1.Summa V, Petrocchi A, Matassa VG, Gardelli C, Muraglia E, Rowley M, Paz OG, Laufer R, Monteagudo E, Pace P.. (2006) 4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species., 49 (23):[PMID:17154493][10.1021/jm060854f]
2.Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V.. (2007) Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors., 50 (9):[PMID:17428043][10.1021/jm070027u]
3.Tang J, Maddali K, Pommier Y, Sham YY, Wang Z.. (2010) Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited., 20 (11):[PMID:20457521][10.1016/j.bmcl.2010.04.048]
4.Day JA, Cohen SM.. (2013) Investigating the selectivity of metalloenzyme inhibitors., 56 (20):[PMID:24074025][10.1021/jm401053m]
5.He T, Edwards TC, Xie J, Aihara H, Geraghty RJ, Wang Z.. (2022) 4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease., 65 (7.0):[PMID:35377638][10.1021/acs.jmedchem.2c00203]