| 1. Nielsen B, Fisker H, Ebert B, Madsen U, Curtis DR, Krogsgaard-Larsen P, Hansen JJ. (1993) Enzymatic resolution of AMPA by use of -chymotrypsin, 3 (1): [10.1016/S0960-894X(00)80102-X] |
| 2. Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P.. (2003) (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology., 46 (8): [PMID:12672235] [10.1021/jm0204441] |
| 3. Madsen U, Frydenvang K, Ebert B, Johansen TN, Brehm L, Krogsgaard-Larsen P.. (1996) N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid., 39 (1): [PMID:8568805] [10.1021/jm950393q] |
| 4. Shimamoto K, Shigeri Y, Nakajima T, Yumoto N, Yoshikawa S, Ohfune Y. (1996) Syntheses of trans-3-substituted-CCG-IV analogs and their characterization to ionotropic glutamate receptors, 6 (20): [10.1016/0960-894X(96)00436-2] |
| 5. Falch E, Brehm L, Mikkelsen I, Johansen TN, Skjaerbaek N, Nielsen B, Stensbøl TB, Ebert B, Krogsgaard-Larsen P.. (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships., 41 (14): [PMID:9651156] [10.1021/jm9801206] |
| 6. Hill RA, Wallace LJ, Miller DD, Weinstein DM, Shams G, Tai H, Layer RT, Willins D, Uretsky NJ, Danthi SN.. (1997) Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines., 40 (20): [PMID:9379437] [10.1021/jm950028z] |
| 7. Bräuner-Osborne H, Sløk FA, Skjaerbaek N, Ebert B, Sekiyama N, Nakanishi S, Krogsgaard-Larsen P.. (1996) A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid., 39 (16): [PMID:8759641] [10.1021/jm9602569] |
| 8. Johansen TN, Frydenvang K, Ebert B, Krogsgaard-Larsen P, Madsen U.. (1994) Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands., 37 (20): [PMID:7523673] [10.1021/jm00046a009] |
| 9. Jane DE, Hoo K, Kamboj R, Deverill M, Bleakman D, Mandelzys A.. (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes., 40 (22): [PMID:9357531] [10.1021/jm9702387] |
| 10. Conti P, De Amici M, De Sarro G, Stensbøl TB, Bräuner-Osborne H, Madsen U, De Micheli C.. (1998) Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity., 41 (20): [PMID:9748350] [10.1021/jm9803020] |
| 11. Conti P, De Amici M, De Sarro G, Rizzo M, Stensbøl TB, Bräuner-Osborne H, Madsen U, Toma L, De Micheli C.. (1999) Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists., 42 (20): [PMID:10514280] [10.1021/jm991081g] |
| 12. Lauridsen J, Honoré T, Krogsgaard-Larsen P.. (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors., 28 (5): [PMID:2859375] [10.1021/jm50001a022] |
| 13. Hansen JJ, Lauridsen J, Nielsen E, Krogsgaard-Larsen P.. (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid., 26 (6): [PMID:6133955] [10.1021/jm00360a021] |
| 14. Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P.. (2005) Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues., 48 (9): [PMID:15857151] [10.1021/jm050014l] |
| 15. Dolman NP, Troop HM, More JC, Alt A, Knauss JL, Nistico R, Jack S, Morley RM, Bortolotto ZA, Roberts PJ, Bleakman D, Collingridge GL, Jane DE.. (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors., 48 (24): [PMID:16302825] [10.1021/jm050584l] |
| 16. Sweetnam PM, Caldwell L, Lancaster J, Bauer C, McMillan B, Kinnier WJ, Price CH.. (1993) The role of receptor binding in drug discovery., 56 (4): [PMID:8496700] [10.1021/np50094a001] |
| 17. Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, Kastrup JS.. (2009) The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization., 52 (15): [PMID:19588945] [10.1021/jm900565c] |
| 18. Patel SA, Rajale T, O'Brien E, Burkhart DJ, Nelson JK, Twamley B, Blumenfeld A, Szabon-Watola MI, Gerdes JM, Bridges RJ, Natale NR.. (2010) Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model., 18 (1): [PMID:19932968] [10.1016/j.bmc.2009.11.001] |
| 19. Stanley NJ, Pedersen DS, Nielsen B, Kvist T, Mathiesen JM, Bräuner-Osborne H, Taylor DK, Abell AD.. (2010) 1,2,3-triazolyl amino acids as AMPA receptor ligands., 20 (24): [PMID:21036612] [10.1016/j.bmcl.2010.09.139] |
| 20. PubChem BioAssay data set, |
| 21. PubChem BioAssay data set, |
| 22. PubChem BioAssay data set, |
| 23. PubChem BioAssay data set, |
| 24. Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP.. (2010) Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid., 53 (23): [PMID:21067182] [10.1021/jm101218a] |
| 25. PubChem BioAssay data set, |
| 26. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
| 27. Sainas S, Temperini P, Farnsworth JC, Yi F, Møllerud S, Jensen AA, Nielsen B, Passoni A, Kastrup JS, Hansen KB, Boschi D, Pickering DS, Clausen RP, Lolli ML.. (2019) Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands., 62 (9): [PMID:30943028] [10.1021/acs.jmedchem.8b01986] |
| 28. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 29. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
