N6-(4-Methylphenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine

ID: ALA2382319

Chembl Id: CHEMBL2382319

PubChem CID: 71680876

Max Phase: Preclinical

Molecular Formula: C14H14N6

Molecular Weight: 266.31

Molecule Type: Small molecule

Names and Identifiers

Canonical SMILES:  Cc1ccc(Nc2cnc3nc(N)nc(N)c3c2)cc1

Standard InChI:  InChI=1S/C14H14N6/c1-8-2-4-9(5-3-8)18-10-6-11-12(15)19-14(16)20-13(11)17-7-10/h2-7,18H,1H3,(H4,15,16,17,19,20)

Standard InChI Key:  VGNVQPHGGGPFOG-UHFFFAOYSA-N

Alternative Forms

1. Parent:

   

   ALA2382319

   6-N-(4-methylphenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Calculated Properties

Molecular Weight: 266.31

Molecular Weight (Monoisotopic): 266.1280

AlogP: 2.24

#Rotatable Bonds: 2

Polar Surface Area: 102.74

Molecular Species: NEUTRAL

HBA: 6

HBD: 3

#RO5 Violations: ┄

HBA (Lipinski): 6

HBD (Lipinski): 5

#RO5 Violations (Lipinski): ┄

CX Acidic pKa: ┄

CX Basic pKa: 3.02

CX LogP: 2.10

CX LogD: 2.10

Aromatic Rings: 3

Heavy Atoms: 20

QED Weighted: 0.66

Np Likeness Score: -1.17

References

1. Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V..  (2013)  Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.,  56  (11): [PMID:23627352] [10.1021/jm400086g]

2. Shah K, Queener S, Cody V, Pace J, Gangjee A..  (2019)  Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.,  29  (15): [PMID:31176699] [10.1016/j.bmcl.2019.06.004]

Source

Source(1):

• Scientific Literature