| 1. Balsamo A, Barontini S, Calvani F, Gentili D, Macchia M, Rossello A, Di Modugno E, Felici A.. (1999) New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity., 9 (7): [PMID:10230635] [10.1016/s0960-894x(99)00127-4] |
| 2. Colmenarejo G, Alvarez-Pedraglio A, Lavandera JL.. (2001) Cheminformatic models to predict binding affinities to human serum albumin., 44 (25): [PMID:11728183] [10.1021/jm010960b] |
| 3. Brandt A, Cerquetti M, Corsi GB, Pascucci G, Simeoni A, Martelli P, Valcavi U.. (1987) Synthesis and pharmacological evaluation of a new class of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins., 30 (5): [PMID:3572964] [10.1021/jm00388a003] |
| 4. Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I.. (2005) Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1., 48 (13): [PMID:15974593] [10.1021/jm048982w] |
| 5. Nielsen EI, Viberg A, Löwdin E, Cars O, Karlsson MO, Sandström M.. (2007) Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments., 51 (1): [PMID:17060524] [10.1128/aac.00604-06] |
| 6. Poirel L, Cattoir V, Soares A, Soussy CJ, Nordmann P.. (2007) Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1., 51 (2): [PMID:17116662] [10.1128/aac.01082-06] |
| 7. Kosowska-Shick K, Credito KL, Pankuch GA, DeWasse B, McGhee P, Appelbaum PC.. (2007) Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents., 51 (2): [PMID:17116666] [10.1128/aac.01150-06] |
| 8. Kim IS, Ki CS, Kim S, Oh WS, Peck KR, Song JH, Lee K, Lee NY.. (2007) Diversity of ampicillin resistance genes and antimicrobial susceptibility patterns in Haemophilus influenzae strains isolated in Korea., 51 (2): [PMID:17116681] [10.1128/aac.00960-06] |
| 9. Chen J, Li C, Guan Y, Kong Q, Li C, Guo X, Chen Q, Jing X, Lv Z, An Y.. (2007) Protection of mice from lethal Escherichia coli infection by chimeric human bactericidal/permeability-increasing protein and immunoglobulin G1 Fc gene delivery., 51 (2): [PMID:17145792] [10.1128/aac.00360-06] |
| 10. Robin F, Delmas J, Schweitzer C, Tournilhac O, Lesens O, Chanal C, Bonnet R.. (2007) Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient., 51 (4): [PMID:17220412] [10.1128/aac.01058-06] |
| 11. Naas T, Aubert D, Ozcan A, Nordmann P.. (2007) Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii., 51 (4): [PMID:17242148] [10.1128/aac.01152-06] |
| 12. Mendonça N, Leitão J, Manageiro V, Ferreira E, Caniça M.. (2007) Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal., 51 (6): [PMID:17371815] [10.1128/aac.01412-06] |
| 13. Poirel L, Corvec S, Rapoport M, Mugnier P, Petroni A, Pasteran F, Faccone D, Galas M, Drugeon H, Cattoir V, Nordmann P.. (2007) Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina., 51 (6): [PMID:17420213] [10.1128/aac.01600-06] |
| 14. Papagiannitsis CC, Loli A, Tzouvelekis LS, Tzelepi E, Arlet G, Miriagou V.. (2007) SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli., 51 (6): [PMID:17353248] [10.1128/aac.01439-06] |
| 15. Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.. (2008) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors., 51 (21): [PMID:18834112] [10.1021/jm800656v] |
| 16. Papagiannitsis CC, Tzouvelekis LS, Tzelepi E, Miriagou V.. (2007) Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli., 51 (10): [PMID:17664321] [10.1128/aac.00389-07] |
| 17. Billal DS, Hotomi M, Yamanaka N.. (2007) Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae?, 51 (9): [PMID:17606681] [10.1128/aac.00190-07] |
