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| 20. Abbate F, Coetzee A, Casini A, Ciattini S, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride., 14 (2): [PMID:14698154] [10.1016/j.bmcl.2003.11.014] |
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| 23. Lehtonen JM, Parkkila S, Vullo D, Casini A, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design., 14 (14): [PMID:15203157] [10.1016/j.bmcl.2004.04.106] |
| 24. Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G, Supuran CT.. (2000) Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action., 43 (23): [PMID:11087579] [10.1021/jm000296j] |
| 25. Casini A, Scozzafava A, Mincione F, Menabuoni L, Ilies MA, Supuran CT.. (2000) Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects., 43 (25): [PMID:11123998] [10.1021/jm001051+] |
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| 27. Weber A, Casini A, Heine A, Kuhn D, Supuran CT, Scozzafava A, Klebe G.. (2004) Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition., 47 (3): [PMID:14736236] [10.1021/jm030912m] |
| 28. Scozzafava A, Menabuoni L, Mincione F, Mincione G, Supuran CT.. (2001) Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties., 11 (4): [PMID:11229775] [10.1016/s0960-894x(00)00722-8] |
| 29. Casini A, Winum JY, Montero JL, Scozzafava A, Supuran CT.. (2003) Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives., 13 (5): [PMID:12617903] [10.1016/s0960-894x(03)00028-3] |
| 30. Casini A, Antel J, Abbate F, Scozzafava A, David S, Waldeck H, Schäfer S, Supuran CT.. (2003) Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV., 13 (5): [PMID:12617904] [10.1016/s0960-894x(03)00029-5] |
| 31. Pastorekova S, Casini A, Scozzafava A, Vullo D, Pastorek J, Supuran CT.. (2004) Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX., 14 (4): [PMID:15012984] [10.1016/j.bmcl.2003.12.029] |
| 32. Winum JY, Dogné JM, Casini A, de Leval X, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties., 48 (6): [PMID:15771455] [10.1021/jm0494826] |
| 33. Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastoreková S, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?, 15 (4): [PMID:15686894] [10.1016/j.bmcl.2004.12.053] |
| 34. Mincione F, Starnotti M, Masini E, Bacciottini L, Scrivanti C, Casini A, Vullo D, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma., 15 (17): [PMID:16039853] [10.1016/j.bmcl.2005.06.054] |
| 35. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides., 15 (17): [PMID:16039848] [10.1016/j.bmcl.2005.06.055] |
| 36. Winum JY, Pastorekova S, Jakubickova L, Montero JL, Scozzafava A, Pastorek J, Vullo D, Innocenti A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates., 15 (3): [PMID:15664816] [10.1016/j.bmcl.2004.11.058] |
| 37. Turkmen H, Durgun M, Yilmaztekin S, Emul M, Innocenti A, Vullo D, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX., 15 (2): [PMID:15603956] [10.1016/j.bmcl.2004.10.070] |
| 38. Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides., 15 (4): [PMID:15686895] [10.1016/j.bmcl.2004.12.052] |
| 39. Innocenti A, Firnges MA, Antel J, Wurl M, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides., 15 (4): [PMID:15686931] [10.1016/j.bmcl.2004.12.009] |
| 40. Garaj V, Puccetti L, Fasolis G, Winum JY, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT.. (2004) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties., 14 (21): [PMID:15454239] [10.1016/j.bmcl.2004.07.087] |
| 41. Zimmerman S, Innocenti A, Casini A, Ferry JG, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides., 14 (24): [PMID:15546717] [10.1016/j.bmcl.2004.09.085] |
| 42. Chazalette C, Masereel B, Rolin S, Thiry A, Scozzafava A, Innocenti A, Supuran CT.. (2004) Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties., 14 (23): [PMID:15501040] [10.1016/j.bmcl.2004.09.061] |
| 43. Cecchi A, Winum JY, Innocenti A, Vullo D, Montero JL, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide., 14 (23): [PMID:15501039] [10.1016/j.bmcl.2004.09.062] |
