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ID: ALA2251438
Max Phase: Preclinical
Molecular Formula: C17H21ClN2O5S
Molecular Weight: 400.88
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: CCOc1c(S(=O)(=O)CC)ccc(C(=O)c2c(C)nc(CC)n2O)c1Cl
Standard InChI: InChI=1S/C17H21ClN2O5S/c1-5-13-19-10(4)15(20(13)22)16(21)11-8-9-12(26(23,24)7-3)17(14(11)18)25-6-2/h8-9,22H,5-7H2,1-4H3
Standard InChI Key: GLQQTLBLHKITKS-UHFFFAOYSA-N
Associated Targets(non-human)
Chenopodium album 769 Activities
Abutilon theophrasti 831 Activities
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Echinochloa crus-galli 3685 Activities
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4-hydroxyphenylpyruvate dioxygenase 49 Activities
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Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Properties
| Molecular Weight: 400.88 | Molecular Weight (Monoisotopic): 400.0860 | AlogP: 3.07 | #Rotatable Bonds: 7 |
| Polar Surface Area: 98.49 | Molecular Species: NEUTRAL | HBA: 7 | HBD: 1 |
| #RO5 Violations: 0 | HBA (Lipinski): 7 | HBD (Lipinski): 1 | #RO5 Violations (Lipinski): 0 |
| CX Acidic pKa: 10.05 | CX Basic pKa: 3.75 | CX LogP: 1.67 | CX LogD: 1.67 |
| Aromatic Rings: 2 | Heavy Atoms: 26 | QED Weighted: 0.57 | Np Likeness Score: -1.21 |
References
| 1. Witschel M.. (2009) Design, synthesis and herbicidal activity of new iron chelating motifs for HPPD-inhibitors., 17 (12): [PMID:19028100] [10.1016/j.bmc.2008.11.006] |
Source
Source(1):