ID: ALA166

Max Phase: Phase

Molecular Formula: C12H15AsN6OS2

Molecular Weight: 398.35

Molecule Type: Small molecule

Representations

Synonyms (4): Mel b | Melarsoprol | RP 3854 | RP-3854
Synonyms from Alternative Forms(4):

Canonical SMILES:  Nc1nc(N)nc(Nc2ccc([As]3SCC(CO)S3)cc2)n1

Standard InChI:  InChI=1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)

Standard InChI Key:  JCYZMTMYPZHVBF-UHFFFAOYSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: Yes

Properties

Molecular Weight: 398.35

Molecular Weight (Monoisotopic): 397.9965

AlogP:

#Rotatable Bonds:

Polar Surface Area:

Molecular Species:

HBA:

HBD:

#RO5 Violations:

HBA (Lipinski):

HBD (Lipinski):

#RO5 Violations (Lipinski):

CX Acidic pKa:

CX Basic pKa:

CX LogP:

CX LogD:

Aromatic Rings:

Heavy Atoms:

QED Weighted:

Np Likeness Score:

References

1. Dardonville C, Brun R..  (2004)  Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.,  47  (9): [PMID:15084128] [10.1021/jm031024u]

2. Girault S, Grellier P, Berecibar A, Maes L, Mouray E, Lemière P, Debreu MA, Davioud-Charvet E, Sergheraert C..  (2000)  Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.,  43  (14): [PMID:10893302] [10.1021/jm990946n]

3. Wright AD, Goclik E, König GM, Kaminsky R..  (2002)  Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp.,  45  (14): [PMID:12086492] [10.1021/jm0110892]

4. Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E..  (2002)  Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.,  12  (24): [PMID:12443785] [10.1016/s0960-894x(02)00788-6]

5. Chowdhury SF, Villamor VB, Guerrero RH, Leal I, Brun R, Croft SL, Goodman JM, Maes L, Ruiz-Perez LM, Pacanowska DG, Gilbert IH..  (1999)  Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.,  42  (21): [PMID:10543874] [10.1021/jm981130+]

6. Ulrich P, Cerami A..  (1982)  Potential antitrypanosomal agents. 1,N2-Disubstituted 2-amino-5-hydroxy-4-methylnaphtho[1,2-d]thiazolium salts and related compounds.,  25  (6): [PMID:7097719] [10.1021/jm00348a009]

7. Baliani A, Bueno GJ, Stewart ML, Yardley V, Brun R, Barrett MP, Gilbert IH..  (2005)  Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.,  48  (17): [PMID:16107157] [10.1021/jm050177+]

8. Hui X, Desrivot J, Bories C, Loiseau PM, Franck X, Hocquemiller R, Figadère B..  (2006)  Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines.,  16  (4): [PMID:16309903] [10.1016/j.bmcl.2005.11.025]

9. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T..  (2006)  Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.,  16  (10): [PMID:16516467] [10.1016/j.bmcl.2006.02.026]

10. Berger H, Seebacher W, Saf R, Kaiser M, Brun R, Weis R..  (2006)  Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes.,  16  (20): [PMID:16889962] [10.1016/j.bmcl.2006.07.057]

11. Hay AE, Ioset JR, Ahua KM, Diallo D, Brun R, Hostettmann K..  (2007)  Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.,  70  (1): [PMID:17253841] [10.1021/np0680230]

12. Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Lombardy RJ, Jones SK, Bridges AS, Zhirnov O, Hall JE, Wenzler T, Brun R, Tidwell RR..  (2007)  Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.,  50  (10): [PMID:17439202] [10.1021/jm0612867]

13. Schlapper C, Seebacher W, Kaiser M, Brun R, Saf R, Weis R..  (2007)  Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals.,  15  (16): [PMID:17544672] [10.1016/j.bmc.2007.05.042]

14. Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Hall JE, Tidwell RR..  (2007)  Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.,  50  (23): [PMID:17948982] [10.1021/jm0708634]

15. Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R..  (2007)  Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.,  50  (23): [PMID:17949068] [10.1021/jm700938n]

16. Tasdemir D, Topaloglu B, Perozzo R, Brun R, O'Neill R, Carballeira NM, Zhang X, Tonge PJ, Linden A, Rüedi P..  (2007)  Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.,  15  (21): [PMID:17765547] [10.1016/j.bmc.2007.07.032]

17. Senn M, Gunzenhauser S, Brun R, Séquin U..  (2007)  Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.,  70  (10): [PMID:17922552] [10.1021/np0702133]

18. Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A..  (2008)  Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.,  18  (7): [PMID:18353643] [10.1016/j.bmcl.2008.03.009]

19. Rodríguez F, Rozas I, Kaiser M, Brun R, Nguyen B, Wilson WD, García RN, Dardonville C..  (2008)  New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.,  51  (4): [PMID:18247550] [10.1021/jm7013088]

20. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC..  (2007)  Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.,  51  (6): [PMID:17371810] [10.1128/aac.01418-06]

21. Bringmann G, Hamm A, Günther C, Michel M, Brun R, Mudogo V..  (2000)  Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.,  63  (11): [PMID:11087584] [10.1021/np000247+]

22. Goclik E, König GM, Wright AD, Kaminsky R..  (2000)  Pelorol from the tropical marine sponge Dactylospongia elegans.,  63  (8): [PMID:10978215] [10.1021/np990502u]

23. Bringmann G, Dreyer M, Rischer H, Wolf K, Hadi HA, Brun R, Meimberg H, Heubl G..  (2004)  Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species ancistrocladusbenomensis.,  67  (12): [PMID:15620251] [10.1021/np0497651]

24. Bringmann G, Dreyer M, Faber JH, Dalsgaard PW, Staerk D, Jaroszewski JW, Ndangalasi H, Mbago F, Brun R, Reichert M, Maksimenka K, Christensen SB..  (2003)  Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.,  66  (9): [PMID:14510589] [10.1021/np030077b]

25. Schlapper C, Seebacher W, Kaiser M, Brun R, Saf R, Weis R..  (2008)  Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity.,  43  (4): [PMID:17698258] [10.1016/j.ejmech.2007.06.007]

26. Bringmann G, Dreyer M, Faber JH, Dalsgaard PW, Staerk D, Jaroszewski JW, Ndangalasi H, Mbago F, Brun R, Christensen SB..  (2004)  Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.,  67  (5): [PMID:15165131] [10.1021/np0340549]

27. Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL..  (2007)  Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).,  51  (8): [PMID:17562801] [10.1128/aac.00225-07]

28. Bakunova SM, Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR..  (2009)  Structure-activity study of pentamidine analogues as antiprotozoal agents.,  52  (7): [PMID:19267462] [10.1021/jm801547t]

29. Faist J, Seebacher W, Schlapper C, Kaiser M, Brun R, Saf R, Weis R..  (2009)  Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.,  17  (10): [PMID:19395265] [10.1016/j.bmc.2009.04.002]

30. Wright AD, Papendorf O, König GM..  (2005)  Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua.,  68  (3): [PMID:15787461] [10.1021/np049640w]

31. Busch J, Grether Y, Ochs D, Séquin U..  (1998)  Total synthesis and biological activities of (+)- and (-)-boscialin and their 1'-epimers.,  61  (5): [PMID:9599255] [10.1021/np970517x]

32. Bringmann G, Messer K, Brun R, Mudogo V..  (2002)  Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.,  65  (8): [PMID:12193010] [10.1021/np010622d]

33. Schlapper C, Seebacher W, Faist J, Kaiser M, Brun R, Saf R, Weis R..  (2009)  Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates.,  44  (2): [PMID:18571774] [10.1016/j.ejmech.2008.05.002]

34. Van Miert S, Hostyn S, Maes BU, Cimanga K, Brun R, Kaiser M, Mátyus P, Dommisse R, Lemière G, Vlietinck A, Pieters L..  (2005)  Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.,  68  (5): [PMID:15921407] [10.1021/np0496284]

35. Bringmann G, Dreyer M, Kopff H, Rischer H, Wohlfarth M, Hadi HA, Brun R, Meimberg H, Heubl G..  (2005)  ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the "new"plant species Ancistrocladus benomensis.,  68  (5): [PMID:15921410] [10.1021/np049626j]

36. Kamnaing P, Tsopmo A, Tanifum EA, Tchuendem MH, Tane P, Ayafor JF, Sterner O, Rattendi D, Iwu MM, Schuster B, Bacchi C..  (2003)  Trypanocidal diarylheptanoids from Aframomum letestuianum.,  66  (3): [PMID:12662093] [10.1021/np020362f]

37. Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ..  (2007)  2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.,  51  (11): [PMID:17698622] [10.1128/aac.00425-07]

38. Berger H, Weis R, Kaiser M, Brun R, Saf R, Seebacher W..  (2008)  Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense.,  16  (12): [PMID:18502136] [10.1016/j.bmc.2008.05.007]

39. Ge JF, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M..  (2008)  Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.,  51  (12): [PMID:18476684] [10.1021/jm8003619]

40. Pontius A, Krick A, Kehraus S, Brun R, König GM..  (2008)  Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.,  71  (9): [PMID:18683985] [10.1021/np800294q]

41. Bakunov SA, Bakunova SM, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR..  (2008)  Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.,  51  (21): [PMID:18841956] [10.1021/jm800918v]

42. Alp M, Göker H, Brun R, Yildiz S..  (2009)  Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines.,  44  (5): [PMID:19010569] [10.1016/j.ejmech.2008.10.003]

43. Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth-Siegel R, Bolognesi ML..  (2009)  Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.,  19  (11): [PMID:19414258] [10.1016/j.bmcl.2009.04.060]

44. Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR..  (2009)  Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine.,  52  (15): [PMID:19606902] [10.1021/jm900805v]

45. Link A, Heidler P, Kaiser M, Brun R..  (2009)  Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.,  44  (9): [PMID:19285758] [10.1016/j.ejmech.2009.02.010]

46. Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Chen H, Jones SK, Wenzler T, Barzcz T, Werbovetz KA, Brun R, Tidwell RR..  (2009)  Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.,  44  (9): [PMID:19409677] [10.1016/j.ejmech.2009.03.014]

47. Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP..  (2009)  Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.,  52  (21): [PMID:19817445] [10.1021/jm901112f]

48. Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA..  (2010)  Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.,  53  (3): [PMID:20047276] [10.1021/jm900723w]

49. Bakunov SA, Bakunova SM, Wenzler T, Ghebru M, Werbovetz KA, Brun R, Tidwell RR..  (2010)  Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.,  53  (1): [PMID:19928900] [10.1021/jm901178d]

50. Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, Pieters L..  (2009)  Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.,  17  (20): [PMID:19781948] [10.1016/j.bmc.2009.08.057]

51. Pagliero RJ, Lusvarghi S, Pierini AB, Brun R, Mazzieri MR..  (2010)  Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines.,  18  (1): [PMID:19942439] [10.1016/j.bmc.2009.11.010]

52. Holloway GA, Parisot JP, Novello PM, Watson KG, Armstrong T, Thompson RC, Street IP, Baell JB..  (2010)  Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.,  20  (6): [PMID:20185305] [10.1016/j.bmcl.2010.02.022]

53. Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T..  (2010)  Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.,  53  (5): [PMID:20131843] [10.1021/jm900946n]

54. Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P..  (2010)  Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.,  18  (7): [PMID:20303767] [10.1016/j.bmc.2010.02.034]

55. Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C..  (2009)  On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.,  52  (18): [PMID:19715342] [10.1021/jm900629w]

56. Ngantchou I, Nyasse B, Denier C, Blonski C, Hannaert V, Schneider B..  (2010)  Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.,  20  (12): [PMID:20529682] [10.1016/j.bmcl.2010.04.145]

57. Regalado EL, Tasdemir D, Kaiser M, Cachet N, Amade P, Thomas OP..  (2010)  Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.,  73  (8): [PMID:20614907] [10.1021/np100348x]

58. Gondela E, Walczak KZ..  (2010)  Synthesis and preliminary bioactivity assays of 3,4-dichloro-5-(omega-hydroxyalkylamino)-2(5H)-furanones.,  45  (9): [PMID:20573426] [10.1016/j.ejmech.2010.05.055]

59. Hall BS, Wu X, Hu L, Wilkinson SR..  (2010)  Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.,  54  (3): [PMID:20028822] [10.1128/aac.01213-09]

60. Tasdemir D, Sanabria D, Lauinger IL, Tarun A, Herman R, Perozzo R, Zloh M, Kappe SH, Brun R, Carballeira NM..  (2010)  2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.,  18  (21): [PMID:20855214] [10.1016/j.bmc.2010.08.055]

61. Bringmann G, Bischof SK, Müller S, Gulder T, Winter C, Stich A, Moll H, Kaiser M, Brun R, Dreher J, Baumann K..  (2010)  QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.,  45  (11): [PMID:20850207] [10.1016/j.ejmech.2010.08.062]

62. Reid CS, Patrick DA, He S, Fotie J, Premalatha K, Tidwell RR, Wang MZ, Liu Q, Gershkovich P, Wasan KM, Wenzler T, Brun R, Werbovetz KA..  (2011)  Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.,  19  (1): [PMID:21112788] [10.1016/j.bmc.2010.11.003]

63. Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R..  (2009)  New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.,  53  (10): [PMID:19620327] [10.1128/aac.00225-09]

64. Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB..  (2009)  Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.,  53  (7): [PMID:19364854] [10.1128/aac.01568-08]

65. Spencer J, Rathnam RP, Harvey AL, Clements CJ, Clark RL, Barrett MP, Wong PE, Male L, Coles SJ, Mackay SP..  (2011)  Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity.,  19  (5): [PMID:21306904] [10.1016/j.bmc.2011.01.010]

66. Dardonville C, Fernández-Fernández C, Gibbons SL, Jagerovic N, Nieto L, Ryan G, Kaiser M, Brun R..  (2009)  Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.,  53  (9): [PMID:19564359] [10.1128/aac.00124-09]

67. Okanya PW, Mohr KI, Gerth K, Jansen R, Müller R..  (2011)  Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes).,  74  (4): [PMID:21456549] [10.1021/np100625a]