| 44. Innocenti A, Casini A, Alcaro MC, Papini AM, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library., 47 (21): [PMID:15456265] [10.1021/jm049692i] |
| 45. Cecchi A, Hulikova A, Pastorek J, Pastoreková S, Scozzafava A, Winum JY, Montero JL, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors., 48 (15): [PMID:16033263] [10.1021/jm0501073] |
| 46. Garaj V, Puccetti L, Fasolis G, Winum JY, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX., 15 (12): [PMID:15905091] [10.1016/j.bmcl.2005.04.056] |
| 47. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds., 15 (9): [PMID:15837325] [10.1016/j.bmcl.2005.02.087] |
| 48. De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies., 15 (9): [PMID:15837316] [10.1016/j.bmcl.2005.03.032] |
| 49. Puccetti L, Fasolis G, Vullo D, Chohan ZH, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes., 15 (12): [PMID:15908204] [10.1016/j.bmcl.2005.04.055] |
| 50. Innocenti A, Villar R, Martinez-Merino V, Gil MJ, Scozzafava A, Vullo D, Supuran CT.. (2005) Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides., 15 (21): [PMID:16165351] [10.1016/j.bmcl.2005.04.078] |
| 51. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT.. (2005) Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors., 48 (24): [PMID:16302824] [10.1021/jm050483n] |
| 52. Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT.. (2006) Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib., 16 (2): [PMID:16290146] [10.1016/j.bmcl.2005.09.040] |
| 53. Nishimori I, Minakuchi T, Morimoto K, Sano S, Onishi S, Takeuchi H, Vullo D, Scozzafava A, Supuran CT.. (2006) Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs., 49 (6): [PMID:16539401] [10.1021/jm0512600] |
| 54. Nishimori I, Vullo D, Minakuchi T, Morimoto K, Onishi S, Scozzafava A, Supuran CT.. (2006) Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori., 16 (8): [PMID:16459077] [10.1016/j.bmcl.2006.01.044] |
| 55. Saczewski F, Sławiński J, Kornicka A, Brzozowski Z, Pomarnacka E, Innocenti A, Scozzafava A, Supuran CT.. (2006) Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors., 16 (18): [PMID:16809036] [10.1016/j.bmcl.2006.06.064] |
| 56. De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT.. (2006) Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX., 49 (18): [PMID:16942027] [10.1021/jm060531j] |
| 57. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Supuran CT, Poulsen SA.. (2006) A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing"., 49 (22): [PMID:17064072] [10.1021/jm060967z] |
| 58. Winum JY, Temperini C, El Cheikh K, Innocenti A, Vullo D, Ciattini S, Montero JL, Scozzafava A, Supuran CT.. (2006) Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue., 49 (24): [PMID:17125255] [10.1021/jm060807n] |
| 59. Nishimori I, Minakuchi T, Onishi S, Vullo D, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors., 50 (2): [PMID:17228881] [10.1021/jm0612057] |
| 60. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Vullo D, Supuran CT, Poulsen SA.. (2007) Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides., 50 (7): [PMID:17343373] [10.1021/jm061320h] |
| 61. Nuti E, Orlandini E, Nencetti S, Rossello A, Innocenti A, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates., 15 (6): [PMID:17276072] [10.1016/j.bmc.2007.01.023] |
| 62. Wilkinson BL, Bornaghi LF, Houston TA, Innocenti A, Vullo D, Supuran CT, Poulsen SA.. (2007) Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides., 17 (4): [PMID:17157501] [10.1016/j.bmcl.2006.11.046] |
| 63. Santos MA, Marques S, Vullo D, Innocenti A, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties., 17 (6): [PMID:17251018] [10.1016/j.bmcl.2006.12.107] |
| 64. Nishimori I, Minakuchi T, Kohsaki T, Onishi S, Takeuchi H, Vullo D, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors., 17 (13): [PMID:17482815] [10.1016/j.bmcl.2007.04.063] |
| 65. Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies., 17 (15): [PMID:17540563] [10.1016/j.bmcl.2007.05.045] |
