1. Gangjee A, Devraj R, McGuire JJ, Kisliuk RL, Queener SF, Barrows LR.. (1994) Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities., 37 (8): [PMID:8164259] [10.1021/jm00034a015] |
2. Gangjee A, Elzein E, Queener SF, McGuire JJ.. (1998) Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases., 41 (9): [PMID:9554874] [10.1021/jm9705420] |
3. Gangjee, A A and 5 more authors. 1994-04-15 Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. [PMID:8164259] |
4. Tarnchompoo, Bongkoch B and 8 more authors. 2002-03-14 Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. [PMID:11881993] |
5. Santos, M Amélia MA and 5 more authors. 2007-02-01 Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. [PMID:17127067] |
6. Thurmond, John J and 17 more authors. 2008-02-14 Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. [PMID:18205293] |
7. Gangjee, Aleem; Jain, Hiteshkumar D; Queener, Sherry F and Kisliuk, Roy L. 2008-08-14 The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents. [PMID:18605720] |
8. Gangjee, Aleem; Qiu, Yibin; Li, Wei and Kisliuk, Roy L. 2008-09-25 Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates. [PMID:18800768] |
9. Izbicka, E and 6 more authors. 2009-10 Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers. [PMID:19221750] |
10. Gangjee, Aleem and 6 more authors. 2009-08-13 Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. [PMID:19719239] |
11. Gangjee, Aleem and 9 more authors. 2009-10-15 Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. [PMID:19748785] |
12. Gangjee, Aleem and 5 more authors. 2010-01-15 2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors. [PMID:20056546] |
13. Gangjee, Aleem and 5 more authors. 2010-02-25 Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. [PMID:20092323] |
14. Zhang, Xin X and 5 more authors. 2011-06-01 Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. [PMID:21550809] |
15. Gangjee, Aleem A and 5 more authors. 2012-07-15 Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. [PMID:22739090] |
16. Gangjee, Aleem and 5 more authors. 2013-06-13 Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles. [PMID:23627352] |
17. Cao, Sheng-Li SL and 10 more authors. 2013-06 Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. [PMID:23665106] |
18. Piras, Sandra S and 7 more authors. 2014-03-21 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. [PMID:24531230] |
19. G-Dayanandan, Narendran and 11 more authors. 2014-03-27 Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. [PMID:24568657] |
20. Chao, Bo; Li, Bingbing X and Xiao, Xiangshu. 2015-04-01 The chemistry and pharmacology of privileged pyrroloquinazolines. [PMID:25937878] |
21. Welsch, Matthew E ME and 9 more authors. 2016-12-08 Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. [PMID:27994750] |
22. Gopalsamy, Ariamala A and 18 more authors. 2017-04-13 Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). [PMID:28257199] |
23. Zaware, Nilesh N, Kisliuk, Roy R, Bastian, Anja A, Ihnat, Michael A MA and Gangjee, Aleem A. 2017-04-01 Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. [PMID:28258797] |
24. Tonelli, Michele M and 8 more authors. 2017-07-28 Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus. [PMID:28477572] |
25. Shah, Khushbu and 5 more authors. 2018-05-15 Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. [PMID:29691153] |
26. Francesconi, Valeria V and 7 more authors. 2018-07-15 Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR). [PMID:29886325] |
27. Hopper, Allen T and 8 more authors. 2019-02-14 Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. [PMID:30624926] |
28. Sharma, Kalicharan K and 8 more authors. 2019-04-01 Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents. [PMID:30827867] |