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2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-2-carbonyl)-hydrazino]-2-oxo-ethyl}-naphthalen-2-yl)-acetamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

ID: ALA2068507

Max Phase: Preclinical

Molecular Formula: C21H20Cl2N6O6Pt

Molecular Weight: 718.41

Molecule Type: Small molecule

This compound is available for customization.

Associated Items:

Bioactivity Summary Target Summary Assay Summary

Alternative Forms

Parent:

ALA2068507
2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-2-carbonyl)-hydrazino]-2-oxo-ethyl}-naphthalen-2-yl)-acetamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

TXNRD1 Tclin Thioredoxin reductase (269 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-MEL-25 (55 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Calu-6 (398 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSR Tclin Glutathione reductase (335 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Molecular Weight: 718.41	Molecular Weight (Monoisotopic): 717.0469	AlogP: ┄	#Rotatable Bonds: ┄
Polar Surface Area: ┄	Molecular Species: ┄	HBA: ┄	HBD: ┄
#RO5 Violations: ┄	HBA (Lipinski): ┄	HBD (Lipinski): ┄	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: ┄	CX Basic pKa: ┄	CX LogP: ┄	CX LogD: ┄
Aromatic Rings: ┄	Heavy Atoms: ┄	QED Weighted: ┄	Np Likeness Score: ┄

1. Millet R, Urig S, Jacob J, Amtmann E, Moulinoux JP, Gromer S, Becker K, Davioud-Charvet E.. (2005) Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors., 48 (22): [PMID:16250662] [10.1021/jm050256l]

Source(1):