68. Finlayson R, Pearce AN, Page MJ, Kaiser M, Bourguet-Kondracki ML, Harper JL, Webb VL, Copp BR..  (2011)  Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp.,  74  (4): [PMID:21348447] [10.1021/np1008619]

69. Gachet MS, Kunert O, Kaiser M, Brun R, Zehl M, Keller W, Muñoz RA, Bauer R, Schuehly W..  (2011)  Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.,  74  (4): [PMID:21438586] [10.1021/np100415m]

70. Chan ST, Pearce AN, Page MJ, Kaiser M, Copp BR..  (2011)  Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum.,  74  (9): [PMID:21846091] [10.1021/np200509g]

71. Shi XL, Ge JF, Liu BQ, Kaiser M, Wittlin S, Brun R, Ihara M..  (2011)  Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.,  21  (19): [PMID:21868222] [10.1016/j.bmcl.2011.07.112]

72. Bouchikhi F, Anizon F, Brun R, Moreau P..  (2011)  Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).,  21  (21): [PMID:21937228] [10.1016/j.bmcl.2011.08.116]

73. Papadopoulou MV, Trunz BB, Bloomer WD, McKenzie C, Wilkinson SR, Prasittichai C, Brun R, Kaiser M, Torreele E..  (2011)  Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.,  54  (23): [PMID:22023653] [10.1021/jm201215n]

74. Faist J, Seebacher W, Saf R, Brun R, Kaiser M, Weis R..  (2012)  New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.,  47  [PMID:22136906] [10.1016/j.ejmech.2011.11.022]

75. Mayence A, Vanden Eynde JJ, Kaiser M, Brun R, Yarlett N, Huang TL..  (2011)  Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents.,  19  (24): [PMID:22061825] [10.1016/j.bmc.2011.10.039]

76. Dürüst Y, Karakuş H, Kaiser M, Tasdemir D..  (2012)  Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles.,  48  [PMID:22217867] [10.1016/j.ejmech.2011.12.028]

77. Capes A, Patterson S, Wyllie S, Hallyburton I, Collie IT, McCarroll AJ, Stevens MF, Frearson JA, Wyatt PG, Fairlamb AH, Gilbert IH..  (2012)  Quinol derivatives as potential trypanocidal agents.,  20  (4): [PMID:22264753] [10.1016/j.bmc.2011.12.018]

78. McCracken ST, Kaiser M, Boshoff HI, Boyd PD, Copp BR..  (2012)  Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.,  20  (4): [PMID:22285027] [10.1016/j.bmc.2011.12.053]

79. Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH..  (2012)  Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,  55  (1): [PMID:22148754] [10.1021/jm201091t]

80. Hiltensperger G, Jones NG, Niedermeier S, Stich A, Kaiser M, Jung J, Puhl S, Damme A, Braunschweig H, Meinel L, Engstler M, Holzgrabe U..  (2012)  Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.,  55  (6): [PMID:22376072] [10.1021/jm101439s]

81. Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP..  (2012)  Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.,  55  (7): [PMID:22352841] [10.1021/jm2015183]

82. Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C..  (2012)  Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.,  55  (6): [PMID:22390399] [10.1021/jm2014259]

83. Arán VJ, Kaiser M, Dardonville C..  (2012)  Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.,  22  (14): [PMID:22738640] [10.1016/j.bmcl.2012.06.004]

84. Papadopoulou MV, Bloomer WD, Rosenzweig HS, Chatelain E, Kaiser M, Wilkinson SR, McKenzie C, Ioset JR..  (2012)  Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.,  55  (11): [PMID:22550999] [10.1021/jm300508n]

85. Trunz BB, Jędrysiak R, Tweats D, Brun R, Kaiser M, Suwiński J, Torreele E..  (2011)  1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.,  46  (5): [PMID:21353728] [10.1016/j.ejmech.2011.01.071]

86. Carballeira NM, Cartagena M, Sanabria D, Tasdemir D, Prada CF, Reguera RM, Balaña-Fouce R..  (2012)  2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.,  22  (19): [PMID:22932312] [10.1016/j.bmcl.2012.08.019]

87. Lizzi F, Veronesi G, Belluti F, Bergamini C, López-Sánchez A, Kaiser M, Brun R, Krauth-Siegel RL, Hall DG, Rivas L, Bolognesi ML..  (2012)  Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.,  55  (23): [PMID:23153330] [10.1021/jm301112z]

88. Zhou L, Stewart G, Rideau E, Westwood NJ, Smith TK..  (2013)  A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.,  56  (3): [PMID:23281892] [10.1021/jm301215e]

89. Liew LP, Kaiser M, Copp BR..  (2013)  Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds.,  23  (2): [PMID:23265884] [10.1016/j.bmcl.2012.11.072]

90. McKeever C, Kaiser M, Rozas I..  (2013)  Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity.,  56  (3): [PMID:23301592] [10.1021/jm301614w]

