1. Bolognesi ML, Banzi R, Bartolini M, Cavalli A, Tarozzi A, Andrisano V, Minarini A, Rosini M, Tumiatti V, Bergamini C, Fato R, Lenaz G, Hrelia P, Cattaneo A, Recanatini M, Melchiorre C.. (2007) Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease., 50 (20): [PMID:17850125] [10.1021/jm070559a] |
2. Cavalli A, Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Recanatini M, Melchiorre C.. (2008) Multi-target-directed ligands to combat neurodegenerative diseases., 51 (3): [PMID:18181565] [10.1021/jm7009364] |
3. Bolognesi ML, Bartolini M, Rosini M, Andrisano V, Melchiorre C.. (2009) Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action., 19 (15): [PMID:19505825] [10.1016/j.bmcl.2009.05.087] |
4. Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C.. (2009) Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks., 52 (23): [PMID:19813747] [10.1021/jm901123n] |
5. Melchiorre C, Bolognesi ML, Minarini A, Rosini M, Tumiatti V.. (2010) Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy., 53 (16): [PMID:20420456] [10.1021/jm100293f] |
6. Bolognesi ML, Bartolini M, Tarozzi A, Morroni F, Lizzi F, Milelli A, Minarini A, Rosini M, Hrelia P, Andrisano V, Melchiorre C.. (2011) Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity., 21 (9): [PMID:21236667] [10.1016/j.bmcl.2010.12.093] |
7. Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C.. (2011) Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease., 46 (11): [PMID:21924801] [10.1016/j.ejmech.2011.09.001] |
8. Bolognesi ML, Chiriano G, Bartolini M, Mancini F, Bottegoni G, Maestri V, Czvitkovich S, Windisch M, Cavalli A, Minarini A, Rosini M, Tumiatti V, Andrisano V, Melchiorre C.. (2011) Synthesis of monomeric derivatives to probe memoquin's bivalent interactions., 54 (24): [PMID:22054058] [10.1021/jm200691d] |
9. Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML.. (2013) Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease., 23 (23): [PMID:24140444] [10.1016/j.bmcl.2013.09.091] |
10. Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D.. (2014) Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents., 57 (6): [PMID:24568372] [10.1021/jm401824w] |
11. Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML.. (2014) Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects., 57 (20): [PMID:25259726] [10.1021/jm5010804] |
12. Prati F, Uliassi E, Bolognesi ML. (2014) Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases, 5 (7): [10.1039/C4MD00069B] |
13. Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M.. (2016) Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography., 59 (1): [PMID:26632651] [10.1021/acs.jmedchem.5b01119] |
14. Pan W, Hu K, Bai P, Yu L, Ma Q, Li T, Zhang X, Chen C, Peng K, Liu W, Sang Z.. (2016) Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease., 26 (10): [PMID:27072909] [10.1016/j.bmcl.2016.03.086] |
15. Song Q, Li Y, Cao Z, Liu H, Tian C, Yang Z, Qiang X, Tan Z, Deng Y.. (2018) Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease., 26 (23-24): [PMID:30470598] [10.1016/j.bmc.2018.11.015] |
16. Sang Z, Wang K, Dong J, Tang L.. (2022) Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress., 238 [PMID:35635955] [10.1016/j.ejmech.2022.114464] |