10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid

ID: ALA169

Cas Number: 77-52-1

PubChem CID: 64945

Product Number: U107242, Order Now?

Max Phase: Phase

Molecular Formula: C30H48O3

Molecular Weight: 456.71

Molecule Type: Small molecule

In stock!

Associated Items:

Names and Identifiers

Synonyms: Malol | Micromerol | Prunol | Ursolic acid | Urson | NSC-167406 | NSC-4060 | Ursolic acid|77-52-1|Prunol|Malol|Urson|3beta-Hydroxyurs-12-en-28-oic acid|Micromerol|(3beta)-3-Hydroxyurs-12-en-28-oic acid|(+)-Ursolic acid|NSC-4060|3beta-Hydroxy-12-ursen-28-ic acid|CCRIS 7123|CHEBI:9908|NSC 167406|ursolic-acid|NSC 4060|EINECS 201-034-0|NSC-167406|UNII-P3M2575F3F|AI3-03109|HSDB 7685|P3M2575F3F|CHEMBL169|Urs-12-en-28-oic acid, 3beta-hydroxy-|.beta.-Ursolic acid|Bungeolic acid|URSOLIC ACID (USP-RS)|URSShow More

Synonyms from Alternative Forms(2): Ursolic Acid Hydrogen Malonate | Ursolic Acid Glutaryl Hemi Ester

Canonical SMILES:  C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12

Standard InChI:  InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1

Standard InChI Key:  WCGUUGGRBIKTOS-GPOJBZKASA-N

Molfile:  

     RDKit          2D

 36 40  0  0  0  0  0  0  0  0999 V2000
    7.7569  -10.8177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7569  -11.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4690  -12.0556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4690  -10.4019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1857  -10.8177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1822  -11.6444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8925  -12.0586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6110  -11.6506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8995  -10.4050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6120  -10.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6255   -9.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9032   -9.5802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3379   -9.5940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3247  -10.4201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0296  -10.8422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7522  -10.4428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0559   -9.1900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7640   -9.6179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4846   -9.2208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5033   -8.3943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7953   -7.9665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0684   -8.3651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0448  -12.0556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8802  -12.6358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6751  -12.8460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1776   -9.9954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1776  -12.4622    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.8948  -11.2242    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   10.6029   -9.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3201  -11.2379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0511  -10.0091    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.3641   -7.9409    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8125   -7.1443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4718  -10.0273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4711  -10.8496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.1842   -9.6168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 16 18  1  0
 17 18  1  0
  5  9  1  0
  6  7  1  0
  7  8  1  0
  8 10  1  0
  9 10  1  0
  2  3  1  0
 17 22  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  1  0
  3  6  1  0
  2 23  1  1
  5  4  1  0
  3 24  1  0
  5  6  1  0
  3 25  1  0
  9 12  1  0
  5 26  1  1
 10 14  1  0
  6 27  1  6
 13 11  2  0
  9 28  1  6
 11 12  1  0
 10 29  1  1
 13 14  1  0
 14 30  1  6
 17 31  1  1
  1  2  1  0
 22 32  1  1
 21 33  1  6
  1  4  1  0
 18 34  1  1
 13 17  1  0
 34 35  2  0
 14 15  1  0
 34 36  1  0
 15 16  1  0
M  END

Associated Targets(Human)

PTPN1 Tchem Protein-tyrosine phosphatase 1B (8528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H9 (1832 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BGC-823 (3035 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CEM-SS (2428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WI-38 VA13 (346 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN2 Tchem T-cell protein-tyrosine phosphatase (1317 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPN6 Tchem Protein-tyrosine phosphatase 1C (687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRF Tchem Receptor-type tyrosine-protein phosphatase F (LAR) (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRA Tchem Receptor-type tyrosine-protein phosphatase alpha (287 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTPRE Tbio Receptor-type tyrosine-protein phosphatase epsilon (68 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-549 (31254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW1353 (113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SP1 Tbio Transcription factor Sp1 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRKAA2 Tchem AMP-activated protein kinase, AMPK (12273 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1723 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD11B2 Tchem 11-beta-hydroxysteroid dehydrogenase 2 (1168 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD11B1 Tclin 11-beta-hydroxysteroid dehydrogenase 1 (5910 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RELA Tchem Nuclear factor NF-kappa-B p65 subunit (627 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KAT2A Tchem Histone acetyltransferase GCN5 (14285 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ca9-22 (362 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC1 Tclin Histone deacetylase (6747 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC1 Tclin Histone deacetylase 1 (10854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC3 Tclin Histone deacetylase 3 (3654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC5 Tclin Histone deacetylase 5 (941 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC6 Tclin Histone deacetylase 6 (20808 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDC25B Tchem Dual specificity phosphatase Cdc25B (1099 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ASPC1 (1310 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PANC-1 (6144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGC-803 (6426 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bcap37 (715 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKR1B10 Tchem Aldo-keto reductase family 1 member B10 (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IMR-32 (1082 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SiHa (2051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW-620 (52400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THP-1 (11052 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSD Tchem Cathepsin D (3201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RORC Tchem Nuclear receptor ROR-gamma (8495 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
8505C (583 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FaDu (1726 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
518A2 (464 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-N87 (850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lu1 (576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-N-MC (815 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP47 Tchem Ubiquitin carboxyl-terminal hydrolase 47 (99 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CETP Tchem Cholesteryl ester transfer protein (2422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Neutrophil (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGAM Tclin Alpha glucosidase (860 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 2.2.15 (869 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T-24 (2342 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMEC (560 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bel-7402 (4577 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549/TR (299 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bel7402/5-FU (373 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562/Adr (229 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LIG1 Tchem DNA ligase 1 (262 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hep 3B2 (2332 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3A Tclin Glycogen synthase kinase-3 (736 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GYS2 Tbio Glycogen [starch] synthase, liver (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGLN2 Tclin Hypoxia-inducible factor prolyl hydroxylase (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW-1736 (356 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBOAT4 Tchem Ghrelin O-acyltransferase (125 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CES1 Tchem Acyl coenzyme A:cholesterol acyltransferase (1029 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPV1 Tclin Vanilloid receptor (8273 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAPAN-1 (772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LN-229 (376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Z-138 (387 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SENP1 Tchem Sentrin-specific protease 1 (681 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
STS Tchem Steryl-sulfatase (1865 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Huh-7 (12904 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ovis aries (854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phospholipase A2 isozyme DE-I (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phospholipase A2 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Phospholipase A2 isozyme PLA-A (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774 (3120 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Histidine-rich protein (528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Artemia (698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nakaseomyces glabratus (9108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
protease Protease (2551 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PYGM Glycogen phosphorylase, muscle form (1331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RHO Rhodopsin (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Polb DNA polymerase beta (216 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (75 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus (3973 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus sp. 'group A' (3417 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ska Streptokinase A (5805 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H22 (575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
vpr Aberrant vpr protein (14595 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FASN Fatty acid synthase (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ache Acetylcholinesterase (12221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gaa Acidic alpha-glucosidase (551 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera litura (1708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera frugiperda (784 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Drosophila melanogaster (359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis C virus (23859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Si Sucrase-isomaltase (908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tph1 Tryptophan 5-monooxygenase 1 (158 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc2a4 Solute carrier family 2, facilitated glucose transporter member 4 (143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ENV GP41 (50 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus spizizenii (1898 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptomyces scabiei (197 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichomonas vaginalis (2376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caenorhabditis elegans (1055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meloidogyne incognita (862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Setaria cervi (263 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AMY2 Pancreatic alpha-amylase (211 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
4T1 (1737 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16-F10 (4610 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lewis lung carcinoma cell line (1243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tlr4 Toll-like receptor 4 (808 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Akt1 RAC-alpha serine/threonine-protein kinase (25 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G6pc1 Glucose-6-phosphatase (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HA Hemagglutinin (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Cyclooxygenase-1 (5266 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DGAT1 Diacylglycerol O-acyltransferase 1 (61 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LRAT Lecithin retinol acyltransferase (88 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (11336 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella enterica subsp. enterica (623 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Listeria innocua (140 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sts Steryl-sulfatase (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: YesOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: YesAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 456.71Molecular Weight (Monoisotopic): 456.3603AlogP: 7.09#Rotatable Bonds: 1
Polar Surface Area: 57.53Molecular Species: ACIDHBA: 2HBD: 2
#RO5 Violations: 1HBA (Lipinski): 3HBD (Lipinski): 2#RO5 Violations (Lipinski): 1
CX Acidic pKa: 4.74CX Basic pKa: CX LogP: 6.58CX LogD: 3.98
Aromatic Rings: Heavy Atoms: 33QED Weighted: 0.41Np Likeness Score: 3.19