91. Mei ZW, Wang L, Lu WJ, Pang CQ, Maeda T, Peng W, Kaiser M, El Sayed I, Inokuchi T..  (2013)  Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines.,  56  (4): [PMID:23360309] [10.1021/jm300887b]

92. Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK..  (2013)  Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).,  56  (7): [PMID:23484493] [10.1021/jm301687p]

93. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG..  (2013)  Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.,  76  (4): [PMID:23445522] [10.1021/np300834q]

94. Gehrke SS, Pinto EG, Steverding D, Pleban K, Tempone AG, Hider RC, Wagner GK..  (2013)  Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators.,  21  (3): [PMID:23266185] [10.1016/j.bmc.2012.11.009]

95. Patel G, Karver CE, Behera R, Guyett PJ, Sullenberger C, Edwards P, Roncal NE, Mensa-Wilmot K, Pollastri MP..  (2013)  Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.,  56  (10): [PMID:23597080] [10.1021/jm400349k]

96. Friggeri L, Scipione L, Costi R, Kaiser M, Moraca F, Zamperini C, Botta B, Di Santo R, De Vita D, Brun R, Tortorella S..  (2013)  New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.,  4  (6): [PMID:24900706] [10.1021/ml400039r]

97. Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR..  (2013)  Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.,  56  (13): [PMID:23795673] [10.1021/jm400508e]

98. Alibu VP, Daunes S, D'Silva C..  (2013)  N-Benzyloxycarbonyl-S-(2,4-dinitrophenyl)glutathione dibutyl diester is inhibitory to melarsoprol resistant cell lines overexpressing the T. bruceiMRPA transporter.,  23  (15): [PMID:23791080] [10.1016/j.bmcl.2013.05.086]

99. Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB..  (2013)  3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.,  66  [PMID:23831695] [10.1016/j.ejmech.2013.05.007]

100. Faist J, Seebacher W, Kaiser M, Brun R, Saf R, Weis R..  (2013)  Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom.,  21  (17): [PMID:23880082] [10.1016/j.bmc.2013.06.059]

101. Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR..  (2013)  Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.,  67  [PMID:23871911] [10.1016/j.ejmech.2013.06.033]

102. Moridi Farimani M, Nejad Ebrahimi S, Salehi P, Bahadori MB, Sonboli A, Khavasi HR, Zimmermann S, Kaiser M, Hamburger M..  (2013)  Antitrypanosomal triterpenoid with an ε-lactone E-ring from Salvia urmiensis.,  76  (9): [PMID:24007549] [10.1021/np400337a]

103. Harel D, Schepmann D, Prinz H, Brun R, Schmidt TJ, Wünsch B..  (2013)  Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.,  56  (18): [PMID:23968432] [10.1021/jm401007p]

104. Papadopoulou MV, Bloomer WD, Rosenzweig HS, Kaiser M, Chatelain E, Ioset JR..  (2013)  Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.,  21  (21): [PMID:24012457] [10.1016/j.bmc.2013.08.022]

105. Patrick DA, Bakunov SA, Bakunova SM, Wenzler T, Brun R, Tidwell RR..  (2014)  Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.,  22  (1): [PMID:24268543] [10.1016/j.bmc.2013.10.050]

106. Dong Y, Wang X, Cal M, Kaiser M, Vennerstrom JL..  (2014)  Activity of diimidazoline amides against African trypanosomiasis.,  24  (3): [PMID:24398295] [10.1016/j.bmcl.2013.12.064]

107. Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R..  (2004)  [Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].,  28  (8-9): [PMID:15646539] [10.1016/s0399-8320(04)95062-2]

108. Ge J, Zhang Q, Lu J, Kaiser M, Wittlin S, Brun R, Ihara M.  (2012)  Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities,  3  (11): [10.1039/C2MD20136D]

109. Grundmann F, Kaiser M, Schiell M, Batzer A, Kurz M, Thanwisai A, Chantratita N, Bode HB..  (2014)  Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4.,  77  (4): [PMID:24673206] [10.1021/np4007525]

110. Ríos Martínez CH, Lagartera L, Kaiser M, Dardonville C..  (2014)  Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.,  81  [PMID:24865793] [10.1016/j.ejmech.2014.04.083]

111. Liu ZY, Wenzler T, Brun R, Zhu X, Boykin DW..  (2014)  Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups.,  83  [PMID:24956553] [10.1016/j.ejmech.2014.06.022]

112. Giannini G, Battistuzzi G..  (2015)  Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.,  25  (3): [PMID:25547934] [10.1016/j.bmcl.2014.12.048]

113. Reimer D, Nollmann FI, Schultz K, Kaiser M, Bode HB..  (2014)  Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila.,  77  (8): [PMID:25080196] [10.1021/np500390b]

114. Giannini G, Battistuzzi G, Vignola D..  (2015)  Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.,  25  (3): [PMID:25563890] [10.1016/j.bmcl.2014.12.051]

