GELDANAMYCIN

ID: ALA278315

Max Phase: Phase

Molecular Formula: C29H40N2O9

Molecular Weight: 560.64

Molecule Type: Small molecule

Associated Items:

Representations

Synonyms (2): Geldanamycin | NSC-122750
Synonyms from Alternative Forms(2):

    Canonical SMILES:  COC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O

    Standard InChI:  InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1

    Standard InChI Key:  QTQAWLPCGQOSGP-KSRBKZBZSA-N

    Associated Targets(Human)

    Heat shock protein HSP 90-alpha 4115 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SK-BR-3 5175 Activities

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    Heat shock protein HSP90 3606 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    A2780 11979 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Cell line 371 Activities

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    HCT-116 91556 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SW-620 52400 Activities

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    HT-29 80576 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    MCF7 126967 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    K562 73714 Activities

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    LS174T 446 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    DLD-1 17511 Activities

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    A549 127892 Activities

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    H4 3266 Activities

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    Serine/threonine-protein kinase PIM1 9629 Activities

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    Serine/threonine-protein kinase PIM2 5873 Activities

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    Serine/threonine-protein kinase PIM3 4133 Activities

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    Serine/threonine-protein kinase GAK 1150 Activities

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    Mitogen-activated protein kinase 6 562 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    MAP kinase p38 beta 2785 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Tyrosine-protein kinase FES 2339 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Mitogen-activated protein kinase kinase kinase 5 1965 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase MST2 3069 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 2 1640 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 10 2119 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Dual specificity mitogen-activated protein kinase kinase 6 1284 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Casein kinase I gamma 1 2496 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PLK4 1882 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PAK6 1915 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Carbonyl reductase [NADPH] 1 138 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Carbonyl reductase [NADPH] 3 42 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Heat shock protein HSP 90-beta 1689 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SH-SY5Y 11521 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Receptor-interacting serine/threonine-protein kinase 1 1548 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    A-431 6446 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    PC-3 62116 Activities

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    Cytochrome P450 2C9 32119 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Cytochrome P450 2D6 33882 Activities

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    Cytochrome P450 3A4 53859 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Liver microsomes 16955 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HERG 29587 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Hsp90 co-chaperone Cdc37 21 Activities

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    NCI-H1975 4994 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Vitamin D receptor 26531 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    78 kDa glucose-regulated protein 3319 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HeLa 62764 Activities

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    HepG2 196354 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    ATPase family AAA domain-containing protein 5 122566 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Heat shock protein 75 kDa, mitochondrial 274 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    BT-474 2113 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    LNCaP 8286 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    MDA-MB-231 73002 Activities

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    HUVEC 11049 Activities

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    SW480 6023 Activities

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    AMP-activated protein kinase, alpha-2 subunit 1328 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    CaM kinase I delta 2141 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    CaM kinase I gamma 570 Activities

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    CaM kinase II alpha 1938 Activities

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    CaM kinase II beta 1626 Activities

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    CaM kinase II delta 2813 Activities

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    CaM kinase II gamma 1752 Activities

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    CaM kinase IV 2116 Activities

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    CaM-kinase kinase beta 1281 Activities

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    Cyclin-dependent kinase 2 9050 Activities

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    Cyclin-dependent kinase 6 1724 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Cyclin-dependent kinase-like 1 420 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase Chk2 4015 Activities

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    Dual specificty protein kinase CLK1 2189 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Dual specificity protein kinase CLK2 3942 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Dual specificity protein kinase CLK3 2711 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Casein kinase I gamma 2 2539 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Casein kinase I isoform gamma-3 2408 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Death-associated protein kinase 3 2108 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Myotonin-protein kinase 927 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Glycogen synthase kinase-3 beta 11785 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Tyrosine-protein kinase JAK1 8569 Activities

