Vancomycin

ID: ALA262777

Chembl Id: CHEMBL262777

Max Phase: Approved

First Approval: 1964

Molecular Formula: C66H75Cl2N9O24

Molecular Weight: 1449.27

Molecule Type: Small molecule

Names and Identifiers

Synonyms: Vancoled | Vancomycin | Vancor

Synonyms from Alternative Forms(14): Vancomycin hydrochloride | Vancomycin monohydrochloride | Firvanq | Vancomycin (as hydrochloride) | Vancomycin hcl | Vancomycin, monohydrochloride | NSC-757377 | Firvanq kit | Vancocin | Vancocin hydrochloride | Vancocin matrigel | Vancoled | Vancor | Vanoled

Canonical SMILES:  CN[C@H](CC(C)C)C(=O)N[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c4cc(O)cc(O)c4-c4cc3ccc4O)[C@H](O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O[C@H]2C[C@](C)(N)[C@H](O)[C@H](C)O2)Oc2ccc(cc2Cl)[C@H]1O

Standard InChI:  InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1

Standard InChI Key:  MYPYJXKWCTUITO-LYRMYLQWSA-N

Alternative Forms

1. Parent:

   

   ALA262777

   VANCOMYCIN

2. Alternative Forms:

   

   ALA262777

   VANCOMYCIN HYDROCHLORIDE

Molecule Features

Natural Product: Yes

Oral: Yes

Chemical Probe: No

Parenteral: Yes

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: Yes

Chirality: Yes

Availability: Yes

Prodrug: No

Calculated Properties

Molecular Weight: 1449.27

Molecular Weight (Monoisotopic): 1447.4302

AlogP:

#Rotatable Bonds:

Polar Surface Area:

Molecular Species:

HBA:

HBD:

#RO5 Violations:

HBA (Lipinski):

HBD (Lipinski):

#RO5 Violations (Lipinski):

CX Acidic pKa:

CX Basic pKa:

CX LogP:

CX LogD:

Aromatic Rings:

Heavy Atoms:

QED Weighted:

Np Likeness Score:

References

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230. Jang KP, Kim CH, Na SW, Jang DS, Kim H, Kang H, Lee E..  (2010)  7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.,  20  (7): [PMID:20207542] [10.1016/j.bmcl.2010.02.037]

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232. Pan B, Huang RZ, Han SQ, Qu D, Zhu ML, Wei P, Ying HJ..  (2010)  Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones.,  20  (8): [PMID:20346668] [10.1016/j.bmcl.2010.03.013]

233. Varshney V, Mishra NN, Shukla PK, Sahu DP..  (2009)  Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial.,  19  (13): [PMID:19447611] [10.1016/j.bmcl.2009.04.133]

234. Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL..  (2010)  Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.,  18  (6): [PMID:20188576] [10.1016/j.bmc.2010.02.005]

235. Yin X, Chen Y, Zhang L, Wang Y, Zabriskie TM..  (2010)  Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus.,  73  (4): [PMID:20353165] [10.1021/np900710q]

236. Ii K, Ichikawa S, Al-Dabbagh B, Bouhss A, Matsuda A..  (2010)  Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria.,  53  (9): [PMID:20405928] [10.1021/jm100243n]

237. Huang X, Zhang A, Chen D, Jia Z, Li X..  (2010)  4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: novel C7 moieties of fluoroquinolones as antibacterial agents.,  20  (9): [PMID:20347299] [10.1016/j.bmcl.2010.03.044]

238. Shi W, Duan Y, Qian Y, Li M, Yang L, Hu W..  (2010)  Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.,  20  (12): [PMID:20510610] [10.1016/j.bmcl.2010.04.123]

239. Al-Qawasmeh RA, Huesca M, Nedunuri V, Peralta R, Wright J, Lee Y, Young A..  (2010)  Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.,  20  (12): [PMID:20483613] [10.1016/j.bmcl.2010.04.137]

240. Bremner JB, Keller PA, Pyne SG, Boyle TP, Brkic Z, Morgan J, Somphol K, Coates JA, Deadman J, Rhodes DI..  (2010)  Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.,  18  (13): [PMID:20627739] [10.1016/j.bmc.2010.05.005]

241. Fernandez J, Hilliard JJ, Abbanat D, Zhang W, Melton JL, Santoro CM, Flamm RK, Bush K..  (2010)  In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa.,  54  (1): [PMID:19884364] [10.1128/aac.00642-09]

242. Miura K, Yamashiro H, Uotani K, Kojima S, Yutsudo T, Lu J, Yoshida O, Yamano Y, Maki H, Arimoto H..  (2010)  Mode of action of Van-M-02, a novel glycopeptide inhibitor of peptidoglycan synthesis, in vancomycin-resistant bacteria.,  54  (2): [PMID:19933802] [10.1128/aac.00927-09]

243. Tattevin P, Basuino L, Bauer D, Diep BA, Chambers HF..  (2010)  Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus.,  54  (2): [PMID:19917746] [10.1128/aac.00886-09]

244. Hossion AM, Otsuka N, Kandahary RK, Tsuchiya T, Ogawa W, Iwado A, Zamami Y, Sasaki K..  (2010)  Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents.,  20  (17): [PMID:20655215] [10.1016/j.bmcl.2010.02.060]

245. Ma WS, Mutka T, Vesley B, Amsler MO, McClintock JB, Amsler CD, Perman JA, Singh MP, Maiese WM, Zaworotko MJ, Kyle DE, Baker BJ..  (2009)  Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.,  72  (10): [PMID:19848433] [10.1021/np900382x]

246. Lauderdale TL, Shiau YR, Lai JF, Chen HC, King CH..  (2010)  Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.,  54  (3): [PMID:20065058] [10.1128/aac.01197-09]

247. Amador G, Gautier H, Le Mabecque V, Miegeville AF, Potel G, Bouler JM, Weiss P, Caillon J, Jacqueline C..  (2010)  In vivo assessment of the antimicrobial activity of a calcium-deficient apatite vancomycin drug delivery system in a methicillin-resistant Staphylococcus aureus rabbit osteomyelitis experimental model.,  54  (2): [PMID:19933800] [10.1128/aac.00434-09]

248. Chanawanno K, Chantrapromma S, Anantapong T, Kanjana-Opas A, Fun HK..  (2010)  Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: pyridinium and quinolinium stilbene benzenesulfonates.,  45  (9): [PMID:20619939] [10.1016/j.ejmech.2010.06.014]

249. Kadlec K, Schwarz S..  (2010)  Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.,  54  (2): [PMID:20008780] [10.1128/aac.01091-09]

250. Aytemir MD, Ozçelik B..  (2010)  A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.,  45  (9): [PMID:20591538] [10.1016/j.ejmech.2010.05.069]

251. Heine HS, Purcell BK, Bassett J, Miller L, Goldstein BP..  (2010)  Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model.,  54  (3): [PMID:20047912] [10.1128/aac.00820-09]

252. Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C..  (2006)  An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus.,  2  (11): [PMID:16980961] [10.1038/nchembio820]

253. Arhin FF, Sarmiento I, Belley A, McKay GA, Draghi DC, Grover P, Sahm DF, Parr TR, Moeck G..  (2008)  Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing.,  52  (5): [PMID:18299406] [10.1128/aac.01513-07]

254. Rose WE, Leonard SN, Sakoulas G, Kaatz GW, Zervos MJ, Sheth A, Carpenter CF, Rybak MJ..  (2008)  daptomycin activity against Staphylococcus aureus following vancomycin exposure in an in vitro pharmacodynamic model with simulated endocardial vegetations.,  52  (3): [PMID:17999971] [10.1128/aac.00869-07]

255. Babakhani F, Seddon J, Robert N, Shue YK, Sears P..  (2010)  Effects of inoculum, pH, and cations on the in vitro activity of fidaxomicin (OPT-80, PAR-101) against Clostridium difficile.,  54  (6): [PMID:20308366] [10.1128/aac.01842-09]

256. Lawrence L, Danese P, DeVito J, Franceschi F, Sutcliffe J..  (2008)  In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.,  52  (5): [PMID:18316525] [10.1128/aac.01383-07]

257. Baltch AL, Ritz WJ, Bopp LH, Michelsen P, Smith RP..  (2008)  Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.,  52  (5): [PMID:18332172] [10.1128/aac.01480-07]