| 66. Smaine FZ, Winum JY, Montero JL, Regainia Z, Vullo D, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides., 17 (18): [PMID:17646100] [10.1016/j.bmcl.2007.07.019] |
| 67. Salmon AJ, Williams ML, Innocenti A, Vullo D, Supuran CT, Poulsen SA.. (2007) Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety., 17 (18): [PMID:17681760] [10.1016/j.bmcl.2007.07.024] |
| 68. Nishimori I, Minakuchi T, Onishi S, Vullo D, Cecchi A, Scozzafava A, Supuran CT.. (2007) Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides., 15 (23): [PMID:17826101] [10.1016/j.bmc.2007.08.037] |
| 69. Supuran CT, Scozzafava A.. (2007) Carbonic anhydrases as targets for medicinal chemistry., 15 (13): [PMID:17475500] [10.1016/j.bmc.2007.04.020] |
| 70. Innocenti A, Vullo D, Scozzafava A, Supuran CT.. (2008) Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV)., 18 (5): [PMID:18242985] [10.1016/j.bmcl.2008.01.077] |
| 71. Wilkinson BL, Innocenti A, Vullo D, Supuran CT, Poulsen SA.. (2008) Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides., 51 (6): [PMID:18307288] [10.1021/jm701426t] |
| 72. Temperini C, Cecchi A, Boyle NA, Scozzafava A, Cabeza JE, Wentworth P, Blackburn GM, Supuran CT.. (2008) Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies., 18 (3): [PMID:18162396] [10.1016/j.bmcl.2007.12.022] |
| 73. Rami M, Winum JY, Innocenti A, Montero JL, Scozzafava A, Supuran CT.. (2008) Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII., 18 (2): [PMID:18042384] [10.1016/j.bmcl.2007.11.025] |
| 74. Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G.. (2008) Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors., 18 (8): [PMID:18359629] [10.1016/j.bmcl.2008.03.023] |
| 75. Temperini C, Cecchi A, Scozzafava A, Supuran CT.. (2008) Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct., 18 (8): [PMID:18374572] [10.1016/j.bmcl.2008.03.051] |
| 76. Cecchi A, Ciani L, Winum JY, Montero JL, Scozzafava A, Ristori S, Supuran CT.. (2008) Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes., 18 (12): [PMID:18513964] [10.1016/j.bmcl.2008.05.051] |
| 77. Saczewski F, Innocenti A, Sławiński J, Kornicka A, Brzozowski Z, Pomarnacka E, Scozzafava A, Temperini C, Supuran CT.. (2008) Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides., 16 (7): [PMID:18242998] [10.1016/j.bmc.2008.01.034] |
| 78. Crocetti L, Maresca A, Temperini C, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT.. (2009) A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases., 19 (5): [PMID:19186056] [10.1016/j.bmcl.2009.01.038] |
| 79. Temperini C, Cecchi A, Scozzafava A, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., 17 (3): [PMID:19119014] [10.1016/j.bmc.2008.12.023] |
| 80. Isik S, Kockar F, Aydin M, Arslan O, Guler OO, Innocenti A, Scozzafava A, Supuran CT.. (2009) Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates., 17 (3): [PMID:19124253] [10.1016/j.bmc.2008.12.035] |
| 81. Güzel O, Maresca A, Scozzafava A, Salman A, Balaban AT, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII., 19 (11): [PMID:19410461] [10.1016/j.bmcl.2009.04.068] |
| 82. Temperini C, Cecchi A, Scozzafava A, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., 52 (2): [PMID:19115843] [10.1021/jm801386n] |
| 83. Hilvo M, Salzano AM, Innocenti A, Kulomaa MS, Scozzafava A, Scaloni A, Parkkila S, Supuran CT.. (2009) Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV., 52 (3): [PMID:19193158] [10.1021/jm801267c] |
| 84. Minakuchi T, Nishimori I, Vullo D, Scozzafava A, Supuran CT.. (2009) Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate., 52 (8): [PMID:19317447] [10.1021/jm9000488] |
| 85. D'Ambrosio K, Vitale RM, Dogné JM, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT.. (2008) Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII., 51 (11): [PMID:18481843] [10.1021/jm800121c] |
| 86. Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Innocenti A, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis., 52 (9): [PMID:19338333] [10.1021/jm9003126] |
| 87. Innocenti A, Hall RA, Schlicker C, Scozzafava A, Steegborn C, Mühlschlegel FA, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides., 17 (13): [PMID:19450983] [10.1016/j.bmc.2009.05.002] |