References

1. Master HE, Khan SI, Poojari KA..  (2003)  Synthesis of low molecular weight compounds with complement inhibition activity.,  13  (7): [PMID:12657256] [10.1016/s0960-894x(03)00112-4]
2. Basappa, Satish Kumar M, Nanjunda Swamy S, Mahendra M, Shashidhara Prasad J, Viswanath BS, Rangappa KS..  (2004)  Novel delta2-isoxazolines as group II phospholipase A2 inhibitors.,  14  (14): [PMID:15203142] [10.1016/j.bmcl.2004.05.012]
3. Khanum SA, Murari SK, Vishwanth BS, Shashikanth S..  (2005)  Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes.,  15  (18): [PMID:15993585] [10.1016/j.bmcl.2005.06.012]
4. Ali Z, Khan SI, Pawar RS, Ferreira D, Khan IA..  (2007)  9,19-cyclolanostane derivatives from the roots of Actaea pachypoda.,  70  (1): [PMID:17253859] [10.1021/np060152t]
5. Cui L, Ndinteh DT, Na M, Thuong PT, Silike-Muruumu J, Njamen D, Mbafor JT, Fomum ZT, Ahn JS, Oh WK..  (2007)  Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.,  70  (6): [PMID:17489632] [10.1021/np060477+]
6. Tatsuzaki J, Taniguchi M, Bastow KF, Nakagawa-Goto K, Morris-Natschke SL, Itokawa H, Baba K, Lee KH..  (2007)  Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.,  15  (18): [PMID:17591444] [10.1016/j.bmc.2007.06.027]
7. Hoet S, Pieters L, Muccioli GG, Habib-Jiwan JL, Opperdoes FR, Quetin-Leclercq J..  (2007)  Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.,  70  (8): [PMID:17637068] [10.1021/np070038q]
8. Pettit GR, Hogan F, Xu JP, Tan R, Nogawa T, Cichacz Z, Pettit RK, Du J, Ye QH, Cragg GM, Herald CL, Hoard MS, Goswami A, Searcy J, Tackett L, Doubek DL, Williams L, Hooper JN, Schmidt JM, Chapuis JC, Tackett DN, Craciunescu F..  (2008)  Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).,  71  (3): [PMID:18327911] [10.1021/np700738k]
9. Gnoatto SC, Susplugas S, Dalla Vechia L, Ferreira TB, Dassonville-Klimpt A, Zimmer KR, Demailly C, Da Nascimento S, Guillon J, Grellier P, Verli H, Gosmann G, Sonnet P..  (2008)  Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.,  16  (2): [PMID:17967541] [10.1016/j.bmc.2007.10.031]
10. Kashiwada Y, Nagao T, Hashimoto A, Ikeshiro Y, Okabe H, Cosentino LM, Lee KH..  (2000)  Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.,  63  (12): [PMID:11141100] [10.1021/np990633v]
11. Na M, Jang J, Njamen D, Mbafor JT, Fomum ZT, Kim BY, Oh WK, Ahn JS..  (2006)  Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.,  69  (11): [PMID:17125223] [10.1021/np0601861]
12. Cao S, Guza RC, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG..  (2004)  Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.,  67  (6): [PMID:15217279] [10.1021/np040058h]
13. Chaturvedula VS, Gao Z, Jones SH, Feng X, Hecht SM, Kingston DG..  (2004)  A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.,  67  (5): [PMID:15165161] [10.1021/np030531b]
14. Taylor CM, Barda Y, Kisselev OG, Marshall GR..  (2008)  Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening.,  51  (17): [PMID:18707087] [10.1021/jm800326q]
15. Gnoatto SC, Dassonville-Klimpt A, Da Nascimento S, Galéra P, Boumediene K, Gosmann G, Sonnet P, Moslemi S..  (2008)  Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.,  43  (9): [PMID:18192087] [10.1016/j.ejmech.2007.11.021]
16. Zhang YN, Zhang W, Hong D, Shi L, Shen Q, Li JY, Li J, Hu LH..  (2008)  Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.,  16  (18): [PMID:18707891] [10.1016/j.bmc.2008.07.080]
17. Meng YQ, Liu D, Cai LL, Chen H, Cao B, Wang YZ..  (2009)  The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.,  17  (2): [PMID:19091579] [10.1016/j.bmc.2008.11.036]
18. Freitas RF, Prokopczyk IM, Zottis A, Oliva G, Andricopulo AD, Trevisan MT, Vilegas W, Silva MG, Montanari CA..  (2009)  Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.,  17  (6): [PMID:19254846] [10.1016/j.bmc.2009.01.079]
19. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH..  (2003)  Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.,  66  (2): [PMID:12608862] [10.1021/np020379y]
20. Hu JF, Garo E, Goering MG, Pasmore M, Yoo HD, Esser T, Sestrich J, Cremin PA, Hough GW, Perrone P, Lee YS, Le NT, O'Neil-Johnson M, Costerton JW, Eldridge GR..  (2006)  Bacterial biofilm inhibitors from Diospyros dendo.,  69  (1): [PMID:16441080] [10.1021/np049600s]
21. Li Y, Ishibashi M, Satake M, Chen X, Oshima Y, Ohizumi Y..  (2003)  Sterol and triterpenoid constituents of Verbena littoralis with NGF-potentiating activity.,  66  (5): [PMID:12762811] [10.1021/np020577p]
22. Tapondjou LA, Lontsi D, Sondengam BL, Shaheen F, Choudhary MI, Atta-ur-Rahman, van Heerden FR, Park HJ, Lee KT..  (2003)  Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production.,  66  (9): [PMID:14510614] [10.1021/np020412g]
23. Hata K, Hori K, Takahashi S..  (2002)  Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.,  65  (5): [PMID:12027734] [10.1021/np0104673]
24. Aquino R, De Feo V, De Simone F, Pizza C, Cirino G..  (1991)  Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa.,  54  (2): [PMID:1919590] [10.1021/np50074a016]
25. Pereda-Miranda R, Delgado G.  (1990)  Triterpenoids and Flavonoids from Hyptis albida,  53  (1): [10.1021/np50067a028]
26. Nozaki H, Matsuura Y, Hirono S, Kasai R, Chang JJ, Lee KH..  (1990)  Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia.,  53  (4): [PMID:2095372] [10.1021/np50070a050]
27. Lin CN, Lu CM, Cheng MK, Gan KH, Won SJ..  (1990)  The cytotoxic principles of Solanum incanum.,  53  (2): [PMID:2380724] [10.1021/np50068a041]
28. Li XC, Joshi AS, ElSohly HN, Khan SI, Jacob MR, Zhang Z, Khan IA, Ferreira D, Walker LA, Broedel SE, Raulli RE, Cihlar RL..  (2002)  Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.,  65  (12): [PMID:12502337] [10.1021/np020289t]
29. Thuong PT, Lee CH, Dao TT, Nguyen PH, Kim WG, Lee SJ, Oh WK..  (2008)  Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.,  71  (10): [PMID:18798681] [10.1021/np800298w]
30. Jaki BU, Franzblau SG, Chadwick LR, Lankin DC, Zhang F, Wang Y, Pauli GF..  (2008)  Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.,  71  (10): [PMID:18798682] [10.1021/np800329j]
31. Topçu G..  (2006)  Bioactive triterpenoids from Salvia species.,  69  (3): [PMID:16562861] [10.1021/np0600402]
32. Deng JZ, Starck SR, Hecht SM..  (1999)  DNA polymerase beta inhibitors from Baeckea gunniana.,  62  (12): [PMID:10654412] [10.1021/np990240w]
33. Taketa AT, Gnoatto SC, Gosmann G, Pires VS, Schenkel EP, Guillaume D..  (2004)  Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.,  67  (10): [PMID:15497942] [10.1021/np040059+]