258. Yin LY, Calhoun JH, Thomas JK, Shapiro S, Schmitt-Hoffmann A..  (2008)  Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus.,  52  (5): [PMID:18332175] [10.1128/aac.00638-07]

259. Higashide M, Kuroda M, Omura CT, Kumano M, Ohkawa S, Ichimura S, Ohta T..  (2008)  Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections.,  52  (6): [PMID:18362191] [10.1128/aac.01150-07]

260. Betriu C, Morales G, Rodríguez-Avial I, Culebras E, Gómez M, López-Fabal F, Picazo JJ..  (2010)  Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.,  54  (5): [PMID:20176900] [10.1128/aac.01653-09]

261. Morrow BJ, He W, Amsler KM, Foleno BD, Macielag MJ, Lynch AS, Bush K..  (2010)  In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.,  54  (5): [PMID:20176911] [10.1128/aac.01374-09]

262. Marcone GL, Beltrametti F, Binda E, Carrano L, Foulston L, Hesketh A, Bibb M, Marinelli F..  (2010)  Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.,  54  (6): [PMID:20308385] [10.1128/aac.00106-10]

263. Biedenbach DJ, Ross JE, Putnam SD, Jones RN..  (2010)  In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp.,  54  (5): [PMID:20308391] [10.1128/aac.00090-10]

264. Mendes RE, Deshpande LM, Castanheira M, DiPersio J, Saubolle MA, Jones RN..  (2008)  First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States.,  52  (6): [PMID:18391032] [10.1128/aac.00231-08]

265. Kihara R, Yanagihara K, Morinaga Y, Araki N, Nakamura S, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Tsukamoto K, Kamihira S, Kohno S..  (2008)  Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus.,  52  (6): [PMID:18391033] [10.1128/aac.01532-07]

266. Mendes RE, Moet GJ, Janechek MJ, Jones RN..  (2010)  In vitro activity of telavancin against a contemporary worldwide collection of Staphylococcus aureus isolates.,  54  (6): [PMID:20385851] [10.1128/aac.00301-10]

267. Montero CI, Stock F, Murray PR..  (2008)  Mechanisms of resistance to daptomycin in Enterococcus faecium.,  52  (3): [PMID:18180351] [10.1128/aac.00774-07]

268. Hsieh YC, Chang KY, Huang YC, Lin HC, Ho YH, Huang LM, Hsueh PR..  (2008)  Clonal spread of highly beta-lactam-resistant Streptococcus pneumoniae isolates in Taiwan.,  52  (6): [PMID:18413298] [10.1128/aac.00046-08]

269. Stone GG, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, Zaniewski RP, Brickner SJ, Wade SK, Le PT, Huband MD..  (2008)  In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A.,  52  (7): [PMID:18426902] [10.1128/aac.01326-07]

270. Kobayashi Y, Ichioka M, Hirose T, Nagai K, Matsumoto A, Matsui H, Hanaki H, Masuma R, Takahashi Y, Omura S, Sunazuka T..  (2010)  Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities.,  20  (20): [PMID:20833545] [10.1016/j.bmcl.2010.08.037]

271. Sader HS, Fritsche TR, Jones RN..  (2008)  Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus.,  52  (3): [PMID:18180353] [10.1128/aac.01351-07]

272. Draghi DC, Benton BM, Krause KM, Thornsberry C, Pillar C, Sahm DF..  (2008)  Comparative surveillance study of telavancin activity against recently collected gram-positive clinical isolates from across the United States.,  52  (7): [PMID:18443115] [10.1128/aac.01641-07]

273. Crane CM, Pierce JG, Leung SS, Tirado-Rives J, Jorgensen WL, Boger DL..  (2010)  Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon.,  53  (19): [PMID:20853900] [10.1021/jm100946e]

274. Kokkotou E, Moss AC, Michos A, Espinoza D, Cloud JW, Mustafa N, O'Brien M, Pothoulakis C, Kelly CP..  (2008)  Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters.,  52  (3): [PMID:18195066] [10.1128/aac.01143-07]

275. Noto MJ, Fox PM, Archer GL..  (2008)  Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.,  52  (4): [PMID:18212094] [10.1128/aac.01164-07]

276. Lodise TP, Lomaestro B, Graves J, Drusano GL..  (2008)  Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity.,  52  (4): [PMID:18227177] [10.1128/aac.01602-07]

277. MacGowan AP, Bowker KE, Noel AR..  (2008)  Pharmacodynamics of the antibacterial effect and emergence of resistance to tomopenem, formerly RO4908463/CS-023, in an in vitro pharmacokinetic model of Staphylococcus aureus infection.,  52  (4): [PMID:18227179] [10.1128/aac.01153-07]

278. Salas C, Calvo J, Martínez-Martínez L..  (2008)  Activity of Tigecycline against Coryneform Bacteria of Clinical Interest and Listeria monocytogenes.,  52  (4): [PMID:18227183] [10.1128/aac.01129-07]

279. Tsuji BT, von Eiff C, Kelchlin PA, Forrest A, Smith PF..  (2008)  Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.,  52  (4): [PMID:18285476] [10.1128/aac.01254-07]

280. Laohavaleeson S, Tessier PR, Nicolau DP..  (2008)  Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains.,  52  (7): [PMID:18411322] [10.1128/aac.01422-07]

281. Amsler KM, Davies TA, Shang W, Jacobs MR, Bush K..  (2008)  In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.,  52  (9): [PMID:18591277] [10.1128/aac.00336-08]

282. McCalla C, Smyth DS, Robinson DA, Steenbergen J, Luperchio SA, Moise PA, Fowler VG, Sakoulas G..  (2008)  Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia.,  52  (9): [PMID:18606839] [10.1128/aac.00357-08]

283. Shaw KJ, Poppe S, Schaadt R, Brown-Driver V, Finn J, Pillar CM, Shinabarger D, Zurenko G..  (2008)  In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.,  52  (12): [PMID:18838596] [10.1128/aac.00859-08]

284. Prakash V, Lewis JS, Jorgensen JH..  (2008)  Vancomycin MICs for methicillin-resistant Staphylococcus aureus isolates differ based upon the susceptibility test method used.,  52  (12): [PMID:18838599] [10.1128/aac.00904-08]

285. Marco F, de la Mària CG, Armero Y, Amat E, Soy D, Moreno A, del Río A, Almela M, Mestres CA, Gatell JM, Jiménez de Anta MT, Miró JM, Hospital Clinic Experimental Endocarditis Study Group..  (2008)  Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus.,  52  (7): [PMID:18426900] [10.1128/aac.00510-07]

286. Zhanel GG, DeCorby M, Laing N, Weshnoweski B, Vashisht R, Tailor F, Nichol KA, Wierzbowski A, Baudry PJ, Karlowsky JA, Lagacé-Wiens P, Walkty A, McCracken M, Mulvey MR, Johnson J, Canadian Antimicrobial Resistance Alliance (CARA), Hoban DJ..  (2008)  Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006.,  52  (4): [PMID:18285482] [10.1128/aac.01538-07]

287. Krause KM, Renelli M, Difuntorum S, Wu TX, Debabov DV, Benton BM..  (2008)  In vitro activity of telavancin against resistant gram-positive bacteria.,  52  (7): [PMID:18443122] [10.1128/aac.01398-07]

288. Finegold SM, Molitoris D, Väisänen ML..  (2009)  Study of the in vitro activities of rifaximin and comparator agents against 536 anaerobic intestinal bacteria from the perspective of potential utility in pathology involving bowel flora.,  53  (1): [PMID:18955526] [10.1128/aac.00441-08]

289. Howden BP, Stinear TP, Allen DL, Johnson PD, Ward PB, Davies JK..  (2008)  Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.,  52  (10): [PMID:18644967] [10.1128/aac.01613-07]

290. Nguyen KT, He X, Alexander DC, Li C, Gu JQ, Mascio C, Van Praagh A, Mortin L, Chu M, Silverman JA, Brian P, Baltz RH..  (2010)  Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties.,  54  (4): [PMID:20086142] [10.1128/aac.01307-09]

291. Pires R, Ardanuy C, Rolo D, Morais A, Brito-Avô A, Gonçalo-Marques J, Liñares J, Santos-Sanches I..  (2010)  Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal.,  54  (6): [PMID:20350943] [10.1128/aac.01536-09]

292. Kedar GC, Brown-Driver V, Reyes DR, Hilgers MT, Stidham MA, Shaw KJ, Finn J, Haselbeck RJ..  (2008)  Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.,  52  (6): [PMID:18378720] [10.1128/aac.01594-07]

293. Saravolatz L, Pawlak J, Johnson L..  (2010)  In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates.,  54  (7): [PMID:20404122] [10.1128/aac.01516-09]

294. Khalil H, Chen T, Riffon R, Wang R, Wang Z..  (2008)  Synergy between polyethylenimine and different families of antibiotics against a resistant clinical isolate of Pseudomonas aeruginosa.,  52  (5): [PMID:18285485] [10.1128/aac.01071-07]

295. García-de-la-Mària C, Marco F, Armero Y, Soy D, Moreno A, del Río A, Almela M, Cervera C, Ninot S, Falces C, Mestres CA, Gatell JM, Jiménez de Anta MT, Miró JM, Hospital Clínic Experimental Endocarditis Study Group..  (2010)  Daptomycin is effective for treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus epidermidis.,  54  (7): [PMID:20421394] [10.1128/aac.01011-09]

296. Watanabe Y, Neoh HM, Cui L, Hiramatsu K..  (2008)  Improved antimicrobial activity of linezolid against vancomycin-intermediate Staphylococcus aureus.,  52  (11): [PMID:18710909] [10.1128/aac.00676-08]

297. Karlowsky JA, Laing NM, Zhanel GG..  (2008)  In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile.,  52  (11): [PMID:18725442] [10.1128/aac.00476-08]

298. Hatfaludi T, Al-Hasani K, Dunstone M, Boyce J, Adler B..  (2008)  Characterization of TolC efflux pump proteins from Pasteurella multocida.,  52  (11): [PMID:18725450] [10.1128/aac.00245-08]

299. Danilchanka O, Mailaender C, Niederweis M..  (2008)  Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis.,  52  (7): [PMID:18458127] [10.1128/aac.00298-08]

300. Chung M, Antignac A, Kim C, Tomasz A..  (2008)  Comparative study of the susceptibilities of major epidemic clones of methicillin-resistant Staphylococcus aureus to oxacillin and to the new broad-spectrum cephalosporin ceftobiprole.,  52  (8): [PMID:18505853] [10.1128/aac.00266-08]

301. Leonard SN, Cheung CM, Rybak MJ..  (2008)  Activities of ceftobiprole, linezolid, vancomycin, and daptomycin against community-associated and hospital-associated methicillin-resistant Staphylococcus aureus.,  52  (8): [PMID:18519721] [10.1128/aac.00257-08]

302. Steidl R, Pearson S, Stephenson RE, Ledala N, Sitthisak S, Wilkinson BJ, Jayaswal RK..  (2008)  Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.,  52  (8): [PMID:18541730] [10.1128/aac.00273-08]

303. Camargo IL, Neoh HM, Cui L, Hiramatsu K..  (2008)  Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype.,  52  (12): [PMID:18824611] [10.1128/aac.00417-08]

304. Snydman DR, Jacobus NV, McDermott LA..  (2008)  In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group.,  52  (12): [PMID:18838581] [10.1128/aac.00696-08]

305. Kosowska-Shick K, Ednie LM, McGhee P, Smith K, Todd CD, Wehler A, Appelbaum PC..  (2008)  Incidence and characteristics of vancomycin nonsusceptible strains of methicillin-resistant Staphylococcus aureus at Hershey Medical Center.,  52  (12): [PMID:18838583] [10.1128/aac.01073-08]

306. Obach RS, Lombardo F, Waters NJ..  (2008)  Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.,  36  (7): [PMID:18426954] [10.1124/dmd.108.020479]

307. del Pozo JL, Rouse MS, Mandrekar JN, Sampedro MF, Steckelberg JM, Patel R..  (2009)  Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms.,  53  (1): [PMID:18725436] [10.1128/aac.00237-08]

308. Cui L, Neoh HM, Shoji M, Hiramatsu K..  (2009)  Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.,  53  (3): [PMID:19124662] [10.1128/aac.01173-08]

309. Yang SJ, Nast CC, Mishra NN, Yeaman MR, Fey PD, Bayer AS..  (2010)  Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms.,  54  (8): [PMID:20498310] [10.1128/aac.00122-10]

310. Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ..  (2010)  Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.,  54  (8): [PMID:20498327] [10.1128/aac.01715-09]

311. Biedenbach DJ, Bell JM, Sader HS, Turnidge JD, Jones RN..  (2009)  Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates.,  53  (3): [PMID:19124664] [10.1128/aac.01453-08]

312. Al-Tel TH, Al-Qawasmeh RA..  (2010)  Post Groebke-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents.,  45  (12): [PMID:20934788] [10.1016/j.ejmech.2010.09.049]

313. Louie TJ, Emery J, Krulicki W, Byrne B, Mah M..  (2009)  OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C. difficile infection.,  53  (1): [PMID:18955523] [10.1128/aac.01443-07]

314. Petersen PJ, Jones CH, Venkatesan AM, Mansour TS, Projan SJ, Bradford PA..  (2009)  Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.,  53  (2): [PMID:19001109] [10.1128/aac.01047-08]

315. Rose WE, Leonard SN, Rossi KL, Kaatz GW, Rybak MJ..  (2009)  Impact of inoculum size and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) on vancomycin activity and emergence of VISA in an in vitro pharmacodynamic model.,  53  (2): [PMID:19015334] [10.1128/aac.01009-08]

316. Zheng B, Tomita H, Inoue T, Ike Y..  (2009)  Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).,  53  (2): [PMID:19029325] [10.1128/aac.00754-08]

317. Traczewski MM, Katz BD, Steenbergen JN, Brown SD..  (2009)  Inhibitory and bactericidal activities of daptomycin, vancomycin, and teicoplanin against methicillin-resistant Staphylococcus aureus isolates collected from 1985 to 2007.,  53  (5): [PMID:19223623] [10.1128/aac.01022-08]

318. Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ..  (2009)  Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection.,  53  (1): [PMID:18955525] [10.1128/aac.01442-07]

319. Ahsman MJ, Wildschut ED, Tibboel D, Mathot RA..  (2009)  Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates.,  53  (1): [PMID:18955527] [10.1128/aac.00636-08]

320. Bhagwat SS, McGhee P, Kosowska-Shick K, Patel MV, Appelbaum PC..  (2009)  In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.,  53  (2): [PMID:19029326] [10.1128/aac.01150-08]

321. Liu Y, Wang H, Du N, Shen E, Chen H, Niu J, Ye H, Chen M..  (2009)  Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals.,  53  (2): [PMID:19029328] [10.1128/aac.00804-08]

322. Belley A, Harris R, Beveridge T, Parr T, Moeck G..  (2009)  Ultrastructural effects of oritavancin on methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.,  53  (2): [PMID:19029329] [10.1128/aac.00603-08]

323. Jakeman DL, Bandi S, Graham CL, Reid TR, Wentzell JR, Douglas SE..  (2009)  Antimicrobial activities of jadomycin B and structurally related analogues.,  53  (3): [PMID:19075054] [10.1128/aac.00801-08]

324. Belley A, Neesham-Grenon E, McKay G, Arhin FF, Harris R, Beveridge T, Parr TR, Moeck G..  (2009)  Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro.,  53  (3): [PMID:19104027] [10.1128/aac.00766-08]

325. Vaara M, Siikanen O, Apajalahti J, Fox J, Frimodt-Møller N, He H, Poudyal A, Li J, Nation RL, Vaara T..  (2010)  A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane.,  54  (8): [PMID:20479195] [10.1128/aac.01439-09]

326. Hardej D, Ashby CR, Khadtare NS, Kulkarni SS, Singh S, Talele TT..  (2010)  The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains.,  45  (12): [PMID:20947220] [10.1016/j.ejmech.2010.09.045]

327. Fehér D, Barlow R, McAtee J, Hemscheidt TK..  (2010)  Highly brominated antimicrobial metabolites from a marine Pseudoalteromonas sp.,  73  (11): [PMID:20973551] [10.1021/np100506z]

