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(2S)-2-[(2R)-2-[(carboxymethyl)amino]-3-phenylpropanamido]-4-methylpentanoic acid ID: ALA1161395
Chembl Id: CHEMBL1161395
PubChem CID: 15580524
Max Phase: Preclinical
Molecular Formula: C17H24N2O5
Molecular Weight: 336.39
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NCC(=O)O)C(=O)O
Standard InChI: InChI=1S/C17H24N2O5/c1-11(2)8-14(17(23)24)19-16(22)13(18-10-15(20)21)9-12-6-4-3-5-7-12/h3-7,11,13-14,18H,8-10H2,1-2H3,(H,19,22)(H,20,21)(H,23,24)/t13-,14+/m1/s1
Standard InChI Key: JETREHBNPJNSMA-KGLIPLIRSA-N
Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 336.39Molecular Weight (Monoisotopic): 336.1685AlogP: 0.89#Rotatable Bonds: 10Polar Surface Area: 115.73Molecular Species: ACIDHBA: 4HBD: 4#RO5 Violations: ┄HBA (Lipinski): 7HBD (Lipinski): 4#RO5 Violations (Lipinski): ┄CX Acidic pKa: 2.96CX Basic pKa: 7.87CX LogP: -0.99CX LogD: -4.09Aromatic Rings: 1Heavy Atoms: 24QED Weighted: 0.50Np Likeness Score: 0.08
References 1. Fournié-Zaluski MC, Chaillet P, Soroca-Lucas E, Marçais-Collado H, Costentin J, Roques BP.. (1983) New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties., 26 (1): [PMID:6298420 ] [10.1021/jm00355a013 ]