34. León F, Quintana J, Rivera A, Estévez F, Bermejo J..  (2004)  Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.,  67  (12): [PMID:15620242] [10.1021/np049762o]
35. Huss U, Ringbom T, Perera P, Bohlin L, Vasänge M..  (2002)  Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.,  65  (11): [PMID:12444669] [10.1021/np020023m]
36. Abdel Bar FM, Zaghloul AM, Bachawal SV, Sylvester PW, Ahmad KF, El Sayed KA..  (2008)  Antiproliferative triterpenes from Melaleuca ericifolia.,  71  (10): [PMID:18826277] [10.1021/np800360a]
37. Kim S, Kim Y, Kong Y, Kim H, Kang J..  (2009)  Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives.,  19  (2): [PMID:19036585] [10.1016/j.bmcl.2008.11.028]
38. Fu L, Zhang S, Li N, Wang J, Zhao M, Sakai J, Hasegawa T, Mitsui T, Kataoka T, Oka S, Kiuchi M, Hirose K, Ando M..  (2005)  Three new triterpenes from Nerium oleander and biological activity of the isolated compounds.,  68  (2): [PMID:15730243] [10.1021/np040072u]
39. Kashiwada Y, Wang HK, Nagao T, Kitanaka S, Yasuda I, Fujioka T, Yamagishi T, Cosentino LM, Kozuka M, Okabe H, Ikeshiro Y, Hu CQ, Yeh E, Lee KH..  (1998)  Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.,  61  (9): [PMID:9748372] [10.1021/np9800710]
40. Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L..  (1998)  Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis.,  61  (10): [PMID:9784154] [10.1021/np980088i]
41. Xu HX, Zeng FQ, Wan M, Sim KY..  (1996)  Anti-HIV triterpene acids from Geum japonicum.,  59  (7): [PMID:8759159] [10.1021/np960165e]
42. Gu JQ, Wang Y, Franzblau SG, Montenegro G, Timmermann BN..  (2004)  Constituents of Senecio chionophilus with potential antitubercular activity.,  67  (9): [PMID:15387646] [10.1021/np049831z]
43. Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT..  (2004)  New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.,  67  (6): [PMID:15217281] [10.1021/np030469i]
44. Prakash Chaturvedula VS, Schilling JK, Johnson RK, Kingston DG..  (2003)  New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.,  66  (3): [PMID:12662105] [10.1021/np0204848]
45. Schun Y, Cordell GA..  (1987)  Cytotoxic steroids of Gelsemium sempervirens.,  50  (2): [PMID:3655795] [10.1021/np50050a012]
46. Hossain CF, Jacob MR, Clark AM, Walker LA, Nagle DG..  (2003)  Genipatriol, a new cycloartane triterpene from Genipa spruceana.,  66  (3): [PMID:12662099] [10.1021/np020431q]
47. Wen X, Sun H, Liu J, Cheng K, Zhang P, Zhang L, Hao J, Zhang L, Ni P, Zographos SE, Leonidas DD, Alexacou KM, Gimisis T, Hayes JM, Oikonomakos NG..  (2008)  Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.,  51  (12): [PMID:18517260] [10.1021/jm8000949]
48. Cui L, Thuong PT, Lee HS, Ndinteh DT, Mbafor JT, Fomum ZT, Oh WK..  (2008)  Flavanones from the stem bark of Erythrina abyssinica.,  16  (24): [PMID:19008110] [10.1016/j.bmc.2008.10.012]
49. Seo C, Sohn JH, Ahn JS, Yim JH, Lee HK, Oh H..  (2009)  Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.,  19  (10): [PMID:19362837] [10.1016/j.bmcl.2009.03.108]
50. Li J, Ding Y, Li XC, Ferreira D, Khan S, Smillie T, Khan IA..  (2009)  Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.,  72  (6): [PMID:19555121] [10.1021/np900068t]
51. Ha do T, Tuan DT, Thu NB, Nhiem NX, Ngoc TM, Yim N, Bae K..  (2009)  Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.,  19  (19): [PMID:19716700] [10.1016/j.bmcl.2009.08.048]
52. Hoang DM, Ngoc TM, Dat NT, Ha do T, Kim YH, Luong HV, Ahn JS, Bae K..  (2009)  Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis.,  19  (23): [PMID:19846295] [10.1016/j.bmcl.2009.09.102]
53. Genet C, Strehle A, Schmidt C, Boudjelal G, Lobstein A, Schoonjans K, Souchet M, Auwerx J, Saladin R, Wagner A..  (2010)  Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.,  53  (1): [PMID:19911773] [10.1021/jm900872z]
54. Yoon G, Lee W, Kim SN, Cheon SH..  (2009)  Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B.,  19  (17): [PMID:19632832] [10.1016/j.bmcl.2009.07.054]
55. Tu HY, Huang AM, Wei BL, Gan KH, Hour TC, Yang SC, Pu YS, Lin CN..  (2009)  Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species.,  17  (20): [PMID:19758808] [10.1016/j.bmc.2009.08.046]
56. Rollinger JM, Kratschmar DV, Schuster D, Pfisterer PH, Gumy C, Aubry EM, Brandstötter S, Stuppner H, Wolber G, Odermatt A..  (2010)  11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.,  18  (4): [PMID:20100662] [10.1016/j.bmc.2010.01.010]
57. Nguyen PH, Le TV, Thuong PT, Dao TT, Ndinteh DT, Mbafor JT, Kang KW, Oh WK..  (2009)  Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.,  19  (23): [PMID:19836230] [10.1016/j.bmcl.2009.09.108]
58. Seo C, Sohn JH, Oh H, Kim BY, Ahn JS..  (2009)  Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.,  19  (21): [PMID:19782562] [10.1016/j.bmcl.2009.09.025]
59. Zhang P, Hao J, Liu J, Lu Q, Sheng H, Zhang L, Sun H..  (2009)  Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.,  72  (8): [PMID:19642687] [10.1021/np9002367]
60. Ren Y, Kardono LB, Riswan S, Chai H, Farnsworth NR, Soejarto DD, Carcache de Blanco EJ, Kinghorn AD..  (2010)  Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.,  73  (5): [PMID:20384315] [10.1021/np1002065]
61. Bibi N, Tanoli SA, Farheen S, Afza N, Siddiqi S, Zhang Y, Kazmi SU, Malik A..  (2010)  In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.,  20  (14): [PMID:20542692] [10.1016/j.bmcl.2010.05.061]
62. Liu Y, Nair MG..  (2010)  An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.,  73  (7): [PMID:20565070] [10.1021/np1000945]
63. Prado-Prado FJ, García-Mera X, González-Díaz H..  (2010)  Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.,  18  (6): [PMID:20185316] [10.1016/j.bmc.2010.01.068]
64. Kwon SH, Park HY, Kim JY, Jeong IY, Lee MK, Seo KI..  (2010)  Apoptotic action of ursolic acid isolated from Corni fructus in RC-58T/h/SA#4 primary human prostate cancer cells.,  20  (22): [PMID:20943386] [10.1016/j.bmcl.2010.09.073]
65. Lee CL, Liao YC, Hwang TL, Wu CC, Chang FR, Wu YC..  (2010)  Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.,  20  (24): [PMID:21106454] [10.1016/j.bmcl.2010.10.058]
66. PubChem BioAssay data set, 
67. PubChem BioAssay data set, 
68. PubChem BioAssay data set, 
69. Acebey-Castellon IL, Voutquenne-Nazabadioko L, Doan Thi Mai H, Roseau N, Bouthagane N, Muhammad D, Le Magrex Debar E, Gangloff SC, Litaudon M, Sevenet T, Hung NV, Lavaud C..  (2011)  Triterpenoid saponins from Symplocos lancifolia.,  74  (2): [PMID:21288041] [10.1021/np100502y]
