Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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D420399-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 |
Lipopeptide antibiotic
Synonyms | DAPTOMYCIN | 103060-53-3 | Cubicin | CHEBI:600103 | LY146032 | N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-1 |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus with reported in vitro bactericidal activity against gram-positive organisms. As a calcium-dependent antibiotic, Daptomycin has been reported to act on the cytoplasmic membrane an |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
ALogP | -5.1 |
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IUPAC Name | (3S)-3-[[(2S)-4-amino-2-[[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-[[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]amino]-4-oxobutanoic acid |
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INCHI | InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1 |
InChi Key | DOAKLVKFURWEDJ-RWDRXURGSA-N |
Canonical SMILES | CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C |
Isomeric SMILES | CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]3[C@H](OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)[C@H](C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C |
PubChem CID | 16134395 |
Molecular Weight | 1620.67 |
Enter Lot Number to search for COA:
Sensitivity | Heat sensitive |
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Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure |
Precautionary Statements | P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P319:Get medical help if you feel unwell. |
Merck Index | 2823 |
1. Dongliang Guan, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Yue Yu, Xinxin Feng, Lefu Lan, Wei Huang. (2023) A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 259 (115638). [PMID:37482019] |
2. Jiahui Guo, Yunru Yu, Yingbo Shen, Xiaoyan Sun, Yan Bi, Yuanjin Zhao. (2023) Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing. Small, 19 (44): (2303887). [PMID:37392054] |
3. Cui Mingxin, Wong Okei, Li Qiang, Wang Wenya. (2023) An Assay Method for Characterizing Bacteriophage T7 RNA Polymerase Activity by Transcription–Translation (TX-TL) System. JOURNAL OF BIOCHEMISTRY, 173 (5): (343-352). [PMID:36638780] |
4. Ya Zhang, Ning Li, Ying Xu, Xiaofang Liu, Yi Ma, Zhen Huang, Huibo Luo, Changjun Hou, Danqun Huo. (2023) A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2. BIOELECTROCHEMISTRY, 150 (108362). [PMID:36608370] |
5. Yanjin Tang, Yuhan Lai, Ruiqin Gao, Yuxuan Chen, Kexin Xiong, Juan Ye, Qi Zheng, Zhenxing Fang, Guangsheng Pang, Hoo-Jeong Lee. (2023) Functional Aerogels Composed of Regenerated Cellulose and Tungsten Oxide for UV Detection and Seawater Desalination. Gels, 9 (1): (10). [PMID:36661778] |
6. Yong Yu, Zhongxiang Yang, Zhichao Shang, Xiaohong Wang. (2023) One-step solution combustion synthesis of Bi/BiOCl nanosheets: Reaction mechanism and photocatalytic RhB degradation. JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 174 (111172). [PMID:] |
7. Li Dai, Di Xu, Peng-Fei Song, Jun Zhang. (2023) Preparation of planar chiral oxazolinyl hydroxyl ferrocene silyl ethers and their desilylation derivatives. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 984 (122575). [PMID:] |
8. Boyu Jia, Tianbao Liu, Juanjuan Wan, Andrei Ivanets, Yujia Xiang, Lijuan Zhang, Xintai Su. (2023) Enhancing the extracellular electron transfer ability via Polydopamine@S. oneidensis MR-1 for Cr(VI) reduction. ENVIRONMENTAL RESEARCH, 217 (114914). [PMID:36427635] |
9. Hangtao Ye, Luojia Huang, Xiaoting Liu, Meiting Yang, Wenya Chen, Yihuang Chen, Weidong Xiang, Shuang Pan, Xiaojuan Liang. (2023) Opportunities and challenges in CsPbX3@Glasses@Film with High Quality for LCD by Process Optimization towards commercialization. CERAMICS INTERNATIONAL, 49 (9010). [PMID:] |
10. Zhichao He, Huitong Luo, Zetao Wang, Dafu Chen, Qi Feng, Xiaodong Cao. (2023) Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation. CARBOHYDRATE POLYMERS, 299 (120180). [PMID:36876795] |
11. Yujie Yang. (2022) Two-Step Calcination-Method-Derived Al-Substituted W-Type SrYb Hexaferrites: Their Microstructural, Spectral, and Magnetic Properties. Magnetochemistry, 8 (10): (118). [PMID:] |
12. Jingsai Cheng, Chunmei Li, Zhiyong Yu, Hanxing Liu. (2023) Efficient photohydrogen production by edge-modified carbon nitride with nonmetallic group. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 629 (739). [PMID:36193618] |
13. Tingting Bao, Hui zhou, Yi Zhang, Chenxu Guo, Wenming Guo, Hang Qin, Pengzhao Gao, Hanning Xiao, Weixiong Liu. (2023) Effect of CeO2 on carbon deposition resistance of Ni/CeO2 catalyst supported on SiC porous ceramic for ethanol steam reforming. JOURNAL OF RARE EARTHS, 41 (1703). [PMID:] |
14. Yaoshen Ye, Kaixin Guo, Ruirui Cui, Min Zhang, Xu Wang, Majed A. Bajaber, Chaoyong Deng. (2022) Enhancing the energy storage density of Bi0.5Na0.5TiO3 thin films by adding an amorphous alumina. Surfaces and Interfaces, 33 (102229). [PMID:] |
15. Wangli Dai, Lin Zhou, Saiqi Gu, Wenjie Wang, Zheng Xu, Xuxia Zhou, Yuting Ding. (2022) Preparation and characterization of chitosan films incorporating epigallocatechin gallate: Microstructure, physicochemical, and bioactive properties. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (729). [PMID:35523362] |
16. Mengyao Li, Yi Zhai, Xubin Zhang, Fumin Wang, Guojun Lv, Ahishakiye Rosine, Mengyue Li, Qing Zhang, Yongkui Liu. (2022) (NH4)2SO4-assisted synthesis of thin-walled Ti-rich hollow titanium silicalite-1 zeolite for 1-hexene epoxidation. MICROPOROUS AND MESOPOROUS MATERIALS, 331 (111655). [PMID:] |
17. Xiawei Dong, Jing Ye, Yun Chen, Tanziela Tanziela, Hui Jiang, Xuemei Wang. (2022) Intelligent peptide-nanorods against drug-resistant bacterial infection and promote wound healing by mild-temperature photothermal therapy. CHEMICAL ENGINEERING JOURNAL, 432 (134061). [PMID:] |
18. Jiupeng Zhang, Jing Zuo, Yang Liu, Junyu Zhang, Wenjing Fu, Jinyi Zhang, Shiding Miao, Cundi Wei. (2021) Universality of mesoporous coal gasification slag for reinforcement and deodorization in four common polymers. NANOTECHNOLOGY, 33 (9): (95703). [PMID:34808606] |
19. Feng Zhao, Qingfeng Bian, Yunting Chu, Yi Zhang, Qianyun Zhao, Jingchang Sun, Chengren Li. (2021) A Wide Tunable Nanophosphor NaYO2:Er3+/Yb3+ by Modulating Power Density. Physica Status Solidi-Rapid Research Letters, 16 (2): (2100517). [PMID:] |
