1. Zhao M, Onakpa MM, Santarsiero BD, Chen WL, Szymulanska-Ramamurthy KM, Swanson SM, Burdette JE, Che CT.. (2015) (9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha., 78 (11): [PMID:26523419] [10.1021/acs.jnatprod.5b00688] |
2. Colley HE, Muthana M, Danson SJ, Jackson LV, Brett ML, Harrison J, Coole SF, Mason DP, Jennings LR, Wong M, Tulasi V, Norman D, Lockey PM, Williams L, Dossetter AG, Griffen EJ, Thompson MJ.. (2015) An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer., 58 (23): [PMID:26580420] [10.1021/acs.jmedchem.5b01312] |
3. Levrier C, Sadowski MC, Nelson CC, Davis RA.. (2015) Cytotoxic C20 Diterpenoid Alkaloids from the Australian Endemic Rainforest Plant Anopterus macleayanus., 78 (12): [PMID:26600001] [10.1021/acs.jnatprod.5b00509] |
4. Hayakawa I, Shioda S, Chinen T, Hatanaka T, Ebisu H, Sakakura A, Usui T, Kigoshi H.. (2016) Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization., 24 (21): [PMID:27665177] [10.1016/j.bmc.2016.09.026] |
5. Henry S, Kidner R, Reisenauer MR, Magedov IV, Kiss R, Mathieu V, Lefranc F, Dasari R, Evidente A, Yu X, Ma X, Pertsemlidis A, Cencic R, Pelletier J, Cavazos DA, Brenner AJ, Aksenov AV, Rogelj S, Kornienko A, Frolova LV.. (2016) 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells., 120 [PMID:27218860] [10.1016/j.ejmech.2016.05.004] |
6. Gherbovet O, García Alvarez MC, Bignon J, Roussi F.. (2016) Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors., 59 (23): [PMID:27753480] [10.1021/acs.jmedchem.6b00525] |
7. Guo B, Onakpa MM, Huang XJ, Santarsiero BD, Chen WL, Zhao M, Zhang XQ, Swanson SM, Burdette JE, Che CT.. (2016) Di-nor- and 17-nor-pimaranes from Icacina trichantha., 79 (7): [PMID:27340832] [10.1021/acs.jnatprod.6b00289] |
8. Subba Rao AV, Swapna K, Shaik SP, Lakshma Nayak V, Srinivasa Reddy T, Sunkari S, Shaik TB, Bagul C, Kamal A.. (2017) Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers., 25 (3): [PMID:28034647] [10.1016/j.bmc.2016.12.010] |
9. (2005) Compounds and therapeutical use thereof, |
10. (2002) Synthesis and biological evaluation of analogs of the antimitotic marine natural product curacin A, |
11. Döbber A, Phoa AF, Abbassi RH, Stringer BW, Day BW, Johns TG, Abadleh M, Peifer C, Munoz L.. (2017) Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent., 8 (4): [PMID:28435525] [10.1021/acsmedchemlett.6b00483] |
12. Cruz-Morales S, Castañeda-Gómez J, Rosas-Ramírez D, Fragoso-Serrano M, Figueroa-González G, Lorence A, Pereda-Miranda R.. (2016) Resin Glycosides from Ipomoea alba Seeds as Potential Chemosensitizers in Breast Carcinoma Cells., 79 (12): [PMID:28006904] [10.1021/acs.jnatprod.6b00782] |
13. Suárez-Ortiz GA, Cerda-García-Rojas CM, Fragoso-Serrano M, Pereda-Miranda R.. (2017) Complementarity of DFT Calculations, NMR Anisotropy, and ECD for the Configurational Analysis of Brevipolides K-O from Hyptis brevipes., 80 (1): [PMID:28099005] [10.1021/acs.jnatprod.6b00953] |
14. Zhou Q, Phoa AF, Abbassi RH, Hoque M, Reekie TA, Font JS, Ryan RM, Stringer BW, Day BW, Johns TG, Munoz L, Kassiou M.. (2017) Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma., 60 (5): [PMID:28206758] [10.1021/acs.jmedchem.6b01840] |
15. Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls CW, Lightfoot-Dunn R, Hamadeh HK.. (2010) Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development., 118 (2): [PMID:20829430] [10.1093/toxsci/kfq269] |
16. Murahari M, Kharkar PS, Lonikar N, Mayur YC.. (2017) Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents., 130 [PMID:28246041] [10.1016/j.ejmech.2017.02.022] |
