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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D126182-1mg | 1mg | In stock | $67.90 | |
D126182-5mg | 5mg | In stock | $142.90 | |
D126182-10mg | 10mg | In stock | $247.90 | |
D126182-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $558.90 | |
D126182-50mg | 50mg | In stock | $770.90 | |
D126182-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,109.90 |
Synonyms | PHA739358 | DTXSID301002864 | AB05523 | Danusertib, PHA-739358 | Danusertib; PHA-739358 | N-(5-((2R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide | (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6- |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Serine/threonine-protein kinase Aurora inhibitor |
Product Description | Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. |
ALogP | 1.8 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide |
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INCHI | InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1 |
InChi Key | XKFTZKGMDDZMJI-HSZRJFAPSA-N |
Canonical SMILES | CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)C(C5=CC=CC=C5)OC |
Isomeric SMILES | CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC |
PubChem CID | 11442891 |
Molecular Weight | 474.55 |
CAS Registry No. | 827318-97-8 |
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PubChem CID | 11442891 |
ChEMBL Ligand | CHEMBL402548 |
RCSB PDB Ligand | 627 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2121177 | Certificate of Analysis | Oct 09, 2023 | D126182 |
L2121180 | Certificate of Analysis | Oct 09, 2023 | D126182 |
L2121181 | Certificate of Analysis | Oct 09, 2023 | D126182 |
L2121182 | Certificate of Analysis | Oct 09, 2023 | D126182 |
Solubility | DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥30mg/mL |
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1. Fancelli D, Moll J, Varasi M, Bravo R, Artico R, Berta D, Bindi S, Cameron A, Candiani I, Cappella P et al.. (2006) 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.. J Med Chem, 49 (24): (7247-51). [PMID:17125279] [10.1021/op500134e] |
2. Willemsen-Seegers N, Uitdehaag JCM, Prinsen MBW, de Vetter JRF, de Man J, Sawa M, Kawase Y, Buijsman RC, Zaman GJR. (2017) Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.. J Mol Biol, 429 (4): (574-586). [PMID:28043854] [10.1021/op500134e] |