| 18. Pérez A, Canle D, Latasa C, Poza M, Beceiro A, Tomás Mdel M, Fernández A, Mallo S, Pérez S, Molina F, Villanueva R, Lasa I, Bou G.. (2007) Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate., 51 (9): [PMID:17638702] [10.1128/aac.00072-07] |
| 19. Jansen WT, Verel A, Verhoef J, Milatovic D.. (2007) In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe., 51 (9): [PMID:17606689] [10.1128/aac.00100-07] |
| 20. Girlich D, Leclercq R, Naas T, Nordmann P.. (2007) Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii., 51 (11): [PMID:17846134] [10.1128/aac.00537-07] |
| 21. Neuwirth C, Siebor E, Robin F, Bonnet R.. (2007) First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France., 51 (12): [PMID:17938180] [10.1128/aac.01462-06] |
| 22. Hotomi M, Fujihara K, Billal DS, Suzuki K, Nishimura T, Baba S, Yamanaka N.. (2007) Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan., 51 (11): [PMID:17698631] [10.1128/aac.00422-07] |
| 23. Robin F, Delmas J, Brebion A, Dubois D, Constantin JM, Bonnet R.. (2007) TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases., 51 (11): [PMID:17709463] [10.1128/aac.00614-07] |
| 24. Daikos GL, Kosmidis C, Tassios PT, Petrikkos G, Vasilakopoulou A, Psychogiou M, Stefanou I, Avlami A, Katsilambros N.. (2007) Enterobacteriaceae bloodstream infections: presence of integrons, risk factors, and outcome., 51 (7): [PMID:17452479] [10.1128/aac.00044-07] |
| 25. García-Cobos S, Campos J, Lázaro E, Román F, Cercenado E, García-Rey C, Pérez-Vázquez M, Oteo J, de Abajo F.. (2007) Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime., 51 (7): [PMID:17470649] [10.1128/aac.00354-07] |
| 26. Power P, Di Conza J, Rodríguez MM, Ghiglione B, Ayala JA, Casellas JM, Radice M, Gutkind G.. (2007) Biochemical characterization of PER-2 and genetic environment of blaPER-2., 51 (7): [PMID:17438050] [10.1128/aac.01395-06] |
| 27. Critchley IA, Brown SD, Traczewski MM, Tillotson GS, Janjic N.. (2007) National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study., 51 (12): [PMID:17908940] [10.1128/aac.00971-07] |
| 28. Meziane-Cherif D, Decré D, Høiby EA, Courvalin P, Périchon B.. (2008) Genetic and biochemical characterization of CAD-1, a chromosomally encoded new class A penicillinase from Carnobacterium divergens., 52 (2): [PMID:18070972] [10.1128/aac.01145-07] |
| 29. Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.. (2009) Physicochemical determinants of human renal clearance., 52 (15): [PMID:19445515] [10.1021/jm900403j] |
| 30. Zong Z, Partridge SR, Iredell JR.. (2008) RmtC 16S rRNA methyltransferase in Australia., 52 (2): [PMID:18025117] [10.1128/aac.01399-07] |
| 31. Miguet L, Zervosen A, Gerards T, Pasha FA, Luxen A, Distèche-Nguyen M, Thomas A.. (2009) Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening., 52 (19): [PMID:19746934] [10.1021/jm900625q] |
| 32. Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.. (2010) Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination., 53 (3): [PMID:20070106] [10.1021/jm901371v] |
| 33. Guerra A, Campillo NE, Páez JA.. (2010) Neural computational prediction of oral drug absorption based on CODES 2D descriptors., 45 (3): [PMID:20022146] [10.1016/j.ejmech.2009.11.034] |
| 34. Rodriguez-Martinez JM, Nordmann P, Fortineau N, Poirel L.. (2010) VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae., 54 (1): [PMID:19917750] [10.1128/aac.00458-09] |
| 35. Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, Kang Y.. (2010) Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance., 54 (1): [PMID:19884366] [10.1128/aac.00966-09] |
