(S)-2,6-Diamino-N6,N6-diethyl-9-[3-fluoro-2-(phosphonomethoxy)propyl]purine

ID: ALA1766278

Chembl Id: CHEMBL1766278

PubChem CID: 54581462

Max Phase: Preclinical

Molecular Formula: C13H22FN6O4P

Molecular Weight: 376.33

Molecule Type: Small molecule

Associated Items:

Names and Identifiers

Canonical SMILES:  CCN(CC)c1nc(N)nc2c1ncn2C[C@@H](CF)OCP(=O)(O)O

Standard InChI:  InChI=1S/C13H22FN6O4P/c1-3-19(4-2)11-10-12(18-13(15)17-11)20(7-16-10)6-9(5-14)24-8-25(21,22)23/h7,9H,3-6,8H2,1-2H3,(H2,15,17,18)(H2,21,22,23)/t9-/m1/s1

Standard InChI Key:  YUGPVYOFDUMEBM-SECBINFHSA-N

Associated Targets(Human)

CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADA Tclin Adenosine deaminase (129 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 2 (5592 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Moloney murine sarcoma virus (182 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 376.33Molecular Weight (Monoisotopic): 376.1424AlogP: 0.74#Rotatable Bonds: 9
Polar Surface Area: 139.62Molecular Species: ACIDHBA: 8HBD: 3
#RO5 Violations: HBA (Lipinski): 10HBD (Lipinski): 4#RO5 Violations (Lipinski):
CX Acidic pKa: 1.40CX Basic pKa: 5.27CX LogP: -2.66CX LogD: -2.15
Aromatic Rings: 2Heavy Atoms: 25QED Weighted: 0.54Np Likeness Score: -0.62

References

1. Baszczyňski O, Jansa P, Dračínský M, Klepetářová B, Holý A, Votruba I, de Clercq E, Balzarini J, Janeba Z..  (2011)  Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.,  19  (7): [PMID:21429755] [10.1016/j.bmc.2011.02.050]

Source