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DAPTA TFA - ≥97% (HPLC), high purity , CAS No.106362-34-9

Item Number
D137982
Grouped product items
SKUSizeAvailabilityPrice Qty
D137982-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$355.90
D137982-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,281.90
D137982-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,883.90
D137982-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$10,380.90
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Chemokine receptor 5 (CCR5) antagonist

Basic Description

SynonymsDAPTA(TFA) | SCHEMBL7706935 | AKOS024457091 | AS-58148 | AC-31499 | D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2 | NCGC00599627-01 | 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1) |
Specifications & PurityMoligand™, ≥97%(HPLC)
Biochemical and Physiological MechanismsChemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Product description

DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.


Associated Targets(Human)

CCR5 Tclin C-C chemokine receptor type 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CD4 Tclin T-cell surface glycoprotein CD4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CD4 Tclin T-cell surface antigen CD4 (114 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCR5 Tclin C-C chemokine receptor type 5 (5640 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2S)-N-[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]butanediamide
INCHI InChI=1S/C35H56N10O15/c1-13(36)29(54)41-22(12-46)32(57)43-26(16(4)49)34(59)45-27(17(5)50)35(60)44-25(15(3)48)33(58)40-21(11-23(37)52)30(55)39-20(10-18-6-8-19(51)9-7-18)31(56)42-24(14(2)47)28(38)53/h6-9,13-17,20-22,24-27,46-51H,10-12,36H2,1-5H3,(H2,37,52)(H2,38,53)(H,39,55)(H,40,58)(H,41,54)(H,42,56)(H,43,57)(H,44,60)(H,45,59)/t13-,14-,15-,16-,17-,20+,21+,22+,24+,25+,26+,27+/m1/s1
InChi Key AKWRNBWMGFUAMF-ZESMOPTKSA-N
Canonical SMILES CC(C(C(=O)N)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(C(C)O)NC(=O)C(CO)NC(=O)C(C)N)O
Isomeric SMILES C[C@H]([C@@H](C(=O)N)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@@H](C)N)O
PubChem CID 184644
Molecular Weight 856.9(free base)

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
F2316659Certificate of AnalysisMay 20, 2023 D137982
F2316662Certificate of AnalysisMay 20, 2023 D137982
F2316663Certificate of AnalysisMay 20, 2023 D137982
F2316664Certificate of AnalysisMay 20, 2023 D137982

Chemical and Physical Properties

SolubilitySoluble to 1 (mg/mL) in water}
Sensitivitylight sensitive; Moisture sensitive

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. [D-Ala1] Peptide T, amide - 10mM in Water, used for , CAS No. 106362-34-9(Water), by Aladdin Scientific
    [D-Ala1] Peptide T, amide

    Starting at $667.90

References

1. Polianova MT, Ruscetti FW, Pert CB, Ruff MR.  (2005)  Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)..  Antiviral Res,  67  (2): (83-92).  [PMID:16002156] [10.1021/op500134e]
2. Yu W et al..  (2021)  miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease..  Front Pharmacol,  12  (551839).  [PMID:33953665]
3. Gao R et al..  (2019)  R5 HIV-1 gp120 Activates p38 MAPK to Induce Rat Cardiomyocyte Injury by the CCR5 Coreceptor..  Pathobiology,  86  (5-6): (274-284).  [PMID:31574524]

Solution Calculators

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