3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone

ID: ALA129510

Chembl Id: CHEMBL129510

Cas Number: 72704-76-8

PubChem CID: 6474896

Max Phase: Preclinical

Molecular Formula: C15H12O3

Molecular Weight: 240.26

Molecule Type: Small molecule

Names and Identifiers

Synonyms: 3,4-Dihydroxychalcone | 3,4-DIHYDROXYCHALCONE|Antioxidant agent-1|(E)-3-(3,4-dihydroxyphenyl)-1-phenylprop-2-en-1-one|CHEMBL129510|72704-76-8|136068-43-4|3-(3,4-Dihydroxyphenyl)-1-phenylprop-2-en-1-one|SCHEMBL1878031|SCHEMBL4972250|BDBM50042963|MS-23402|HY-145104|CS-0356367|3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone|(E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone|2-Propen-1-one,3-(3,4-dihydroxyphenyl)-1-phenyl-|(E)-3-(3,4-dihydroxyphenyl)-1-phenyl-prop-2-en-1-one

Canonical SMILES:  O=C(/C=C/c1ccc(O)c(O)c1)c1ccccc1

Standard InChI:  InChI=1S/C15H12O3/c16-13(12-4-2-1-3-5-12)8-6-11-7-9-14(17)15(18)10-11/h1-10,17-18H/b8-6+

Standard InChI Key:  HHKVOYUYPYZFHJ-SOFGYWHQSA-N

Alternative Forms

1. Parent:

   

   ALA129510

   3,4-Dihydroxychalcone

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 240.26

Molecular Weight (Monoisotopic): 240.0786

AlogP: 2.99

#Rotatable Bonds: 3

Polar Surface Area: 57.53

Molecular Species: NEUTRAL

HBA: 3

HBD: 2

#RO5 Violations: ┄

HBA (Lipinski): 3

HBD (Lipinski): 2

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: 9.00

CX Basic pKa: ┄

CX LogP: 3.28

CX LogD: 3.27

Aromatic Rings: 2

Heavy Atoms: 18

QED Weighted: 0.49

Np Likeness Score: 0.51

References

1. Sogawa S, Nihro Y, Ueda H, Izumi A, Miki T, Matsumoto H, Satoh T..  (1993)  3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.,  36  (24): [PMID:8254620] [10.1021/jm00076a019]

2. Artico M, Di Santo R, Costi R, Novellino E, Greco G, Massa S, Tramontano E, Marongiu ME, De Montis A, La Colla P..  (1998)  Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.,  41  (21): [PMID:9767632] [10.1021/jm9707232]

3. Buolamwini JK, Assefa H..  (2002)  CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.,  45  (4): [PMID:11831895] [10.1021/jm010399h]

4. Seo WD, Kim JH, Kang JE, Ryu HW, Curtis-Long MJ, Lee HS, Yang MS, Park KH..  (2005)  Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors.,  15  (24): [PMID:16202584] [10.1016/j.bmcl.2005.08.087]

5. Batovska D, Parushev S, Slavova A, Bankova V, Tsvetkova I, Ninova M, Najdenski H..  (2007)  Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.,  42  (1): [PMID:17007965] [10.1016/j.ejmech.2006.08.012]

6. Lahtchev KL, Batovska DI, Parushev SP, Ubiyvovk VM, Sibirny AA..  (2008)  Antifungal activity of chalcones: a mechanistic study using various yeast strains.,  43  (10): [PMID:18280009] [10.1016/j.ejmech.2007.12.027]

7. Batovska D, Parushev S, Stamboliyska B, Tsvetkova I, Ninova M, Najdenski H..  (2009)  Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.,  44  (5): [PMID:18584918] [10.1016/j.ejmech.2008.05.010]

8. Fioravanti R, Celestino I, Costi R, Cuzzucoli Crucitti G, Pescatori L, Mattiello L, Novellino E, Checconi P, Palamara AT, Nencioni L, Di Santo R..  (2012)  Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.,  20  (16): [PMID:22743086] [10.1016/j.bmc.2012.05.062]

9. Sharma MC.  (2013)  Molecular modeling studies of substituted 3,4-dihydroxychalcone derivatives as 5-lipoxygenase and cyclooxygenase inhibitors,  [10.1007/s00044-013-0745-7]

10. Hofmann E, Webster J, Do T, Kline R, Snider L, Hauser Q, Higginbottom G, Campbell A, Ma L, Paula S..  (2016)  Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.,  24  (4): [PMID:26762836] [10.1016/j.bmc.2015.12.024]

Source

Source(1):

• Scientific Literature