| 36. Faure S, Perrin-Guyomard A, Delmas JM, Chatre P, Laurentie M.. (2010) Transfer of plasmid-mediated CTX-M-9 from Salmonella enterica serotype Virchow to Enterobacteriaceae in human flora-associated rats treated with cefixime., 54 (1): [PMID:19901088] [10.1128/aac.00310-09] |
| 37. Girlich D, Poirel L, Nordmann P.. (2010) Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France., 54 (1): [PMID:19901091] [10.1128/aac.00961-09] |
| 38. Robin F, Aggoune-Khinache N, Delmas J, Naim M, Bonnet R.. (2010) Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria., 54 (1): [PMID:19901092] [10.1128/aac.00017-09] |
| 39. Doublet B, Robin F, Casin I, Fabre L, Le Fleche A, Bonnet R, Weill FX.. (2010) Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola., 54 (1): [PMID:19884377] [10.1128/aac.00427-09] |
| 40. Girlich D, Poirel L, Nordmann P.. (2010) First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii isolate., 54 (1): [PMID:19884362] [10.1128/aac.00861-09] |
| 41. Poirel L, Docquier JD, De Luca F, Verlinde A, Ide L, Rossolini GM, Nordmann P.. (2010) BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa., 54 (1): [PMID:19884378] [10.1128/aac.00859-09] |
| 42. Kotsakis SD, Papagiannitsis CC, Tzelepi E, Legakis NJ, Miriagou V, Tzouvelekis LS.. (2010) GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa., 54 (3): [PMID:20065056] [10.1128/aac.01561-09] |
| 43. Meziane-Cherif D, Lambert T, Dupêchez M, Courvalin P, Galimand M.. (2008) Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442., 52 (4): [PMID:18212108] [10.1128/aac.00684-07] |
| 44. Sevillano D, Aguilar L, Alou L, Giménez MJ, Torrico M, González N, Cafini F, Relaño MT, Coronel P, Prieto J.. (2008) Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil., 52 (3): [PMID:18160517] [10.1128/aac.01247-07] |
| 45. Hernould M, Gagné S, Fournier M, Quentin C, Arpin C.. (2008) Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance., 52 (4): [PMID:18268083] [10.1128/aac.01052-07] |
| 46. Mendonça N, Manageiro V, Bonnet R, Caniça M.. (2008) Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae., 52 (5): [PMID:18316524] [10.1128/aac.01525-07] |
| 47. Smith K, Ednie LM, Appelbaum PC, Hawser S, Lociuro S.. (2008) Antistreptococcal activity of AR-709 compared to that of other agents., 52 (6): [PMID:18362189] [10.1128/aac.01620-07] |
| 48. Novais A, Cantón R, Coque TM, Moya A, Baquero F, Galán JC.. (2008) Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance., 52 (7): [PMID:18443114] [10.1128/aac.01658-07] |
| 49. Nannini EC, Stryjewski ME, Singh KV, Rude TH, Corey GR, Fowler VG, Murray BE.. (2010) Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus., 54 (5): [PMID:20211890] [10.1128/aac.01325-09] |
| 50. Salas C, Calvo J, Martínez-Martínez L.. (2008) Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes., 52 (4): [PMID:18227183] [10.1128/aac.01129-07] |
| 51. Mendonça N, Manageiro V, Robin F, Salgado MJ, Ferreira E, Caniça M, Bonnet R.. (2008) The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition., 52 (5): [PMID:18316518] [10.1128/aac.01381-07] |
| 52. Takahata S, Kato Y, Sanbongi Y, Maebashi K, Ida T.. (2008) Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes., 52 (5): [PMID:18347113] [10.1128/aac.00936-07] |
| 53. San Millan A, Garcia-Cobos S, Escudero JA, Hidalgo L, Gutierrez B, Carrilero L, Campos J, Gonzalez-Zorn B.. (2010) Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination., 54 (4): [PMID:20086141] [10.1128/aac.01489-09] |
| 54. De Luca F, Giraud-Morin C, Rossolini GM, Docquier JD, Fosse T.. (2010) Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes., 54 (4): [PMID:20124004] [10.1128/aac.01252-09] |
