Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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D129529-10mg | 10mg | In stock | $28.90 | |
D129529-50mg | 50mg | In stock | $89.90 | |
D129529-100mg | 100mg | In stock | $139.90 | |
D129529-250mg | 250mg | In stock | $279.90 | |
D129529-1g | 1g | In stock | $899.90 |
Lipopeptide antibiotic
Synonyms | DAPTOMYCIN | 103060-53-3 | Cubicin | CHEBI:600103 | LY146032 | N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-1 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus with reported in vitro bactericidal activity against gram-positive organisms. As a calcium-dependent antibiotic, Daptomycin has been reported to act on the cytoplasmic membrane an |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
ALogP | -5.1 |
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IUPAC Name | (3S)-3-[[(2S)-4-amino-2-[[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-[[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]amino]-4-oxobutanoic acid |
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INCHI | InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1 |
InChi Key | DOAKLVKFURWEDJ-RWDRXURGSA-N |
Canonical SMILES | CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C |
Isomeric SMILES | CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]3[C@H](OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)[C@H](C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C |
PubChem CID | 16134395 |
Molecular Weight | 1620.67 |
PubChem CID | 16134395 |
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ChEMBL Ligand | CHEMBL387675 |
CAS Registry No. | 103060-53-3 |
Antibiotic DB | 1975 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C2406147 | Certificate of Analysis | Feb 20, 2024 | D129529 |
C2406146 | Certificate of Analysis | Feb 20, 2024 | D129529 |
C2406145 | Certificate of Analysis | Feb 20, 2024 | D129529 |
C2218481 | Certificate of Analysis | Jan 05, 2024 | D129529 |
C2218639 | Certificate of Analysis | Jan 05, 2024 | D129529 |
C2218482 | Certificate of Analysis | Jan 05, 2024 | D129529 |
J2311277 | Certificate of Analysis | Sep 21, 2023 | D129529 |
J2311278 | Certificate of Analysis | Sep 21, 2023 | D129529 |
J2311279 | Certificate of Analysis | Sep 21, 2023 | D129529 |
J2311280 | Certificate of Analysis | Sep 21, 2023 | D129529 |
J2311281 | Certificate of Analysis | Sep 21, 2023 | D129529 |
J2311282 | Certificate of Analysis | Sep 21, 2023 | D129529 |
C2218484 | Certificate of Analysis | Feb 22, 2022 | D129529 |
C2218483 | Certificate of Analysis | Feb 22, 2022 | D129529 |
B2301912 | Certificate of Analysis | Feb 22, 2022 | D129529 |
G2320189 | Certificate of Analysis | Feb 22, 2022 | D129529 |
H2310103 | Certificate of Analysis | Feb 22, 2022 | D129529 |
Solubility | Soluble in water (100 mg/ml at 25 °C), ethanol (50 mM), methanol (5 mg/ml), DMSO (100 mM), and DMF. |
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Sensitivity | Heat sensitive |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure |
Precautionary Statements | P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P319:Get medical help if you feel unwell. |
Merck Index | 2823 |
Starting at $285.90
Starting at $49.90
Starting at $813.90
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2. Jiahui Guo, Yunru Yu, Yingbo Shen, Xiaoyan Sun, Yan Bi, Yuanjin Zhao. (2023) Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing. Small, 19 (44): (2303887). [PMID:37392054] |
3. Cui Mingxin, Wong Okei, Li Qiang, Wang Wenya. (2023) An Assay Method for Characterizing Bacteriophage T7 RNA Polymerase Activity by Transcription–Translation (TX-TL) System. JOURNAL OF BIOCHEMISTRY, 173 (5): (343-352). [PMID:36638780] |
4. Ya Zhang, Ning Li, Ying Xu, Xiaofang Liu, Yi Ma, Zhen Huang, Huibo Luo, Changjun Hou, Danqun Huo. (2023) A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2. BIOELECTROCHEMISTRY, 150 (108362). [PMID:36608370] |
5. Yanjin Tang, Yuhan Lai, Ruiqin Gao, Yuxuan Chen, Kexin Xiong, Juan Ye, Qi Zheng, Zhenxing Fang, Guangsheng Pang, Hoo-Jeong Lee. (2023) Functional Aerogels Composed of Regenerated Cellulose and Tungsten Oxide for UV Detection and Seawater Desalination. Gels, 9 (1): (10). [PMID:36661778] |
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8. Boyu Jia, Tianbao Liu, Juanjuan Wan, Andrei Ivanets, Yujia Xiang, Lijuan Zhang, Xintai Su. (2023) Enhancing the extracellular electron transfer ability via Polydopamine@S. oneidensis MR-1 for Cr(VI) reduction. ENVIRONMENTAL RESEARCH, 217 (114914). [PMID:36427635] |
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14. Yaoshen Ye, Kaixin Guo, Ruirui Cui, Min Zhang, Xu Wang, Majed A. Bajaber, Chaoyong Deng. (2022) Enhancing the energy storage density of Bi0.5Na0.5TiO3 thin films by adding an amorphous alumina. Surfaces and Interfaces, 33 (102229). [PMID:] |
