Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D125841-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $48.90 | |
D125841-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $78.90 | |
D125841-50mg | 50mg | In stock | $256.90 | |
D125841-250mg | 250mg | In stock | $1,156.90 | |
D125841-1g | 1g | In stock | $4,163.90 |
Highly potent HIV protease inhibitor
Synonyms | AIDS073035 | s5250 | NCGC00168773-01 | BCP0726000058 | BDBM8125 | Darunavirum [INN-Latin] | HSDB 7788 | 2ien | Darunavir [USAN:INN:BAN] | 2f8g | 4ll3 | CJBJHOAVZSMMDJ-HEXNFIEUSA-N | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobuty |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Highly potent HIV protease inhibitor (IC50= 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.The product is only used for biomedical rese |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Human immunodeficiency virus type 1 protease inhibitor |
Note | 5/10mg卖完停产,不再备货 |
Product Description | HIV-1 antiviral structurally similar to amprenavir. Second generation HIV-1-protease inhibitor. |
ALogP | 2.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate |
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INCHI | InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1 |
InChi Key | CJBJHOAVZSMMDJ-HEXNFIEUSA-N |
Canonical SMILES | CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N |
Isomeric SMILES | CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N |
WGK Germany | 3 |
PubChem CID | 213039 |
Molecular Weight | 547.66 |
PubChem CID | 213039 |
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RCSB PDB Ligand | 017 |
ChEMBL Ligand | CHEMBL1323 |
ChEBI | CHEBI:367163 |
DrugBank Ligand | DB01264 |
CAS Registry No. | 206361-99-1 |
Wikipedia | Darunavir |
PEP | darunavir |
Reactome Reaction | R-HSA-9697043 |
DrugCentral Ligand | 4143 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2212304 | Certificate of Analysis | Aug 23, 2024 | D125841 |
K2212312 | Certificate of Analysis | Aug 23, 2024 | D125841 |
K2212421 | Certificate of Analysis | Aug 23, 2024 | D125841 |
B1525026 | Certificate of Analysis | Jun 06, 2024 | D125841 |
E2019050 | Certificate of Analysis | Apr 13, 2022 | D125841 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 54.77, Max Conc. mM: 100 |
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Melt Point(°C) | 74-76°C |
WGK Germany | 3 |
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1. Fenglun Zhao, Zheng Xiang, Junping Han, Jie Pan, Yuchen Qu, Kai Fan, Zhiqiang Wu, Delai Xu, Yunli Yu, Zhu Shen, Cunjin Su. (2024) Simultaneous quantification of nirmatrelvir/ritonavir in human serum by LC–HRMS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 237 (13): (115796). [PMID:37839266] [10.1016/j.jpba.2023.115796] |
2. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005] |
1. Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y et al.. (2003) Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.. Antimicrob Agents Chemother, 47 (10): (3123-9). [PMID:14506019] [10.1021/op500134e] |
2. Chen J, Xia L, Liu L, Xu Q, Ling Y, Huang D, Huang W, Song S, Xu S, Shen Y et al.. (2020) Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19.. Open Forum Infect Dis, 7 (7): (ofaa241). [PMID:32671131] [10.1021/op500134e] |
3. Fenglun Zhao, Zheng Xiang, Junping Han, Jie Pan, Yuchen Qu, Kai Fan, Zhiqiang Wu, Delai Xu, Yunli Yu, Zhu Shen, Cunjin Su. (2024) Simultaneous quantification of nirmatrelvir/ritonavir in human serum by LC–HRMS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 237 (13): (115796). [PMID:37839266] [10.1016/j.jpba.2023.115796] |
4. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005] |