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    Dual specificity mitogen-activated protein kinase kinase 2 1262 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    MAP kinase ERK1 4725 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase MST4 1915 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase NEK2 3514 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase NEK6 1986 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase OSR1 463 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PAK 4 3212 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PAK7 1760 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PCTAIRE-1 829 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    3-phosphoinositide dependent protein kinase-1 3758 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase PLK1 28605 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    cAMP-dependent protein kinase alpha-catalytic subunit 3475 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase RIO2 621 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Ribosomal protein S6 kinase alpha 3 4284 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 16 910 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 17A 1791 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 38 498 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase MST1 2643 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    TRAF2- and NCK-interacting kinase 1174 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    PDZ-binding kinase 995 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase VRK1 258 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase VRK2 740 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Inactive serine/threonine-protein kinase VRK3 156 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Serine/threonine-protein kinase 25 577 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Liver microsome 8277 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HEK293 82097 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    RPMI-8226 44974 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Bcr/Abl fusion protein 1667 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    BGC-823 3035 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    A-375 9258 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SW1990 722 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HL-60 67320 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    CNE2Z 34 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SMMC-7721 5516 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SK-OV-3 52876 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    U-87 MG 3946 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    RWPE-1 201 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    LNCaP C4-2B 271 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    CWR22R 2180 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    NCI-H446 443 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    MGC-803 6426 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Histone deacetylase 6 20808 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Lysine-specific demethylase 4B 165 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Lysine-specific demethylase 4C 1129 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Lysine-specific demethylase 5A 893 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Lysine-specific demethylase 6B 280 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HT-1080 3966 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Associated Targets(non-human)

    Mus musculus 284745 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Heat shock protein HSP 90 (HSP82) 42 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    P19 309 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Rattus norvegicus 775804 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Lepidium sativum 398 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Putative fructose-1,6-bisphosphate aldolase 15559 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Nuclear receptor ROR-gamma 89407 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Heat shock protein HSP 90 63 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Hepatitis C virus 23859 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Liver microsomes 8692 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Liver 8163 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Heat shock protein 90 beta 139 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Human immunodeficiency virus 1 70413 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    HSP90 947 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Plasmodium falciparum 966862 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    L6 7924 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    PC-12 7051 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Replicase polyprotein 1ab 11336 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    SARS-CoV-2 38078 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Staphylococcus aureus 210822 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Bacillus amyloliquefaciens 102 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Shewanella oneidensis 35 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    661W 31 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Staphylococcus 1598 Activities

    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Molecule Features

    Natural Product: NoOral: NoChemical Probe: NoParenteral: No
    Molecule Type: Small moleculeTopical: NoFirst In Class: NoBlack Box: No
    Chirality: YesAvailability: NoProdrug: No

    Drug Indications

    MESH IDMESH Heading EFO IDsEFO TermsMax Phase for IndicationReferences

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Properties

    Molecular Weight: 560.64Molecular Weight (Monoisotopic): 560.2734AlogP: 2.41#Rotatable Bonds: 4
    Polar Surface Area: 163.48Molecular Species: NEUTRALHBA: 9HBD: 3
    #RO5 Violations: 1HBA (Lipinski): 11HBD (Lipinski): 4#RO5 Violations (Lipinski): 2
    CX Acidic pKa: 12.77CX Basic pKa: CX LogP: 2.15CX LogD: 2.15
    Aromatic Rings: 0Heavy Atoms: 40QED Weighted: 0.35Np Likeness Score: 2.76