328. Zhang J, Redman N, Litke AP, Zeng J, Zhan J, Chan KY, Chang CW..  (2011)  Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs.,  19  (1): [PMID:21111625] [10.1016/j.bmc.2010.11.001]

329. Schaadt R, Sweeney D, Shinabarger D, Zurenko G..  (2009)  In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.,  53  (8): [PMID:19528279] [10.1128/aac.00228-09]

330. Wolff KA, Nguyen HT, Cartabuke RH, Singh A, Ogwang S, Nguyen L..  (2009)  Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.,  53  (8): [PMID:19528288] [10.1128/aac.00012-09]

331. Sun W, Chen H, Liu Y, Zhao C, Nichols WW, Chen M, Zhang J, Ma Y, Wang H..  (2009)  Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China.,  53  (9): [PMID:19546358] [10.1128/aac.00206-09]

332. Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K..  (2009)  Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.,  53  (9): [PMID:19546371] [10.1128/aac.00200-09]

333. Ramón-García S, Martín C, Thompson CJ, Aínsa JA..  (2009)  Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth.,  53  (9): [PMID:19564371] [10.1128/aac.00550-09]

334. Hurdle JG, Yendapally R, Sun D, Lee RE..  (2009)  Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.,  53  (9): [PMID:19581456] [10.1128/aac.00457-09]

335. Svetlíková Z, Skovierová H, Niederweis M, Gaillard JL, McDonnell G, Jackson M..  (2009)  Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs.,  53  (9): [PMID:19581465] [10.1128/aac.00590-09]

336. Murillo O, Garrigós C, Pachón ME, Euba G, Verdaguer R, Cabellos C, Cabo J, Gudiol F, Ariza J..  (2009)  Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.,  53  (10): [PMID:19635963] [10.1128/aac.00208-09]

337. Rukayadi Y, Lee K, Han S, Yong D, Hwang JK..  (2009)  In vitro activities of panduratin A against clinical Staphylococcus strains.,  53  (10): [PMID:19651906] [10.1128/aac.00624-09]

338. Laue H, Valensise T, Seguin A, Lociuro S, Islam K, Hawser S..  (2009)  In vitro bactericidal activity of iclaprim in human plasma.,  53  (10): [PMID:19651909] [10.1128/aac.00766-09]

339. Arias CA, Panesso D, Singh KV, Rice LB, Murray BE..  (2009)  Cotransfer of antibiotic resistance genes and a hylEfm-containing virulence plasmid in Enterococcus faecium.,  53  (10): [PMID:19667280] [10.1128/aac.00242-09]

340. Koomanachai P, Crandon JL, Banevicius MA, Peng L, Nicolau DP..  (2009)  Pharmacodynamic profile of tigecycline against methicillin-resistant Staphylococcus aureus in an experimental pneumonia model.,  53  (12): [PMID:19738006] [10.1128/aac.00985-09]

341. Arhin FF, Draghi DC, Pillar CM, Parr TR, Moeck G, Sahm DF..  (2009)  Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.,  53  (11): [PMID:19738026] [10.1128/aac.00952-09]

342. Bowker KE, Caspers P, Gaucher B, MacGowan AP..  (2009)  In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria.,  53  (11): [PMID:19738027] [10.1128/aac.00845-09]

343. Jacqueline C, Caillon J, Le Mabecque V, Miègeville AF, Ge Y, Biek D, Batard E, Potel G..  (2009)  In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and vancomycin.,  53  (12): [PMID:19752276] [10.1128/aac.00984-09]

344. Miller CH, Nisa S, Dempsey S, Jack C, O'Toole R..  (2009)  Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.,  53  (12): [PMID:19786608] [10.1128/aac.00803-09]

345. Locke JB, Hilgers M, Shaw KJ..  (2009)  Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.,  53  (12): [PMID:19805557] [10.1128/aac.01032-09]

346. Patel N, Lubanski P, Ferro S, Bonafede M, Harrington S, Evans A, Stellrecht K, Lodise TP..  (2009)  Correlation between vancomycin MIC values and those of other agents against gram-positive bacteria among patients with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.,  53  (12): [PMID:19805558] [10.1128/aac.00307-09]

347. Lee CH, Wang MC, Huang IW, Chen FJ, Lauderdale TL..  (2010)  Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment.,  54  (9): [PMID:20585116] [10.1128/aac.00533-10]

348. Huang DB, Reisman A, Hogan P..  (2010)  Clinical outcomes by methicillin-resistant Staphylococcus aureus staphylococcal cassette chromosome mec type: isolates recovered from a phase IV clinical trial of linezolid and vancomycin for complicated skin and skin structure infections.,  54  (9): [PMID:20585131] [10.1128/aac.00044-10]

349. Dai L, Wu CM, Wang MG, Wang Y, Wang Y, Huang SY, Xia LN, Li BB, Shen JZ..  (2010)  First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces.,  54  (9): [PMID:20585133] [10.1128/aac.00169-10]

350. Bowker KE, Noel AR, Macgowan AP..  (2008)  Pharmacodynamics of minocycline against Staphylococcus aureus in an in vitro pharmacokinetic model.,  52  (12): [PMID:18519719] [10.1128/aac.00922-07]

351. Banères-Roquet F, Gualtieri M, Villain-Guillot P, Pugnière M, Leonetti JP..  (2009)  Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions.,  53  (4): [PMID:19164148] [10.1128/aac.00971-08]

352. Clark C, Ednie LM, Lin G, Smith K, Kosowska-Shick K, McGhee P, Dewasse B, Beachel L, Caspers P, Gaucher B, Mert G, Shapiro S, Appelbaum PC..  (2009)  Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs.,  53  (4): [PMID:19188385] [10.1128/aac.01619-08]

353. Schulthess B, Meier S, Homerova D, Goerke C, Wolz C, Kormanec J, Berger-Bächi B, Bischoff M..  (2009)  Functional characterization of the sigmaB-dependent yabJ-spoVG operon in Staphylococcus aureus: role in methicillin and glycopeptide resistance.,  53  (5): [PMID:19223635] [10.1128/aac.01255-08]

354. Depardieu F, Foucault ML, Bell J, Dubouix A, Guibert M, Lavigne JP, Levast M, Courvalin P..  (2009)  New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.,  53  (5): [PMID:19258279] [10.1128/aac.01348-08]

355. San Millan A, Depardieu F, Godreuil S, Courvalin P..  (2009)  VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.,  53  (5): [PMID:19273676] [10.1128/aac.00034-09]

356. Lemaire S, Glupczynski Y, Duval V, Joris B, Tulkens PM, Van Bambeke F..  (2009)  Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus.,  53  (6): [PMID:19289525] [10.1128/aac.01135-08]

357. Weiss EC, Spencer HJ, Daily SJ, Weiss BD, Smeltzer MS..  (2009)  Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation.,  53  (6): [PMID:19289527] [10.1128/aac.01432-08]

358. Sader HS, Fritsche TR, Jones RN..  (2009)  Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates.,  53  (5): [PMID:19289528] [10.1128/aac.00129-09]

359. Mishra NN, Yang SJ, Sawa A, Rubio A, Nast CC, Yeaman MR, Bayer AS..  (2009)  Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.,  53  (6): [PMID:19332678] [10.1128/aac.01682-08]

360. Foucault ML, Courvalin P, Grillot-Courvalin C..  (2009)  Fitness cost of VanA-type vancomycin resistance in methicillin-resistant Staphylococcus aureus.,  53  (6): [PMID:19332680] [10.1128/aac.01702-08]

361. McKay GA, Beaulieu S, Sarmiento I, Arhin FF, Parr TR, Moeck G..  (2009)  Impact of human serum albumin on oritavancin in vitro activity against enterococci.,  53  (6): [PMID:19349514] [10.1128/aac.00197-09]

362. Vaudaux P, Fleury B, Gjinovci A, Huggler E, Tangomo-Bento M, Lew DP..  (2009)  Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.,  53  (7): [PMID:19364855] [10.1128/aac.01612-08]

363. Darouiche RO, Mansouri MD, Schneidkraut MJ..  (2009)  Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits.,  53  (6): [PMID:19364874] [10.1128/aac.01101-08]