| 88. Bertucci A, Innocenti A, Zoccola D, Scozzafava A, Tambutté S, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides., 17 (14): [PMID:19520577] [10.1016/j.bmc.2009.05.063] |
| 89. Carta F, Maresca A, Covarrubias AS, Mowbray SL, Jones TA, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c., 19 (23): [PMID:19846301] [10.1016/j.bmcl.2009.10.009] |
| 90. Maresca A, Carta F, Vullo D, Scozzafava A, Supuran CT.. (2009) Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides., 19 (17): [PMID:19651511] [10.1016/j.bmcl.2009.07.088] |
| 91. Joseph P, Turtaut F, Ouahrani-Bettache S, Montero JL, Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Köhler S, Winum JY, Supuran CT.. (2010) Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis., 53 (5): [PMID:20158185] [10.1021/jm901855h] |
| 92. Oltulu O, Yaşar MM, Eroğlu E.. (2009) A QSAR study on relationship between structure of sulfonamides and their carbonic anhydrase inhibitory activity using the eigenvalue (EVA) method., 44 (9): [PMID:19303173] [10.1016/j.ejmech.2009.02.016] |
| 93. Brzozowski Z, Sławiński J, Saczewski F, Innocenti A, Supuran CT.. (2010) Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides., 45 (6): [PMID:20202722] [10.1016/j.ejmech.2010.02.020] |
| 94. Brzozowski Z, Sławiński J, Innocenti A, Supuran CT.. (2010) Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII., 45 (9): [PMID:20554082] [10.1016/j.ejmech.2010.05.011] |
| 95. PubChem BioAssay data set, |
| 96. PubChem BioAssay data set, |
| 97. Bertucci A, Innocenti A, Scozzafava A, Tambutté S, Zoccola D, Supuran CT.. (2011) Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata., 21 (2): [PMID:21208801] [10.1016/j.bmcl.2010.11.124] |
| 98. Joseph P, Ouahrani-Bettache S, Montero JL, Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Winum JY, Köhler S, Supuran CT.. (2011) A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth., 19 (3): [PMID:21251841] [10.1016/j.bmc.2010.12.048] |
| 99. Maresca A, Supuran CT.. (2011) (R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases., 21 (5): [PMID:21300547] [10.1016/j.bmcl.2011.01.050] |
| 100. Cincinelli A, Martellini T, Innocenti A, Scozzafava A, Supuran CT.. (2011) Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii., 19 (6): [PMID:21377369] [10.1016/j.bmc.2011.02.015] |
| 101. Unpublished dataset, |
| 102. Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT.. (2011) Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms., 19 (12): [PMID:21620713] [10.1016/j.bmc.2011.05.006] |
| 103. Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Supuran CT.. (2011) Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates., 19 (16): [PMID:21757360] [10.1016/j.bmc.2011.06.038] |
| 104. Brzozowski Z, Sławiński J, Gdaniec M, Innocenti A, Supuran CT.. (2011) Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives., 46 (9): [PMID:21820216] [10.1016/j.ejmech.2011.07.011] |
| 105. Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.. (2011) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)., 7 (12): [PMID:22194678] [10.1371/journal.pcbi.1002310] |
| 106. Ohradanova A, Vullo D, Pastorekova S, Pastorek J, Jackson DJ, Wörheide G, Supuran CT.. (2012) Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana., 20 (4): [PMID:22285172] [10.1016/j.bmc.2012.01.007] |
| 107. Hewitson KS, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran CT.. (2012) Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target., 55 (7): [PMID:22424239] [10.1021/jm300203r] |
| 108. Uwai Y, Saito H, Hashimoto Y, Inui KI.. (2000) Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1., 295 (1): [PMID:10991988] |
| 109. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
| 110. Del Prete S, Isik S, Vullo D, De Luca V, Carginale V, Scozzafava A, Supuran CT, Capasso C.. (2012) DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae., 55 (23): [PMID:23181552] [10.1021/jm301611m] |
