5-Hydroxymethyl-3-methyl-furo[3,2-g]chromen-7-one

Names and Identifiers

Canonical SMILES: Cc1coc2cc3oc(=O)cc(CO)c3cc12

Standard InChI: InChI=1S/C13H10O4/c1-7-6-16-11-4-12-10(3-9(7)11)8(5-14)2-13(15)17-12/h2-4,6,14H,5H2,1H3

Standard InChI Key: XWLZQVPQMAEKBX-UHFFFAOYSA-N

Molfile:

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M  END

Alternative Forms

Parent:

ALA141791
5-(Hydroxymethyl)-3-methylfuro[3,2-g]chromen-7-one

Associated Targets(Human)

KCNA1 Tclin Voltage-gated potassium channel subunit Kv1.1 (248 Activities)

Discover Target: KCNA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Molecule Features

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

Drug Indications

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Calculated Properties

Molecular Weight: 230.22	Molecular Weight (Monoisotopic): 230.0579	AlogP: 2.34	#Rotatable Bonds: 1
Polar Surface Area: 63.58	Molecular Species: NEUTRAL	HBA: 4	HBD: 1
#RO5 Violations: ┄	HBA (Lipinski): 4	HBD (Lipinski): 1	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: ┄	CX Basic pKa: ┄	CX LogP: 1.47	CX LogD: 1.47
Aromatic Rings: 3	Heavy Atoms: 17	QED Weighted: 0.65	Np Likeness Score: 0.50

References

1. Wulff H, Rauer H, Düring T, Hanselmann C, Ruff K, Wrisch A, Grissmer S, Hänsel W.. (1998) Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity., 41 (23): [PMID:9804693] [10.1021/jm981032o]
2. Campos-Toimil M, Orallo F, Santana L, Uriarte E.. (2002) Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives., 12 (5): [PMID:11859002] [10.1016/s0960-894x(02)00015-x]
3. Pérez-Montoto LG, Santana L, González-Díaz H.. (2009) Scoring function for DNA-drug docking of anticancer and antiparasitic compounds based on spectral moments of 2D lattice graphs for molecular dynamics trajectories., 44 (11): [PMID:19604606] [10.1016/j.ejmech.2009.06.011]

Source

Source(1):

Scientific Literature