| 1. Angelo M, Ortwine D, Worth D, Werbel LM, McCall JW.. (1983) Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]- 2-pyrimidinyl]-N'-phenylguanidines., 26 (9): [PMID:6887202] [10.1021/jm00363a010] |
| 2. O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK.. (1994) The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine., 37 (9): [PMID:8176713] [10.1021/jm00035a017] |
| 3. Go ML, Ngiam TL, Wan AS.. (1981) Synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds., 24 (12): [PMID:7031248] [10.1021/jm00144a020] |
| 4. Raynes KJ, Stocks PA, O'Neill PM, Park BK, Ward SA.. (1999) New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain., 42 (15): [PMID:10425085] [10.1021/jm9901374] |
| 5. Delarue S, Girault S, Maes L, Debreu-Fontaine MA, Labaeïd M, Grellier P, Sergheraert C.. (2001) Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines., 44 (17): [PMID:11495593] [10.1021/jm010842o] |
| 6. O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK.. (1997) Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues., 40 (4): [PMID:9046333] [10.1021/jm960370r] |
| 7. O'Neill PM, Mukhtar A, Stocks PA, Randle LE, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK.. (2003) Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials., 46 (23): [PMID:14584944] [10.1021/jm030796n] |
| 8. Kesten SJ, Johnson J, Werbel LM.. (1987) Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl] -6-alkylphenols and their N omega-oxides., 30 (5): [PMID:3553599] [10.1021/jm00388a027] |
| 9. Werbel LM, Cook PD, Elslager EF, Hung JH, Johnson JL, Kesten SJ, McNamara DJ, Ortwine DF, Worth DF.. (1986) Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl] [1,1'-biphenyl]-2-ols and N omega-oxides., 29 (6): [PMID:3712383] [10.1021/jm00156a009] |
| 10. de Mello H, Echevarria A, Bernardino AM, Canto-Cavalheiro M, Leon LL.. (2004) Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis., 47 (22): [PMID:15481980] [10.1021/jm0401006] |
| 11. Gemma S, Kukreja G, Fattorusso C, Persico M, Romano MP, Altarelli M, Savini L, Campiani G, Fattorusso E, Basilico N, Taramelli D, Yardley V, Butini S.. (2006) Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains., 16 (20): [PMID:16890433] [10.1016/j.bmcl.2006.07.060] |
| 12. Huy NT, Uyen DT, Maeda A, Trang DT, Oida T, Harada S, Kamei K.. (2007) Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds., 51 (1): [PMID:17088494] [10.1128/aac.00985-06] |
| 13. Friebolin W, Jannack B, Wenzel N, Furrer J, Oeser T, Sanchez CP, Lanzer M, Yardley V, Becker K, Davioud-Charvet E.. (2008) Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum., 51 (5): [PMID:18260613] [10.1021/jm7009292] |
| 14. Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.. (2008) Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles., 51 (7): [PMID:18341274] [10.1021/jm701435h] |
| 15. Fivelman QL, Adagu IS, Warhurst DC.. (2007) Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains., 51 (6): [PMID:17404003] [10.1128/aac.01479-06] |
| 16. Zsila F, Visy J, Mády G, Fitos I.. (2008) Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein., 16 (7): [PMID:18289858] [10.1016/j.bmc.2008.01.053] |
| 17. Delarue-Cochin S, Paunescu E, Maes L, Mouray E, Sergheraert C, Grellier P, Melnyk P.. (2008) Synthesis and antimalarial activity of new analogues of amodiaquine., 43 (2): [PMID:17485145] [10.1016/j.ejmech.2007.03.008] |
| 18. Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P.. (2008) Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline., 43 (10): [PMID:18226428] [10.1016/j.ejmech.2007.11.003] |
| 19. O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA.. (2009) Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century., 52 (5): [PMID:19222165] [10.1021/jm8012618] |
| 20. O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA.. (2009) Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine., 52 (7): [PMID:19284751] [10.1021/jm8012757] |
| 21. Pedersen JM, Matsson P, Bergström CA, Norinder U, Hoogstraate J, Artursson P.. (2008) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2)., 51 (11): [PMID:18457386] [10.1021/jm7015683] |
| 22. Farag NA, Mohamed SR, Soliman GA.. (2008) Design, synthesis, and docking studies of novel benzopyrone derivatives as H(1)-antihistaminic agents., 16 (19): [PMID:18789706] [10.1016/j.bmc.2008.08.039] |
| 23. de Souza MV, Pais KC, Kaiser CR, Peralta MA, de L Ferreira M, Lourenço MC.. (2009) Synthesis and in vitro antitubercular activity of a series of quinoline derivatives., 17 (4): [PMID:19188070] [10.1016/j.bmc.2009.01.013] |