| 55. Izdebski R, Rutschmann J, Fiett J, Sadowy E, Gniadkowski M, Hryniewicz W, Hakenbeck R.. (2008) Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20., 52 (3): [PMID:18160523] [10.1128/aac.01082-07] |
| 56. Endimiani A, Carias LL, Hujer AM, Bethel CR, Hujer KM, Perez F, Hutton RA, Fox WR, Hall GS, Jacobs MR, Paterson DL, Rice LB, Jenkins SG, Tenover FC, Bonomo RA.. (2008) Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States., 52 (7): [PMID:18426899] [10.1128/aac.00158-08] |
| 57. Hu RM, Huang KJ, Wu LT, Hsiao YJ, Yang TC.. (2008) Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia., 52 (3): [PMID:18086856] [10.1128/aac.00682-07] |
| 58. Marchiaro P, Tomatis PE, Mussi MA, Pasteran F, Viale AM, Limansky AS, Vila AJ.. (2008) Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain., 52 (6): [PMID:18362187] [10.1128/aac.01025-07] |
| 59. Doi Y, Poirel L, Paterson DL, Nordmann P.. (2008) Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans., 52 (6): [PMID:18362192] [10.1128/aac.01463-07] |
| 60. Guillon H, Eb F, Mammeri H.. (2010) Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena., 54 (5): [PMID:20308380] [10.1128/aac.00791-09] |
| 61. Chen TL, Wu RC, Shaio MF, Fung CP, Cho WL.. (2008) Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii., 52 (7): [PMID:18443121] [10.1128/aac.00393-08] |
| 62. Stoczko M, Frère JM, Rossolini GM, Docquier JD.. (2008) Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora., 52 (7): [PMID:18443127] [10.1128/aac.01062-07] |
| 63. Krause KM, Renelli M, Difuntorum S, Wu TX, Debabov DV, Benton BM.. (2008) In vitro activity of telavancin against resistant gram-positive bacteria., 52 (7): [PMID:18443122] [10.1128/aac.01398-07] |
| 64. Pränting M, Negrea A, Rhen M, Andersson DI.. (2008) Mechanism and fitness costs of PR-39 resistance in Salmonella enterica serovar Typhimurium LT2., 52 (8): [PMID:18519732] [10.1128/aac.00205-08] |
| 65. Dahesh S, Hensler ME, Van Sorge NM, Gertz RE, Schrag S, Nizet V, Beall BW.. (2008) Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics., 52 (8): [PMID:18541727] [10.1128/aac.00461-08] |
| 66. Pérez-Trallero E, Martín-Herrero JE, Mazón A, García-Delafuente C, Robles P, Iriarte V, Dal-Ré R, García-de-Lomas J, Spanish Surveillance Group for Respiratory Pathogens.. (2010) Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007)., 54 (7): [PMID:20439616] [10.1128/aac.01548-09] |
| 67. Petrella S, Ziental-Gelus N, Mayer C, Renard M, Jarlier V, Sougakoff W.. (2008) Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France., 52 (10): [PMID:18625772] [10.1128/aac.00163-08] |
| 68. Fenoll A, Aguilar L, Robledo O, Giménez MJ, Granizo JJ, Biek D, Tarragó D.. (2008) In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime., 52 (11): [PMID:18725443] [10.1128/aac.00712-08] |
| 69. Chen TL, Chang WC, Kuo SC, Lee YT, Chen CP, Siu LK, Cho WL, Fung CP.. (2010) Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU., 54 (8): [PMID:20516281] [10.1128/aac.00128-10] |
| 70. Dubois V, Poirel L, Demarthe F, Arpin C, Coulange L, Minarini LA, Bezian MC, Nordmann P, Quentin C.. (2008) Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae., 52 (10): [PMID:18663019] [10.1128/aac.00387-08] |
| 71. Sevillano D, Giménez MJ, Cercenado E, Cafini F, Gené A, Alou L, Marco F, Martínez-Martínez L, Coronel P, Aguilar L.. (2009) Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers., 53 (1): [PMID:18955529] [10.1128/aac.00402-08] |
