SID852922

ID: ALA1390274

Chembl Id: CHEMBL1390274

PubChem CID: 655565

Max Phase: Preclinical

Molecular Formula: C21H26N2O5

Molecular Weight: 386.45

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CCOc1ccc2nc(O)c(CN(CC3COCCO3)C(=O)C3CC3)cc2c1

Standard InChI:  InChI=1S/C21H26N2O5/c1-2-27-17-5-6-19-15(10-17)9-16(20(24)22-19)11-23(21(25)14-3-4-14)12-18-13-26-7-8-28-18/h5-6,9-10,14,18H,2-4,7-8,11-13H2,1H3,(H,22,24)

Standard InChI Key:  HPLSDZDHRCCDEF-UHFFFAOYSA-N

Associated Targets(Human)

HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
YWHAG Tchem 14-3-3 protein gamma (58 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

clpP ATP-dependent Clp protease proteolytic subunit (20705 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
vpr Aberrant vpr protein (14595 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 386.45Molecular Weight (Monoisotopic): 386.1842AlogP: 2.49#Rotatable Bonds: 7
Polar Surface Area: 81.12Molecular Species: NEUTRALHBA: 6HBD: 1
#RO5 Violations: HBA (Lipinski): 7HBD (Lipinski): 1#RO5 Violations (Lipinski):
CX Acidic pKa: 11.38CX Basic pKa: 1.68CX LogP: 2.36CX LogD: 2.36
Aromatic Rings: 2Heavy Atoms: 28QED Weighted: 0.79Np Likeness Score: -1.32

References

1. PubChem BioAssay data set, 

Source

Source(1):