115. Cretton S, Breant L, Pourrez L, Ambuehl C, Marcourt L, Ebrahimi SN, Hamburger M, Perozzo R, Karimou S, Kaiser M, Cuendet M, Christen P..  (2014)  Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica.,  77  (10): [PMID:25314007] [10.1021/np5006554]

116. Venkatraj M, Ariën KK, Heeres J, Joossens J, Dirié B, Lyssens S, Michiels J, Cos P, Lewi PJ, Vanham G, Maes L, Van der Veken P, Augustyns K..  (2014)  From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.,  22  (19): [PMID:25199582] [10.1016/j.bmc.2014.08.005]

117. Papadopoulou MV, Bloomer WD, Rosenzweig HS, Wilkinson SR, Kaiser M..  (2014)  Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.,  87  [PMID:25240098] [10.1016/j.ejmech.2014.09.045]

118. Ferrins L, Gazdik M, Rahmani R, Varghese S, Sykes ML, Jones AJ, Avery VM, White KL, Ryan E, Charman SA, Kaiser M, Bergström CA, Baell JB..  (2014)  Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.,  57  (15): [PMID:24978605] [10.1021/jm500191u]

119. Seebacher W, Wolkinger V, Faist J, Kaiser M, Brun R, Saf R, Bucar F, Gröblacher B, Brantner A, Merino V, Kalia Y, Scapozza L, Perozzo R, Weis R..  (2015)  Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.,  25  (7): [PMID:25746816] [10.1016/j.bmcl.2015.02.044]

120. De Mieri M, Kaiser M, Brun R, Thormann U, Imanidis G, Hamburger M..  (2015)  Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin.,  23  (7): [PMID:25740635] [10.1016/j.bmc.2015.02.005]

121. Papadopoulou MV, Bloomer WD, Lepesheva GI, Rosenzweig HS, Kaiser M, Aguilera-Venegas B, Wilkinson SR, Chatelain E, Ioset JR..  (2015)  Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.,  58  (3): [PMID:25580906] [10.1021/jm5015742]

122. Montalvo-Quirós S, Taladriz-Sender A, Kaiser M, Dardonville C..  (2015)  Antiprotozoal activity and DNA binding of dicationic acridones.,  58  (4): [PMID:25642604] [10.1021/jm5018303]

123. Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML..  (2015)  2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.,  58  (16): [PMID:26237241] [10.1021/acs.jmedchem.5b00748]

124. Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA, Baell JB..  (2015)  6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.,  58  (17): [PMID:26247439] [10.1021/acs.jmedchem.5b00438]

125. Papadopoulou MV, Bloomer WD, Rosenzweig HS, O'Shea IP, Wilkinson SR, Kaiser M, Chatelain E, Ioset JR..  (2015)  Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.,  23  (19): [PMID:26344593] [10.1016/j.bmc.2015.08.014]

126. Papadopoulou MV, Bloomer WD, Rosenzweig HS, O'Shea IP, Wilkinson SR, Kaiser M..  (2015)  3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.,  103  [PMID:26363868] [10.1016/j.ejmech.2015.08.042]

127. Manos-Turvey A, Watson EE, Sykes ML, Jones AJ, Baell JB, Kaiser M, Avery VM, Payne RJ.  (2015)  Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents,  6  (3): [10.1039/C4MD00406J]

128. Bhambra AS, Edgar M, Elsegood MR, Li Y, Weaver GW, Arroo RR, Yardley V, Burrell-Saward H, Krystof V..  (2016)  Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes.,  108  [PMID:26698538] [10.1016/j.ejmech.2015.11.043]

129. Patrick DA, Wenzler T, Yang S, Weiser PT, Wang MZ, Brun R, Tidwell RR..  (2016)  Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.,  24  (11): [PMID:27102161] [10.1016/j.bmc.2016.04.006]

130. Papadopoulou MV, Bloomer WD, Rosenzweig HS, Wilkinson SR, Szular J, Kaiser M..  (2016)  Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.,  117  [PMID:27092415] [10.1016/j.ejmech.2016.04.010]

131. Faist J, Seebacher W, Saf R, Brun R, Kaiser M, Weis R..  (2016)  Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.,  24  (16): [PMID:27344215] [10.1016/j.bmc.2016.06.024]

132. Karaaslan C, Kaiser M, Brun R, Göker H..  (2016)  Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.,  24  (18): [PMID:27387356] [10.1016/j.bmc.2016.06.047]

133. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, 

134. WHO Anatomical Therapeutic Chemical Classification, 

135. Faist J, Hinteregger C, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R..  (2017)  New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity.,  25  (3): [PMID:28031151] [10.1016/j.bmc.2016.12.006]