    References

    1. Kuduk SD, Zheng FF, Sepp-Lorenzino L, Rosen N, Danishefsky SJ..  (1999)  Synthesis and evaluation of geldanamycin-estradiol hybrids.,  (9): [PMID:10340605] [10.1016/s0960-894x(99)00185-7]
    2. Toogood PL..  (2002)  Inhibition of protein-protein association by small molecules: approaches and progress.,  45  (8): [PMID:11931608] [10.1021/jm010468s]
    3. Wells G, Seaton A, Stevens MF..  (2000)  Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents.,  43  (8): [PMID:10780912] [10.1021/jm990947f]
    4. Kasuya Y, Lu Z, Kopecková P, Kopecek J..  (2001)  Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.,  11  (16): [PMID:11514145] [10.1016/s0960-894x(01)00374-2]
    5. Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH..  (1999)  Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.,  42  (2): [PMID:9925731] [10.1021/jm980403y]
    6. Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, Moyer JD, DiOrio CI, Barbacci EG..  (1995)  Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.,  38  (19): [PMID:7562911] [10.1021/jm00019a010]
    7. Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, DiOrio CI, Barbacci EG, Miller PE..  (1995)  erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships.,  38  (19): [PMID:7562912] [10.1021/jm00019a011]
    8. Kreusch A, Han S, Brinker A, Zhou V, Choi HS, He Y, Lesley SA, Caldwell J, Gu XJ..  (2005)  Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.,  15  (5): [PMID:15713410] [10.1016/j.bmcl.2004.12.087]
    9. Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P..  (2005)  The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.,  15  (14): [PMID:15955698] [10.1016/j.bmcl.2005.05.046]
    10. Cheng H, Cao X, Xian M, Fang L, Cai TB, Ji JJ, Tunac JB, Sun D, Wang PG..  (2005)  Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.,  48  (2): [PMID:15658879] [10.1021/jm049693a]
    11. Chiosis G, Aguirre J, Nicchitta CV..  (2006)  Synthesis of Hsp90 dimerization modulators.,  16  (13): [PMID:16621545] [10.1016/j.bmcl.2006.03.092]
    12. Fang L, Battisti RF, Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW, Wang PG, Sun D..  (2006)  Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.,  49  (21): [PMID:17034135] [10.1021/jm060647f]
    13. Ansar S, Burlison JA, Hadden MK, Yu XM, Desino KE, Bean J, Neckers L, Audus KL, Michaelis ML, Blagg BS..  (2007)  A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.,  17  (7): [PMID:17276679] [10.1016/j.bmcl.2007.01.017]
    14. Tadtong S, Meksuriyen D, Tanasupawat S, Isobe M, Suwanborirux K..  (2007)  Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons.,  17  (10): [PMID:17442565] [10.1016/j.bmcl.2006.12.041]
    15. Park H, Kim YJ, Hahn JS..  (2007)  A novel class of Hsp90 inhibitors isolated by structure-based virtual screening.,  17  (22): [PMID:17869098] [10.1016/j.bmcl.2007.08.069]
    16. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS..  (2007)  Derrubone, an inhibitor of the Hsp90 protein folding machinery.,  70  (12): [PMID:18020309] [10.1021/np070190s]
    17. Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F..  (2008)  Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.,  51  (3): [PMID:18197612] [10.1021/jm701385c]
    18. Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M..  (2008)  Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.,  18  (5): [PMID:18243703] [10.1016/j.bmcl.2008.01.072]
    19. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J..  (2007)  Small molecule regulators of autophagy identified by an image-based high-throughput screen.,  104  (48): [PMID:18024584] [10.1073/pnas.0709695104]
    20. Heisey RM, Putnam AR..  (1986)  Herbicidal effects of geldanamycin and nigericin, antibiotics from Streptomyces hygroscopicus.,  49  (5): [PMID:3819734] [10.1021/np50047a016]