17. Shaik TB, Hussaini SMA, Nayak VL, Sucharitha ML, Malik MS, Kamal A.. (2017) Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents., 27 (11): [PMID:28400235] [10.1016/j.bmcl.2017.03.089] |
18. Lukesh JC, Carney DW, Dong H, Cross RM, Shukla V, Duncan KK, Yang S, Brody DM, Brütsch MM, Radakovic A, Boger DL.. (2017) Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance., 60 (17): [PMID:28857558] [10.1021/acs.jmedchem.7b00958] |
19. Allemann O, Cross RM, Brütsch MM, Radakovic A, Boger DL.. (2017) Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent., 27 (14): [PMID:28551101] [10.1016/j.bmcl.2017.05.058] |
20. Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.. (2013) A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development., 136 (1): [PMID:23956101] [10.1093/toxsci/kft176] |
21. Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.. (2016) DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans., 21 (4): [PMID:26948801] [10.1016/j.drudis.2016.02.015] |
22. Paguigan ND, Al-Huniti MH, Raja HA, Czarnecki A, Burdette JE, González-Medina M, Medina-Franco JL, Polyak SJ, Pearce CJ, Croatt MP, Oberlies NH.. (2017) Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites., 25 (20): [PMID:28802670] [10.1016/j.bmc.2017.07.041] |
23. Zhu L, Luo K, Li K, Jin Y, Lin J.. (2017) Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors., 25 (21): [PMID:28988750] [10.1016/j.bmc.2017.09.004] |
24. Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.. (2018) Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors., 61 (8): [PMID:29624387] [10.1021/acs.jmedchem.8b00035] |
25. Zhou Y, Yan W, Cao D, Shao M, Li D, Wang F, Yang Z, Chen Y, He L, Wang T, Shen M, Chen L.. (2017) Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents., 138 [PMID:28763646] [10.1016/j.ejmech.2017.07.040] |
26. Bortolozzi R, Mattiuzzo E, Dal Pra M, Sturlese M, Moro S, Hamel E, Carta D, Viola G, Ferlin MG.. (2018) Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs., 143 [PMID:29197729] [10.1016/j.ejmech.2017.11.038] |
27. Zhang Y, Yuan YX, Goto M, Guo LL, Li XN, Morris-Natschke SL, Lee KH, Hao XJ.. (2018) Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa., 81 (3): [PMID:29319316] [10.1021/acs.jnatprod.7b00949] |
28. May DS, Kang HS, Santarsiero BD, Krunic A, Shen Q, Burdette JE, Swanson SM, Orjala J.. (2018) Ribocyclophanes A-E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria., 81 (3): [PMID:29381355] [10.1021/acs.jnatprod.7b00954] |
29. Li Y, Yan W, Yang J, Yang Z, Hu M, Bai P, Tang M, Chen L.. (2018) Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance., 152 [PMID:29754076] [10.1016/j.ejmech.2018.05.003] |
30. Radakovic A, Boger DL.. (2018) High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs., 28 (5): [PMID:29439899] [10.1016/j.bmcl.2018.02.006] |
31. Tsepaeva OV, Nemtarev AV, Abdullin TI, Grigor'eva LR, Kuznetsova EV, Akhmadishina RA, Ziganshina LE, Cong HH, Mironov VF.. (2017) Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin., 80 (8): [PMID:28782948] [10.1021/acs.jnatprod.7b00105] |
32. Tanaka M, Zhu Y, Shionyu M, Ota N, Shibata N, Watanabe C, Mizusawa A, Sasaki R, Mizukami T, Shiina I, Hasegawa M.. (2018) Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death., 146 [PMID:29407987] [10.1016/j.ejmech.2018.01.045] |
33. Tran HT, Pferschy-Wenzig EM, Kretschmer N, Kunert O, Huynh L, Bauer R.. (2018) Antiproliferative Carvotacetones from Sphaeranthus africanus., 81 (8): [PMID:30074787] [10.1021/acs.jnatprod.8b00309] |
34. Devine SM, Yong C, Amenuvegbe D, Aurelio L, Muthiah D, Pouton C, Callaghan R, Capuano B, Scammells PJ.. (2018) Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents., 61 (18): [PMID:30156410] [10.1021/acs.jmedchem.8b00986] |
35. Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, Rui M, Siciliano AM, Collina S.. (2018) Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead., 28 (17): [PMID:30122223] [10.1016/j.bmcl.2018.06.044] |
36. Ali I, Lone MN, Aboul-Enein HY.. (2017) Imidazoles as potential anticancer agents., 8 (9): [PMID:30108886] [10.1039/C7MD00067G] |
37. La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.. (2018) New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors., 152 [PMID:29730191] [10.1016/j.ejmech.2018.04.042] |
38. Castro SJ, Casero CN, Padrón JM, Padrón JM, Nicotra VE.. (2019) Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea., 82 (5): [PMID:31070367] [10.1021/acs.jnatprod.9b00117] |
39. Takada H, Kaieda A, Tawada M, Nagino T, Sasa K, Oikawa T, Oki A, Sameshima T, Miyamoto K, Miyamoto M, Kokubu Y, Tozawa R, Sakurai H, Saito B.. (2019) Identification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells., 62 (20): [PMID:31550153] [10.1021/acs.jmedchem.9b01100] |
40. Wan Y, Li Y, Yan C, Yan M, Tang Z.. (2019) Indole: A privileged scaffold for the design of anti-cancer agents., 183 [PMID:31536895] [10.1016/j.ejmech.2019.111691] |
41. Koovits PJ, Dessoy MA, Matheeussen A, Maes L, Caljon G, Mowbray CE, Kratz JM, Dias LC.. (2020) Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi., 30 (1): [PMID:31706667] [10.1016/j.bmcl.2019.126779] |
42. Krishnan P, Lee FK, Yap VA, Low YY, Kam TS, Yong KT, Ting KN, Lim KH.. (2020) Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii., 83 (1): [PMID:31935094] [10.1021/acs.jnatprod.9b01160] |
43. Lagunes I, Begines P, Silva A, Galán AR, Puerta A, Fernandes MX, Maya I, Fernández-Bolaños JG, López Ó, Padrón JM, Padrón JM.. (2019) Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations., 179 [PMID:31271961] [10.1016/j.ejmech.2019.06.073] |
44. Ceramella J, Caruso A, Occhiuzzi MA, Iacopetta D, Barbarossa A, Rizzuti B, Dallemagne P, Rault S, El-Kashef H, Saturnino C, Grande F, Sinicropi MS.. (2019) Benzothienoquinazolinones as new multi-target scaffolds: Dual inhibition of human Topoisomerase I and tubulin polymerization., 181 [PMID:31400710] [10.1016/j.ejmech.2019.111583] |
45. Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S.. (2019) Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents., 162 [PMID:30448418] [10.1016/j.ejmech.2018.11.004] |
46. Radakovic A, Boger DL.. (2019) Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound., 29 (11): [PMID:30952593] [10.1016/j.bmcl.2019.03.036] |
47. Chang SM, Jain V, Chen TL, Patel AS, Pidugu HB, Lin YW, Wu MH, Huang JR, Wu HC, Shah A, Su TL, Lee TC.. (2019) Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1- a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links., 62 (5): [PMID:30776229] [10.1021/acs.jmedchem.8b01689] |
48. Martínez-Fructuoso L, Pereda-Miranda R, Rosas-Ramírez D, Fragoso-Serrano M, Cerda-García-Rojas CM, da Silva AS, Leitão GG, Leitão SG.. (2019) Structure Elucidation, Conformation, and Configuration of Cytotoxic 6-Heptyl-5,6-dihydro-2 H-pyran-2-ones from Hyptis Species and Their Molecular Docking to α-Tubulin., 82 (3): [PMID:30601004] [10.1021/acs.jnatprod.8b00908] |
49. Ling T, Maier J, Das S, Budhraja A, Bassett R, Potts MB, Shelat A, Rankovic Z, Opferman JT, Rivas F.. (2019) Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents., 164 [PMID:30611980] [10.1016/j.ejmech.2018.12.059] |
50. Cao D, Liu Y, Yan W, Wang C, Bai P, Wang T, Tang M, Wang X, Yang Z, Ma B, Ma L, Lei L, Wang F, Xu B, Zhou Y, Yang T, Chen L.. (2016) Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors., 59 (12): [PMID:27213819] [10.1021/acs.jmedchem.6b00158] |
