Standard InChI: InChI=1S/C28H36N4O4/c1-18(29-2)26(34)30-23-15-14-22(33)17-21-13-16-24(32(21)28(23)36)27(35)31-25(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,18,21-25,29,33H,13-17H2,1-2H3,(H,30,34)(H,31,35)/t18-,21+,22+,23-,24-/m0/s1
1.Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S.. (2010) Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins., 53 (17):[PMID:20684551][10.1021/jm100487z]
2.Sato, Shinichi S, Aoyama, Hiroshi H, Miyachi, Hiroyuki H, Naito, Mikihiko M and Hashimoto, Yuichi Y. 2008-06-01 Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs. [PMID:18448338]
3.Zhang, Bin and 8 more authors. 2008-12-11 Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. [PMID:19012392]
4.Sun, Wei and 9 more authors. 2009-02-12 Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. [PMID:19138149]
5.Sun, Haiying and 6 more authors. 2010-05-15 Cyclopeptide Smac mimetics as antagonists of IAP proteins. [PMID:20443226]
6.Cai, Qian and 17 more authors. 2011-04-28 A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. [PMID:21443232]
7.Sun, Haiying and 11 more authors. 2011-05-12 Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. [PMID:21462933]
8.Flygare, John A JA and 41 more authors. 2012-05-10 Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). [PMID:22413863]
9.Sheng, Rong R and 13 more authors. 2013-05-23 A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. [PMID:23651223]
10.Zhang, Yong Y and 20 more authors. 2015-07-09 Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer. [PMID:26191364]
11.Baggio, Carlo C and 8 more authors. 2018-07-26 Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. [PMID:29940121]