136. Tran HA, Zheng Z, Wen X, Manivannan S, Pastor A, Kaiser M, Brun R, Snyder FF, Back TG..  (2017)  Synthesis and activity of nucleoside-based antiprotozoan compounds.,  25  (7): [PMID:28284860] [10.1016/j.bmc.2017.02.016]

137. Bhambra AS, Ruparelia KC, Tan HL, Tasdemir D, Burrell-Saward H, Yardley V, Beresford KJM, Arroo RRJ..  (2017)  Synthesis and antitrypanosomal activities of novel pyridylchalcones.,  128  [PMID:28189085] [10.1016/j.ejmech.2017.01.027]

138. De Mieri M, Monteleone G, Ismajili I, Kaiser M, Hamburger M..  (2017)  Antiprotozoal Activity-Based Profiling of a Dichloromethane Extract from Anthemis nobilis Flowers.,  80  (2): [PMID:28116906] [10.1021/acs.jnatprod.6b00980]

139. Pagliero RJ, Kaiser M, Brun R, Nieto MJ, Mazzieri MR..  (2017)  Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.,  27  (17): [PMID:28789893] [10.1016/j.bmcl.2017.07.081]

140. Giroud M, Kuhn B, Saint-Auret S, Kuratli C, Martin RE, Schuler F, Diederich F, Kaiser M, Brun R, Schirmeister T, Haap W..  (2018)  2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.,  61  (8): [PMID:29590751] [10.1021/acs.jmedchem.7b01870]

141. Li J, Seupel R, Feineis D, Mudogo V, Kaiser M, Brun R, Brünnert D, Chatterjee M, Seo EJ, Efferth T, Bringmann G..  (2017)  Dioncophyllines C2, D2, and F and Related Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ileboensis with Potent Activities against Plasmodium falciparum and against Multiple Myeloma and Leukemia Cell Lines.,  80  (2): [PMID:28121440] [10.1021/acs.jnatprod.6b00967]

142. Papadopoulou MV, Bloomer WD, Rosenzweig HS, Kaiser M..  (2017)  The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.,  138  [PMID:28763645] [10.1016/j.ejmech.2017.07.060]

143. Chianese G, Silber J, Luciano P, Merten C, Erpenbeck D, Topaloglu B, Kaiser M, Tasdemir D..  (2017)  Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros.,  80  (9): [PMID:28840725] [10.1021/acs.jnatprod.7b00543]

144. Li J, Seupel R, Bruhn T, Feineis D, Kaiser M, Brun R, Mudogo V, Awale S, Bringmann G..  (2017)  Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line.,  80  (10): [PMID:29043798] [10.1021/acs.jnatprod.7b00650]

145. Kimani NM, Matasyoh JC, Kaiser M, Brun R, Schmidt TJ..  (2018)  Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.,  81  (1): [PMID:29244495] [10.1021/acs.jnatprod.7b00747]

146. Mohsin NU, Seebacher W, Faist J, Hochegger P, Kaiser M, Mäser P, Belaj F, Saf R, Kretschmer N, Alajlani M, Turek I, Brantner A, Bauer R, Bucar F, Weis R..  (2018)  Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.,  143  [PMID:29172086] [10.1016/j.ejmech.2017.11.025]

147. Venkatraj M, Salado IG, Heeres J, Joossens J, Lewi PJ, Caljon G, Maes L, Van der Veken P, Augustyns K..  (2018)  Novel triazine dimers with potent antitrypanosomal activity.,  143  [PMID:29197735] [10.1016/j.ejmech.2017.11.075]

148. Farimani MM, Khodaei B, Moradi H, Aliabadi A, Ebrahimi SN, De Mieri M, Kaiser M, Hamburger M..  (2018)  Phytochemical Study of Salvia leriifolia Roots: Rearranged Abietane Diterpenoids with Antiprotozoal Activity.,  81  (6): [PMID:29896963] [10.1021/acs.jnatprod.7b01019]

149. Ugwu DI, Okoro UC, Mishra NK..  (2018)  Synthesis of proline derived benzenesulfonamides: A potent anti-Trypanosoma brucei gambiense agent.,  154  [PMID:29778893] [10.1016/j.ejmech.2018.05.017]

150. Tshitenge DT, Feineis D, Mudogo V, Kaiser M, Brun R, Seo EJ, Efferth T, Bringmann G..  (2018)  Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.,  81  (4): [PMID:29560715] [10.1021/acs.jnatprod.7b01041]

151. Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Costi R, Di Santo R..  (2018)  Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.,  156  [PMID:30006174] [10.1016/j.ejmech.2018.06.063]

152. Unpublished dataset, 

153. Fayez S, Li J, Feineis D, Aké Assi L, Kaiser M, Brun R, Anany MA, Wajant H, Bringmann G..  (2019)  A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.,  82  (11): [PMID:31642313] [10.1021/acs.jnatprod.9b00589]

