 Activities)

Discover Target: KDM2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGLN1 Tclin Egl nine homolog 1 (1702 Activities)

Discover Target: EGLN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HIF1AN Tbio Hypoxia-inducible factor 1-alpha inhibitor (79 Activities)

Discover Target: HIF1AN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)

Discover Target: KDM4C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)

Discover Target: KDM2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)

Discover Target: KDM6B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PHF8 Tchem Histone lysine demethylase PHF8 (151 Activities)

Discover Target: PHF8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6A Tchem Lysine-specific demethylase 6A (39 Activities)

Discover Target: KDM6A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BBOX1 Tchem Gamma-butyrobetaine dioxygenase (162 Activities)

Discover Target: BBOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)

Discover Target: KDM5C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM7A Tchem Lysine-specific demethylase 7 (35 Activities)

Discover Target: KDM7A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5A Tchem Lysine-specific demethylase 5A (893 Activities)

Discover Target: KDM5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A085R Prolyl 4-hydroxylase (72 Activities)

Discover Target: A085R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid
INCHI	InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
InChi Key	NOQGZXFMHARMLW-UHFFFAOYSA-N
Canonical SMILES	CN(C)NC(=O)CCC(=O)O
Isomeric SMILES	CN(C)NC(=O)CCC(=O)O
WGK Germany	2
RTECS	WM9625000
PubChem CID	15331
Molecular Weight	160.17
Beilstein	1863230
Reaxy-Rn	1863230

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
I1803030	Certificate of Analysis	Apr 27, 2022	D105966

Chemical and Physical Properties

Solubility	Soluble in water, insoluble in hydrocarbons.
Melt Point(°C)	154-155°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	2
RTECS	WM9625000
Reaxy-Rn	1863230
Merck Index	2810

Citations of This Product

1. Pengshuai Zhang, Jixiu Deng, Xiaoyu Jiang, Liang Xu, Yu Huang, Han Sun, Mi Gao, Xianghan Wang, Yulong Gao, Kangning Fan, Lu Zhang, Shuoye Yang. (2024) Equilibrium solubility and thermodynamic study of daminozide in twelve neat solvents from (283.15 to 323.15) K. JOURNAL OF CHEMICAL THERMODYNAMICS, 189 (30): (107202). [PMID:19762596]
2. Linlu Shen, Hongyi Wang, Jing Kang, Jimin Shen, Pengwei Yan, Yingxu Gong, Jiaxu Zhang, Gang Fu, Shuyu Wang, Yizhen Cheng, Shengxin Zhao, Zhonglin Chen. (2023) Simultaneous elimination of N,N-dimethylhydrazine compounds and its oxidation by-product N-nitrosodimethylamine by UV-activated peroxymonosulfate process: Multiple-path mechanism validation and toxicity alteration. CHEMICAL ENGINEERING JOURNAL, 474 (15): (145837). [PMID:19010891]

References

1. Pengshuai Zhang, Jixiu Deng, Xiaoyu Jiang, Liang Xu, Yu Huang, Han Sun, Mi Gao, Xianghan Wang, Yulong Gao, Kangning Fan, Lu Zhang, Shuoye Yang. (2024) Equilibrium solubility and thermodynamic study of daminozide in twelve neat solvents from (283.15 to 323.15) K. JOURNAL OF CHEMICAL THERMODYNAMICS, 189 (30): (107202). [PMID:19762596]
2. Linlu Shen, Hongyi Wang, Jing Kang, Jimin Shen, Pengwei Yan, Yingxu Gong, Jiaxu Zhang, Gang Fu, Shuyu Wang, Yizhen Cheng, Shengxin Zhao, Zhonglin Chen. (2023) Simultaneous elimination of N,N-dimethylhydrazine compounds and its oxidation by-product N-nitrosodimethylamine by UV-activated peroxymonosulfate process: Multiple-path mechanism validation and toxicity alteration. CHEMICAL ENGINEERING JOURNAL, 474 (15): (145837). [PMID:19010891]

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Daminozide - analytical standard, high purity , CAS No.1596-84-5, Inhibitor of lysine demethylase 2A;Inhibitor of lysine demethylase 7A;Inhibitor of PHD finger protein 8