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(S)-2-((S)-1-((S)-2-(biphenyl-4-yl)-1-carboxyethylamino)-5-methyl-1-oxohexan-2-ylamino)-4-phenylbutanoic acid ID: ALA1778526
Chembl Id: CHEMBL1778526
PubChem CID: 54584674
Max Phase: Preclinical
Molecular Formula: C32H38N2O5
Molecular Weight: 530.67
Molecule Type: Small molecule
Associated Items:
Names and Identifiers Canonical SMILES: CC(C)CC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)O
Standard InChI: InChI=1S/C32H38N2O5/c1-22(2)13-19-27(33-28(31(36)37)20-16-23-9-5-3-6-10-23)30(35)34-29(32(38)39)21-24-14-17-26(18-15-24)25-11-7-4-8-12-25/h3-12,14-15,17-18,22,27-29,33H,13,16,19-21H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)/t27-,28-,29-/m0/s1
Standard InChI Key: VSYYVORPLMQOJQ-AWCRTANDSA-N
Associated Targets(Human) Molecule Features Natural Product: NoOral: NoChemical Probe: NoParenteral: NoMolecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: NoChirality: NoAvailability: NoProdrug: No
Drug Indications MESH ID MESH Heading EFO IDs EFO Terms Max Phase for Indication References
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Calculated Properties Molecular Weight: 530.67Molecular Weight (Monoisotopic): 530.2781AlogP: 4.95#Rotatable Bonds: 15Polar Surface Area: 115.73Molecular Species: ACIDHBA: 4HBD: 4#RO5 Violations: 1HBA (Lipinski): 7HBD (Lipinski): 4#RO5 Violations (Lipinski): 1CX Acidic pKa: 3.23CX Basic pKa: 8.14CX LogP: 3.72CX LogD: 0.83Aromatic Rings: 3Heavy Atoms: 39QED Weighted: 0.22Np Likeness Score: 0.11
References 1. Glossop MS, Bazin RJ, Dack KN, Fox DN, MacDonald GA, Mills M, Owen DR, Phillips C, Reeves KA, Ringer TJ, Strang RS, Watson CA.. (2011) Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors., 21 (11): [PMID:21515054 ] [10.1016/j.bmcl.2011.03.109 ]