11-(1-benzylpiperidin-4-ylamino)-5-methyl-10H-indolo[3,2-b]quinolin-5-ium chloride

ID: ALA1290488

Chembl Id: CHEMBL1290488

PubChem CID: 51051402

Max Phase: Preclinical

Molecular Formula: C28H29ClN4

Molecular Weight: 421.57

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  C[n+]1c2ccccc2c(NC2CCN(Cc3ccccc3)CC2)c2[nH]c3ccccc3c21.[Cl-]

Standard InChI:  InChI=1S/C28H28N4.ClH/c1-31-25-14-8-6-12-23(25)26(27-28(31)22-11-5-7-13-24(22)30-27)29-21-15-17-32(18-16-21)19-20-9-3-2-4-10-20;/h2-14,21H,15-19H2,1H3,(H,29,30);1H

Standard InChI Key:  DLTKQMNGTNFZKJ-UHFFFAOYSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 421.57

Molecular Weight (Monoisotopic): 421.2387

AlogP: 5.38

#Rotatable Bonds: 4

Polar Surface Area: 34.94

Molecular Species: BASE

HBA: 2

HBD: 2

#RO5 Violations: 1

HBA (Lipinski): 4

HBD (Lipinski): 2

#RO5 Violations (Lipinski): 1

CX Acidic pKa: 9.97

CX Basic pKa: 8.91

CX LogP: -0.12

CX LogD: -1.36

Aromatic Rings: 5

Heavy Atoms: 32

QED Weighted: 0.38

Np Likeness Score: -0.34

References

1. Lavrado J, Reszka AP, Moreira R, Neidle S, Paulo A..  (2010)  C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization.,  20  (23): [PMID:20952194] [10.1016/j.bmcl.2010.09.110]

2. Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A..  (2011)  Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.,  54  (3): [PMID:21207937] [10.1021/jm101383f]

3. Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R..  (2012)  Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.,  22  (19): [PMID:22926067] [10.1016/j.bmcl.2012.07.104]

Source

Source(1):

• Scientific Literature