| 1. Pfefferkorn JA, Lou J, Minich ML, Filipski KJ, He M, Zhou R, Ahmed S, Benbow J, Perez AG, Tu M, Litchfield J, Sharma R, Metzler K, Bourbonais F, Huang C, Beebe DA, Oates PJ.. (2009) Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle., 19 (12): [PMID:19435665] [10.1016/j.bmcl.2009.04.107] |
| 2. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
| 3. Sarabu R, Bizzarro FT, Corbett WL, Dvorozniak MT, Geng W, Grippo JF, Haynes NE, Hutchings S, Garofalo L, Guertin KR, Hilliard DW, Kabat M, Kester RF, Ka W, Liang Z, Mahaney PE, Marcus L, Matschinsky FM, Moore D, Racha J, Radinov R, Ren Y, Qi L, Pignatello M, Spence CL, Steele T, Tengi J, Grimsby J.. (2012) Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients., 55 (16): [PMID:22809456] [10.1021/jm3008689] |
| 4. Sarabu R, Bizzarro FT, Corbett WL, Dvorozniak MT, Geng W, Grippo JF, Haynes NE, Hutchings S, Garofalo L, Guertin KR, Hilliard DW, Kabat M, Kester RF, Ka W, Liang Z, Mahaney PE, Marcus L, Matschinsky FM, Moore D, Racha J, Radinov R, Ren Y, Qi L, Pignatello M, Spence CL, Steele T, Tengi J, Grimsby J.. (2012) Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients., 55 (16): [PMID:22809456] [10.1021/jm3008689] |
| 5. Qian Y, Corbett WL, Berthel SJ, Choi DS, Dvorozniak MT, Geng W, Gillespie P, Guertin KR, Haynes NE, Kester RF, Mennona FA, Moore D, Racha J, Radinov R, Sarabu R, Scott NR, Grimsby J, Mallalieu NL.. (2013) Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes., 4 (4): [PMID:24900686] [10.1021/ml400027y] |
| 6. PubChem BioAssay data set, |
| 7. Pfefferkorn JA, Guzman-Perez A, Oates PJ, Litchfield J, Aspnes G, Basak A, Benbow J, Berliner MA, Bian J, Choi C, Freeman-Cook K, Corbett JW, Didiuk M, Dunetz JR, Filipski KJ, Hungerford WM, Jones CS, Karki K, Ling A, Li J, Patel L, Perreault C, Risley H, Saenz J, Song W, Tu M, Aiello R, Atkinson K, Barucci N, Beebe D, Bourassa P, Bourbounais F, Brodeur AM, Burbey R, Chen J, D'Aquila T, Derksen DR, Haddish-Berhane N, Huang C, Landro J, Lee Lapworth A, MacDougall M, Perregaux D, Pettersen J, Robertson A, Tan B, Treadway JL, Liu S, Qiu X, Knafels J, Ammirati M, Song X, DaSilva-Jardine P, Liras S, Sweet L, Rolph TP. (2011) Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus, 2 (9): [10.1039/C1MD00116G] |
| 8. Mark Wenlock and Nicholas Tomkinson. Experimental in vitro DMPK and physicochemical data on a set of publicly disclosed compounds, [10.6019/CHEMBL3301361] |
| 9. Borzilleri KA, Pfefferkorn JA, Guzman-Perez A, Liu S, Qiu X, Chrunyk BA, Song X, Tu M, Filipski KJ, Aiello R, Derksen DR, Bourbonais FJ, Landro J, Bourassa P, D'Aquila T, Baker L, Barrucci N, Litchfield J, Atkinson K, Rolph TP, Withka JM. (2014) Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk, 5 (6): [10.1039/C4MD00027G] |
| 10. Paczal A, Bálint B, Wéber C, Szabó ZB, Ondi L, Theret I, De Ceuninck F, Bernard C, Ktorza A, Perron-Sierra F, Kotschy A.. (2016) Structure-Activity Relationship of Azaindole-Based Glucokinase Activators., 59 (2): [PMID:26685731] [10.1021/acs.jmedchem.5b01594] |
| 11. Fujieda H, Kogami M, Sakairi M, Kato N, Makino M, Takahashi N, Miyazawa T, Harada S, Yamashita T.. (2018) Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus., 156 [PMID:30006171] [10.1016/j.ejmech.2018.06.060] |
| 12. Mollica L, Theret I, Antoine M, Perron-Sierra F, Charton Y, Fourquez JM, Wierzbicki M, Boutin JA, Ferry G, Decherchi S, Bottegoni G, Ducrot P, Cavalli A.. (2016) Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times., 59 (15): [PMID:27391254] [10.1021/acs.jmedchem.6b00632] |
