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Darovasertib - 99%, high purity , CAS No.1874276-76-2, Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta

Moligand™
≥99%

CAS#: 1874276-76-2
Formula: C₂₂H₂₃F₃N₈O
Molecular Weight: 472.47
PubChem CID: 118873253

Item Number

D413600

Grouped product items
SKU	Size	Availability	Price
D413600-2mg	2mg	In stock	$86.90
D413600-5mg	5mg	In stock	$168.90
D413600-10mg	10mg	In stock	$255.90
D413600-25mg	25mg	In stock	$444.90
D413600-50mg	50mg	In stock	$663.90
D413600-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,000.90

PKC Inhibitors

View related series

protein kinase C alpha Inhibitor protein kinase C theta Inhibitor

Basic Description

Synonyms	darovasertib\|LXS196\|1874276-76-2\|LXS-196\|NVP-LXS196\|IDE-196\|NVP-LXS-196\|IDE196\|Darovasertib [USAN]\|3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide\|E0YF0M8O09\|3-amino-N-[3-(4-amino-4-meth
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta
Product Description	Information Darovasertib (LXS-196) Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC) . Targets PKC

ALogP

1.6

HBD Count

Rotatable Bond

Associated Targets

JMJD7 Tbio JmjC domain-containing protein 7 0 Activities

Discover Target: JMJD7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCA Tchem Protein kinase C alpha type 2 Activities

Discover Target: PRKCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCQ Tchem Protein kinase C theta type 2 Activities

Discover Target: PRKCQ

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide
INCHI	InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
InChi Key	XXJXHXJWQSCNPX-UHFFFAOYSA-N
Canonical SMILES	CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
Isomeric SMILES	CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
PubChem CID	118873253
Molecular Weight	472.47

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
F2229297	Certificate of Analysis	Jun 05, 2022	D413600
F2229298	Certificate of Analysis	Jun 05, 2022	D413600
F2229299	Certificate of Analysis	Jun 05, 2022	D413600
F2229300	Certificate of Analysis	Jun 05, 2022	D413600
F2229307	Certificate of Analysis	Jun 05, 2022	D413600
F2229308	Certificate of Analysis	Jun 05, 2022	D413600

Solubility

Solubility (25°C) In vitro DMSO: 60 mg/mL (126.99 mM); Ethanol: 20 mg/mL (42.33 mM); Water: Insoluble;

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

46.5638029927826

Water(mg / mL) Max Solubility

＜1

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