7,8-Dichloro-2-hydroxyphenazine5,10-dioxide

ID: ALA1288605

Chembl Id: CHEMBL1288605

PubChem CID: 136032536

Max Phase: Preclinical

Molecular Formula: C12H6Cl2N2O3

Molecular Weight: 297.10

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  [O-][n+]1c2ccc(O)cc2[n+]([O-])c2cc(Cl)c(Cl)cc21

Standard InChI:  InChI=1S/C12H6Cl2N2O3/c13-7-4-11-12(5-8(7)14)16(19)10-3-6(17)1-2-9(10)15(11)18/h1-5,17H

Standard InChI Key:  SPDZOGVSSSQFAS-UHFFFAOYSA-N

Molfile:  

     RDKit          2D

 19 21  0  0  0  0  0  0  0  0999 V2000
    3.1849    2.2422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1838    1.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.0039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8956    2.6542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6099    2.2458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6106    1.4203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3247    1.0100    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3191    2.6593    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0338    2.2527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0374    1.4244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7553    1.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4701    1.4332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4625    2.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7440    2.6700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1718    2.6831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3147    3.4828    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3204    0.1872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4716    2.6538    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.4702    1.0049    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  5  4  2  0
  4  1  1  0
  9 10  1  0
 10 11  1  0
  2  3  1  0
 11 12  2  0
  5  6  1  0
 12 13  1  0
  3  6  2  0
 13 14  2  0
 14  9  1  0
  6  7  1  0
 13 15  1  0
  7 10  2  0
  8 16  1  0
  1  2  2  0
  7 17  1  0
  9  8  2  0
  1 18  1  0
  8  5  1  0
  2 19  1  0
M  CHG  4   7   1   8   1  16  -1  17  -1
M  END

Alternative Forms

  1. Parent:

    ALA1288605

    ---

Associated Targets(Human)

TPI1 Tbio Triosephosphate isomerase (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

V79 (1637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calf thymus DNA (4845 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Triosephosphate isomerase, glycosomal (493 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 297.10Molecular Weight (Monoisotopic): 295.9755AlogP: 2.27#Rotatable Bonds:
Polar Surface Area: 74.11Molecular Species: ACIDHBA: 3HBD: 1
#RO5 Violations: HBA (Lipinski): 5HBD (Lipinski): 1#RO5 Violations (Lipinski):
CX Acidic pKa: 6.05CX Basic pKa: 2.79CX LogP: 2.09CX LogD: 0.82
Aromatic Rings: 3Heavy Atoms: 19QED Weighted: 0.39Np Likeness Score: -0.05

References

1. Lavaggi ML, Nieves M, Cabrera M, Olea-Azar C, López de Ceráin A, Monge A, Cerecetto H, González M..  (2010)  Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins.,  45  (11): [PMID:20846761] [10.1016/j.ejmech.2010.08.061]
2. Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A..  (2010)  Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.,  45  (12): [PMID:20889239] [10.1016/j.ejmech.2010.09.034]

Source