70. Yang H, Jeong EJ, Kim J, Sung SH, Kim YC..  (2011)  Antiproliferative triterpenes from the leaves and twigs of Juglans sinensis on HSC-T6 cells.,  74  (4): [PMID:21309591] [10.1021/np1008202]
71. Liu Z, Lee W, Kim SN, Yoon G, Cheon SH..  (2011)  Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors.,  21  (12): [PMID:21555221] [10.1016/j.bmcl.2011.04.057]
72. Tanaka R, Tsujii H, Yamada T, Kajimoto T, Amano F, Hasegawa J, Hamashima Y, Node M, Katoh K, Takebe Y..  (2009)  Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.,  17  (14): [PMID:19515569] [10.1016/j.bmc.2009.05.049]
73. Chen IH, Lu MC, Du YC, Yen MH, Wu CC, Chen YH, Hung CS, Chen SL, Chang FR, Wu YC..  (2009)  Cytotoxic triterpenoids from the stems of Microtropis japonica.,  72  (7): [PMID:19534471] [10.1021/np800694b]
74. Shao JW, Dai YC, Xue JP, Wang JC, Lin FP, Guo YH..  (2011)  In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives.,  46  (7): [PMID:21514015] [10.1016/j.ejmech.2011.03.050]
75. Liang Z, Zhang L, Li L, Liu J, Li H, Zhang L, Chen L, Cheng K, Zheng M, Wen X, Zhang P, Hao J, Gong Y, Zhang X, Zhu X, Chen J, Liu H, Jiang H, Luo C, Sun H..  (2011)  Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.,  46  (6): [PMID:21439694] [10.1016/j.ejmech.2011.02.053]
76. Truong NB, Pham CV, Doan HT, Nguyen HV, Nguyen CM, Nguyen HT, Zhang HJ, Fong HH, Franzblau SG, Soejarto DD, Chau MV..  (2011)  Antituberculosis cycloartane triterpenoids from Radermachera boniana.,  74  (5): [PMID:21469696] [10.1021/np200022b]
77. Nguyen PH, Dao TT, Kim J, Phong do T, Ndinteh DT, Mbafor JT, Oh WK..  (2011)  New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity.,  19  (11): [PMID:21571537] [10.1016/j.bmc.2011.04.037]
78. Sun LP, Shen Q, Piao HH, Ma WP, Gao LX, Zhang W, Nan FJ, Li J, Piao HR..  (2011)  Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.,  46  (9): [PMID:21680062] [10.1016/j.ejmech.2011.05.027]
79. Jia Y, Bhuiyan MJ, Jun HJ, Lee JH, Hoang MH, Lee HJ, Kim N, Lee D, Hwang KY, Hwang BY, Choi DW, Lee SJ..  (2011)  Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.,  21  (19): [PMID:21855333] [10.1016/j.bmcl.2011.07.095]
80. Jilani K, Abed M, Zelenak C, Lang E, Qadri SM, Lang F..  (2011)  Triggering of erythrocyte cell membrane scrambling by ursolic acid.,  74  (10): [PMID:21923134] [10.1021/np2005133]
81. Hwang JS, Lee SA, Hong SS, Han XH, Lee C, Lee D, Lee CK, Hong JT, Kim Y, Lee MK, Hwang BY..  (2012)  Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.,  22  (1): [PMID:22079762] [10.1016/j.bmcl.2011.10.043]
82. Bai KK, Yu Z, Chen FL, Li F, Li WY, Guo YH..  (2012)  Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents.,  22  (7): [PMID:22370266] [10.1016/j.bmcl.2012.02.009]
83. Gatbonton-Schwager TN, Letterio JJ, Tochtrop GP..  (2012)  Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.,  75  (4): [PMID:22339499] [10.1021/np200823p]
84. Liu YW, Cheng YB, Liaw CC, Chen CH, Guh JH, Hwang TL, Tsai JS, Wang WB, Shen YC..  (2012)  Bioactive diterpenes from Callicarpa longissima.,  75  (4): [PMID:22429052] [10.1021/np200932k]
85. Yu MS, Lee J, Lee JM, Kim Y, Chin YW, Jee JG, Keum YS, Jeong YJ..  (2012)  Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.,  22  (12): [PMID:22578462] [10.1016/j.bmcl.2012.04.081]
86. Kato E, Takahashi N..  (2012)  Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels.,  20  (12): [PMID:22579618] [10.1016/j.bmc.2012.04.029]
87. Choi YH, Zhou W, Oh J, Choe S, Kim DW, Lee SH, Na M..  (2012)  Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.,  22  (19): [PMID:22940448] [10.1016/j.bmcl.2012.08.029]
88. Ramírez-Espinosa JJ, Rios MY, López-Martínez S, López-Vallejo F, Medina-Franco JL, Paoli P, Camici G, Navarrete-Vázquez G, Ortiz-Andrade R, Estrada-Soto S, Estrada-Soto S..  (2011)  Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.,  46  (6): [PMID:21453996] [10.1016/j.ejmech.2011.03.005]
89. Liobikas J, Majiene D, Trumbeckaite S, Kursvietiene L, Masteikova R, Kopustinskiene DM, Savickas A, Bernatoniene J..  (2011)  Uncoupling and antioxidant effects of ursolic acid in isolated rat heart mitochondria.,  74  (7): [PMID:21648406] [10.1021/np200060p]
90. Leal AS, Wang R, Salvador JA, Jing Y..  (2012)  Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.,  20  (19): [PMID:22959527] [10.1016/j.bmc.2012.08.010]
91. Liu MC, Yang SJ, Jin LH, Hu DY, Xue W, Song BA, Yang S..  (2012)  Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety.,  58  [PMID:23124210] [10.1016/j.ejmech.2012.08.048]
92. Bai KK, Chen FL, Yu Z, Zheng YQ, Li YN, Guo YH..  (2011)  Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823.,  19  (13): [PMID:21664827] [10.1016/j.bmc.2011.05.017]
93. Nguyen PH, Sharma G, Dao TT, Uddin MN, Kang KW, Ndinteh DT, Mbafor JT, Oh WK..  (2012)  New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.,  20  (21): [PMID:23022281] [10.1016/j.bmc.2012.08.024]
94. Takemura M, Endo S, Matsunaga T, Soda M, Zhao HT, El-Kabbani O, Tajima K, Iinuma M, Hara A..  (2011)  Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.,  74  (5): [PMID:21561086] [10.1021/np200118q]
95. Abramson HN..  (2011)  The lipogenesis pathway as a cancer target.,  54  (16): [PMID:21726077] [10.1021/jm2005805]
96. Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P..  (2012)  Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.,  20  (22): [PMID:23062825] [10.1016/j.bmc.2012.09.040]
97. Cui Y, Yim JH, Lee DS, Kim YC, Oh H..  (2012)  New diterpene furanoids from the Antarctic lichen Huea sp.,  22  (24): [PMID:23141910] [10.1016/j.bmcl.2012.10.063]
98. Chang X, Kang W.  (2012)  Antioxidant and -glucosidase inhibitory compounds from Pimpinella candolleana Wight et Arn.,  21  (12): [10.1007/s00044-012-9974-4]
99. Kang W, Wang J.  (2010)  In vitro antioxidant properties and in vivo lowering blood lipid of Forsythia suspense leaves,  19  (7): [10.1007/s00044-009-9217-5]
100. Kang W, Song Y, Zhang L.  (2011)  -Glucosidase inhibitory and antioxidant properties and antidiabetic activity of Hypericum ascyron L.,  20  (7): [10.1007/s00044-010-9391-5]
101. Joshi P, Tanwar O, Rambhade S, Bhaisare M, Jain D.  (2012)  2-D QSAR studies of steroidal natural products oleanic acid and their semisynthetic derivatives as potent protein tyrosine phosphatase 1B inhibitors,  21  (3): [10.1007/s00044-010-9529-5]
102. Muñoz E, Escalona D, Salazar JR, Alarcón J, Céspedes CL..  (2013)  Insect growth regulatory effects by diterpenes from Calceolaria talcana Grau & Ehrhart (Calceolariaceae: Scrophulariaceae) against Spodoptera frugiperda and Drosophila melanogaster,  45  [10.1016/j.indcrop.2012.12.038]