| 24. Kouznetsov VV, Gómez-Barrio A.. (2009) Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation., 44 (8): [PMID:19361896] [10.1016/j.ejmech.2009.02.024] |
| 25. Guglielmo S, Bertinaria M, Rolando B, Crosetti M, Fruttero R, Yardley V, Croft SL, Gasco A.. (2009) A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity., 44 (12): [PMID:19811859] [10.1016/j.ejmech.2009.09.012] |
| 26. Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA.. (2008) In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen., 105 (26): [PMID:18579783] [10.1073/pnas.0802982105] |
| 27. Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK.. (2010) Chemical genetics of Plasmodium falciparum., 465 (7296): [PMID:20485428] [10.1038/nature09099] |
| 28. Wenzel NI, Chavain N, Wang Y, Friebolin W, Maes L, Pradines B, Lanzer M, Yardley V, Brun R, Herold-Mende C, Biot C, Tóth K, Davioud-Charvet E.. (2010) Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA., 53 (8): [PMID:20329733] [10.1021/jm9018383] |
| 29. Cretton S, Glauser G, Humam M, Jeannerat D, Muñoz O, Maes L, Christen P, Hostettmann K.. (2010) Isomeric tropane alkaloids from the aerial parts of Schizanthus tricolor., 73 (5): [PMID:20166702] [10.1021/np900780w] |
| 30. Abu Khalaf R, Abu Sheikha G, Bustanji Y, Taha MO.. (2010) Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration., 45 (4): [PMID:20116902] [10.1016/j.ejmech.2009.12.070] |
| 31. Prado-Prado FJ, García-Mera X, González-Díaz H.. (2010) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species., 18 (6): [PMID:20185316] [10.1016/j.bmc.2010.01.068] |
| 32. Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN, Clark TD, Dorsey G, Lindegardh N, Annerberg A, Rosenthal PJ, Kamya MR, Aweeka F.. (2010) Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda., 54 (1): [PMID:19841149] [10.1128/aac.00679-09] |
| 33. Cairns M, Cisse B, Sokhna C, Cames C, Simondon K, Ba EH, Trape JF, Gaye O, Greenwood BM, Milligan PJ.. (2010) Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children., 54 (3): [PMID:20065053] [10.1128/aac.01161-09] |
| 34. Gozalbes R, Pineda-Lucena A.. (2010) QSAR-based solubility model for drug-like compounds., 18 (19): [PMID:20810286] [10.1016/j.bmc.2010.08.003] |
| 35. Roberts L, Egan TJ, Joiner KA, Hoppe HC.. (2008) Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum., 52 (5): [PMID:18316523] [10.1128/aac.01478-07] |
| 36. Russell B, Chalfein F, Prasetyorini B, Kenangalem E, Piera K, Suwanarusk R, Brockman A, Prayoga P, Sugiarto P, Cheng Q, Tjitra E, Anstey NM, Price RN.. (2008) Determinants of in vitro drug susceptibility testing of Plasmodium vivax., 52 (3): [PMID:18180357] [10.1128/aac.01334-07] |
| 37. PubChem BioAssay data set, |
| 38. Pelletier DJ, Gehlhaar D, Tilloy-Ellul A, Johnson TO, Greene N.. (2007) Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential., 47 (1): [PMID:17428028] [10.1021/ci6004542] |
| 39. Adjei GO, Kristensen K, Goka BQ, Hoegberg LC, Alifrangis M, Rodrigues OP, Kurtzhals JA.. (2008) Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria., 52 (12): [PMID:18779360] [10.1128/aac.00673-07] |
| 40. Hasugian AR, Tjitra E, Ratcliff A, Siswantoro H, Kenangalem E, Wuwung RM, Purba HL, Piera KA, Chalfien F, Marfurt J, Penttinen PM, Russell B, Anstey NM, Price RN.. (2009) In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax., 53 (3): [PMID:19104023] [10.1128/aac.01511-08] |
| 41. Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF.. (2009) Colorimetric high-throughput screen for detection of heme crystallization inhibitors., 53 (6): [PMID:19307367] [10.1128/aac.01466-08] |
| 42. Masseno V, Muriithi S, Nzila A.. (2009) In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid., 53 (7): [PMID:19364853] [10.1128/aac.01689-08] |
| 43. Price RN, Marfurt J, Chalfein F, Kenangalem E, Piera KA, Tjitra E, Anstey NM, Russell B.. (2010) In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax., 54 (12): [PMID:20876370] [10.1128/aac.00801-10] |
| 44. Siswantoro H, Russell B, Ratcliff A, Prasetyorini B, Chalfein F, Marfurt J, Kenangalem E, Wuwung M, Piera KA, Ebsworth EP, Anstey NM, Tjitra E, Price RN.. (2011) In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia., 55 (1): [PMID:20937779] [10.1128/aac.01122-10] |
| 45. Marfurt J, Chalfein F, Prayoga P, Wabiser F, Kenangalem E, Piera KA, Fairlie DP, Tjitra E, Anstey NM, Andrews KT, Price RN.. (2011) Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax., 55 (3): [PMID:21135175] [10.1128/aac.01220-10] |
| 46. Lowe R, Glen RC, Mitchell JB.. (2010) Predicting phospholipidosis using machine learning., 7 (5): [PMID:20799726] [10.1021/mp100103e] |
