(3S,6S,9S,12S,15S)-3-((S)-2-acetamidopropanamido)-12-benzyl-15-((S)-1-((4R,7S,13S,16S,19S,22S,25S,28R)-7,25-bis((1H-imidazol-5-yl)methyl)-4-((2R,3R)-1-((S)-6-acetamido-1-(1-amino-2-methyl-1-oxopropan-2-ylamino)-1-oxohexan-2-ylamino)-3-hydroxy-1-oxobutan-2-ylcarbamoyl)-19-sec-butyl-22-(4-hydroxybenzyl)-13-isobutyl-10,10-dimethyl-6,9,12,15,18,21,24,27-octaoxo-16-(4-(2-(2-oxo-2-(4-(3-oxo-3-(2-oxoazetidin-1-yl)propyl)phenylamino)ethoxy)acetamido)butyl)-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosan-28-ylamino)-3-methyl-1-oxobutan-2-ylcarbamoyl)-6,9,14-trimethyl-4,7,10,13-tetraoxo-5,8,11,14-tetraazaoctadecane-1,18-dioic acid

ID: ALA1689483

Chembl Id: CHEMBL1689483

PubChem CID: 53325419

Max Phase: Preclinical

Molecular Formula: C116H168N28O32S2

Molecular Weight: 2530.92

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(C)=O)C(C)C)CSSC[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)[C@@H](C)O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O

Standard InChI:  InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1

Standard InChI Key:  XZZZULWTZVXHQA-LEJPJESASA-N

Alternative Forms

1. Parent:

   

   ALA1689483

   (4S)-5-[[(2S)-1-[[(4R,7S,13S,16S,19S,22S,25S,28R)-4-[[(2R,3R)-1-[[(2S)-6-acetamido-1-[(1-amino-2-methyl-1-oxopropan-2-yl)amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-19-[(2S)-butan-2-yl]-22-[(4-hydroxyphenyl)methyl]-7,25-bis(1H-imida

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 2530.92

Molecular Weight (Monoisotopic): 2529.1821

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References

1. Bower KE, Lam SN, Oates BD, Del Rosario JR, Corner E, Osothprarop TF, Kinhikar AG, Hoye JA, Preston RR, Murphy RE, Campbell LA, Huang H, Jimenez J, Cao X, Chen G, Ainekulu ZW, Datt AB, Levin NJ, Doppalapudi VR, Pirie-Shepherd SR, Bradshaw C, Woodnutt G, Lappe RW..  (2011)  Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.,  54  (5): [PMID:21280651] [10.1021/jm101226k]

Source

Source(1):

• Scientific Literature