| 111. Brzozowski Z, Sławiński J, Vullo D, Supuran CT.. (2012) Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII., 56 [PMID:22910138] [10.1016/j.ejmech.2012.08.006] |
| 112. Pan P, Vermelho AB, Capaci Rodrigues G, Scozzafava A, Tolvanen ME, Parkkila S, Capasso C, Supuran CT.. (2013) Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease., 56 (4): [PMID:23391336] [10.1021/jm4000616] |
| 113. Gao R, Liao S, Zhang C, Zhu W, Wang L, Huang J, Zhao Z, Li H, Qian X, Xu Y.. (2013) Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship., 62 [PMID:23429054] [10.1016/j.ejmech.2013.01.030] |
| 114. Vullo D, Luca VD, Scozzafava A, Carginale V, Rossi M, Supuran CT, Capasso C.. (2013) The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides., 21 (6): [PMID:22883029] [10.1016/j.bmc.2012.07.024] |
| 115. Vullo D, Leewattanapasuk W, Mühlschlegel FA, Mastrolorenzo A, Capasso C, Supuran CT.. (2013) Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides., 23 (9): [PMID:23511020] [10.1016/j.bmcl.2013.02.092] |
| 116. Sethi KK, Verma SM, Tanç M, Carta F, Supuran CT.. (2013) Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety., 21 (17): [PMID:23867389] [10.1016/j.bmc.2013.06.035] |
| 117. Sethi KK, Vullo D, Verma SM, Tanç M, Carta F, Supuran CT.. (2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety., 21 (19): [PMID:23965175] [10.1016/j.bmc.2013.07.044] |
| 118. Syrjänen L, Vermelho AB, Rodrigues Ide A, Corte-Real S, Salonen T, Pan P, Vullo D, Parkkila S, Capasso C, Supuran CT.. (2013) Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis., 56 (18): [PMID:23977960] [10.1021/jm400939k] |
| 119. De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP.. (2013) Structure-based identification of OATP1B1/3 inhibitors., 83 (6): [PMID:23571415] [10.1124/mol.112.084152] |
| 120. Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C.. (2014) Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii., 24 (1): [PMID:24314394] [10.1016/j.bmcl.2013.11.021] |
| 121. Vullo D, Del Prete S, Osman SM, De Luca V, Scozzafava A, Alothman Z, Supuran CT, Capasso C.. (2014) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis., 24 (1): [PMID:24316122] [10.1016/j.bmcl.2013.11.030] |
| 122. Żołnowska B, Sławiński J, Pogorzelska A, Chojnacki J, Vullo D, Supuran CT.. (2014) Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII., 71 [PMID:24291567] [10.1016/j.ejmech.2013.10.081] |
| 123. Sethi KK, Verma SM, Tanç M, Purper G, Calafato G, Carta F, Supuran CT.. (2014) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties., 22 (5): [PMID:24513184] [10.1016/j.bmc.2014.01.031] |
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| 125. PubChem BioAssay data set, |
| 126. Nishimori I, Vullo D, Minakuchi T, Scozzafava A, Capasso C, Supuran CT.. (2014) Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila., 22 (11): [PMID:24792813] [10.1016/j.bmc.2014.04.006] |
| 127. Nasr G, Cristian A, Barboiu M, Vullo D, Winum JY, Supuran CT.. (2014) Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties., 22 (10): [PMID:24746465] [10.1016/j.bmc.2014.03.041] |
| 128. Sławiński J, Pogorzelska A, Żołnowska B, Brożewicz K, Vullo D, Supuran CT.. (2014) Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII., 82 [PMID:24871996] [10.1016/j.ejmech.2014.05.039] |
| 129. Prete SD, Vullo D, Osman SM, Scozzafava A, AlOthman Z, Capasso C, Supuran CT.. (2014) Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes., 22 (17): [PMID:25129169] [10.1016/j.bmc.2014.07.048] |
| 130. Sławiński J, Brzozowski Z, Żołnowska B, Szafrański K, Pogorzelska A, Vullo D, Supuran CT.. (2014) Synthesis of a new series of N⁴-substituted 4-(2-aminoethyl)benzenesulfonamides and their inhibitory effect on human carbonic anhydrase cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII., 84 [PMID:25016228] [10.1016/j.ejmech.2014.06.074] |
| 131. Vullo D, Del Prete S, Fisher GM, Andrews KT, Poulsen SA, Capasso C, Supuran CT.. (2015) Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum., 23 (3): [PMID:25533402] [10.1016/j.bmc.2014.12.009] |