    21. Zimmermann TJ, Niesen FH, Pilka ES, Knapp S, Oppermann U, Maier ME..  (2009)  Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.,  17  (2): [PMID:19097799] [10.1016/j.bmc.2008.11.076]
    22. Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y..  (2009)  Potent cytotoxic C-11 modified geldanamycin analogues.,  52  (10): [PMID:19405528] [10.1021/jm900098v]
    23. Brandt GE, Schmidt MD, Prisinzano TE, Blagg BS..  (2008)  Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.,  51  (20): [PMID:18816111] [10.1021/jm8007486]
    24. Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ..  (2008)  Molecular characterization of macbecin as an Hsp90 inhibitor.,  51  (9): [PMID:18357975] [10.1021/jm701558c]
    25. Taldone T, Sun W, Chiosis G..  (2009)  Discovery and development of heat shock protein 90 inhibitors.,  17  (6): [PMID:19017562] [10.1016/j.bmc.2008.10.087]
    26. Lu Y, Ansar S, Michaelis ML, Blagg BS..  (2009)  Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.,  17  (4): [PMID:19138859] [10.1016/j.bmc.2008.12.047]
    27. Hong TJ, Park H, Kim YJ, Jeong JH, Hahn JS..  (2009)  Identification of new Hsp90 inhibitors by structure-based virtual screening.,  19  (16): [PMID:19560353] [10.1016/j.bmcl.2009.06.040]
    28. Jadhav VD, Duerfeldt AS, Blagg BS..  (2009)  Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors.,  19  (24): [PMID:19896848] [10.1016/j.bmcl.2009.10.091]
    29. Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC..  (2010)  Heat shock protein 90: inhibitors in clinical trials.,  53  (1): [PMID:20055425] [10.1021/jm9004708]
    30. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J..  (2008)  Identification of RIP1 kinase as a specific cellular target of necrostatins.,  (5): [PMID:18408713] [10.1038/nchembio.83]
    31. Musso L, Dallavalle S, Merlini L, Bava A, Nasini G, Penco S, Giannini G, Giommarelli C, De Cesare A, Zuco V, Vesci L, Pisano C, Castorina M, Milazzo F, Cervoni ML, Dal Piaz F, De Tommasi N, Zunino F..  (2010)  Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.,  18  (16): [PMID:20655237] [10.1016/j.bmc.2010.06.068]
    32. MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK..  (2006)  Identifying off-target effects and hidden phenotypes of drugs in human cells.,  (6): [PMID:16680159] [10.1038/nchembio790]
    33. PubChem BioAssay data set, 
    34. Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS..  (2011)  A systematic protocol for the characterization of Hsp90 modulators.,  19  (1): [PMID:21129982] [10.1016/j.bmc.2010.10.029]
    35. Flint M, Mullen S, Deatly AM, Chen W, Miller LZ, Ralston R, Broom C, Emini EA, Howe AY..  (2009)  Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034).,  53  (2): [PMID:18936191] [10.1128/aac.01081-08]
    36. Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A..  (2010)  Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.,  23  (1): [PMID:20014752] [10.1021/tx900326k]
    37. Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Ingalls C, Sutherland AG, Sonye JP, Eid CN, Golas J, Liu H, Boschelli F, Hu Y, Vogan E, Levin JI..  (2011)  Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.,  21  (8): [PMID:21420297] [10.1016/j.bmcl.2011.02.101]
    38. Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS..  (2011)  Identification and initial SAR of silybin: an Hsp90 inhibitor.,  21  (9): [PMID:21273068] [10.1016/j.bmcl.2010.12.088]
    39. Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI..  (2011)  Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.,  21  (12): [PMID:21605975] [10.1016/j.bmcl.2011.04.102]
    40. Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL..  (2011)  Gambogic acid, a natural product inhibitor of Hsp90.,  74  (5): [PMID:21486005] [10.1021/np200029q]
    41. Zapf CW, Bloom JD, Li Z, Dushin RG, Nittoli T, Otteng M, Nikitenko A, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Olland A, Johnson M, Levin JI..  (2011)  Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.,  21  (15): [PMID:21715165] [10.1016/j.bmcl.2011.05.102]
