1. Nordmann R, Graff P, Maurer R, Gähwiler BH.. (1985) Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP., 28 (8): [PMID:2991521] [10.1021/jm00146a024] |
2. O'Donnell JP, Johnson DA, Azzaro AJ.. (1980) (+/-)-trans-2-(Aminomethyl)cyclobutanecarboxylic acid hydrochloride: a rigid analogue of gamma-aminobutyric acid., 23 (10): [PMID:7420361] [10.1021/jm00184a017] |
3. Chebib M, Johnston GA.. (2000) GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology., 43 (8): [PMID:10780899] [10.1021/jm9904349] |
4. Krogsgaard-Larsen P, Nielsen L, Falch E, Curtis DR.. (1985) GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol., 28 (11): [PMID:2999396] [10.1021/jm00149a012] |
5. Andrews PR, Craik DJ, Martin JL.. (1984) Functional group contributions to drug-receptor interactions., 27 (12): [PMID:6094812] [10.1021/jm00378a021] |
6. Frølund B, Jørgensen AT, Tagmose L, Stensbøl TB, Vestergaard HT, Engblom C, Kristiansen U, Sanchez C, Krogsgaard-Larsen P, Liljefors T.. (2002) Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling., 45 (12): [PMID:12036354] [10.1021/jm020027o] |
7. Melikian A, Schlewer G, Chambon JP, Wermuth CG.. (1992) Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists., 35 (22): [PMID:1331456] [10.1021/jm00100a015] |
8. Sarges R, Howard HR, Koe BK, Weissman A.. (1989) A novel class of "GABAergic" agents: 1-aryl-3-(aminoalkylidene)oxindoles., 32 (2): [PMID:2536440] [10.1021/jm00122a025] |
9. Frølund B, Tagmose L, Liljefors T, Stensbøl TB, Engblom C, Kristiansen U, Krogsgaard-Larsen P.. (2000) A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology., 43 (26): [PMID:11150163] [10.1021/jm000371q] |
10. Ali FE, Bondinell WE, Dandridge PA, Frazee JS, Garvey E, Girard GR, Kaiser C, Ku TW, Lafferty JJ, Moonsammy GI.. (1985) Orally active and potent inhibitors of gamma-aminobutyric acid uptake., 28 (5): [PMID:2985785] [10.1021/jm50001a020] |
11. Kaplan JP, Raizon BM, Desarmenien M, Feltz P, Headley PM, Worms P, Lloyd KG, Bartholini G.. (1980) New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide., 23 (6): [PMID:7392039] [10.1021/jm00180a029] |
12. Berthelot P, Vaccher C, Musadad A, Flouquet N, Debaert M, Luyckx M.. (1987) Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites., 30 (4): [PMID:3031294] [10.1021/jm00387a031] |
13. Witiak DT, Tomita K, Patch RJ, Enna SJ.. (1981) Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro., 24 (7): [PMID:6268788] [10.1021/jm00139a005] |
14. Minetti P, Tinti MO, Carminati P, Castorina M, Di Cesare MA, Di Serio S, Gallo G, Ghirardi O, Giorgi F, Giorgi L, Piersanti G, Bartoccini F, Tarzia G.. (2005) 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization., 48 (22): [PMID:16250647] [10.1021/jm058018d] |
15. Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B.. (2007) 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists., 50 (17): [PMID:17655213] [10.1021/jm070447j] |
16. Kumar RJ, Chebib M, Hibbs DE, Kim HL, Johnston GA, Salam NK, Hanrahan JR.. (2008) Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships., 51 (13): [PMID:18528996] [10.1021/jm7015842] |
17. Sweetnam PM, Caldwell L, Lancaster J, Bauer C, McMillan B, Kinnier WJ, Price CH.. (1993) The role of receptor binding in drug discovery., 56 (4): [PMID:8496700] [10.1021/np50094a001] |
18. Ferraris D, Duvall B, Ko YS, Thomas AG, Rojas C, Majer P, Hashimoto K, Tsukamoto T.. (2008) Synthesis and biological evaluation of D-amino acid oxidase inhibitors., 51 (12): [PMID:18507366] [10.1021/jm800200u] |
19. PubChem BioAssay data set, |
20. PubChem BioAssay data set, |
21. PubChem BioAssay data set, |
22. Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR.. (2012) Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy., 55 (15): [PMID:22779770] [10.1021/jm300353r] |
23. Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B.. (2013) Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists., 56 (3): [PMID:23294161] [10.1021/jm301473k] |
24. Gavande N, Kim HL, Doddareddy MR, Johnston GA, Chebib M, Hanrahan JR.. (2013) Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors., 4 (4): [PMID:24900684] [10.1021/ml300476v] |
25. Nakada K, Yoshikawa M, Ide S, Suemasa A, Kawamura S, Kobayashi T, Masuda E, Ito Y, Hayakawa W, Katayama T, Yamada S, Arisawa M, Minami M, Shuto S.. (2013) Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports., 21 (17): [PMID:23886812] [10.1016/j.bmc.2013.06.063] |
26. Atkinson JG, Girard Y, Rokach J, Rooney CS, McFarlane CS, Rackham A, Share NN.. (1979) Kojic amine--a novel gamma-aminobutyric acid analogue., 22 (1): [PMID:423190] [10.1021/jm00187a022] |
27. Petersen JG, Sørensen T, Damgaard M, Nielsen B, Jensen AA, Balle T, Bergmann R, Frølund B.. (2014) Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists., 84 [PMID:25038482] [10.1016/j.ejmech.2014.07.039] |
28. Klein AB, Nittegaard-Nielsen M, Christensen JT, Al-Khawaja A, Wellendorph P. (2016) Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAAreceptors, 7 (3): [10.1039/C5MD00442J] |
29. Unpublished dataset, |
30. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
31. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
32. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
33. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
34. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
35. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |