5-fluoro-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)pyridine

Names and Identifiers

Canonical SMILES: Fc1ccc(-c2ccc(C3(C(F)(F)F)CC3)cc2)nc1

Standard InChI: InChI=1S/C15H11F4N/c16-12-5-6-13(20-9-12)10-1-3-11(4-2-10)14(7-8-14)15(17,18)19/h1-6,9H,7-8H2

Standard InChI Key: RSFGMSBZSCCKNM-UHFFFAOYSA-N

Molfile:

     RDKit          2D

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   14.3834  -20.7393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3824  -21.5548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9348  -20.7403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3426  -21.4497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1591  -21.4503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5687  -20.7421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1558  -20.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3408  -20.0349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1176  -20.7401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7105  -20.0312    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8940  -20.0307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4845  -20.7388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8973  -21.4490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7124  -21.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6673  -20.7397    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.7937  -20.0331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6109  -20.0353    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.3870  -19.3243    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   15.1965  -19.3196    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0
  3  2  1  0
  1  3  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  2  0
  9  4  1  0
  4 10  1  0
  7  2  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 15 10  1  0
 13 16  1  0
  2 17  1  0
 17 18  1  0
 17 19  1  0
 17 20  1  0
M  END

Alternative Forms

Parent:

ALA2386141
5-Fluoro-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]pyridine

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4/3A5 (100 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Liver microsomes (8692 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Molecule Features

Natural Product: No	Oral: No	Chemical Probe: No	Parenteral: No
Molecule Type: Small molecule	Topical: No	First In Class: No	Black Box: No
Chirality: No	Availability: No	Prodrug: No

Drug Indications

MESH ID	MESH Heading	EFO IDs	EFO Terms	Max Phase for Indication	References

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Calculated Properties

Molecular Weight: 281.25	Molecular Weight (Monoisotopic): 281.0828	AlogP: 4.48	#Rotatable Bonds: 2
Polar Surface Area: 12.89	Molecular Species: NEUTRAL	HBA: 1	HBD: ┄
#RO5 Violations: ┄	HBA (Lipinski): 1	HBD (Lipinski): ┄	#RO5 Violations (Lipinski): ┄
CX Acidic pKa: ┄	CX Basic pKa: 1.82	CX LogP: 4.38	CX LogD: 4.38
Aromatic Rings: 2	Heavy Atoms: 20	QED Weighted: 0.74	Np Likeness Score: -0.79

References

1. Barnes-Seeman D, Jain M, Bell L, Ferreira S, Cohen S, Chen XH, Amin J, Snodgrass B, Hatsis P.. (2013) Metabolically Stable tert-Butyl Replacement., 4 (6): [PMID:24900702] [10.1021/ml400045j]

Source

Source(1):

Scientific Literature