Darovasertib - 99%, high purity , CAS No.1874276-76-2, Inhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta

Item Number
D413600
Grouped product items
SKUSizeAvailabilityPrice Qty
D413600-2mg
2mg
In stock
$86.90
D413600-5mg
5mg
In stock
$168.90
D413600-10mg
10mg
In stock
$255.90
D413600-25mg
25mg
In stock
$444.90
D413600-50mg
50mg
In stock
$663.90
D413600-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,000.90

PKC Inhibitors

Basic Description

SynonymsUNII-E0YF0M8O09 | EN300-26212118 | darovasertib | TOLTERODINE [WHO-DD] | 3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide | AKOS040758778 | GTPL11186 | NSC800030 | NSC-800030 | US9452998,
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsDarovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of protein kinase C alpha;Inhibitor of protein kinase C theta
Product Description

Information

Darovasertib (LXS-196) Darovasertib (LXS-196, IDE-196) is a selective inhibitor of protein kinase C (PKC) .


Targets

PKC

Product Properties

ALogP1.6
HBD Count3
Rotatable Bond5

Associated Targets(Human)

PRKCA Tchem Protein kinase C alpha type (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCQ Tchem Protein kinase C theta type (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCA Tchem Protein kinase C alpha (5923 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKCQ Tchem Protein kinase C theta (3319 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide
INCHI InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
InChi Key XXJXHXJWQSCNPX-UHFFFAOYSA-N
Canonical SMILES CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
Isomeric SMILES CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
PubChem CID 118873253
Molecular Weight 472.47

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
F2229297Certificate of AnalysisJun 05, 2022 D413600
F2229298Certificate of AnalysisJun 05, 2022 D413600
F2229299Certificate of AnalysisJun 05, 2022 D413600
F2229300Certificate of AnalysisJun 05, 2022 D413600
F2229307Certificate of AnalysisJun 05, 2022 D413600
F2229308Certificate of AnalysisJun 05, 2022 D413600

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 60 mg/mL (126.99 mM); Ethanol: 20 mg/mL (42.33 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility22
DMSO(mM) Max Solubility46.5638029927826
Water(mg / mL) Max Solubility<1

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Solution Calculators