154. Zhao L, Awori RM, Kaiser M, Groß J, Opatz T, Bode HB..  (2019)  Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1.,  82  (12): [PMID:31799840] [10.1021/acs.jnatprod.9b00932]

155. Wang X, Cal M, Kaiser M, Buckner FS, Lepesheva GI, Sanford AG, Wallick AI, Davis PH, Vennerstrom JL..  (2020)  A new chemotype with promise against Trypanosoma cruzi.,  30  (1): [PMID:31706668] [10.1016/j.bmcl.2019.126778]

156. Nair JJ, van Staden J..  (2019)  Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.,  29  (20): [PMID:31515186] [10.1016/j.bmcl.2019.126642]

157. Tabefam M, Moridi Farimani M, Danton O, Ramseyer J, Nejad Ebrahimi S, Neuburger M, Kaiser M, Salehi P, Potterat O, Hamburger M..  (2018)  Antiprotozoal Isoprenoids from Salvia hydrangea.,  81  (12): [PMID:30565934] [10.1021/acs.jnatprod.8b00498]

158. Zhao L, Cai X, Kaiser M, Bode HB..  (2018)  Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli.,  81  (10): [PMID:30302998] [10.1021/acs.jnatprod.8b00425]

159. Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R..  (2019)  Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.,  62  (3): [PMID:30615444] [10.1021/acs.jmedchem.8b01464]

160. Tshitenge DT, Bruhn T, Feineis D, Schmidt D, Mudogo V, Kaiser M, Brun R, Würthner F, Awale S, Bringmann G..  (2019)  Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells.,  82  (11): [PMID:31630523] [10.1021/acs.jnatprod.9b00755]

161. Babanezhad Harikandei K, Salehi P, Ebrahimi SN, Bararjanian M, Kaiser M, Al-Harrasi A..  (2020)  Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives.,  28  (1): [PMID:31784198] [10.1016/j.bmc.2019.115185]

162. Brown, Ronald W., Abdel-Megeed, Ashraf M., Keller, Paul A., Jones, Amy J., Sykes, Melissa L., Kaiser, Marcel, Baell, Jonathan B., Avery, Vicky M., Hyland, Christopher J. T..  (2020)  Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness,  11  (12): [PMID:34095848] [10.1039/d0md00277a]

163. Papadopoulou MV,Bloomer WD,Rosenzweig HS,Wilkinson SR,Szular J,Kaiser M.  (2016)  Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.,  123  [PMID:27543881] [10.1016/j.ejmech.2016.08.002]

164. Robinson WJ,Taylor AE,Lauga-Cami S,Weaver GW,Arroo RRJ,Kaiser M,Gul S,Kuzikov M,Ellinger B,Singh K,Schirmeister T,Botana A,Eurtivong C,Bhambra AS.  (2021)  The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines.,  209  [PMID:33070078] [10.1016/j.ejmech.2020.112871]

165. Petritsch M,Seebacher W,Mohsin NU,Dolensky J,Hochegger P,Kaiser M,Mäser P,Belaj F,Saf R,Kretschmer N,Alajlani M,Brantner A,Bauer R,Schühly W,Weis R.  (2021)  Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.,  210  [PMID:33148495] [10.1016/j.ejmech.2020.112969]

166. Kalt MM,Schuehly W,Saf R,Ochensberger S,Solnier J,Bucar F,Kaiser M,Presser A.  (2020)  Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents.,  207  [PMID:33002847] [10.1016/j.ejmech.2020.112837]

167. Lombe BK, Feineis D, Mudogo V, Kaiser M, Bringmann G..  (2021)  Spirombandakamine A₃ and Cyclombandakamines A₈ and A₉, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant.,  84  (4.0): [PMID:33843232] [10.1021/acs.jnatprod.1c00063]

168. Doganc F, Celik I, Eren G, Kaiser M, Brun R, Goker H..  (2021)  Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles.,  221  [PMID:34091216] [10.1016/j.ejmech.2021.113545]

169. Uth JF, Börgel F, Lehmkuhl K, Schepmann D, Kaiser M, Jabor VAP, Nonato MC, Krauth-Siegel RL, Schmidt TJ, Wünsch B..  (2021)  Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.,  64  (9.0): [PMID:33901399] [10.1021/acs.jmedchem.1c00483]

170. Li J, Tajuddeen N, Feineis D, Mudogo V, Kaiser M, Seo EJ, Efferth T, Bringmann G..  (2023)  Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities.,  86  [PMID:36972793] [10.1016/j.bmcl.2023.129258]

171. Sutherland JJ, Yonchev D, Fekete A, Urban L..  (2023)  A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.,  14  (1): [PMID:37468498] [10.1038/s41467-023-40064-9]

Source

Source(4):

• Scientific Literature
• Clinical Candidates
• USP Dictionary of USAN and International Drug Names
• WHO Anatomical Therapeutic Chemical Classification