    42. Kusuma BR, Peterson LB, Zhao H, Vielhauer G, Holzbeierlein J, Blagg BS..  (2011)  Targeting the heat shock protein 90 dimer with dimeric inhibitors.,  54  (18): [PMID:21861487] [10.1021/jm200553w]
    43. Alexander LD, Partridge JR, Agard DA, McAlpine SR..  (2011)  A small molecule that preferentially binds the closed conformation of Hsp90.,  21  (23): [PMID:22014826] [10.1016/j.bmcl.2011.09.096]
    44. Brandt GE, Blagg BS..  (2011)  Monoenomycin: A Simplified Trienomycin A Analogue that Manifests Anticancer Activity.,  (10): [PMID:22162786] [10.1021/ml200108y]
    45. Li T, Ni S, Jia C, Wang H, Sun G, Wu L, Gan M, Shan G, He W, Lin L, Zhou H, Wang Y..  (2012)  Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.,  75  (8): [PMID:22849774] [10.1021/np3001738]
    46. PubChem BioAssay data set, 
    47. Chang DJ, An H, Kim KS, Kim HH, Jung J, Lee JM, Kim NJ, Han YT, Yun H, Lee S, Lee G, Lee S, Lee JS, Cha JH, Park JH, Park JW, Lee SC, Kim SG, Kim JH, Lee HY, Kim KW, Suh YG..  (2012)  Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.,  55  (24): [PMID:23186287] [10.1021/jm301488q]
    48. Al-Shaer MA, Taha MO.  (2012)  Rational exploration of new pyridinium-based HSP90 inhibitors tailored to thiamine structure,  21  (4): [10.1007/s00044-011-9557-9]
    49. Li S, Ni S, Wu L, Li L, Jiang B, Wang H, Sun G, Gan M, Li J, He W, Lin L, Wang Y, Bai S, Si S..  (2013)  19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997.,  76  (5): [PMID:23656556] [10.1021/np4000679]
    50. Adam Hendricks J, Hanson RN, Amolins M, Mihelcic JM, Blagg BS..  (2013)  Synthesis and preliminary evaluation steroidal antiestrogen-geldanamycin conjugates.,  23  (12): [PMID:23648180] [10.1016/j.bmcl.2013.03.116]
    51. Shaaban KA, Wang X, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS..  (2013)  Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.,  76  (9): [PMID:23947794] [10.1021/np400308w]
    52. Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G..  (2013)  Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.,  56  (17): [PMID:23965125] [10.1021/jm400619b]
    53. Gunaherath GM, Marron MT, Wijeratne EM, Whitesell L, Gunatilaka AA..  (2013)  Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.,  21  (17): [PMID:23859777] [10.1016/j.bmc.2013.06.042]
    54. Madathil MM, Khdour OM, Jaruvangsanti J, Hecht SM..  (2013)  A structurally simplified analogue of geldanamycin exhibits neuroprotective activity.,  (10): [PMID:24900591] [10.1021/ml400207m]
    55. Unpublished dataset, 
    56. Mejia EJ, Loveridge ST, Stepan G, Tsai A, Jones GS, Barnes T, White KN, Drašković M, Tenney K, Tsiang M, Geleziunas R, Cihlar T, Pagratis N, Tian Y, Yu H, Crews P..  (2014)  Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.,  77  (3): [PMID:24495105] [10.1021/np400889x]
    57. Chen CY, Yang SC, Lee KH, Yang X, Wei LY, Chow LP, Wang TC, Hong TM, Lin JC, Kuan C, Yang PC..  (2014)  The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.,  57  (3): [PMID:24428777] [10.1021/jm401686b]
    58. Wang T, Bisson WH, Mäser P, Scapozza L, Picard D..  (2014)  Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.,  57  (6): [PMID:24580531] [10.1021/jm401801t]
    59. Ren J, Li J, Wang Y, Chen W, Shen A, Liu H, Chen D, Cao D, Li Y, Zhang N, Xu Y, Geng M, He J, Xiong B, Shen J..  (2014)  Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.,  24  (11): [PMID:24751441] [10.1016/j.bmcl.2014.03.100]
    60. Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK, Ramachandran S..  (2014)  Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.,  57  (13): [PMID:24914738] [10.1021/jm500535j]
    61. Vasiljevik T, Groer CE, Lehner K, Navarro H, Prisinzano TE..  (2014)  Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.,  77  (8): [PMID:25075762] [10.1021/np5002048]