51. Sonawane V, Mohd Siddique MU, Jadav SS, Sinha BN, Jayaprakash V, Chaudhuri B.. (2019) Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy., 165 [PMID:30665142] [10.1016/j.ejmech.2019.01.011] |
52. Suzuki Y, Otake A, Ueno S, Hayashi K, Ishii H, Miyoshi N, Kuroiwa K, Tachikawa M, Fujimaki Y, Nishiyama K, Manabe K, Yamazaki R, Asai A.. (2020) Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity., 11 (6): [PMID:32551013] [10.1021/acsmedchemlett.0c00119] |
53. Yang J,Hu S,Wang C,Song J,Chen C,Fan Y,Ben-David Y,Pan W. (2020) Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway., 186 [PMID:31784186] [10.1016/j.ejmech.2019.111898] |
54. Sundriyal S,Eeda V,Lagisetty P,Awasthi V. (2021) Tubulin inhibitory activity of a novel colchicine-binding compounds based on a dinaphthospiropyranran scaffold., 29 [PMID:33223461] [10.1016/j.bmc.2020.115874] |
55. Abolhasani H,Zarghi A,Komeili Movahhed T,Abolhasani A,Daraei B,Dastmalchi S. (2021) Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents., 32 [PMID:33477020] [10.1016/j.bmc.2020.115960] |
56. Zhang B. (2019) Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids., 168 [PMID:30826511] [10.1016/j.ejmech.2019.02.055] |
57. Yi WF,Ding X,Chen YZ,Adelakun TA,Zhang Y,Hao XJ. (2020) Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon., 83 (11): [PMID:33112136] [10.1021/acs.jnatprod.9b00768] |
58. Rassias G,Leonardi S,Rigopoulou D,Vachlioti E,Afratis K,Piperigkou Z,Koutsakis C,Karamanos NK,Gavras H,Papaioannou D. (2021) Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?, 210 [PMID:33139111] [10.1016/j.ejmech.2020.112948] |
59. Patel AS,Jain V,Rao VN,Lin YW,Shah A,Lai KC,Su TL,Lee TC. (2020) Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives., 202 [PMID:32622270] [10.1016/j.ejmech.2020.112516] |
60. Chen TL, Patel AS, Jain V, Kuppusamy R, Lin YW, Hou MH, Su TL, Lee TC.. (2021) Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links., 64 (17.0): [PMID:34459195] [10.1021/acs.jmedchem.0c01733] |
61. Liu JT, Jaunky DB, Larocque K, Chen F, Mckibbon K, Sirouspour M, Taylor S, Shafeii A, Campbell D, Braga H, Piekny A, Forgione P.. (2021) Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent., 52 [PMID:34416378] [10.1016/j.bmcl.2021.128327] |
62. Liang D, Yu C, Ma Z, Hu M, Wang J, Dong X, Du L, Li M.. (2022) Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC., 238 [PMID:35576703] [10.1016/j.ejmech.2022.114450] |
63. Ran F, Liu Y, Xu Z, Meng C, Yang D, Qian J, Deng X, Zhang Y, Ling Y.. (2022) Recent development of BTK-based dual inhibitors in the treatment of cancers., 233 [PMID:35247756] [10.1016/j.ejmech.2022.114232] |
64. Moreno-Velasco A, Flores-Tafoya PJ, Fragoso-Serrano M, Leitão SG, Pereda-Miranda R.. (2022) Resin Glycosides from Operculina hamiltonii and Their Synergism with Vinblastine in Cancer Cells., 85 (10.0): [PMID:36162138] [10.1021/acs.jnatprod.2c00594] |
65. Salehian F, Nadri H, Jalili-Baleh L, Youseftabar-Miri L, Abbas Bukhari SN, Foroumadi A, Tüylü Küçükkilinç T, Sharifzadeh M, Khoobi M.. (2021) A review: Biologically active 3,4-heterocycle-fused coumarins., 212 [PMID:33276991] [10.1016/j.ejmech.2020.113034] |
66. Ren X, Xie X, Chen B, Liu L, Jiang C, Qian Q.. (2021) Marine Natural Products: A Potential Source of Anti-hepatocellular Carcinoma Drugs., 64 (12.0): [PMID:34128674] [10.1021/acs.jmedchem.0c02026] |
67. Hall A, Chanteux H, Ménochet K, Ledecq M, Schulze MED.. (2021) Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches., 64 (10.0): [PMID:34003642] [10.1021/acs.jmedchem.0c02245] |