364. Sader HS, Rhomberg PR, Jones RN..  (2009)  Nine-hospital study comparing broth microdilution and Etest method results for vancomycin and daptomycin against methicillin-resistant Staphylococcus aureus.,  53  (7): [PMID:19398641] [10.1128/aac.00093-09]

365. Leonard SN, Vidaillac C, Rybak MJ..  (2009)  Activity of telavancin against Staphylococcus aureus strains with various vancomycin susceptibilities in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.,  53  (7): [PMID:19414568] [10.1128/aac.01544-08]

366. Clark C, Kosowska-Shick K, McGhee P, Dewasse B, Beachel L, Appelbaum PC..  (2009)  Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains.,  53  (7): [PMID:19433566] [10.1128/aac.00183-09]

367. Katayama Y, Murakami-Kuroda H, Cui L, Hiramatsu K..  (2009)  Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem.,  53  (8): [PMID:19451283] [10.1128/aac.00834-08]

368. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, Cao Z, Li W..  (2009)  Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion Isometrus maculates.,  53  (8): [PMID:19451300] [10.1128/aac.01436-08]

369. LaPlante KL, Mermel LA..  (2009)  In vitro activities of telavancin and vancomycin against biofilm-producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis strains.,  53  (7): [PMID:19451302] [10.1128/aac.01642-08]

370. Llarrull LI, Fisher JF, Mobashery S..  (2009)  Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.,  53  (10): [PMID:19470504] [10.1128/aac.00084-09]

371. Lunde CS, Hartouni SR, Janc JW, Mammen M, Humphrey PP, Benton BM..  (2009)  Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.,  53  (8): [PMID:19470513] [10.1128/aac.01710-08]

372. Karlowsky JA, Kaplan N, Hafkin B, Hoban DJ, Zhanel GG..  (2009)  AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity.,  53  (8): [PMID:19487444] [10.1128/aac.00400-09]

373. Horne KC, Howden BP, Grabsch EA, Graham M, Ward PB, Xie S, Mayall BC, Johnson PD, Grayson ML..  (2009)  Prospective comparison of the clinical impacts of heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-susceptible MRSA.,  53  (8): [PMID:19506056] [10.1128/aac.01365-08]

374. Haas W, Pillar CM, Zurenko GE, Lee JC, Brunner LS, Morris TW..  (2009)  Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.,  53  (8): [PMID:19506065] [10.1128/aac.00418-09]

375. Shi W, Ma H, Duan Y, Aubart K, Fang Y, Zonis R, Yang L, Hu W..  (2011)  Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors.,  21  (3): [PMID:21185180] [10.1016/j.bmcl.2010.11.102]

376. Labbé AC, Poirier L, Maccannell D, Louie T, Savoie M, Béliveau C, Laverdière M, Pépin J..  (2008)  Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain.,  52  (9): [PMID:18573937] [10.1128/aac.00146-08]

377. Vaara M, Fox J, Loidl G, Siikanen O, Apajalahti J, Hansen F, Frimodt-Møller N, Nagai J, Takano M, Vaara T..  (2008)  Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.,  52  (9): [PMID:18591267] [10.1128/aac.00405-08]

378. Long F, Rouquette-Loughlin C, Shafer WM, Yu EW..  (2008)  Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli.,  52  (9): [PMID:18591276] [10.1128/aac.00475-08]

379. Ge Y, Biek D, Talbot GH, Sahm DF..  (2008)  In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States.,  52  (9): [PMID:18625769] [10.1128/aac.00149-08]

380. Hilliard JJ, Fernandez J, Melton J, Macielag MJ, Goldschmidt R, Bush K, Abbanat D..  (2009)  In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.,  53  (5): [PMID:19273686] [10.1128/aac.00833-08]

381. Périchon B, Courvalin P..  (2009)  VanA-type vancomycin-resistant Staphylococcus aureus.,  53  (11): [PMID:19506057] [10.1128/aac.00346-09]

382. Entenza JM, Haldimann A, Giddey M, Lociuro S, Hawser S, Moreillon P..  (2009)  Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.,  53  (9): [PMID:19564362] [10.1128/aac.00325-09]

383. Finegold SM, Bolanos M, Sumannen PH, Molitoris DR..  (2009)  In vitro activities of telavancin and six comparator agents against anaerobic bacterial isolates.,  53  (9): [PMID:19581457] [10.1128/aac.00908-08]

384. Osborne CS, Neckermann G, Fischer E, Pecanka R, Yu D, Manni K, Goldovitz J, Amaral K, Dzink-Fox J, Ryder NS..  (2009)  In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.,  53  (9): [PMID:19596876] [10.1128/aac.00026-09]

385. Xu X, Cai L, Xiao M, Kong F, Oftadeh S, Zhou F, Gilbert GL..  (2010)  Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates.,  54  (3): [PMID:20065057] [10.1128/aac.01268-09]

386. Jacobs MR, Good CE, Windau AR, Bajaksouzian S, Biek D, Critchley IA, Sader HS, Jones RN..  (2010)  Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States.,  54  (6): [PMID:20308374] [10.1128/aac.01797-09]

387. Hill CM, Krause KM, Lewis SR, Blais J, Benton BM, Mammen M, Humphrey PP, Kinana A, Janc JW..  (2010)  Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin.,  54  (7): [PMID:20404117] [10.1128/aac.01737-09]

388. Lee Y, Park Y, Kim MS, Yong D, Jeong SH, Lee K, Chong Y..  (2010)  Antimicrobial susceptibility patterns for recent clinical isolates of anaerobic bacteria in South Korea.,  54  (9): [PMID:20585132] [10.1128/aac.00481-10]

389. Bourne CR, Barrow EW, Bunce RA, Bourne PC, Berlin KD, Barrow WW..  (2010)  Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1.,  54  (9): [PMID:20606069] [10.1128/aac.00361-10]

390. Butler MM, Williams JD, Peet NP, Moir DT, Panchal RG, Bavari S, Shinabarger DL, Bowlin TL..  (2010)  Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates.,  54  (9): [PMID:20625154] [10.1128/aac.00484-10]

391. Hajdu S, Holinka J, Reichmann S, Hirschl AM, Graninger W, Presterl E..  (2010)  Increased temperature enhances the antimicrobial effects of daptomycin, vancomycin, tigecycline, fosfomycin, and cefamandole on staphylococcal biofilms.,  54  (10): [PMID:20679509] [10.1128/aac.00275-10]

392. Parra-Ruiz J, Vidaillac C, Rose WE, Rybak MJ..  (2010)  Activities of high-dose daptomycin, vancomycin, and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm.,  54  (10): [PMID:20696880] [10.1128/aac.00455-10]

393. Joo HS, Chan JL, Cheung GY, Otto M..  (2010)  Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol-soluble modulin cytolysins in community-associated methicillin-resistant Staphylococcus aureus.,  54  (11): [PMID:20713669] [10.1128/aac.00064-10]

394. Severin JA, Lestari ES, Kuntaman K, Pastink M, Snijders SV, Lemmens-den Toom N, Horst-Kreft D, Hadi U, Duerink DO, Goessens WH, Fluit AC, van Wamel W, van Belkum A, Verbrugh HA, AMRIN Study Group..  (2010)  Nasal carriage of methicillin-resistant and methicillin-sensitive strains of Staphylococcus sciuri in the Indonesian population.,  54  (12): [PMID:20837756] [10.1128/aac.00426-10]

395. Jeong JW, Jung SJ, Lee HH, Kim YZ, Park TK, Cho YL, Chae SE, Baek SY, Woo SH, Lee HS, Kwak JH..  (2010)  In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.,  54  (12): [PMID:20855730] [10.1128/aac.00723-10]

396. Xu L, Zhang L, Jones R, Bryant C, Boddeker N, Mabery E, Bahador G, Watson J, Clough J, Arimilli M, Gillette W, Colagiovanni D, Wang K, Gibbs C, Kim CU..  (2011)  SAR studies on dihydropyrimidinone antibiotics.,  21  (6): [PMID:21324685] [10.1016/j.bmcl.2011.01.099]

397. Nguyen HA, Denis O, Vergison A, Theunis A, Tulkens PM, Struelens MJ, Van Bambeke F..  (2009)  Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.,  53  (4): [PMID:19188393] [10.1128/aac.01145-08]