20. Yi Yu, Yu Cheng, Lei Tan, Xiangmei Liu, Zhaoyang Li, Yufeng Zheng, Tao Wu, Yanqin Liang, Zhenduo Cui, Shengli Zhu, Shuilin Wu. (2022) Theory-screened MOF-based single-atom catalysts for facile and effective therapy of biofilm-induced periodontitis. CHEMICAL ENGINEERING JOURNAL, 431 (133279). [PMID:] |
21. Yueyang Jiang, Song Lin, Houchun Yan, Hongyue Guo, Qingsong Li. (2022) Liquid-liquid equilibrium data measurement and thermodynamic modelling for ternary mixtures composed of water, diethylene glycol dimethyl ether and different solvents at 298.2 K. JOURNAL OF CHEMICAL THERMODYNAMICS, 165 (106669). [PMID:] |
22. Dong Wu, Zeang Zhao, Hongshuai Lei, Hao-Sen Chen, Qiang Zhang, Panding Wang, Daining Fang. (2022) Bio-inspired 3D printing of self-growing multinetwork elastomer composites. COMPOSITE STRUCTURES, 279 (114777). [PMID:] |
1. Dongliang Guan, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Yue Yu, Xinxin Feng, Lefu Lan, Wei Huang. (2023) A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 259 (115638). [PMID:37482019] |
2. Jiahui Guo, Yunru Yu, Yingbo Shen, Xiaoyan Sun, Yan Bi, Yuanjin Zhao. (2023) Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing. Small, 19 (44): (2303887). [PMID:37392054] |
3. Cui Mingxin, Wong Okei, Li Qiang, Wang Wenya. (2023) An Assay Method for Characterizing Bacteriophage T7 RNA Polymerase Activity by Transcription–Translation (TX-TL) System. JOURNAL OF BIOCHEMISTRY, 173 (5): (343-352). [PMID:36638780] |
4. Ya Zhang, Ning Li, Ying Xu, Xiaofang Liu, Yi Ma, Zhen Huang, Huibo Luo, Changjun Hou, Danqun Huo. (2023) A novel electrochemical biosensor based on AMNFs@ZIF-67 nano composite material for ultrasensitive detection of HER2. BIOELECTROCHEMISTRY, 150 (108362). [PMID:36608370] |
5. Yanjin Tang, Yuhan Lai, Ruiqin Gao, Yuxuan Chen, Kexin Xiong, Juan Ye, Qi Zheng, Zhenxing Fang, Guangsheng Pang, Hoo-Jeong Lee. (2023) Functional Aerogels Composed of Regenerated Cellulose and Tungsten Oxide for UV Detection and Seawater Desalination. Gels, 9 (1): (10). [PMID:36661778] |
6. Yong Yu, Zhongxiang Yang, Zhichao Shang, Xiaohong Wang. (2023) One-step solution combustion synthesis of Bi/BiOCl nanosheets: Reaction mechanism and photocatalytic RhB degradation. JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 174 (111172). [PMID:] |
7. Li Dai, Di Xu, Peng-Fei Song, Jun Zhang. (2023) Preparation of planar chiral oxazolinyl hydroxyl ferrocene silyl ethers and their desilylation derivatives. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 984 (122575). [PMID:] |
8. Boyu Jia, Tianbao Liu, Juanjuan Wan, Andrei Ivanets, Yujia Xiang, Lijuan Zhang, Xintai Su. (2023) Enhancing the extracellular electron transfer ability via Polydopamine@S. oneidensis MR-1 for Cr(VI) reduction. ENVIRONMENTAL RESEARCH, 217 (114914). [PMID:36427635] |
9. Hangtao Ye, Luojia Huang, Xiaoting Liu, Meiting Yang, Wenya Chen, Yihuang Chen, Weidong Xiang, Shuang Pan, Xiaojuan Liang. (2023) Opportunities and challenges in CsPbX3@Glasses@Film with High Quality for LCD by Process Optimization towards commercialization. CERAMICS INTERNATIONAL, 49 (9010). [PMID:] |
10. Zhichao He, Huitong Luo, Zetao Wang, Dafu Chen, Qi Feng, Xiaodong Cao. (2023) Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation. CARBOHYDRATE POLYMERS, 299 (120180). [PMID:36876795] |