| 132. Syrjänen L, Kuuslahti M, Tolvanen M, Vullo D, Parkkila S, Supuran CT.. (2015) The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides., 23 (10): [PMID:25882523] [10.1016/j.bmc.2015.03.081] |
| 133. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT.. (2015) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune., 23 (8): [PMID:25773015] [10.1016/j.bmc.2015.02.045] |
| 134. Durgun M, Turkmen H, Ceruso M, Supuran CT.. (2015) Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII., 25 (11): [PMID:25913118] [10.1016/j.bmcl.2015.04.007] |
| 135. Dedeoglu N, DeLuca V, Isik S, Yildirim H, Kockar F, Capasso C, Supuran CT.. (2015) Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans., 25 (11): [PMID:25913199] [10.1016/j.bmcl.2015.04.037] |
| 136. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Capasso C, Supuran CT.. (2015) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis., 25 (17): [PMID:26174556] [10.1016/j.bmcl.2015.06.079] |
| 137. Cincinelli A, Martellini T, Vullo D, Supuran CT.. (2015) Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus., 25 (23): [PMID:26525863] [10.1016/j.bmcl.2015.10.074] |
| 138. Vullo D, Bhatt A, Mahon BP, McKenna R, Supuran CT.. (2016) Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA., 26 (2): [PMID:26691758] [10.1016/j.bmcl.2015.11.104] |
| 139. Del Prete S, Vullo D, De Luca V, Carginale V, Ferraroni M, Osman SM, AlOthman Z, Supuran CT, Capasso C.. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae., 24 (5): [PMID:26850377] [10.1016/j.bmc.2016.01.037] |
| 140. Vullo D, De Luca V, Del Prete S, Carginale V, Scozzafava A, Osman SM, AlOthman Z, Capasso C, Supuran CT.. (2016) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea., 26 (4): [PMID:26832216] [10.1016/j.bmcl.2016.01.023] |
| 141. Eminoğlu A, Vullo D, Aşık A, Çolak DN, Çanakçı S, Beldüz AO, Supuran CT.. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13., 26 (7): [PMID:26920803] [10.1016/j.bmcl.2016.02.032] |
| 142. Del Prete S, Vullo D, De Luca V, Carginale V, Osman SM, AlOthman Z, Supuran CT, Capasso C.. (2016) Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae., 26 (8): [PMID:26972117] [10.1016/j.bmcl.2016.03.014] |
| 143. WHO Anatomical Therapeutic Chemical Classification, |
| 144. British National Formulary (72nd edition), |
| 145. Del Prete S, Vullo D, Di Fonzo P, Osman SM, AlOthman Z, Donald WA, Supuran CT, Capasso C.. (2017) Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis., 27 (3): [PMID:28025002] [10.1016/j.bmcl.2016.12.035] |
| 146. Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.. (2016) DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans., 21 (4): [PMID:26948801] [10.1016/j.drudis.2016.02.015] |
| 147. Del Prete S, Vullo D, Osman SM, AlOthman Z, Supuran CT, Capasso C.. (2017) Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia., 25 (13): [PMID:28511911] [10.1016/j.bmc.2017.05.007] |
| 148. Żołnowska B, Sławiński J, Szafrański K, Angeli A, Supuran CT, Kawiak A, Wieczór M, Zielińska J, Bączek T, Bartoszewska S.. (2018) Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies., 143 [PMID:29146134] [10.1016/j.ejmech.2017.11.005] |
| 149. Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M.. (2017) Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors., 8 (9): [PMID:28947941] [10.1021/acsmedchemlett.7b00229] |
| 150. Unpublished dataset, |
| 151. Katie Heiser, Peter F. McLean, Chadwick T. Davis, Ben Fogelson, Hannah B. Gordon, Pamela Jacobson, Brett Hurst, Ben Miller, Ronald W. Alfa, Berton A. Earnshaw, Mason L. Victors, Yolanda T. Chong, Imran S. Haque, Adeline S. Low, Christopher C. Gibson. (2020) Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2, [10.1101/2020.04.21.054387] |
| 152. Krasavin M, Shetnev A, Baykov S, Kalinin S, Nocentini A, Sharoyko V, Poli G, Tuccinardi T, Korsakov M, Tennikova TB, Supuran CT.. (2019) Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines., 168 [PMID:30826507] [10.1016/j.ejmech.2019.02.044] |
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