N-(2-chlorophenyl)-6-(piperidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

Names and Identifiers

Canonical SMILES: O=C(Nc1ccccc1Cl)c1cnc2ccc(N3CCCCC3)cn12

Standard InChI: InChI=1S/C19H19ClN4O/c20-15-6-2-3-7-16(15)22-19(25)17-12-21-18-9-8-14(13-24(17)18)23-10-4-1-5-11-23/h2-3,6-9,12-13H,1,4-5,10-11H2,(H,22,25)

Standard InChI Key: PAPLYPMKGDNISY-UHFFFAOYSA-N

Molfile:

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M  END

Alternative Forms

Parent:

ALA1078840
N-(2-chlorophenyl)-6-(piperidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

Associated Targets(Human)

EPHB3 Tchem Ephrin type-B receptor 3 (1881 Activities)

Discover Target: EPHB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Molecule Features

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

Drug Indications

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Calculated Properties

Molecular Weight: 354.84	Molecular Weight (Monoisotopic): 354.1247	AlogP: 4.23	#Rotatable Bonds: 3
Polar Surface Area: 49.64	Molecular Species: NEUTRAL	HBA: 4	HBD: 1
#RO5 Violations: ┄	HBA (Lipinski): 5	HBD (Lipinski): 1	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: ┄	CX Basic pKa: 5.34	CX LogP: 3.33	CX LogD: 3.33
Aromatic Rings: 3	Heavy Atoms: 25	QED Weighted: 0.77	Np Likeness Score: -1.97

References

1. Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD.. (2009) Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors., 19 (21): [PMID:19783434] [10.1016/j.bmcl.2009.09.010]

Source

Source(1):

Scientific Literature