11. Yujie Yang. (2022) Two-Step Calcination-Method-Derived Al-Substituted W-Type SrYb Hexaferrites: Their Microstructural, Spectral, and Magnetic Properties. Magnetochemistry, 8 (10): (118). [PMID:] |
12. Jingsai Cheng, Chunmei Li, Zhiyong Yu, Hanxing Liu. (2023) Efficient photohydrogen production by edge-modified carbon nitride with nonmetallic group. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 629 (739). [PMID:36193618] |
13. Tingting Bao, Hui zhou, Yi Zhang, Chenxu Guo, Wenming Guo, Hang Qin, Pengzhao Gao, Hanning Xiao, Weixiong Liu. (2023) Effect of CeO2 on carbon deposition resistance of Ni/CeO2 catalyst supported on SiC porous ceramic for ethanol steam reforming. JOURNAL OF RARE EARTHS, 41 (1703). [PMID:] |
14. Yaoshen Ye, Kaixin Guo, Ruirui Cui, Min Zhang, Xu Wang, Majed A. Bajaber, Chaoyong Deng. (2022) Enhancing the energy storage density of Bi0.5Na0.5TiO3 thin films by adding an amorphous alumina. Surfaces and Interfaces, 33 (102229). [PMID:] |
15. Wangli Dai, Lin Zhou, Saiqi Gu, Wenjie Wang, Zheng Xu, Xuxia Zhou, Yuting Ding. (2022) Preparation and characterization of chitosan films incorporating epigallocatechin gallate: Microstructure, physicochemical, and bioactive properties. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (729). [PMID:35523362] |
16. Mengyao Li, Yi Zhai, Xubin Zhang, Fumin Wang, Guojun Lv, Ahishakiye Rosine, Mengyue Li, Qing Zhang, Yongkui Liu. (2022) (NH4)2SO4-assisted synthesis of thin-walled Ti-rich hollow titanium silicalite-1 zeolite for 1-hexene epoxidation. MICROPOROUS AND MESOPOROUS MATERIALS, 331 (111655). [PMID:] |
17. Xiawei Dong, Jing Ye, Yun Chen, Tanziela Tanziela, Hui Jiang, Xuemei Wang. (2022) Intelligent peptide-nanorods against drug-resistant bacterial infection and promote wound healing by mild-temperature photothermal therapy. CHEMICAL ENGINEERING JOURNAL, 432 (134061). [PMID:] |
18. Jiupeng Zhang, Jing Zuo, Yang Liu, Junyu Zhang, Wenjing Fu, Jinyi Zhang, Shiding Miao, Cundi Wei. (2021) Universality of mesoporous coal gasification slag for reinforcement and deodorization in four common polymers. NANOTECHNOLOGY, 33 (9): (95703). [PMID:34808606] |
19. Feng Zhao, Qingfeng Bian, Yunting Chu, Yi Zhang, Qianyun Zhao, Jingchang Sun, Chengren Li. (2021) A Wide Tunable Nanophosphor NaYO2:Er3+/Yb3+ by Modulating Power Density. Physica Status Solidi-Rapid Research Letters, 16 (2): (2100517). [PMID:] |
20. Yi Yu, Yu Cheng, Lei Tan, Xiangmei Liu, Zhaoyang Li, Yufeng Zheng, Tao Wu, Yanqin Liang, Zhenduo Cui, Shengli Zhu, Shuilin Wu. (2022) Theory-screened MOF-based single-atom catalysts for facile and effective therapy of biofilm-induced periodontitis. CHEMICAL ENGINEERING JOURNAL, 431 (133279). [PMID:] |
21. Yueyang Jiang, Song Lin, Houchun Yan, Hongyue Guo, Qingsong Li. (2022) Liquid-liquid equilibrium data measurement and thermodynamic modelling for ternary mixtures composed of water, diethylene glycol dimethyl ether and different solvents at 298.2 K. JOURNAL OF CHEMICAL THERMODYNAMICS, 165 (106669). [PMID:] |
22. Dong Wu, Zeang Zhao, Hongshuai Lei, Hao-Sen Chen, Qiang Zhang, Panding Wang, Daining Fang. (2022) Bio-inspired 3D printing of self-growing multinetwork elastomer composites. COMPOSITE STRUCTURES, 279 (114777). [PMID:] |