| 72. Pomba C, da Fonseca JD, Baptista BC, Correia JD, Martínez-Martínez L.. (2009) Detection of the pandemic O25-ST131 human virulent Escherichia coli CTX-M-15-producing clone harboring the qnrB2 and aac(6')-Ib-cr genes in a dog., 53 (1): [PMID:19001117] [10.1128/aac.00896-08] |
| 73. Sekiguchi J, Morita K, Kitao T, Watanabe N, Okazaki M, Miyoshi-Akiyama T, Kanamori M, Kirikae T.. (2008) KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate., 52 (11): [PMID:18765691] [10.1128/aac.01337-07] |
| 74. Juan C, Beceiro A, Gutiérrez O, Albertí S, Garau M, Pérez JL, Bou G, Oliver A.. (2008) Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain., 52 (10): [PMID:18644957] [10.1128/aac.00465-08] |
| 75. Huang YW, Lin CW, Hu RM, Lin YT, Chung TC, Yang TC.. (2010) AmpN-AmpG operon is essential for expression of L1 and L2 beta-lactamases in Stenotrophomonas maltophilia., 54 (6): [PMID:20385866] [10.1128/aac.01283-09] |
| 76. Samuelsen Ø, Castanheira M, Walsh TR, Spencer J.. (2008) Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family., 52 (8): [PMID:18559652] [10.1128/aac.00166-08] |
| 77. Obach RS, Lombardo F, Waters NJ.. (2008) Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds., 36 (7): [PMID:18426954] [10.1124/dmd.108.020479] |
| 78. Morgenstern K, Baljer G, Norris DE, Kraiczy P, Hanssen-Hübner C, Hunfeld KP.. (2009) In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease., 53 (3): [PMID:19075048] [10.1128/aac.01247-08] |
| 79. Jones CH, Ruzin A, Tuckman M, Visalli MA, Petersen PJ, Bradford PA.. (2009) Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155., 53 (3): [PMID:19075050] [10.1128/aac.01155-08] |
| 80. Poirel L, Rodriguez-Martinez JM, Plésiat P, Nordmann P.. (2009) Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex., 53 (3): [PMID:19075063] [10.1128/aac.00946-08] |
| 81. Zioga A, Whichard JM, Kotsakis SD, Tzouvelekis LS, Tzelepi E, Miriagou V.. (2009) CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids., 53 (3): [PMID:19104021] [10.1128/aac.01284-08] |
| 82. Schneider I, Queenan AM, Markovska R, Markova B, Keuleyan E, Bauernfeind A.. (2009) New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria., 53 (10): [PMID:19620330] [10.1128/aac.00461-09] |
| 83. Zeba B, De Luca F, Dubus A, Delmarcelle M, Simporé J, Nacoulma OG, Rossolini GM, Frère JM, Docquier JD.. (2009) IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso., 53 (10): [PMID:19651915] [10.1128/aac.01607-08] |
| 84. Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR.. (2009) Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India., 53 (12): [PMID:19770275] [10.1128/aac.00774-09] |
| 85. Rodríguez-Martínez JM, Nordmann P, Ronco E, Poirel L.. (2010) Extended-spectrum cephalosporinase in Acinetobacter baumannii., 54 (8): [PMID:20547808] [10.1128/aac.00050-10] |
| 86. Talevi A, Goodarzi M, Ortiz EV, Duchowicz PR, Bellera CL, Pesce G, Castro EA, Bruno-Blanch LE.. (2011) Prediction of drug intestinal absorption by new linear and non-linear QSPR., 46 (1): [PMID:21112128] [10.1016/j.ejmech.2010.11.005] |
| 87. Beceiro A, Pérez A, Fernández-Cuenca F, Martínez-Martínez L, Pascual A, Vila J, Rodríguez-Baño J, Cisneros JM, Pachón J, Bou G, Spanish Group for Nosocomial Infection (GEIH).. (2009) Genetic variability among ampC genes from acinetobacter genomic species 3., 53 (3): [PMID:19029333] [10.1128/aac.00485-08] |
| 88. Hedberg ST, Fredlund H, Nicolas P, Caugant DA, Olcén P, Unemo M.. (2009) Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives., 53 (4): [PMID:19188396] [10.1128/aac.00994-08] |
