meso(R,S)-dichloro-[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum (II)

ID: ALA2068419

Chembl Id: CHEMBL2068419

Max Phase: Preclinical

Molecular Formula: C14H14Cl2N2O2Pt

Molecular Weight: 508.26

Molecule Type: Small molecule

Associated Items:

Associated Targets(Human)

MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ESR2 Estrogen receptor (627 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADJ/PC6 (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Calculated Properties

Molecular Weight: 508.26Molecular Weight (Monoisotopic): 507.0080AlogP: #Rotatable Bonds:
Polar Surface Area: Molecular Species: HBA: HBD:
#RO5 Violations: HBA (Lipinski): HBD (Lipinski): #RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: CX LogP: CX LogD:
Aromatic Rings: Heavy Atoms: QED Weighted: Np Likeness Score:

References

1. Wappes B, Jennerwein M, von Angerer E, Schönenberger H, Engel J, Berger M, Wrobel KH..  (1984)  Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma.,  27  (10): [PMID:6481764] [10.1021/jm00376a009]
2. Wappes B, Jennerwein M, von Angerer E, Schönenberger H, Engel J, Berger M, Wrobel KH..  (1984)  Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma.,  27  (10): [PMID:6481764] [10.1021/jm00376a009]
3. Wappes B, Jennerwein M, von Angerer E, Schönenberger H, Engel J, Berger M, Wrobel KH..  (1984)  Dichloro[1,2-bis(4-hydroxyphenyl)ethylenediamine]platinum(II) complexes: an approach to develop compounds with a specific effect on the hormone-dependent mammary carcinoma.,  27  (10): [PMID:6481764] [10.1021/jm00376a009]

Source