103. Mallavadhani UV, Mahapatra A, Raja SS, Manjula C..  (2003)  Antifeedant activity of some pentacyclic triterpene acids and their fatty acid ester analogues.,  51  (7): [PMID:12643657] [10.1021/jf020691d]
104. Mallavadhani UV, Mahapatra A, Pattnaik B, Vanga N, Suri N, Saxena AK.  (2013)  Synthesis and anti-cancer activity of some novel C-17 analogs of ursolic and oleanolic acids,  22  (3): [10.1007/s00044-012-0106-y]
105. Ghosh S, Chattopadhyay D, Mandal A, Kaity S, Samanta A.  (2013)  Bioactivity guided isolation of antiinflammatory, analgesic, and antipyretic constituents from the leaves of Pedilanthus tithymaloides (L.),  22  (9): [10.1007/s00044-012-0449-4]
106. Chaturvedi AK, Luqman S, Dubey V, Thakur JP, Saikia D, Chanotiya CS, Shanker K, Negi AS.  (2013)  Inhibition of Cathepsin D protease activity by Punica granatum fruit peel extracts, isolates, and semisynthetic analogs,  22  (8): [10.1007/s00044-012-0397-z]
107. Saifudin A, Tanaka K, Kadota S, Tezuka Y..  (2013)  Sesquiterpenes from the rhizomes of Curcuma heyneana.,  76  (2): [PMID:23387824] [10.1021/np300694a]
108. Yu F, Wang Q, Zhang Z, Peng Y, Qiu Y, Shi Y, Zheng Y, Xiao S, Wang H, Huang X, Zhu L, Chen K, Zhao C, Zhang C, Yu M, Sun D, Zhang L, Zhou D..  (2013)  Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.,  56  (11): [PMID:23662817] [10.1021/jm301910a]
109. Rashid S, Dar BA, Majeed R, Hamid A, Bhat BA..  (2013)  Synthesis and biological evaluation of ursolic acid-triazolyl derivatives as potential anti-cancer agents.,  66  [PMID:23811086] [10.1016/j.ejmech.2013.05.029]
110. De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP..  (2013)  Structure-based identification of OATP1B1/3 inhibitors.,  83  (6): [PMID:23571415] [10.1124/mol.112.084152]
111. Nguyen PH, Yang JL, Uddin MN, Park SL, Lim SI, Jung DW, Williams DR, Oh WK..  (2013)  Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.,  76  (11): [PMID:24224843] [10.1021/np400533h]
112. Thao NP, Luyen BT, Tai BH, Yang SY, Jo SH, Cuong NX, Nam NH, Kwon YI, Minh CV, Kim YH..  (2014)  Rat intestinal sucrase inhibition of constituents from the roots of Rosa rugosa Thunb.,  24  (4): [PMID:24461297] [10.1016/j.bmcl.2013.12.098]
113. Heinrich M, Frei Haller B, Leonti M..  (2014)  A perspective on natural products research and ethnopharmacology in Mexico: the eagle and the serpent on the prickly pear cactus.,  77  (3): [PMID:24559070] [10.1021/np4009927]
114. PubChem BioAssay data set, 
115. Kamenecka TM, Lyda B, Chang MR, Griffin PR.  (2013)  Synthetic modulators of the retinoic acid receptor-related orphan receptors,  (5): [10.1039/C3MD00005B]
116. Zhang Y, Xue X, Jin X, Song Y, Li J, Luo X, Song M, Yan W, Song H, Xu Y..  (2014)  Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation.,  78  [PMID:24704616] [10.1016/j.ejmech.2014.03.065]
117. Fu HJ, Zhou YR, Bao BH, Jia MX, Zhao Y, Zhang L, Li JX, He HL, Zhou XM..  (2014)  Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis.,  57  (11): [PMID:24844139] [10.1021/jm5002293]
118. Wang C, Yang J, Zhao P, Zhou Q, Mei Z, Yang G, Yang X, Feng Y..  (2014)  Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities.,  24  (14): [PMID:24894556] [10.1016/j.bmcl.2014.05.014]
119. Wang C, Lu L, Na H, Li X, Wang Q, Jiang X, Xu X, Yu F, Zhang T, Li J, Zhang Z, Zheng B, Liang G, Cai L, Jiang S, Liu K..  (2014)  Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.,  57  (17): [PMID:25156906] [10.1021/jm500763m]
120. Dang Thi TA, Kim Tuyet NT, Pham The C, Thanh Nguyen H, Ba Thi C, Doan Duy T, D'hooghe M, Van Nguyen T..  (2014)  Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.,  24  (22): [PMID:25442310] [10.1016/j.bmcl.2014.09.079]
121. Wang Z, Liu Z, Lee W, Kim SN, Yoon G, Cheon SH..  (2014)  Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.,  24  (15): [PMID:24953600] [10.1016/j.bmcl.2014.05.099]
122. Li MM, Su XQ, Sun J, Gu YF, Huang Z, Zeng KW, Zhang Q, Zhao YF, Ferreira D, Zjawiony JK, Li J, Tu PF..  (2014)  Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.,  77  (10): [PMID:25245917] [10.1021/np500509q]
123. Nguyen PH, Zhao BT, Ali MY, Choi JS, Rhyu DY, Min BS, Woo MH..  (2015)  Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.,  78  (1): [PMID:25559759] [10.1021/np5005856]
124. Huang L, Luo H, Li Q, Wang D, Zhang J, Hao X, Yang X..  (2015)  Pentacyclic triterpene derivatives possessing polyhydroxyl ring A inhibit gram-positive bacteria growth by regulating metabolism and virulence genes expression.,  95  [PMID:25794790] [10.1016/j.ejmech.2015.01.015]
125. Hua SX, Huang RZ, Ye MY, Pan YM, Yao GY, Zhang Y, Wang HS..  (2015)  Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents.,  95  [PMID:25841199] [10.1016/j.ejmech.2015.03.051]
126. Nguyen PH, Ji DJ, Han YR, Choi JS, Rhyu DY, Min BS, Woo MH..  (2015)  Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.,  23  (13): [PMID:25907369] [10.1016/j.bmc.2015.04.007]
127. Heller L, Schwarz S, Perl V, Köwitsch A, Siewert B, Csuk R..  (2015)  Incorporation of a Michael acceptor enhances the antitumor activity of triterpenoic acids.,  101  [PMID:26177446] [10.1016/j.ejmech.2015.07.004]
128. Wang H, Yu F, Peng Y, Wang Q, Han X, Xu R, Zhou X, Wan C, Fan Z, Jiao P, Zhang Y, Zhang L, Zhou D, Xiao S..  (2015)  Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors.,  102  [PMID:26318066] [10.1016/j.ejmech.2015.08.034]
129. Nelson AT, Camelio AM, Claussen KR, Cho J, Tremmel L, DiGiovanni J, Siegel D..  (2015)  Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.,  25  (19): [PMID:26259803] [10.1016/j.bmcl.2015.07.029]
130. Zhao CH, Zhang CL, Shi JJ, Hou XY, Feng B, Zhao LX..  (2015)  Design, synthesis, and biofunctional evaluation of novel pentacyclic triterpenes bearing O-[4-(1-piperazinyl)-4-oxo-butyryl moiety as antiproliferative agents.,  25  (20): [PMID:26343825] [10.1016/j.bmcl.2015.08.076]
131. Kim HJ, Fei X, Cho SC, Choi BY, Ahn HC, Lee K, Seo SY, Keum YS..  (2015)  Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.,  25  (23): [PMID:26508549] [10.1016/j.bmcl.2015.10.034]
132. Zhang CC, Yin X, Cao CY, Wei J, Zhang Q, Gao JM..  (2015)  Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells.,  25  (22): [PMID:26481911] [10.1016/j.bmcl.2015.10.016]
133. Wiemann J, Heller L, Csuk R..  (2016)  Targeting cancer cells with oleanolic and ursolic acid derived hydroxamates.,  26  (3): [PMID:26750249] [10.1016/j.bmcl.2015.12.064]
