(2S,4R)-4-(3-Hydroxyamino-3-oxopropyl)glutamic Acid

ID: ALA2312683

Chembl Id: CHEMBL2312683

PubChem CID: 71574838

Max Phase: Preclinical

Molecular Formula: C8H14N2O6

Molecular Weight: 234.21

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  N[C@@H](C[C@@H](CCC(=O)NO)C(=O)O)C(=O)O

Standard InChI:  InChI=1S/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1

Standard InChI Key:  VMZWGONYFYNQHE-UHNVWZDZSA-N

Alternative Forms

1. Parent:

   

   ALA2312683

   (2S,4R)-2-amino-4-[3-(hydroxyamino)-3-oxopropyl]pentanedioic acid

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 234.21

Molecular Weight (Monoisotopic): 234.0852

AlogP: -1.23

#Rotatable Bonds: 7

Polar Surface Area: 149.95

Molecular Species: ZWITTERION

HBA: 5

HBD: 5

#RO5 Violations: ┄

HBA (Lipinski): 8

HBD (Lipinski): 6

#RO5 Violations (Lipinski): 1

CX Acidic pKa: 1.80

CX Basic pKa: 9.62

CX LogP: -3.95

CX LogD: -7.02

Aromatic Rings: ┄

Heavy Atoms: 16

QED Weighted: 0.27

Np Likeness Score: 0.80

References

1. Assaf Z, Larsen AP, Venskutonytė R, Han L, Abrahamsen B, Nielsen B, Gajhede M, Kastrup JS, Jensen AA, Pickering DS, Frydenvang K, Gefflaut T, Bunch L..  (2013)  Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.,  56  (4): [PMID:23414088] [10.1021/jm301433m]

2. Huynh TH, Erichsen MN, Tora AS, Goudet C, Sagot E, Assaf Z, Thomsen C, Brodbeck R, Stensbøl TB, Bjørn-Yoshimoto WE, Nielsen B, Pin JP, Gefflaut T, Bunch L..  (2016)  New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.,  59  (3): [PMID:26814576] [10.1021/acs.jmedchem.5b01333]

Source

Source(1):

• Scientific Literature