| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ID: ALA279275
Max Phase: Preclinical
Molecular Formula: C22H14ClN3O3S
Molecular Weight: 435.89
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: O=C(O)Cc1nn(Cc2nc3c(ccc4ccccc43)s2)c(=O)c2ccc(Cl)cc12
Standard InChI: InChI=1S/C22H14ClN3O3S/c23-13-6-7-15-16(9-13)17(10-20(27)28)25-26(22(15)29)11-19-24-21-14-4-2-1-3-12(14)5-8-18(21)30-19/h1-9H,10-11H2,(H,27,28)
Standard InChI Key: QNAYWPPENIEFMQ-UHFFFAOYSA-N
Associated Targets(Human)
Aldose reductase 1404 Activities
Associated Targets(non-human)
Sorbitol dehydrogenase 84 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Properties
| Molecular Weight: 435.89 | Molecular Weight (Monoisotopic): 435.0444 | AlogP: 4.49 | #Rotatable Bonds: 4 |
| Polar Surface Area: 85.08 | Molecular Species: ACID | HBA: 6 | HBD: 1 |
| #RO5 Violations: 0 | HBA (Lipinski): 6 | HBD (Lipinski): 1 | #RO5 Violations (Lipinski): 0 |
| CX Acidic pKa: 4.10 | CX Basic pKa: 2.17 | CX LogP: 4.39 | CX LogD: 1.38 |
| Aromatic Rings: 5 | Heavy Atoms: 30 | QED Weighted: 0.45 | Np Likeness Score: -1.49 |
References
| 1. Mylari BL, Larson ER, Beyer TA, Zembrowski WJ, Aldinger CE, Dee MF, Siegel TW, Singleton DH.. (1991) Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners., 34 (1): [PMID:1899452] [10.1021/jm00105a018] |
Source
Source(1):