    62. Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y..  (2014)  Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.,  87  [PMID:25277067] [10.1016/j.ejmech.2014.09.078]
    63. Li Z, Jia L, Wang J, Wu X, Hao H, Xu H, Wu Y, Shi G, Lu C, Shen Y..  (2014)  Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.,  85  [PMID:25105924] [10.1016/j.ejmech.2014.07.101]
    64. Gavenonis J, Jonas NE, Kritzer JA..  (2014)  Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.,  22  (15): [PMID:24984936] [10.1016/j.bmc.2014.06.006]
    65. Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S..  (2007)  A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.,  104  (51): [PMID:18077363] [10.1073/pnas.0708800104]
    66. Zheng N, Zou P, Wang S, Sun D..  (2011)  In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes.,  39  (4): [PMID:21177985] [10.1124/dmd.110.036418]
    67. Hall JA, Seedarala S, Rice N, Kopel L, Halaweish F, Blagg BS..  (2015)  Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.,  78  (4): [PMID:25756299] [10.1021/acs.jnatprod.5b00054]
    68. Katane M, Kaneko Y, Watanabe M, Doi Y, Tanaka T, Kasuga Y, Yoshida N, Kumakubo S, Nakayama K, Matsuda S, Furuchi T, Saitoh Y, Sekine M, Koyama N, Tomoda H, Homma H..  (2016)  Identification and characterization of natural microbial products that alter the free d-aspartate content of mammalian cells.,  26  (2): [PMID:26642769] [10.1016/j.bmcl.2015.11.073]
    69. Hall JA, Seedarala S, Zhao H, Garg G, Ghosh S, Blagg BS..  (2016)  Novobiocin Analogues That Inhibit the MAPK Pathway.,  59  (3): [PMID:26745854] [10.1021/acs.jmedchem.5b01354]
    70. Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS..  (2016)  Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.,  59  (7): [PMID:27003516] [10.1021/acs.jmedchem.6b00085]
    71. Qu S, Mulamoottil VA, Nayak A, Ryu S, Hou X, Song J, Yu J, Sahu PK, Zhao LX, Choi S, Lee SK, Jeong LS..  (2016)  Design, synthesis, and anticancer activity of C8-substituted-4'-thionucleosides as potential HSP90 inhibitors.,  24  (16): [PMID:27283788] [10.1016/j.bmc.2016.05.041]
    72. Liang C, Hao H, Wu X, Li Z, Zhu J, Lu C, Shen Y..  (2016)  Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors.,  121  [PMID:27266997] [10.1016/j.ejmech.2016.05.033]
    73. Jiaranaikulwanitch J, Tadtong S, Govitrapong P, Fokin VV, Vajragupta O..  (2017)  Neuritogenic activity of bi-functional bis-tryptoline triazole.,  25  (3): [PMID:28043778] [10.1016/j.bmc.2016.12.027]
    74. Jeong JH, Oh YJ, Lho Y, Park SY, Liu KH, Ha E, Seo YH..  (2016)  Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.,  124  [PMID:27783977] [10.1016/j.ejmech.2016.10.038]
    75. Khandelwal A, Crowley VM, Blagg BSJ..  (2017)  Resorcinol-Based Grp94-Selective Inhibitors.,  (10): [PMID:29057043] [10.1021/acsmedchemlett.7b00193]
    76. Liang C, Wu X, Li Z, Zhu J, Lu C, Shen Y..  (2018)  Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors.,  143  [PMID:29172085] [10.1016/j.ejmech.2017.11.013]
    77.  (2016)  (11): [10.1039/C6MD00340K]
    78. Jin L, Huang R, Huang X, Zhang B, Ji M, Wang H..  (2018)  Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.,  26  (8): [PMID:29486954] [10.1016/j.bmc.2018.02.021]
    79. Yao L, Ohlson S, Dymock BW..  (2018)  Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).,  28  (8): [PMID:29545103] [10.1016/j.bmcl.2018.03.009]
    80. Park SY, Oh YJ, Lho Y, Jeong JH, Liu KH, Song J, Kim SH, Ha E, Seo YH..  (2018)  Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors.,  143  [PMID:29202402] [10.1016/j.ejmech.2017.11.054]
    81. Unpublished dataset, 
    82. Zhang Z, Banerjee M, Davis RE, Blagg BSJ..  (2019)  Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity.,  29  (22): [PMID:31591016] [10.1016/j.bmcl.2019.126676]
    83. Egbert M, Whitty A, Keserű GM, Vajda S..  (2019)  Why Some Targets Benefit from beyond Rule of Five Drugs.,  62  (22): [PMID:31188592] [10.1021/acs.jmedchem.8b01732]
