(RR/SS)-trans-1,2-Diaminocyclohexane[2-(4-{10,15,20-tris[4-(poly(ethylene glycol)-750-monomethyl ether-1-yl)phenyl] porphyrin-5-yl}phenoxy)malonato]platinum (II)

ID: ALA2068525

Max Phase: Preclinical

Molecular Formula: C158H252N6O59Pt

Molecular Weight: 3374.82

Molecule Type: Unknown

This compound is available for customization.

Associated Items:

Alternative Forms

  1. Parent:

Associated Targets(Human)

TCC-SUP (149 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Molecule Features

Natural Product: NoOral: NoChemical Probe: NoParenteral: No
Molecule Type: UnknownTopical: NoFirst In Class: NoBlack Box: No
Chirality: NoAvailability: NoProdrug: No

Drug Indications

MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Biocomponents

Calculated Properties

Molecular Weight: 3374.82Molecular Weight (Monoisotopic): 3372.6551AlogP: #Rotatable Bonds:
Polar Surface Area: Molecular Species: HBA: HBD:
#RO5 Violations: HBA (Lipinski): HBD (Lipinski): #RO5 Violations (Lipinski):
CX Acidic pKa: CX Basic pKa: CX LogP: CX LogD:
Aromatic Rings: Heavy Atoms: QED Weighted: Np Likeness Score:

References

1. Lottner C, Bart KC, Bernhardt G, Brunner H..  (2002)  Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agents.,  45  (10): [PMID:11985475] [10.1021/jm0110690]

Source