134. Wang Y, Yuk HJ, Kim JY, Kim DW, Song YH, Tan XF, Curtis-Long MJ, Park KH..  (2016)  Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.,  26  (2): [PMID:26704263] [10.1016/j.bmcl.2015.12.021]
135. Dar BA, Lone AM, Shah WA, Qurishi MA..  (2016)  Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents.,  111  [PMID:26854375] [10.1016/j.ejmech.2016.01.026]
136. Pedada SR, Yarla NS, Tambade PJ, Dhananjaya BL, Bishayee A, Arunasree KM, Philip GH, Dharmapuri G, Aliev G, Putta S, Rangaiah G..  (2016)  Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents.,  112  [PMID:26907155] [10.1016/j.ejmech.2016.02.025]
137. Su Q, Dalal S, Goetz M, Cassera MB, Kingston DG..  (2016)  Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera.,  24  (11): [PMID:27112454] [10.1016/j.bmc.2016.04.020]
138. Vieira Pde B, Silva NL, da Silva GN, Silva DB, Lopes NP, Gnoatto SC, da Silva MV, Macedo AJ, Bastida J, Tasca T..  (2016)  Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis.,  26  (9): [PMID:27020521] [10.1016/j.bmcl.2016.03.061]
139. Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, Yu S, Ye M..  (2016)  Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.,  79  (2): [PMID:26841168] [10.1021/acs.jnatprod.5b00877]
140. Na H, Li X, Zou C, Wang C, Wang C, Liu K..  (2016)  Triterpene sapogenin-polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains.,  24  (13): [PMID:27209170] [10.1016/j.bmc.2016.05.008]
141. Yoon Y, Lim JW, Kim J, Kim Y, Chun KH..  (2016)  Discovery of ursolic acid prodrug (NX-201): Pharmacokinetics and in vivo antitumor effects in PANC-1 pancreatic cancer.,  26  (22): [PMID:27769622] [10.1016/j.bmcl.2016.10.008]
142. Mendes VIS, Bartholomeusz GA, Ayres M, Gandhi V, Salvador JAR..  (2016)  Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.,  123  [PMID:27484517] [10.1016/j.ejmech.2016.07.045]
143. Ivanov A, Ejaz SA, Shah SJA, Ehlers P, Villinger A, Frank E, Schneider G, Wölfling J, Rahman Q, Iqbal J, Langer P..  (2017)  Synthesis, functionalization and biological activity of arylated derivatives of (+)-estrone.,  25  (3): [PMID:28034648] [10.1016/j.bmc.2016.12.009]
144.  (2016)  (10): [10.1039/C6MD00292G]
145. Sommerwerk S, Heller L, Kerzig C, Kramell AE, Csuk R..  (2017)  Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations.,  127  [PMID:28033541] [10.1016/j.ejmech.2016.12.040]
146. Wang C, Wu P, Tian S, Xue J, Xu L, Li H, Wei X..  (2016)  Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus.,  79  (11): [PMID:27797185] [10.1021/acs.jnatprod.6b00715]
147. Chen Y, Li C, Zheng Y, Gao Y, Hu J, Chen H..  (2017)  Discovery of FZU-03,010 as a self-assembling anticancer amphiphile for acute myeloid leukemia.,  27  (4): [PMID:28073673] [10.1016/j.bmcl.2016.12.071]
148. Wen Q, Lu Y, Chao Z, Chen DF..  (2017)  Anticomplement triterpenoids from the roots of Ilex asprella.,  27  (4): [PMID:28094185] [10.1016/j.bmcl.2017.01.007]
149. Romero-Benavides JC, Ruano AL, Silva-Rivas R, Castillo-Veintimilla P, Vivanco-Jaramillo S, Bailon-Moscoso N..  (2017)  Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies.,  129  [PMID:28231520] [10.1016/j.ejmech.2017.02.005]
150. Nguyen TT, Truong BN, Doan Thi Mai H, Litaudon M, Nguyen VH, Do Thi T, Chau VM, Pham VC..  (2017)  Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum.,  27  (8): [PMID:28318944] [10.1016/j.bmcl.2017.03.014]
151. Liu F, Yuan T, Liu W, Ma H, Seeram NP, Li Y, Xu L, Mu Y, Huang X, Li L..  (2017)  Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.,  80  (2): [PMID:28134521] [10.1021/acs.jnatprod.6b01073]
152. Sonar VP, Corona A, Distinto S, Maccioni E, Meleddu R, Fois B, Floris C, Malpure NV, Alcaro S, Tramontano E, Cottiglia F..  (2017)  Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase.,  130  [PMID:28254698] [10.1016/j.ejmech.2017.02.054]
153. Zhang C, Xu SH, Ma BL, Wang WW, Yu BY, Zhang J..  (2017)  New derivatives of ursolic acid through the biotransformation by Bacillus megaterium CGMCC 1.1741 as inhibitors on nitric oxide production.,  27  (11): [PMID:28427811] [10.1016/j.bmcl.2017.03.076]
154. Jung HA, Paudel P, Seong SH, Min BS, Choi JS..  (2017)  Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.,  27  (11): [PMID:28454670] [10.1016/j.bmcl.2017.04.054]
155. Lin Y, Kuang Y, Li K, Wang S, Song W, Qiao X, Sabir G, Ye M..  (2017)  Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.,  25  (14): [PMID:28522265] [10.1016/j.bmc.2017.05.009]
156. Gulipalli KC, Bodige S, Ravula P, Endoori S, Vanaja GR, Suresh Babu G, Narendra Sharath Chandra JN, Seelam N..  (2017)  Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.,  27  (15): [PMID:28579122] [10.1016/j.bmcl.2017.05.047]
157. Tan XF, Uddin Z, Park C, Song YH, Son M, Lee KW, Park KH..  (2017)  Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism.,  25  (8): [PMID:28318895] [10.1016/j.bmc.2017.03.010]
158. Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L, Wei W..  (2017)  An Ursolic Acid Derived Small Molecule Triggers Cancer Cell Death through Hyperstimulation of Macropinocytosis.,  60  (15): [PMID:28678485] [10.1021/acs.jmedchem.7b00592]
159. Yoshioka T, Murakami K, Ido K, Hanaki M, Yamaguchi K, Midorikawa S, Taniwaki S, Gunji H, Irie K..  (2016)  Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation.,  79  (10): [PMID:27700077] [10.1021/acs.jnatprod.6b00392]
160. Yang JL, Ha TKQ, Lee BW, Kim J, Oh WK..  (2017)  PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.,  27  (22): [PMID:28951079] [10.1016/j.bmcl.2017.09.031]
161. Zhang BW, Xing Y, Wen C, Yu XX, Sun WL, Xiu ZL, Dong YS..  (2017)  Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.,  27  (22): [PMID:28964635] [10.1016/j.bmcl.2017.09.027]
162. Li K, Ji S, Song W, Kuang Y, Lin Y, Tang S, Cui Z, Qiao X, Yu S, Ye M..  (2017)  Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.,  80  (2): [PMID:28140583] [10.1021/acs.jnatprod.6b00783]
163. Gu W, Jin XY, Li DD, Wang SF, Tao XB, Chen H..  (2017)  Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid.,  27  (17): [PMID:28733083] [10.1016/j.bmcl.2017.07.033]
164. Wu J, Kumar S, Wang F, Wang H, Chen L, Arsenault P, Mattern M, Weinstock J..  (2018)  Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.,  61  (2): [PMID:28768102] [10.1021/acs.jmedchem.7b00498]
165. Chen D, Huang X, Zhou H, Luo H, Wang P, Chang Y, He X, Ni S, Shen Q, Cao G, Sun H, Wen X, Liu J..  (2017)  Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.,  139  [PMID:28802120] [10.1016/j.ejmech.2017.08.012]
