(+/-)-Norepinephrine (+)bitartrate

ID: ALA1356607

Chembl Id: CHEMBL1356607

Cas Number: 51-40-1

PubChem CID: 11957447

Max Phase: Preclinical

Molecular Formula: C12H17NO9

Molecular Weight: 169.18

Molecule Type: Small molecule

Names and Identifiers

Trade Names(5): Adrenor | Aktamin | Levarterenol Bitartrate | Levophed | Noradrenaline

Canonical SMILES:  NC[C@H](O)c1ccc(O)c(O)c1.O=C(O)C(O)C(O)C(=O)O

Standard InChI:  InChI=1S/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;/m0./s1

Standard InChI Key:  WNPNNLQNNJQYFA-QRPNPIFTSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 169.18

Molecular Weight (Monoisotopic): 169.0739

AlogP: 0.09

#Rotatable Bonds: 2

Polar Surface Area: 86.71

Molecular Species: BASE

HBA: 4

HBD: 4

#RO5 Violations: ┄

HBA (Lipinski): 4

HBD (Lipinski): 5

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: 9.50

CX Basic pKa: 8.85

CX LogP: -0.68

CX LogD: -1.82

Aromatic Rings: 1

Heavy Atoms: 12

QED Weighted: 0.47

Np Likeness Score: 1.19

References

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3. PubChem BioAssay data set, 

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6. Pulgar VM, Keith Harp J..  (2014)  Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors.,  24  (11): [PMID:24792462] [10.1016/j.bmcl.2014.04.040]

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8. Suzuki S, Okano T, Horiuchi R, Hareyama N, Amikura K, Yamamoto N, Yoshizawa Y, Yagi M, Serizawa K, Hayashi R..  (2015)  Discovery of potent α1L-adrenoceptor agonists: Design and synthesis of bicyclic derivatives.,  25  (16): [PMID:26087939] [10.1016/j.bmcl.2015.05.049]

9. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek.  (2020)  Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection,  [10.21203/rs.3.rs-23951/v1]

10. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani.  (2020)  Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen,  [10.6019/CHEMBL4495564]

11. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen.  (2020)  Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort,  [10.6019/CHEMBL4495565]

Source

Source(3):

• Scientific Literature
• PubChem BioAssays
• SARS-CoV-2 Screening Data 2020-21