| 89. Sandberg A, Hessler JH, Skov RL, Blom J, Frimodt-Møller N.. (2009) Intracellular activity of antibiotics against Staphylococcus aureus in a mouse peritonitis model., 53 (5): [PMID:19223616] [10.1128/aac.01605-07] |
| 90. Kosowska-Shick K, McGhee P, Appelbaum PC.. (2009) Binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities., 53 (5): [PMID:19237649] [10.1128/aac.01566-08] |
| 91. Wang M, Guo Q, Xu X, Wang X, Ye X, Wu S, Hooper DC, Wang M.. (2009) New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis., 53 (5): [PMID:19258263] [10.1128/aac.01400-08] |
| 92. Doublet B, Granier SA, Robin F, Bonnet R, Fabre L, Brisabois A, Cloeckaert A, Weill FX.. (2009) Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg., 53 (5): [PMID:19273683] [10.1128/aac.01581-08] |
| 93. Lemaire S, Glupczynski Y, Duval V, Joris B, Tulkens PM, Van Bambeke F.. (2009) Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus., 53 (6): [PMID:19289525] [10.1128/aac.01135-08] |
| 94. Kosowska-Shick K, Ednie LM, McGhee P, Appelbaum PC.. (2009) Comparative antipneumococcal activities of sulopenem and other drugs., 53 (6): [PMID:19307366] [10.1128/aac.01531-08] |
| 95. Potron A, Poirel L, Croizé J, Chanteperdrix V, Nordmann P.. (2009) Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii., 53 (7): [PMID:19380596] [10.1128/aac.01164-08] |
| 96. Doi Y, Paterson DL, Adams-Haduch JM, Sidjabat HE, O'Keefe A, Endimiani A, Bonomo RA.. (2009) Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase., 53 (7): [PMID:19414578] [10.1128/aac.00133-09] |
| 97. Yang TC, Huang YW, Hu RM, Huang SC, Lin YT.. (2009) AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia., 53 (7): [PMID:19414581] [10.1128/aac.01513-08] |
| 98. Kotsakis SD, Papagiannitsis CC, Tzelepi E, Tzouvelekis LS, Miriagou V.. (2009) Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase., 53 (8): [PMID:19470510] [10.1128/aac.00219-09] |
| 99. Griggs DJ, Peake L, Johnson MM, Ghori S, Mott A, Piddock LJ.. (2009) Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni., 53 (8): [PMID:19506058] [10.1128/aac.01655-08] |
| 100. Papagiannitsis CC, Tzouvelekis LS, Miriagou V.. (2009) Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter., 53 (1): [PMID:19001114] [10.1128/aac.00912-08] |
| 101. Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN.. (2010) Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States., 54 (6): [PMID:20308374] [10.1128/aac.01797-09] |
| 102. Collins B, Curtis N, Cotter PD, Hill C, Ross RP.. (2010) The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics., 54 (10): [PMID:20643901] [10.1128/aac.00503-10] |
| 103. Collins B, Joyce S, Hill C, Cotter PD, Ross RP.. (2010) TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics., 54 (11): [PMID:20713661] [10.1128/aac.00290-10] |
| 104. Borgianni L, Vandenameele J, Matagne A, Bini L, Bonomo RA, Frère JM, Rossolini GM, Docquier JD.. (2010) Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding., 54 (8): [PMID:20498317] [10.1128/aac.01336-09] |
| 105. Bent ZW, Young GM.. (2010) Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B., 54 (9): [PMID:20547799] [10.1128/aac.01754-09] |
| 106. Buvens G, Bogaerts P, Glupczynski Y, Lauwers S, Piérard D.. (2010) Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26., 54 (11): [PMID:20733038] [10.1128/aac.00551-10] |
| 107. Mammeri H, Guillon H, Eb F, Nordmann P.. (2010) Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC β-lactamases., 54 (11): [PMID:20733047] [10.1128/aac.01762-09] |
| 108. Borgianni L, Prandi S, Salden L, Santella G, Hanson ND, Rossolini GM, Docquier JD.. (2011) Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States., 55 (1): [PMID:21041509] [10.1128/aac.00858-10] |