166. Cargnin ST, Staudt AF, Medeiros P, de Medeiros Sol Sol D, de Azevedo Dos Santos AP, Zanchi FB, Gosmann G, Puyet A, Garcia Teles CB, Gnoatto SB..  (2018)  Semisynthesis, cytotoxicity, antimalarial evaluation and structure-activity relationship of two series of triterpene derivatives.,  28  (3): [PMID:29326018] [10.1016/j.bmcl.2017.12.060]
167. Kuo PC, Hung HY, Nian CW, Hwang TL, Cheng JC, Kuo DH, Lee EJ, Tai SH, Wu TS..  (2017)  Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.,  80  (4): [PMID:28218000] [10.1021/acs.jnatprod.6b01141]
168. Li ZP, Song YH, Uddin Z, Wang Y, Park KH..  (2018)  Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.,  26  (3): [PMID:29306546] [10.1016/j.bmc.2017.12.043]
169. Zhang J, Sasaki T, Li W, Nagata K, Higai K, Feng F, Wang J, Cheng M, Koike K..  (2018)  Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps.,  28  (7): [PMID:29525218] [10.1016/j.bmcl.2018.02.052]
170. Pompermaier L, Heiss EH, Alilou M, Mayr F, Monizi M, Lautenschlaeger T, Schuster D, Schwaiger S, Stuppner H..  (2018)  Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.,  81  (9): [PMID:30207720] [10.1021/acs.jnatprod.8b00450]
171. Dal Prà M, Carta D, Szabadkai G, Suman M, Frión-Herrera Y, Paccagnella N, Castellani G, De Martin S, Ferlin MG..  (2018)  Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders.,  26  (8): [PMID:29477813] [10.1016/j.bmc.2018.02.018]
172. Li Z, Min Q, Huang H, Liu R, Zhu Y, Zhu Q..  (2018)  Design, synthesis and biological evaluation of seco-A-pentacyclic triterpenoids-3,4-lactone as potent non-nucleoside HBV inhibitors.,  28  (9): [PMID:29627260] [10.1016/j.bmcl.2018.03.076]
173. Wei ZY, Chi KQ, Wang KS, Wu J, Liu LP, Piao HR..  (2018)  Design, synthesis, evaluation, and molecular docking of ursolic acid derivatives containing a nitrogen heterocycle as anti-inflammatory agents.,  28  (10): [PMID:29678461] [10.1016/j.bmcl.2018.04.021]
174. Ren Y, Anaya-Eugenio GD, Czarnecki AA, Ninh TN, Yuan C, Chai HB, Soejarto DD, Burdette JE, de Blanco EJC, Kinghorn AD..  (2018)  Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.,  26  (15): [PMID:30057155] [10.1016/j.bmc.2018.07.025]
175. Medvedeva NI, Kazakova OB, Lopatina TV, Smirnova IE, Giniyatullina GV, Baikova IP, Kataev VE..  (2018)  Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.,  143  [PMID:29202408] [10.1016/j.ejmech.2017.11.035]
176. Liu X, Li B, Zhang Z, Wei Y, Xu Z, Qin S, Liu N, Zhao R, Peng J, Yang G, Qi M, Liu T, Xie M, Liu S, Gao X, Lu C, Zhu L, Long X, Kang H, Sun T, Zhou H, Wei M, Yang G, Yang C..  (2018)  Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.,  61  (23): [PMID:30433783] [10.1021/acs.jmedchem.8b01445]
177. Huang RZ, Hua SX, Liao ZX, Huang XC, Wang HS..  (2017)  Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-κB) pathway and cell proliferation.,  (7): [PMID:30108853] [10.1039/C7MD00105C]
178. Itoh T, Katsurayama K, Efdi M, Ninomiya M, Koketsu M..  (2018)  Sentulic acid isolated from Sandoricum koetjape Merr attenuates lipopolysaccharide and interferon gamma co-stimulated nitric oxide production in murine macrophage RAW264 cells.,  28  (22): [PMID:30318438] [10.1016/j.bmcl.2018.10.008]
179. Salvador JAR, Leal AS, Valdeira AS, Gonçalves BMF, Alho DPS, Figueiredo SAC, Silvestre SM, Mendes VIS..  (2017)  Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.,  142  [PMID:28754470] [10.1016/j.ejmech.2017.07.013]
180. Unpublished dataset, 
181. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek.  (2020)  Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection,  [10.21203/rs.3.rs-23951/v1]
182. Liu CM, Huang JY, Sheng LX, Wen XA, Cheng KG..  (2019)  Synthesis and antitumor activity of fluorouracil - oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates.,  10  (8): [PMID:31673307] [10.1039/C9MD00246D]
183. Saquib M, Ansari MI, Johnson CR, Khatoon S, Kamil Hussain M, Coop A..  (2019)  Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.,  182  [PMID:31499361] [10.1016/j.ejmech.2019.111657]
184. Wu J, Zhang ZH, Zhang LH, Jin XJ, Ma J, Piao HR..  (2019)  Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway.,  29  (6): [PMID:30728113] [10.1016/j.bmcl.2018.12.060]
185. Brandes B, Hoenke S, Fischer L, Csuk R..  (2020)  Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids.,  185  [PMID:31718946] [10.1016/j.ejmech.2019.111858]
186. Zhang LH, Zhang ZH, Li MY, Wei ZY, Jin XJ, Piao HR..  (2019)  Synthesis and evaluation of the HIF-1α inhibitory activities of novel ursolic acid tetrazole derivatives.,  29  (12): [PMID:31006525] [10.1016/j.bmcl.2019.04.028]
187. Deng Y, Wu T, Zhai SQ, Li CH..  (2019)  Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening.,  183  [PMID:31585276] [10.1016/j.ejmech.2019.111711]
188. Kasangana PB, Haddad PS, Eid HM, Nachar A, Stevanovic T..  (2018)  Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes.,  81  (10): [PMID:30336025] [10.1021/acs.jnatprod.8b00079]
189. Minassi A, Rogati F, Cruz C, Prados ME, Galera N, Jinénez C, Appendino G, Bellido ML, Calzado MA, Caprioglio D, Muñoz E..  (2018)  Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.,  81  (10): [PMID:30350996] [10.1021/acs.jnatprod.8b00514]
190. Li H, Li M, Xu R, Wang S, Zhang Y, Zhang L, Zhou D, Xiao S..  (2019)  Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates.,  163  [PMID:30554131] [10.1016/j.ejmech.2018.12.006]
191. Hodon J, Borkova L, Pokorny J, Kazakova A, Urban M..  (2019)  Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.,  182  [PMID:31499360] [10.1016/j.ejmech.2019.111653]
192. Vo NNQ, Nomura Y, Muranaka T, Fukushima EO..  (2019)  Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.,  82  (12): [PMID:31774676] [10.1021/acs.jnatprod.9b00538]
193.  (2013)  Method for treating skin with retinoids and retinoid boosters, 
194. Zhao Y, Cao Y, Chen H, Zhuang F, Wu C, Yoon G, Zhu W, Su Y, Zheng S, Liu Z, Cheon SH..  (2019)  Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.,  27  (6): [PMID:30737132] [10.1016/j.bmc.2019.01.034]
195. Sommerwerk S, Heller L, Kuhfs J, Csuk R..  (2016)  Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines.,  119  [PMID:27149037] [10.1016/j.ejmech.2016.04.051]
196.  (2017)  Ghrelin o-acyltransferase inhibitors, 
197. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani.  (2020)  Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen,  [10.6019/CHEMBL4495564]
198. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani.  (2020)  Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen,  [10.6019/CHEMBL4495564]
199. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen.  (2020)  Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort,  [10.6019/CHEMBL4495565]
200. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen.  (2020)  Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort,  [10.6019/CHEMBL4495565]
201. Chen C, Sun R, Sun Y, Chen X, Li F, Wen X, Yuan H, Chen D..  (2020)  Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors.,  30  (2): [PMID:31780304] [10.1016/j.bmcl.2019.126824]
202. Li SJ, Liu Q, He XB, Liu JP, Liu XL, Hu J, Tang ZP, Peng QY, Cui LJ, Zhang HN, Yang XL, Wang Q, Zhang ZJ..  (2020)  Pyrola incarnata demonstrates neuroprotective effects against β-amyloid-induced memory impairment in mice.,  30  (2): [PMID:31836444] [10.1016/j.bmcl.2019.126858]
203. Nguyen TA, Ha MT, Park SE, Choi JS, Min BS, Kim JA..  (2020)  Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Polygonum multiflorum.,  83  (2): [PMID:31944695] [10.1021/acs.jnatprod.9b00777]
204. Fan JR, Kuang Y, Dong ZY, Yi Y, Zhou YX, Li B, Qiao X, Ye M..  (2020)  Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors.,  83  (4): [PMID:32196343] [10.1021/acs.jnatprod.9b00262]
205. Hasan Abdali M, Afshar S, Sedighi Pashaki A, Dastan D, Gholami MH, Mahmoudi R, Saidijam M..  (2020)  Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate ‌ on HCT-116 cell line.,  28  (1): [PMID:31771799] [10.1016/j.bmc.2019.115152]
206. Rangel-Grimaldo M, Macías-Rubalcava ML, González-Andrade M, Raja H, Figueroa M, Mata R..  (2020)  α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from Malbranchea circinata.,  83  (3): [PMID:31898904] [10.1021/acs.jnatprod.9b01108]
207. Tawila AM, Sun S, Kim MJ, Omar AM, Dibwe DF, Ueda JY, Toyooka N, Awale S..  (2020)  Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line.,  30  (16): [PMID:32631550] [10.1016/j.bmcl.2020.127352]
208. Lawrence JA, Huang Z, Rathinavelu S, Hu JF, Garo E, Ellis M, Norman VL, Buckle R, Williams RB, Starks CM, Eldridge GR..  (2020)  Optimized plant compound with potent anti-biofilm activity across gram-negative species.,  28  (5): [PMID:32033878] [10.1016/j.bmc.2019.115229]
209. Liu Q, Liu JP, Mei JH, Li SJ, Shi LQ, Lin ZH, Xie BY, Sun WG, Wang ZY, Yang XL, Zou Y, Fang W..  (2020)  Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design.,  30  (12): [PMID:32334913] [10.1016/j.bmcl.2020.127193]
210. Xu XT,Deng XY,Chen J,Liang QM,Zhang K,Li DL,Wu PP,Zheng X,Zhou RP,Jiang ZY,Ma AJ,Chen WH,Wang SH.  (2020)  Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors.,  189  [PMID:31972390] [10.1016/j.ejmech.2019.112013]
211. Rivera-Chávez J,Bustos-Brito C,Aguilar-Ramírez E,Martínez-Otero D,Rosales-Vázquez LD,Dorazco-González A,Cano-Sánchez P.  (2020)  Hydroxy-neo-Clerodanes and 5,10-seco-neo-Clerodanes from Salvia decora.,  83  (7): [PMID:32597650] [10.1021/acs.jnatprod.0c00313]
212. Zhang JF,Zhong WC,Li YC,Song YQ,Xia GY,Tian GH,Ge GB,Lin S.  (2020)  Bioactivity-Guided Discovery of Human Carboxylesterase Inhibitors from the Roots of Paeonia lactiflora.,  83  (10): [PMID:32951423] [10.1021/acs.jnatprod.0c00464]
213. Vitale RM,Avonto C,Del Prete D,Moriello AS,Amodeo P,Appendino G,De Petrocellis L.  (2020)  Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides.,  83  (11): [PMID:33136399] [10.1021/acs.jnatprod.0c00639]
214. Liu L,Li H,Hu K,Xu Q,Wen X,Cheng K,Chen C,Yuan H,Dai L,Sun H.  (2021)  Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.,  209  [PMID:33131725] [10.1016/j.ejmech.2020.112932]
215. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius.  (2021)  HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators,  [10.6019/CHEMBL4808148]
216. Wang R, Li Y, Hu H, Persoons L, Daelemans D, De Jonghe S, Luyten W, Krasniqi B, Dehaen W..  (2021)  Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells.,  224  [PMID:34352711] [10.1016/j.ejmech.2021.113727]
217. Liang C, Kjaerulff L, Hansen PR, Kongstad KT, Staerk D..  (2021)  Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Rhododendron capitatum.,  84  (9.0): [PMID:34460246] [10.1021/acs.jnatprod.1c00454]
218. Lee YG, Kang KW, Hong W, Kim YH, Oh JT, Park DW, Ko M, Bai YF, Seo YJ, Lee SM, Kim H, Kang SC..  (2021)  Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2.,  45  [PMID:34329818] [10.1016/j.bmc.2021.116329]
219. Hu C, Li G, Mu Y, Wu W, Cao B, Wang Z, Yu H, Guan P, Han L, Li L, Huang X..  (2021)  Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, In Vitro and In Vivo Investigations of Jamunones.,  64  (9.0): [PMID:33860662] [10.1021/acs.jmedchem.1c00085]
220. Hua D, Wu X..  (2022)  Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.,  233  [PMID:35247754] [10.1016/j.ejmech.2022.114227]
221. Romero-Estrada A, Boto A, González-Christen J, Romero-Estudillo I, Garduño-Ramírez ML, Razo-Hernández RS, Marquina S, Maldonado-Magaña A, Columba-Palomares MC, Sánchez-Carranza JN, Alvarez L..  (2022)  Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of α-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation.,  85  (4.0): [PMID:35175765] [10.1021/acs.jnatprod.1c00827]
222. Wei H, Guo J, Sun X, Gou W, Ning H, Shang H, Liu Q, Hou W, Li Y..  (2022)  Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.,  85  (5.0): [PMID:35500202] [10.1021/acs.jnatprod.1c01166]
223. Wei H, Guo J, Sun X, Gou W, Ning H, Fang Z, Liu Q, Hou W, Li Y..  (2022)  Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.,  227  [PMID:34688014] [10.1016/j.ejmech.2021.113918]
224. Qin N, Lu X, Liu Y, Qiao Y, Qu W, Feng F, Sun H..  (2021)  Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry.,  210  [PMID:33148492] [10.1016/j.ejmech.2020.112960]
225. Wei J, Wang H, Zheng Q, Zhang J, Chen Z, Wang J, Ouyang L, Wang Y..  (2022)  Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers.,  241  [PMID:35939992] [10.1016/j.ejmech.2022.114650]
226. Haider K, Haider MR, Neha K, Yar MS..  (2020)  Free radical scavengers: An overview on heterocyclic advances and medicinal prospects.,  204  [PMID:32721784] [10.1016/j.ejmech.2020.112607]
227. Li P, Liu HM..  (2020)  Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.,  191  [PMID:32092586] [10.1016/j.ejmech.2020.112107]
228. Tanwar AK, Dhiman N, Kumar A, Jaitak V..  (2021)  Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach.,  213  [PMID:33257172] [10.1016/j.ejmech.2020.113037]
229. Xu GB, Xiao YH, Zhang QY, Zhou M, Liao SG..  (2018)  Hepatoprotective natural triterpenoids.,  145  [PMID:29353722] [10.1016/j.ejmech.2018.01.011]