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20. Feng Zhao, Qingfeng Bian, Yunting Chu, Yi Zhang, Qianyun Zhao, Jingchang Sun, Chengren Li. (2021) A Wide Tunable Nanophosphor NaYO2:Er3+/Yb3+ by Modulating Power Density. Physica Status Solidi-Rapid Research Letters, 16 (2): (2100517). [PMID:] |
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1. Ge Y, Biek D, Talbot GH, Sahm DF. (2008) In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.. Antimicrob Agents Chemother, 52 (9): (3398-407). [PMID:18625769] |
2. Dongliang Guan, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Yue Yu, Xinxin Feng, Lefu Lan, Wei Huang. (2023) A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 259 (115638). [PMID:37482019] |
3. Jiahui Guo, Yunru Yu, Yingbo Shen, Xiaoyan Sun, Yan Bi, Yuanjin Zhao. (2023) Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing. Small, 19 (44): (2303887). [PMID:37392054] |
4. Cui Mingxin, Wong Okei, Li Qiang, Wang Wenya. (2023) An Assay Method for Characterizing Bacteriophage T7 RNA Polymerase Activity by Transcription–Translation (TX-TL) System. JOURNAL OF BIOCHEMISTRY, 173 (5): (343-352). [PMID:36638780] |
5. Ya Zhang, Ning Li, Ying Xu, Xiaofang Liu, Yi Ma, Zhen Huang, Huibo Luo, Changjun Hou, Danqun Huo. (2023) A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2. BIOELECTROCHEMISTRY, 150 (108362). [PMID:36608370] |
6. Yanjin Tang, Yuhan Lai, Ruiqin Gao, Yuxuan Chen, Kexin Xiong, Juan Ye, Qi Zheng, Zhenxing Fang, Guangsheng Pang, Hoo-Jeong Lee. (2023) Functional Aerogels Composed of Regenerated Cellulose and Tungsten Oxide for UV Detection and Seawater Desalination. Gels, 9 (1): (10). [PMID:36661778] |
7. Yong Yu, Zhongxiang Yang, Zhichao Shang, Xiaohong Wang. (2023) One-step solution combustion synthesis of Bi/BiOCl nanosheets: Reaction mechanism and photocatalytic RhB degradation. JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 174 (111172). [PMID:] |
8. Li Dai, Di Xu, Peng-Fei Song, Jun Zhang. (2023) Preparation of planar chiral oxazolinyl hydroxyl ferrocene silyl ethers and their desilylation derivatives. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 984 (122575). [PMID:] |
9. Boyu Jia, Tianbao Liu, Juanjuan Wan, Andrei Ivanets, Yujia Xiang, Lijuan Zhang, Xintai Su. (2023) Enhancing the extracellular electron transfer ability via Polydopamine@S. oneidensis MR-1 for Cr(VI) reduction. ENVIRONMENTAL RESEARCH, 217 (114914). [PMID:36427635] |
10. Hangtao Ye, Luojia Huang, Xiaoting Liu, Meiting Yang, Wenya Chen, Yihuang Chen, Weidong Xiang, Shuang Pan, Xiaojuan Liang. (2023) Opportunities and challenges in CsPbX3@Glasses@Film with High Quality for LCD by Process Optimization towards commercialization. CERAMICS INTERNATIONAL, 49 (9010). [PMID:] |
11. Zhichao He, Huitong Luo, Zetao Wang, Dafu Chen, Qi Feng, Xiaodong Cao. (2023) Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation. CARBOHYDRATE POLYMERS, 299 (120180). [PMID:36876795] |
12. Yujie Yang. (2022) Two-Step Calcination-Method-Derived Al-Substituted W-Type SrYb Hexaferrites: Their Microstructural, Spectral, and Magnetic Properties. Magnetochemistry, 8 (10): (118). [PMID:] |
13. Jingsai Cheng, Chunmei Li, Zhiyong Yu, Hanxing Liu. (2023) Efficient photohydrogen production by edge-modified carbon nitride with nonmetallic group. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 629 (739). [PMID:36193618] |
14. Tingting Bao, Hui zhou, Yi Zhang, Chenxu Guo, Wenming Guo, Hang Qin, Pengzhao Gao, Hanning Xiao, Weixiong Liu. (2023) Effect of CeO2 on carbon deposition resistance of Ni/CeO2 catalyst supported on SiC porous ceramic for ethanol steam reforming. JOURNAL OF RARE EARTHS, 41 (1703). [PMID:] |
15. Yaoshen Ye, Kaixin Guo, Ruirui Cui, Min Zhang, Xu Wang, Majed A. Bajaber, Chaoyong Deng. (2022) Enhancing the energy storage density of Bi0.5Na0.5TiO3 thin films by adding an amorphous alumina. Surfaces and Interfaces, 33 (102229). [PMID:] |
16. Wangli Dai, Lin Zhou, Saiqi Gu, Wenjie Wang, Zheng Xu, Xuxia Zhou, Yuting Ding. (2022) Preparation and characterization of chitosan films incorporating epigallocatechin gallate: Microstructure, physicochemical, and bioactive properties. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (729). [PMID:35523362] |
17. Liu Xiao, Wu Jingping, Qiao Keke, Liu Guohan, Wang Zhengjin, Lu Tongqing, Suo Zhigang, Hu Jian. (2022) Topoarchitected polymer networks expand the space of material properties. Nature Communications, 13 (1): (1-8). [PMID:35338139] |
18. Mengyao Li, Yi Zhai, Xubin Zhang, Fumin Wang, Guojun Lv, Ahishakiye Rosine, Mengyue Li, Qing Zhang, Yongkui Liu. (2022) (NH4)2SO4-assisted synthesis of thin-walled Ti-rich hollow titanium silicalite-1 zeolite for 1-hexene epoxidation. MICROPOROUS AND MESOPOROUS MATERIALS, 331 (111655). [PMID:] |
19. Xiawei Dong, Jing Ye, Yun Chen, Tanziela Tanziela, Hui Jiang, Xuemei Wang. (2022) Intelligent peptide-nanorods against drug-resistant bacterial infection and promote wound healing by mild-temperature photothermal therapy. CHEMICAL ENGINEERING JOURNAL, 432 (134061). [PMID:] |
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