| 109. Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.. (2004) Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling., 1 (4): [PMID:16472241] [10.2174/1570163043334794] |
| 110. Gozalbes R, Jacewicz M, Annand R, Tsaioun K, Pineda-Lucena A.. (2011) QSAR-based permeability model for drug-like compounds., 19 (8): [PMID:21458999] [10.1016/j.bmc.2011.03.011] |
| 111. Pedretti A, De Luca L, Marconi C, Regazzoni L, Aldini G, Vistoli G.. (2011) Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping., 19 (15): [PMID:21741846] [10.1016/j.bmc.2011.06.027] |
| 112. Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.. (2011) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)., 7 (12): [PMID:22194678] [10.1371/journal.pcbi.1002310] |
| 113. Plech T, Wujec M, Kosikowska U, Malm A, Kaproń B.. (2012) Studies on the synthesis and antibacterial activity of 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles., 47 [PMID:22100136] [10.1016/j.ejmech.2011.10.055] |
| 114. Brvar M, Perdih A, Hodnik V, Renko M, Anderluh G, Jerala R, Solmajer T.. (2012) In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B., 20 (8): [PMID:22444877] [10.1016/j.bmc.2012.02.052] |
| 115. Sarkar A, Anderson KC, Kellogg GE.. (2012) Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics., 52 [PMID:22483632] [10.1016/j.ejmech.2012.03.008] |
| 116. Luckner P, Brandsch M.. (2005) Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1., 59 (1): [PMID:15567297] [10.1016/j.ejpb.2004.07.008] |
| 117. Luckner P, Brandsch M.. (2005) Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1., 59 (1): [PMID:15567297] [10.1016/j.ejpb.2004.07.008] |
| 118. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
| 119. Brvar M, Perdih A, Renko M, Anderluh G, Turk D, Solmajer T.. (2012) Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors., 55 (14): [PMID:22731783] [10.1021/jm300395d] |
| 120. Popiołek L, Kosikowska U, Mazur L, Dobosz M, Malm A.. (2013) Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives., 22 (7): [PMID:23710121] [10.1007/s00044-012-0302-9] |
| 121. Plech T, Wujec M, Majewska M, Kosikowska U, Malm A.. (2013) Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity., 22 (5): [PMID:23543889] [10.1007/s00044-012-0248-y] |
| 122. Thomas AA, Hunt KW, Volgraf M, Watts RJ, Liu X, Vigers G, Smith D, Sammond D, Tang TP, Rhodes SP, Metcalf AT, Brown KD, Otten JN, Burkard M, Cox AA, Do MK, Dutcher D, Rana S, DeLisle RK, Regal K, Wright AD, Groneberg R, Scearce-Levie K, Siu M, Purkey HE, Lyssikatos JP, Gunawardana IW.. (2014) Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system., 57 (3): [PMID:24397738] [10.1021/jm401635n] |
| 123. Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.. (2004) [Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs]., 28 (8-9): [PMID:15646539] [10.1016/s0399-8320(04)95062-2] |
| 124. Foss MH, Eun YJ, Grove CI, Pauw DA, Sorto NA, Rensvold JW, Pagliarini DJ, Shaw JT, Weibel DB.. (2013) Inhibitors of bacterial tubulin target bacterial membranes in vivo., 4 (1): [PMID:23539337] [10.1039/c2md20127e] |
| 125. Perdih A, Hrast M, Barreteau H, Gobec S, Wolber G, Solmajer T.. (2014) Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF)., 22 (15): [PMID:24953950] [10.1016/j.bmc.2014.05.058] |
| 126. de Waart DR, van de Wetering K, Kunne C, Duijst S, Paulusma CC, Oude Elferink RP.. (2012) Oral availability of cefadroxil depends on ABCC3 and ABCC4., 40 (3): [PMID:22166395] [10.1124/dmd.111.041731] |
