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(S)-2-Amino-9-[3-fluoro-2-(phosphonomethoxy)-propyl]-6-(pyrrolidin-1-yl)purine ID: ALA1766280
Chembl Id: CHEMBL1766280
PubChem CID: 54581463
Max Phase: Preclinical
Molecular Formula: C13H20FN6O4P
Molecular Weight: 374.31
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: Nc1nc(N2CCCC2)c2ncn(C[C@@H](CF)OCP(=O)(O)O)c2n1
Standard InChI: InChI=1S/C13H20FN6O4P/c14-5-9(24-8-25(21,22)23)6-20-7-16-10-11(19-3-1-2-4-19)17-13(15)18-12(10)20/h7,9H,1-6,8H2,(H2,15,17,18)(H2,21,22,23)/t9-/m1/s1
Standard InChI Key: FOVANXUAPNKSDQ-SECBINFHSA-N
Associated Targets(Human) Associated Targets(non-human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 374.31Molecular Weight (Monoisotopic): 374.1268AlogP: 0.50#Rotatable Bonds: 7Polar Surface Area: 139.62Molecular Species: ACIDHBA: 8HBD: 3#RO5 Violations: ┄HBA (Lipinski): 10HBD (Lipinski): 4#RO5 Violations (Lipinski): ┄CX Acidic pKa: 1.40CX Basic pKa: 5.26CX LogP: -2.98CX LogD: -2.48Aromatic Rings: 2Heavy Atoms: 25QED Weighted: 0.59Np Likeness Score: -0.70
References 1. Baszczyňski O, Jansa P, Dračínský M, Klepetářová B, Holý A, Votruba I, de Clercq E, Balzarini J, Janeba Z.. (2011) Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines., 19 (7): [PMID:21429755 ] [10.1016/j.bmc.2011.02.050 ]