| 47. Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.. (2010) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species., 23 (1): [PMID:20014752] [10.1021/tx900326k] |
| 48. Kruhlak NL, Choi SS, Contrera JF, Weaver JL, Willard JM, Hastings KL, Sancilio LF.. (2008) Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models., 18 (2): [PMID:20020916] [10.1080/15376510701857262] |
| 49. (2008) Casarett and Doull's Toxicology The Basic Science of Poisons, 7th edition, |
| 50. Bertinaria M, Guglielmo S, Rolando B, Giorgis M, Aragno C, Fruttero R, Gasco A, Parapini S, Taramelli D, Martins YC, Carvalho LJ.. (2011) Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria., 46 (5): [PMID:21396743] [10.1016/j.ejmech.2011.02.029] |
| 51. Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.. (2011) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)., 7 (12): [PMID:22194678] [10.1371/journal.pcbi.1002310] |
| 52. Zhu S, Chandrashekar G, Meng L, Robinson K, Chatterji D.. (2012) Febrifugine analogue compounds: synthesis and antimalarial evaluation., 20 (2): [PMID:22182577] [10.1016/j.bmc.2011.11.053] |
| 53. Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K.. (2012) Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation., 22 (15): [PMID:22749280] [10.1016/j.bmcl.2012.06.010] |
| 54. Lee SG, Alpert TD, Jez JM.. (2012) Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine., 22 (15): [PMID:22771008] [10.1016/j.bmcl.2012.06.032] |
| 55. Samari F, Shamsipur M, Hemmateenejad B, Khayamian T, Gharaghani S.. (2012) Investigation of the interaction between amodiaquine and human serum albumin by fluorescence spectroscopy and molecular modeling., 54 [PMID:22658498] [10.1016/j.ejmech.2012.05.007] |
| 56. Sakatis MZ, Reese MJ, Harrell AW, Taylor MA, Baines IA, Chen L, Bloomer JC, Yang EY, Ellens HM, Ambroso JL, Lovatt CA, Ayrton AD, Clarke SE.. (2012) Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., 25 (10): [PMID:22931300] [10.1021/tx300075j] |
| 57. Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P.. (2012) Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions., 55 (10): [PMID:22541068] [10.1021/jm300212s] |
| 58. Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, Guy RK.. (2012) Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials., 55 (9): [PMID:22435599] [10.1021/jm201642z] |
| 59. Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S.. (2012) Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents., 55 (23): [PMID:23145816] [10.1021/jm300831b] |
| 60. Acharya BN, Kaushik MP. (2007) Pharmacophore-based predictive model generation for potent antimalarials targeting haem detoxification pathway, 16 (5): [10.1007/s00044-007-9025-8] |
| 61. Gozalbes R, Mosulén S, Ortí L, Rodríguez-Díaz J, Carbajo RJ, Melnyk P, Pineda-Lucena A.. (2013) Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches., 21 (7): [PMID:23415087] [10.1016/j.bmc.2013.01.033] |
| 62. Biamonte MA, Wanner J, Le Roch KG.. (2013) Recent advances in malaria drug discovery., 23 (10): [PMID:23587422] [10.1016/j.bmcl.2013.03.067] |
| 63. Gorka AP, de Dios A, Roepe PD.. (2013) Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities., 56 (13): [PMID:23586757] [10.1021/jm400282d] |
| 64. Tukulula M, Njoroge M, Mugumbate GC, Gut J, Rosenthal PJ, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K.. (2013) Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents., 21 (17): [PMID:23896611] [10.1016/j.bmc.2013.06.067] |
| 65. Flannery EL, Fidock DA, Winzeler EA.. (2013) Using genetic methods to define the targets of compounds with antimalarial activity., 56 (20): [PMID:23927658] [10.1021/jm400325j] |
| 66. Sykes ML, Avery VM.. (2013) Approaches to protozoan drug discovery: phenotypic screening., 56 (20): [PMID:23927763] [10.1021/jm4004279] |
| 67. Joshi MC, Wicht KJ, Taylor D, Hunter R, Smith PJ, Egan TJ.. (2013) In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles., 69 [PMID:24077524] [10.1016/j.ejmech.2013.08.046] |
| 68. Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.. (2004) [Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs]., 28 (8-9): [PMID:15646539] [10.1016/s0399-8320(04)95062-2] |
| 69. Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ.. (2012) A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases()., 3 (12): [PMID:23205265] [10.1039/c2md20238g] |
| 70. Wang N, Wicht KJ, Imai K, Wang MQ, Anh Ngoc T, Kiguchi R, Kaiser M, Egan TJ, Inokuchi T.. (2014) Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11., 22 (9): [PMID:24721829] [10.1016/j.bmc.2014.03.030] |
