(5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2-[(2-(Z)-benzylideneamino)ethylamino]-3,5-dihydro-4H-imidazol-4-one

ID: ALA1081244

Chembl Id: CHEMBL1081244

PubChem CID: 135860184

Max Phase: Preclinical

Molecular Formula: C21H20N4O3

Molecular Weight: 376.42

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1NCC/N=C/c1ccccc1

Standard InChI:  InChI=1S/C21H20N4O3/c1-25-20(26)17(11-16-7-8-18-19(12-16)28-14-27-18)24-21(25)23-10-9-22-13-15-5-3-2-4-6-15/h2-8,11-13H,9-10,14H2,1H3,(H,23,24)/b17-11-,22-13+

Standard InChI Key:  KXFRGMJOUGKRIA-HOCVSBDUSA-N

Alternative Forms

  1. Parent:

    ALA1081244

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Associated Targets(Human)

CSNK2B Tbio Casein kinase I isoform alpha/subunit beta (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK5 Tchem Cyclin-dependent kinase 5/CDK5 activator 1 (3697 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3A Tclin Glycogen synthase kinase-3 (736 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 376.42Molecular Weight (Monoisotopic): 376.1535AlogP: 2.29#Rotatable Bonds: 5
Polar Surface Area: 75.52Molecular Species: NEUTRALHBA: 6HBD: 1
#RO5 Violations: HBA (Lipinski): 7HBD (Lipinski): 1#RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: 6.47CX LogP: 2.62CX LogD: 2.57
Aromatic Rings: 2Heavy Atoms: 28QED Weighted: 0.49Np Likeness Score: -0.56

References

1. Debdab M, Renault S, Lozach O, Meijer L, Paquin L, Carreaux F, Bazureau JP..  (2010)  Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.,  45  (2): [PMID:19879673] [10.1016/j.ejmech.2009.10.009]

Source