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639. Garrison AT, Abouelhassan Y, Kallifidas D, Tan H, Kim YS, Jin S, Luesch H, Huigens RW..  (2018)  An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.,  61  (9): [PMID:29638121] [10.1021/acs.jmedchem.7b01903]

640. Zakeyah AA, Whitt J, Duke C, Gilmore DF, Meeker DG, Smeltzer MS, Alam MA..  (2018)  Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid.,  28  (17): [PMID:30017319] [10.1016/j.bmcl.2018.07.016]

641. Garrison AT, Abouelhassan Y, Yang H, Yousaf HH, Nguyen TJ, Huigens Iii RW..  (2017)  Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria.,  8  (4): [PMID:30108790] [10.1039/C6MD00381H]

642. Lopes SMM, Novais JS, Costa DCS, Castro HC, Figueiredo AMS, Ferreira VF, Pinho E Melo TMVD, da Silva FC..  (2018)  Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile.,  143  [PMID:29232578] [10.1016/j.ejmech.2017.11.052]

643. Ni S, Li B, Chen F, Wei H, Mao F, Liu Y, Xu Y, Qiu X, Li X, Liu W, Hu L, Ling D, Wang M, Zheng X, Zhu J, Lan L, Li J..  (2018)  Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.,  9  (3): [PMID:29541366] [10.1021/acsmedchemlett.7b00501]

644. Zhao L, Liu H, Huo L, Wang M, Yang B, Zhang W, Xu Z, Tan H, Qiu SX..  (2018)  Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains.,  9  (10): [PMID:30429974] [10.1039/C8MD00257F]

645. Deng Y, Su M, Kang D, Liu X, Wen Z, Li Y, Qiu L, Shen B, Duan Y, Huang Y..  (2018)  Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions.,  61  (24): [PMID:30461269] [10.1021/acs.jmedchem.8b01580]

646. Sun N, Zheng YY, Du RL, Cai SY, Zhang K, So LY, Cheung KC, Zhuo C, Lu YJ, Wong KY..  (2017)  New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study.,  8  (10): [PMID:30108711] [10.1039/C7MD00387K]

647. Gatadi S, Gour J, Shukla M, Kaul G, Das S, Dasgupta A, Malasala S, Borra RS, Madhavi YV, Chopra S, Nanduri S..  (2018)  Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus.,  157  [PMID:30176536] [10.1016/j.ejmech.2018.08.070]

648. Kunkle T, Abdeen S, Salim N, Ray AM, Stevens M, Ambrose AJ, Victorino J, Park Y, Hoang QQ, Chapman E, Johnson SM..  (2018)  Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.,  61  (23): [PMID:30392371] [10.1021/acs.jmedchem.8b01293]

649. Stierle AA, Stierle DB, Decato D, Priestley ND, Alverson JB, Hoody J, McGrath K, Klepacki D..  (2017)  The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.,  80  (4): [PMID:28326781] [10.1021/acs.jnatprod.7b00133]

650. Dias FRF, Novais JS, Devillart TADNS, da Silva WA, Ferreira MO, Loureiro RS, Campos VR, Ferreira VF, de Souza MCBV, Castro HC, Cunha AC..  (2018)  Synthesis and antimicrobial evaluation of amino sugar-based naphthoquinones and isoquinoline-5,8-diones and their halogenated compounds.,  156  [PMID:30006155] [10.1016/j.ejmech.2018.06.050]

651. Subedi YP, Alfindee MN, Shrestha JP, Chang CT..  (2018)  Tuning the biological activity of cationic anthraquinone analogues specifically toward Staphylococcus aureus.,  157  [PMID:30130717] [10.1016/j.ejmech.2018.08.018]

652. Unpublished dataset, 

653. Pasero C, D'Agostino I, De Luca F, Zamperini C, Deodato D, Truglio GI, Sannio F, Del Prete R, Ferraro T, Visaggio D, Mancini A, Guglielmi MB, Visca P, Docquier JD, Botta M..  (2018)  Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.,  61  (20): [PMID:30265809] [10.1021/acs.jmedchem.8b00619]

654. Abo-Ashour MF, Eldehna WM, George RF, Abdel-Aziz MM, Elaasser MM, Abdel Gawad NM, Gupta A, Bhakta S, Abou-Seri SM..  (2018)  Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents.,  160  [PMID:30317025] [10.1016/j.ejmech.2018.10.008]

655. Shruthi TG, Eswaran S, Shivarudraiah P, Narayanan S, Subramanian S..  (2019)  Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety.,  29  (1): [PMID:30448235] [10.1016/j.bmcl.2018.11.002]

656. Tevyashova AN, Bychkova EN, Korolev AM, Isakova EB, Mirchink EP, Osterman IA, Erdei R, Szücs Z, Batta G..  (2019)  Synthesis and evaluation of biological activity for dual-acting antibiotics on the basis of azithromycin and glycopeptides.,  29  (2): [PMID:30473176] [10.1016/j.bmcl.2018.11.038]

657. Lyu Y, Chen T, Shang L, Yang Y, Li Z, Zhu J, Shan A..  (2019)  Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.,  62  (15): [PMID:31276398] [10.1021/acs.jmedchem.9b00288]

658. Li C, Zhu C, Ren B, Yin X, Shim SH, Gao Y, Zhu J, Zhao P, Liu C, Yu R, Xia X, Zhang L..  (2019)  Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus.,  183  [PMID:31520928] [10.1016/j.ejmech.2019.111686]

659. Wang J, Song J, Yang Z, He S, Yang Y, Feng X, Dou X, Shan A..  (2019)  Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.,  62  (5): [PMID:30742437] [10.1021/acs.jmedchem.8b01348]

660. Craft KM, Nguyen JM, Berg LJ, Townsend SD..  (2019)  Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype.,  10  (8): [PMID:31534648] [10.1039/C9MD00044E]

661. Abouelhassan Y, Garrison AT, Yang H, Chávez-Riveros A, Burch GM, Huigens RW..  (2019)  Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.,  62  (17): [PMID:30951303] [10.1021/acs.jmedchem.9b00370]

662. Hickey SM, Ashton TD, Boer G, Bader CA, Thomas M, Elliott AG, Schmuck C, Yu HY, Li J, Nation RL, Cooper MA, Plush SE, Brooks DA, Pfeffer FM..  (2018)  Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane.,  160  [PMID:30316060] [10.1016/j.ejmech.2018.09.072]

663. Fang Z, Zheng S, Chan KF, Yuan W, Guo Q, Wu W, Lui HK, Lu Y, Leung YC, Chan TH, Wong KY, Sun N..  (2019)  Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.,  161  [PMID:30347327] [10.1016/j.ejmech.2018.10.039]

664. Letourneau JJ, Stroke IL, Hilbert DW, Cole AG, Sturzenbecker LJ, Marinelli BA, Quintero JG, Sabalski J, Li Y, Ma L, Pechik I, Stein PD, Webb ML..  (2018)  Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB).,  28  (23-24): [PMID:30392779] [10.1016/j.bmcl.2018.10.047]

665. Qiao Y, Yan J, Jia J, Xue J, Qu X, Hu Y, Deng Z, Bi H, Zhu D..  (2019)  Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.,  82  (2): [PMID:30747534] [10.1021/acs.jnatprod.8b00753]

666. Wu JW, Li BL, Tang C, Ke CQ, Zhu NL, Qiu SX, Ye Y..  (2019)  Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis.,  82  (7): [PMID:31276403] [10.1021/acs.jnatprod.9b00064]

667. Hammad A, Abutaleb NS, Elsebaei MM, Norvil AB, Alswah M, Ali AO, Abdel-Aleem JA, Alattar A, Bayoumi SA, Gowher H, Seleem MN, Mayhoub AS..  (2019)  From Phenylthiazoles to Phenylpyrazoles: Broadening the Antibacterial Spectrum toward Carbapenem-Resistant Bacteria.,  62  (17): [PMID:31369262] [10.1021/acs.jmedchem.9b00720]

668. Shao X, AbdelKhalek A, Abutaleb NS, Velagapudi UK, Yoganathan S, Seleem MN, Talele TT..  (2019)  Chemical Space Exploration around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors.,  62  (21): [PMID:31584822] [10.1021/acs.jmedchem.9b01198]