| 127. Wolman AT, Gionfriddo MR, Heindel GA, Mukhija P, Witkowski S, Bommareddy A, Vanwert AL.. (2013) Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., 41 (4): [PMID:23344796] [10.1124/dmd.112.049569] |
| 128. Viveka S, Dinesha, Shama P, Nagaraja GK, Ballav S, Kerkar S.. (2015) Design and synthesis of some new pyrazolyl-pyrazolines as potential anti-inflammatory, analgesic and antibacterial agents., 101 [PMID:26186150] [10.1016/j.ejmech.2015.07.002] |
| 129. WHO Anatomical Therapeutic Chemical Classification, |
| 130. Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.. (2016) DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans., 21 (4): [PMID:26948801] [10.1016/j.drudis.2016.02.015] |
| 131. Giacomini D, Musumeci R, Galletti P, Martelli G, Assennato L, Sacchetti G, Guerrini A, Calaresu E, Martinelli M, Cocuzza C.. (2017) 4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties., 140 [PMID:28992569] [10.1016/j.ejmech.2017.09.048] |
| 132. Unpublished dataset, |
| 133. Katie Heiser, Peter F. McLean, Chadwick T. Davis, Ben Fogelson, Hannah B. Gordon, Pamela Jacobson, Brett Hurst, Ben Miller, Ronald W. Alfa, Berton A. Earnshaw, Mason L. Victors, Yolanda T. Chong, Imran S. Haque, Adeline S. Low, Christopher C. Gibson. (2020) Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2, [10.1101/2020.04.21.054387] |
| 134. Dargó G, Bajusz D, Simon K, Müller J, Balogh GT.. (2020) Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design., 63 (4): [PMID:31995375] [10.1021/acs.jmedchem.0c00046] |
| 135. Lui HK, Gao W, Cheung KC, Jin WB, Sun N, Kan JWY, Wong ILK, Chiou J, Lin D, Chan EWC, Leung YC, Chan TH, Chen S, Chan KF, Wong KY.. (2019) Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor., 163 [PMID:30503946] [10.1016/j.ejmech.2018.11.052] |
| 136. Wang X, Chen J, Wang W, Jaunarajs A, Wang X.. (2019) Tryptoline-based benzothiazoles re-sensitize MRSA to β-lactam antibiotics., 27 (21): [PMID:31521461] [10.1016/j.bmc.2019.115095] |
| 137. Soares Romeiro LA, da Costa Nunes JL, de Oliveira Miranda C, Simões Heyn Roth Cardoso G, de Oliveira AS, Gandini A, Kobrlova T, Soukup O, Rossi M, Senger J, Jung M, Gervasoni S, Vistoli G, Petralla S, Massenzio F, Monti B, Bolognesi ML.. (2019) Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer's Disease., 10 (4): [PMID:30996816] [10.1021/acsmedchemlett.9b00071] |
| 138. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 139. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 140. Unpublished dataset, |
| 141. van Oosten LN, Klein CD.. (2020) Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening., 63 (16): [PMID:32191034] [10.1021/acs.jmedchem.0c00040] |
| 142. Ellen Van Damme. (2021) Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity, [10.6019/CHEMBL4651402] |
| 143. Sobolova K,Hrabinova M,Hepnarova V,Kucera T,Kobrlova T,Benkova M,Janockova J,Dolezal R,Prchal L,Benek O,Mezeiova E,Jun D,Soukup O,Korabecny J. (2020) Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile., 203 [PMID:32688201] [10.1016/j.ejmech.2020.112593] |
| 144. Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA.. (2022) Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases., 228 [PMID:34865870] [10.1016/j.ejmech.2021.113975] |
| 145. Qin HL, Zhang ZW, Ravindar L, Rakesh KP.. (2020) Antibacterial activities with the structure-activity relationship of coumarin derivatives., 207 [PMID:32971428] [10.1016/j.ejmech.2020.112832] |
| 146. Sutherland JJ, Yonchev D, Fekete A, Urban L.. (2023) A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs., 14 (1): [PMID:37468498] [10.1038/s41467-023-40064-9] |