    84. Wang M, Shen A, Zhang C, Song Z, Ai J, Liu H, Sun L, Ding J, Geng M, Zhang A..  (2016)  Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.,  59  (12): [PMID:26844689] [10.1021/acs.jmedchem.5b01106]
    85. Zhang Z, Xue N, Bian C, Yan R, Jin L, Chen X, Yu X..  (2016)  C15-methoxyphenylated 18-deoxy-herbimycin A analogues, their in vitro anticancer activity and heat shock protein 90 binding affinity.,  26  (17): [PMID:27476419] [10.1016/j.bmcl.2016.07.040]
    86. Wang T, Mäser P, Picard D..  (2016)  Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.,  59  (13): [PMID:27312008] [10.1021/acs.jmedchem.6b00591]
    87. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani.  (2020)  Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen,  [10.6019/CHEMBL4495564]
    88. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen.  (2020)  Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort,  [10.6019/CHEMBL4495565]
    89. Miura K, Matsuki W, Ogura A, Takao KI, Simizu S..  (2020)  Identification of vibsanin A analog as a novel HSP90 inhibitor.,  28  (2): [PMID:31859027] [10.1016/j.bmc.2019.115253]
    90. Nong XH, Tu ZC, Qi SH..  (2020)  Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.,  30  (11): [PMID:32273216] [10.1016/j.bmcl.2020.127168]
    91. Li HM, Li B, Sun X, Ma H, Zhu M, Dai Y, Ma T, Li Y, Hong YS, Wu CZ..  (2020)  Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents.,  30  (15): [PMID:32527461] [10.1016/j.bmcl.2020.127282]
    92. Mishra SJ,Liu W,Beebe K,Banerjee M,Kent CN,Munthali V,Koren J,Taylor JA,Neckers LM,Holzbeierlein J,Blagg BSJ.  (2021)  The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.,  64  (3.0): [PMID:33428418] [10.1021/acs.jmedchem.0c01700]
    93. Nguyen CT,Ann J,Sahu R,Byun WS,Lee S,Nam G,Park HJ,Park S,Kim YJ,Kim JY,Seo JH,Lee J.  (2020)  Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).,  30  (17): [PMID:32738983] [10.1016/j.bmcl.2020.127374]
    94. Skrzypczak N,Pyta K,Ruszkowski P,Gdaniec M,Bartl F,Przybylski P.  (2020)  Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.,  202  [PMID:32663707] [10.1016/j.ejmech.2020.112624]
    95. Xie Y, Guo L, Huang J, Huang X, Cong Z, Liu Q, Wang Q, Pang X, Xiang S, Zhou X, Liu Y, Wang J, Wang J..  (2021)  Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from Streptomyces malaysiensis as Potential Anti-Androgens against Prostate Cancer Cells.,  84  (7.0): [PMID:34225450] [10.1021/acs.jnatprod.1c00297]
    96. Nguyen CT, Thanh La M, Ann J, Nam G, Park HJ, Min Park J, Kim YJ, Young Kim J, Hong Seo J, Lee J..  (2021)  Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer.,  45  [PMID:34044120] [10.1016/j.bmcl.2021.128134]
    97. Liu YM, Tu HJ, Wu CH, Lai MJ, Yu SC, Chao MW, Wu YW, Teng CM, Pan SL, Liou JP..  (2021)  Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.,  219  [PMID:33934008] [10.1016/j.ejmech.2021.113428]
    98. Patel OPS, Beteck RM, Legoabe LJ..  (2021)  Antimalarial application of quinones: A recent update.,  210  [PMID:33333397] [10.1016/j.ejmech.2020.113084]
    99. Chae HY, Park SY, Jha S, Gupta SK, Kim M, Ha E, Seo YH..  (2022)  Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay.,  240  [PMID:35834905] [10.1016/j.ejmech.2022.114582]
    100. Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J..  (2022)  Recent Advances with KDM4 Inhibitors and Potential Applications.,  65  (14.0): [PMID:35838529] [10.1021/acs.jmedchem.2c00680]
    101. Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao KI, Simizu S..  (2022)  Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor.,  60  [PMID:35093502] [10.1016/j.bmcl.2022.128589]
    102. Choi JW, Lee Y, Kim J, Kwon H, Deyrup ST, Lee JW, Lee D, Kang HS, Joo H, Shim SH..  (2023)  Discovery of Bioactive Metabolites by Acidic Stress to a Geldanamycin Producer, Streptomyces samsunensis.,  86  (4): [PMID:37042709] [10.1021/acs.jnatprod.2c01151]