669. Jiao WH, Salim AA, Khalil ZG, Dewapriya P, Lin HW, Butler MS, Capon RJ..  (2019)  Trivirensols: Selectively Bacteriostatic Sesquiterpene Trimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16.,  82  (11): [PMID:31625738] [10.1021/acs.jnatprod.9b00760]

670. Jayanetti DR, Braun DR, Barns KJ, Rajski SR, Bugni TS..  (2019)  Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp.,  82  (7): [PMID:31181927] [10.1021/acs.jnatprod.9b00312]

671. Yang B, He Y, Lin S, Zhang J, Li H, Wang J, Hu Z, Zhang Y..  (2019)  Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic Fungus Stachybotrys chartarum.,  82  (7): [PMID:31265296] [10.1021/acs.jnatprod.9b00305]

672. Bae JY, Ali Z, Wang YH, Chittiboyina AG, Zaki AA, Viljoen AM, Khan IA..  (2019)  Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis.,  82  (7): [PMID:31287681] [10.1021/acs.jnatprod.9b00187]

673. Yang YS, Lu X, Zeng QX, Pang J, Fan TY, You XF, Tang S, Wang YX, Song DQ..  (2019)  Synthesis and biological evaluation of 7-substituted cycloberberine derivatives as potent antibacterial agents against MRSA.,  168  [PMID:30825723] [10.1016/j.ejmech.2019.02.058]

674. Raksat A, Maneerat W, Rujanapun N, Andersen RJ, Pyne SG, Laphookhieo S..  (2019)  Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa.,  82  (8): [PMID:31403786] [10.1021/acs.jnatprod.9b00216]

675. Lin S, Yu H, Yang B, Li F, Chen X, Li H, Zhang S, Wang J, Hu Y, Hu Z, Zhang Y..  (2020)  Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus Neosartorya fischeri.,  83  (1): [PMID:31920082] [10.1021/acs.jnatprod.9b01000]

676. Boudreau MA, Ding D, Meisel JE, Janardhanan J, Spink E, Peng Z, Qian Y, Yamaguchi T, Testero SA, O'Daniel PI, Leemans E, Lastochkin E, Song W, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Chang M..  (2020)  Structure-Activity Relationship for the Oxadiazole Class of Antibacterials.,  11  (3): [PMID:32184964] [10.1021/acsmedchemlett.9b00379]

677. Cheng AV, Kim W, Escobar IE, Mylonakis E, Wuest WM..  (2020)  Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids.,  11  (3): [PMID:32184975] [10.1021/acsmedchemlett.9b00159]

678. Li H, Hu Y, Pu Q, He T, Zhang Q, Wu W, Xia X, Zhang J..  (2020)  Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides.,  63  (8): [PMID:32216308] [10.1021/acs.jmedchem.9b02025]

679. Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR, Feltzer R, Mobashery S, Chang M..  (2020)  Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials.,  63  (10): [PMID:32343145] [10.1021/acs.jmedchem.0c00153]

680. Gao F, Wang T, Xiao J, Huang G..  (2019)  Antibacterial activity study of 1,2,4-triazole derivatives.,  173  [PMID:31009913] [10.1016/j.ejmech.2019.04.043]

681. Xu WC, Silverman MH, Yu XY, Wright G, Brown N..  (2019)  Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections.,  27  (15): [PMID:31221610] [10.1016/j.bmc.2019.06.017]

682. Kulkarni A, Soni I, Kelkar DS, Dharmaraja AT, Sankar RK, Beniwal G, Rajendran A, Tamhankar S, Chopra S, Kamat SS, Chakrapani H..  (2019)  Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus.,  62  (14): [PMID:31241934] [10.1021/acs.jmedchem.9b00774]

683. Cappoen D, Torfs E, Meiresonne T, Claes P, Semina E, Holvoet F, de Macedo MB, Cools F, Piller T, Matheeussen A, Van Calster K, Caljon G, Delputte P, Maes L, Neyrolles O, De Kimpe N, Mangelinckx S, Cos P..  (2019)  The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.,  181  [PMID:31376569] [10.1016/j.ejmech.2019.07.052]

684. Zhong C, Liu T, Gou S, He Y, Zhu N, Zhu Y, Wang L, Liu H, Zhang Y, Yao J, Ni J..  (2019)  Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.,  182  [PMID:31466017] [10.1016/j.ejmech.2019.111636]

685. Subedi YP, Pandey U, Alfindee MN, Montgomery H, Roberts P, Wight J, Nichols G, Grilley M, Takemoto JY, Chang CT..  (2019)  Scalable and cost-effective tosylation-mediated synthesis of antifungal and fungal diagnostic 6″-Modified amphiphilic kanamycins.,  182  [PMID:31470306] [10.1016/j.ejmech.2019.111639]

686. Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Barua N, Zhang Y, Ip M, Chan PK, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C..  (2019)  Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.,  178  [PMID:31185412] [10.1016/j.ejmech.2019.05.090]

687. Alniss HY..  (2019)  Thermodynamics of DNA Minor Groove Binders.,  62  (2): [PMID:30059627] [10.1021/acs.jmedchem.8b00233]

688. Dang T, Nizamov IS, Salikhov RZ, Sabirzyanova LR, Vorobev VV, Burganova TI, Shaidoullina MM, Batyeva ES, Cherkasov RA, Abdullin TI..  (2019)  Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection.,  27  (1): [PMID:30503413] [10.1016/j.bmc.2018.11.017]

689. Monciardini P, Bernasconi A, Iorio M, Brunati C, Sosio M, Campochiaro L, Landini P, Maffioli SI, Donadio S..  (2019)  Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.,  82  (1): [PMID:30615447] [10.1021/acs.jnatprod.8b00354]

690. Dey R, De K, Mukherjee R, Ghosh S, Haldar J..  (2019)  Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus.,  10  (11): [PMID:32206237] [10.1039/C9MD00329K]

691. Magarò G, Prati F, Garofalo B, Corso G, Furlotti G, Apicella C, Mangano G, D'Atanasio N, Robinson D, Di Giorgio FP, Ombrato R..  (2019)  Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.,  62  (16): [PMID:31276392] [10.1021/acs.jmedchem.9b00394]

692. Kong H, Cheng W, Wei H, Yuan Y, Yang Z, Zhang X..  (2019)  An overview of recent progress in siderophore-antibiotic conjugates.,  182  [PMID:31434038] [10.1016/j.ejmech.2019.111615]

693. Hosny Y, Abutaleb NS, Omara M, Alhashimi M, Elsebaei MM, Elzahabi HS, Seleem MN, Mayhoub AS..  (2020)  Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness.,  185  [PMID:31718945] [10.1016/j.ejmech.2019.111830]

694. Haney EF, Barbosa SC, Baquir B, Hancock REW..  (2019)  Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides.,  62  (22): [PMID:31664827] [10.1021/acs.jmedchem.9b01344]

695. Lee PS, Lapointe G, Madera AM, Simmons RL, Xu W, Yifru A, Tjandra M, Karur S, Rico A, Thompson K, Bojkovic J, Xie L, Uehara K, Liu A, Shu W, Bellamacina C, McKenney D, Morris L, Tonn GR, Osborne C, Benton BM, McDowell L, Fu J, Sweeney ZK..  (2018)  Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.,  61  (20): [PMID:30226381] [10.1021/acs.jmedchem.8b01287]

696. Ameryckx A, Thabault L, Pochet L, Leimanis S, Poupaert JH, Wouters J, Joris B, Van Bambeke F, Frédérick R..  (2018)  1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.,  159  [PMID:30300845] [10.1016/j.ejmech.2018.09.067]

697. Su L, Li J, Zhou Z, Huang D, Zhang Y, Pei H, Guo W, Wu H, Wang X, Liu M, Yang CG, Chen Y..  (2019)  Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.,  162  [PMID:30447433] [10.1016/j.ejmech.2018.11.016]

698. Bi F, Song D, Qin Y, Liu X, Teng Y, Zhang N, Zhang P, Zhang N, Ma S..  (2019)  Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains.,  27  (14): [PMID:31200986] [10.1016/j.bmc.2019.06.010]

699. Cheenpracha S, Pyne SG, Patrick BO, Andersen RJ, Maneerat W, Laphookhieo S..  (2019)  Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis.,  82  (8): [PMID:31318550] [10.1021/acs.jnatprod.9b00182]

700. Thanh ND, Hai DS, Ngoc Bich VT, Thu Hien PT, Ky Duyen NT, Mai NT, Dung TT, Toan VN, Kim Van HT, Dang LH, Toan DN, Thanh Van TT..  (2019)  Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities.,  167  [PMID:30784879] [10.1016/j.ejmech.2019.01.060]

701. Tague AJ, Putsathit P, Hammer KA, Wales SM, Knight DR, Riley TV, Keller PA, Pyne SG..  (2019)  Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies.,  168  [PMID:30831407] [10.1016/j.ejmech.2019.02.013]

702. Zhang W, Lun S, Liu LL, Xiao S, Duan G, Gunosewoyo H, Yang F, Tang J, Bishai WR, Yu LF..  (2019)  Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.,  62  (7): [PMID:30875203] [10.1021/acs.jmedchem.9b00010]

703. Kyei-Baffour K, Mohammad H, Seleem MN, Dai M..  (2019)  Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus.,  27  (9): [PMID:30926310] [10.1016/j.bmc.2019.03.034]

704. Tague AJ, Putsathit P, Hutton ML, Hammer KA, Wales SM, Knight DR, Riley TV, Lyras D, Keller PA, Pyne SG..  (2019)  Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model.,  170  [PMID:30901686] [10.1016/j.ejmech.2019.02.068]

705. Elsebaei MM, Mohammad H, Samir A, Abutaleb NS, Norvil AB, Michie AR, Moustafa MM, Samy H, Gowher H, Seleem MN, Mayhoub AS..  (2019)  Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.,  175  [PMID:31075608] [10.1016/j.ejmech.2019.04.063]

706. Gatadi S, Gour J, Shukla M, Kaul G, Kaul G, Dasgupta A, Madhavi YV, Chopra S, Nanduri S..  (2019)  Synthesis and evaluation of new quinazolin-4(3H)-one derivatives as potent antibacterial agents against multidrug resistant Staphylococcus aureus and Mycobacterium tuberculosis.,  175  [PMID:31096152] [10.1016/j.ejmech.2019.04.067]

707. Grzywacz D, Paduszyńska M, Norkowska M, Kamysz W, Myszka H, Liberek B..  (2019)  N-Aminoacyl and N-hydroxyacyl derivatives of diosgenyl 2-amino-2-deoxy-β-d-glucopyranoside: Synthesis, antimicrobial and hemolytic activities.,  27  (20): [PMID:31153729] [10.1016/j.bmc.2019.05.036]

708. Gao F, Wang T, Gao M, Zhang X, Liu Z, Zhao S, Lv Z, Xiao J..  (2019)  Benzofuran-isatin-imine hybrids tethered via different length alkyl linkers: Design, synthesis and in vitro evaluation of anti-tubercular and anti-bacterial activities as well as cytotoxicity.,  165  [PMID:30690301] [10.1016/j.ejmech.2019.01.042]

709. Wang X, Zeng Y, Sheng L, Larson P, Liu X, Zou X, Wang S, Guo K, Ma C, Zhang G, Cui H, Ferguson DM, Li Y, Zhang J, Aldrich CC..  (2019)  A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae.,  62  (5): [PMID:30779564] [10.1021/acs.jmedchem.8b01353]

710. Guo J, Chen B, Yu Y, Cheng B, Cheng Y, Ju Y, Gu Q, Xu J, Zhou H..  (2020)  Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping.,  187  [PMID:31821989] [10.1016/j.ejmech.2019.111941]

711. Ju Y, He L, Zhou Y, Yang T, Sun K, Song R, Yang Y, Li C, Sang Z, Bao R, Luo Y..  (2020)  Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.,  63  (6): [PMID:32031798] [10.1021/acs.jmedchem.9b01746]

712. Gatadi S, Gour J, Nanduri S..  (2019)  Natural product derived promising anti-MRSA drug leads: A review.,  27  (17): [PMID:31324564] [10.1016/j.bmc.2019.07.023]

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788. Unpublished dataset, 

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801. Yu JH, Xu XF, Hou W, Meng Y, Huang MY, Lin J, Chen WM..  (2021)  Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms.,  224  [PMID:34274830] [10.1016/j.ejmech.2021.113691]

802. Zhang N, Song D, Chen W, Zhang S, Zhang P, Zhang N, Ma S..  (2021)  Modification of 5-methylphenanthridium from benzothiazoles to indoles as potent FtsZ inhibitors: Broadening the antibacterial spectrum toward vancomycin-resistant enterococci.,  224  [PMID:34340044] [10.1016/j.ejmech.2021.113723]

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804. Hao X, Li S, Ni J, Wang G, Li F, Li Q, Chen S, Shu J, Gan M..  (2021)  Acremopeptaibols A-F, 16-Residue Peptaibols from the Sponge-Derived Acremonium sp. IMB18-086 Cultivated with Heat-Killed Pseudomonas aeruginosa.,  84  (11.0): [PMID:34781681] [10.1021/acs.jnatprod.1c00834]

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839. He T, Xu L, Hu Y, Tang X, Qu R, Zhao X, Bai H, Li L, Chen W, Luo G, Fu G, Wang W, Xia X, Zhang J..  (2022)  Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.,  65  (15.0): [PMID:35920072] [10.1021/acs.jmedchem.2c00661]

840. Mu N, Guo H, Zhang E, Yin Y, Wang W, Chen D, Wang S, Liu W..  (2022)  Mutasynthesis Generates Antibacterial Benzothiophenic-Containing Nosiheptide Analogues.,  85  (10.0): [PMID:36122372] [10.1021/acs.jnatprod.2c00273]

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846. Wu T, Salim AA, Khalil ZG, Bernhardt PV, Capon RJ..  (2022)  Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041.,  85  (6.0): [PMID:35640100] [10.1021/acs.jnatprod.2c00444]

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850. Hu Y, Li H, Qu R, He T, Tang X, Chen W, Li L, Bai H, Li C, Wang W, Fu G, Luo G, Xia X, Zhang J..  (2022)  Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo.,  65  (1.0): [PMID:34968054] [10.1021/acs.jmedchem.1c01754]

851. Lohan S, Mandal D, Choi W, Konshina AG, Tiwari RK, Efremov RG, Maslennikov I, Parang K..  (2022)  Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.,  65  (1.0): [PMID:34978443] [10.1021/acs.jmedchem.1c01782]

852. Wang X, Qiu H, Yang N, Xie H, Liang W, Lin J, Zhu H, Zhou Y, Wang N, Tan X, Zhou J, Cui W, Teng D, Wang J, Liang H..  (2022)  Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo.,  230  [PMID:35007859] [10.1016/j.ejmech.2021.114099]

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855. Dewangan RP, Verma DP, Verma NK, Gupta A, Pant G, Mitra K, Habib S, Ghosh JK..  (2022)  Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents.,  65  (7.0): [PMID:35297625] [10.1021/acs.jmedchem.1c01809]

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858. Xie YP, Sangaraiah N, Meng JP, Zhou CH..  (2022)  Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria.,  65  (8.0): [PMID:35389643] [10.1021/acs.jmedchem.2c00001]

859. Zha L, Xie Y, Wu C, Lei M, Lu X, Tang W, Zhang J..  (2022)  Novel benzothiazole‒urea hybrids: Design, synthesis and biological activity as potent anti-bacterial agents against MRSA.,  236  [PMID:35397402] [10.1016/j.ejmech.2022.114333]

860. Huan X, Wang Y, Peng X, Xie S, He Q, Zhang X, Lan L, Yang C..  (2022)  Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm.,  236  [PMID:35398730] [10.1016/j.ejmech.2022.114309]

861. Zhong DX, She MT, Guo XC, Zheng BX, Huang XH, Zhang YH, Ser HL, Wong WL, Sun N, Lu YJ..  (2022)  Design and synthesis of quinolinium-based derivatives targeting FtsZ for antibacterial evaluation and mechanistic study.,  236  [PMID:35421657] [10.1016/j.ejmech.2022.114360]

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Source

Source(9):

• Scientific Literature
• Clinical Candidates
• FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book)
• USP Dictionary of USAN and International Drug Names
• DrugMatrix
• TP-search Transporter Database
• Patent Bioactivity Data
• WHO Anatomical Therapeutic Chemical Classification
• IMI-CARE SARS-CoV-2 Data