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(S)-N6-Allyl-2,6-diamino-9-[3-fluoro-2-(phosphonomethoxy)propyl]purine ID: ALA1766199
Chembl Id: CHEMBL1766199
PubChem CID: 54581460
Max Phase: Preclinical
Molecular Formula: C12H18FN6O4P
Molecular Weight: 360.29
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: C=CCNc1nc(N)nc2c1ncn2C[C@@H](CF)OCP(=O)(O)O
Standard InChI: InChI=1S/C12H18FN6O4P/c1-2-3-15-10-9-11(18-12(14)17-10)19(6-16-9)5-8(4-13)23-7-24(20,21)22/h2,6,8H,1,3-5,7H2,(H2,20,21,22)(H3,14,15,17,18)/t8-/m1/s1
Standard InChI Key: CNCWSZLZMUZNIC-MRVPVSSYSA-N
Associated Targets(Human) Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 360.29Molecular Weight (Monoisotopic): 360.1111AlogP: 0.50#Rotatable Bonds: 9Polar Surface Area: 148.41Molecular Species: ACIDHBA: 8HBD: 4#RO5 Violations: ┄HBA (Lipinski): 10HBD (Lipinski): 5#RO5 Violations (Lipinski): ┄CX Acidic pKa: -5.46CX Basic pKa: 6.35CX LogP: -3.29CX LogD: -2.77Aromatic Rings: 2Heavy Atoms: 24QED Weighted: 0.37Np Likeness Score: -0.57
References 1. Baszczyňski O, Jansa P, Dračínský M, Klepetářová B, Holý A, Votruba I, de Clercq E, Balzarini J, Janeba Z.. (2011) Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines., 19 (7): [PMID:21429755 ] [10.1016/j.bmc.2011.02.050 ]